Variant ID: 11-116652423-G-C

NM_003904.3(ZPR1):c.1179+451C>G

This variant was identified in 62 publications




Publications:


Genome-wide association study of metabolic syndrome in Korean populations.

Plos One
SW Oh, JE Lee, E Shin, H Kwon, EK Choe, SY Choi, H Rhee, SH Choi
Publication Date: 2020

Variant appearance in text: rs6589566
PubMed Link: 31910446
Variant Present in the following documents:
  • Main text
View BVdb publication page



Progressive effects of single-nucleotide polymorphisms on 16 phenotypic traits based on longitudinal data.

Genes & Genomics
D Li, H Kang, S Lee, S Won
Publication Date: 2020-04

Variant appearance in text: rs6589566
PubMed Link: 31902109
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride.

Oxidative Medicine And Cellular Longevity
HS Lee, S Leem, B Oh, T Park
Publication Date: 2019

Variant appearance in text: rs6589566
PubMed Link: 30931082
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population.

Human Genomics
S Moon, Y Lee, S Won, J Lee
Publication Date: 2018-11-01

Variant appearance in text: rs6589566
PubMed Link: 30382898
Variant Present in the following documents:
  • 40246_2018_180_MOESM1_ESM.pdf
  • aaaaaMain text
View BVdb publication page



Genetic and secondary causes of severe HDL deficiency and cardiovascular disease.

Journal Of Lipid Research
AS Geller, EY Polisecki, MR Diffenderfer, BF Asztalos, SK Karathanasis, RA Hegele, EJ Schaefer
Publication Date: 2018-12

Variant appearance in text: rs6589566
PubMed Link: 30333156
Variant Present in the following documents:
  • Main text
  • jlrM088203.pdf
View BVdb publication page



New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population.

Scientific Reports
HS Lee, Y Kim, T Park
Publication Date: 2018-04-09

Variant appearance in text: rs6589566
PubMed Link: 29632305
Variant Present in the following documents:
  • 41598_2018_23074_MOESM1_ESM.docx
  • aaaaaMain text
View BVdb publication page



Prediction of cholesterol ratios within a Korean population.

Royal Society Open Science
JS Lee, HS Cheong, HD Shin
Publication Date: 2018-01

Variant appearance in text: rs6589566
PubMed Link: 29410832
Variant Present in the following documents:
  • Main text
  • rsos171204supp1.docx
View BVdb publication page



Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

Plos Genetics
JP Davis, JR Huyghe, AE Locke, AU Jackson, X Sim, HM Stringham, TM Teslovich, RP Welch, C Fuchsberger, N Narisu, PS Chines, AJ Kangas, P Soininen, M Ala-Korpela, J Kuusisto, FS Collins, M Laakso, M Boehnke, KL Mohlke
Publication Date: 2017-10

Variant appearance in text: rs6589566
PubMed Link: 29084231
Variant Present in the following documents:
  • pgen.1007079.s010.xlsx
View BVdb publication page



Quantitative trait loci at the 11q23.3 chromosomal region related to dyslipidemia in the population of Andhra Pradesh, India.

Lipids In Health And Disease
R Pranavchand, BM Reddy
Publication Date: 2017-06-13

Variant appearance in text: rs6589566
PubMed Link: 28610615
Variant Present in the following documents:
  • 12944_2017_507_MOESM2_ESM.docx
  • 12944_2017_507_MOESM3_ESM.docx
  • 12944_2017_507_MOESM4_ESM.docx
  • 12944_2017_507_MOESM5_ESM.docx
  • aaaaaMain text
View BVdb publication page



Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.

Nature Communications
L Southam, A Gilly, D Süveges, AE Farmaki, J Schwartzentruber, I Tachmazidou, A Matchan, NW Rayner, E Tsafantakis, M Karaleftheri, Y Xue, G Dedoussis, E Zeggini
Publication Date: 2017-05-26

Variant appearance in text: rs6589566
PubMed Link: 28548082
Variant Present in the following documents:
  • ncomms15606-s1.pdf
View BVdb publication page



The impact of rare and low-frequency genetic variants in common disease.

Genome Biology
L Bomba, K Walter, N Soranzo
Publication Date: 2017-04-27

Variant appearance in text: rs6589566
PubMed Link: 28449691
Variant Present in the following documents:
  • 13059_2017_1212_MOESM1_ESM.xlsx
View BVdb publication page



Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.

Journal Of Cellular And Molecular Medicine
Y Zhu, D Zhang, D Zhou, Z Li, Z Li, L Fang, M Yang, Z Shan, H Li, J Chen, X Zhou, W Ye, S Yu, H Li, L Cai, C Liu, J Zhang, L Wang, Y Lai, L Ruan, Z Sun, S Zhang, H Wang, Y Liu, Y Xu, J Ling, C Xu, Y Zhang, D Lv, Z Yuan, J Zhang, Y Zhang, Y Shi, M Lai
Publication Date: 2017-06

Variant appearance in text: rs6589566
PubMed Link: 28371326
Variant Present in the following documents:
  • JCMM-21-1106-s002.xlsx
View BVdb publication page



Genetic determinants of clinical heterogeneity of the coronary artery disease in the population of Hyderabad, India.

Human Genomics
R Pranavchand, AS Kumar, BM Reddy
Publication Date: 2017-03-04

Variant appearance in text: rs6589566
PubMed Link: 28257648
Variant Present in the following documents:
  • 40246_2017_99_MOESM3_ESM.docx
  • 40246_2017_99_MOESM4_ESM.docx
  • aaaaaMain text
View BVdb publication page



Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.

Plos One
EJ Parra, A Mazurek, CR Gignoux, A Sockell, M Agostino, AP Morris, LE Petty, CL Hanis, NJ Cox, A Valladares-Salgado, JE Below, M Cruz
Publication Date: 2017

Variant appearance in text: rs6589566
PubMed Link: 28245265
Variant Present in the following documents:
  • pone.0172880.s002.xlsx
View BVdb publication page



Combinatorial bZIP dimers display complex DNA-binding specificity landscapes.

Elife
JA Rodríguez-Martínez, AW Reinke, D Bhimsaria, AE Keating, AZ Ansari
Publication Date: 2017-02-10

Variant appearance in text: rs6589566
PubMed Link: 28186491
Variant Present in the following documents:
  • elife-19272-supp1.xlsx
View BVdb publication page



Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202.

Pharmacogenetics And Genomics
A Verma, Y Bradford, SS Verma, SA Pendergrass, ES Daar, C Venuto, GD Morse, MD Ritchie, DW Haas
Publication Date: 2017-03

Variant appearance in text: rs6589566
PubMed Link: 28099408
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-Wide Association Study Reveals Four Loci for Lipid Ratios in the Korean Population and the Constitutional Subgroup.

Plos One
T Kim, AY Park, Y Baek, S Cha
Publication Date: 2017

Variant appearance in text: rs6589566
PubMed Link: 28046027
Variant Present in the following documents:
  • Main text
View BVdb publication page



Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.

International Journal Of Epidemiology
TV Varga, A Kurbasic, M Aine, P Eriksson, A Ali, G Hindy, S Gustafsson, J Luan, D Shungin, Y Chen, CA Schulz, PM Nilsson, G Hallmans, I Barroso, P Deloukas, C Langenberg, RA Scott, NJ Wareham, L Lind, E Ingelsson, O Melander, M Orho-Melander, F Renström, PW Franks
Publication Date: 2017-08-01

Variant appearance in text: rs6589566
PubMed Link: 27864399
Variant Present in the following documents:
  • dyw245_supplementary_method_2.docx
  • dyw245_supplementary_table_7.xlsx
View BVdb publication page



Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population.

Scientific Reports
E Lin, PH Kuo, YL Liu, AC Yang, CF Kao, SJ Tsai
Publication Date: 2016-11-09

Variant appearance in text: rs6589566
PubMed Link: 27827461
Variant Present in the following documents:
  • srep36830-s1.pdf
View BVdb publication page



Two-stage association study to identify the genetic susceptibility of a novel common variant of rs2075290 in ZPR1 to type 2 diabetes.

Scientific Reports
F Guan, Y Niu, T Zhang, S Liu, L Ma, T Qi, J Feng, H Zuo, G Li, X Liu, S Wang
Publication Date: 2016-07-14

Variant appearance in text: rs6589566
PubMed Link: 27411854
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits.

Plos One
P Volkov, AH Olsson, L Gillberg, SW Jørgensen, C Brøns, KF Eriksson, L Groop, PA Jansson, E Nilsson, T Rönn, A Vaag, C Ling
Publication Date: 2016

Variant appearance in text: rs6589566
PubMed Link: 27322064
Variant Present in the following documents:
  • pone.0157776.s004.xlsx
View BVdb publication page



Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India.

Plos One
R Pranav Chand, AS Kumar, K Anuj, S Vishnupriya, B Mohan Reddy
Publication Date: 2016

Variant appearance in text: rs6589566
PubMed Link: 27257688
Variant Present in the following documents:
  • Main text
  • pone.0153720.s002.docx
  • pone.0153720.s003.xlsx
  • pone.0153720.s004.docx
  • pone.0153720.s006.docx
View BVdb publication page



Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.

Scientific Reports
JE Below, EJ Parra, ER Gamazon, J Torres, S Krithika, S Candille, Y Lu, A Manichakul, J Peralta-Romero, Q Duan, Y Li, AP Morris, O Gottesman, E Bottinger, XQ Wang, KD Taylor, YD Ida Chen, JI Rotter, SS Rich, RJ Loos, H Tang, NJ Cox, M Cruz, CL Hanis, A Valladares-Salgado
Publication Date: 2016-01-19

Variant appearance in text: rs6589566
PubMed Link: 26780889
Variant Present in the following documents:
  • srep19429-s3.xls
View BVdb publication page



Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.

Plos One
Q Fu, X Tang, J Chen, L Su, M Zhang, L Wang, J Jing, L Zhou
Publication Date: 2015

Variant appearance in text: rs6589566
PubMed Link: 26397108
Variant Present in the following documents:
  • Main text
  • pone.0138652.s001.doc
View BVdb publication page



Evaluation of transethnic fine mapping with population-specific and cosmopolitan imputation reference panels in diverse Asian populations.

European Journal Of Human Genetics : Ejhg
X Wang, CY Cheng, J Liao, X Sim, J Liu, KS Chia, ES Tai, P Little, CC Khor, T Aung, TY Wong, YY Teo
Publication Date: 2016-04

Variant appearance in text: rs6589566
PubMed Link: 26130488
Variant Present in the following documents:
  • ejhg2015150x4.xls
View BVdb publication page



Networks in Coronary Heart Disease Genetics As a Step towards Systems Epidemiology.

Plos One
F Drenos, E Grossi, M Buscema, SE Humphries
Publication Date: 2015

Variant appearance in text: rs6589566
PubMed Link: 25951190
Variant Present in the following documents:
  • Main text
  • pone.0125876.s006.xlsx
  • pone.0125876.s007.xlsx
  • pone.0125876.s008.xlsx
View BVdb publication page



Genome-wide association study of metabolic syndrome in koreans.

Genomics & Informatics
SW Jeong, M Chung, SJ Park, SB Cho, KW Hong
Publication Date: 2014-12

Variant appearance in text: rs6589566
PubMed Link: 25705157
Variant Present in the following documents:
  • Main text
  • gni-12-187-s001.pdf
View BVdb publication page



Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population.

Meta Gene
I Radovica, D Fridmanis, I Silamikelis, L Nikitina-Zake, J Klovins
Publication Date: 2014-12

Variant appearance in text: rs6589566
PubMed Link: 25606439
Variant Present in the following documents:
  • mmc1.docx
View BVdb publication page



On the analysis of a repeated measure design in genome-wide association analysis.

International Journal Of Environmental Research And Public Health
Y Lee, S Park, S Moon, J Lee, RC Elston, W Lee, S Won
Publication Date: 2014-11-28

Variant appearance in text: rs6589566
PubMed Link: 25464127
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans.

Bmc Complementary And Alternative Medicine
SK Chung, H Yu, AY Park, JY Kim, S Cha
Publication Date: 2014-07-09

Variant appearance in text: rs6589566
PubMed Link: 25005712
Variant Present in the following documents:
  • 1472-6882-14-230-S1.xls
  • aaaaaMain text
View BVdb publication page



Association between the MLX interacting protein-like, BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels.

Scientific Reports
LH Aung, RX Yin, JZ Wu, DF Wu, W Wang, H Li
Publication Date: 2014-07-03

Variant appearance in text: rs6589566
PubMed Link: 24989072
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.

Circulation. Cardiovascular Genetics
JM Kocarnik, SA Pendergrass, CL Carty, JS Pankow, FR Schumacher, I Cheng, P Durda, JL Ambite, E Deelman, NR Cook, S Liu, J Wactawski-Wende, C Hutter, K Brown-Gentry, S Wilson, LG Best, N Pankratz, CP Hong, SA Cole, VS Voruganti, P Bůžkova, NW Jorgensen, NS Jenny, LR Wilkens, CA Haiman, LN Kolonel, A Lacroix, K North, R Jackson, L Le Marchand, LA Hindorff, DC Crawford, M Gross, U Peters
Publication Date: 2014-04

Variant appearance in text: rs6589566
PubMed Link: 24622110
Variant Present in the following documents:
  • NIHMS575195-supplement-000173_-_Supplemental_Material.pdf
View BVdb publication page



Effects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans.

Lipids In Health And Disease
S Cha, H Yu, AY Park, KH Song
Publication Date: 2014-03-12

Variant appearance in text: rs6589566
PubMed Link: 24618354
Variant Present in the following documents:
  • 1476-511X-13-45-S2.xls
  • aaaaaMain text
View BVdb publication page



ChIP-seq in steatohepatitis and normal liver tissue identifies candidate disease mechanisms related to progression to cancer.

Bmc Medical Genomics
M Bysani, O Wallerman, S Bornelöv, K Zatloukal, J Komorowski, C Wadelius
Publication Date: 2013-11-08

Variant appearance in text: rs6589566
PubMed Link: 24206787
Variant Present in the following documents:
  • 1755-8794-6-50-S2.docx
View BVdb publication page



Properties of local interactions and their potential value in complementing genome-wide association studies.

Plos One
W Wei, A Gyenesei, CA Semple, CS Haley
Publication Date: 2013

Variant appearance in text: rs6589566
PubMed Link: 23940718
Variant Present in the following documents:
  • pone.0071203.s003.xlsx
View BVdb publication page



Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study.

Cardiovascular Diabetology
LM Raffield, AJ Cox, FC Hsu, MC Ng, CD Langefeld, JJ Carr, BI Freedman, DW Bowden
Publication Date: 2013-06-25

Variant appearance in text: rs6589566
PubMed Link: 23799899
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.

American Journal Of Human Genetics
MA Coram, Q Duan, TJ Hoffmann, T Thornton, JW Knowles, NA Johnson, HM Ochs-Balcom, TA Donlon, LW Martin, CB Eaton, JG Robinson, NJ Risch, X Zhu, C Kooperberg, Y Li, AP Reiner, H Tang
Publication Date: 2013-06-06

Variant appearance in text: rs6589566
PubMed Link: 23726366
Variant Present in the following documents:
  • Main text
View BVdb publication page



The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.

Plos One
I Radovica, D Fridmanis, I Vaivade, L Nikitina-Zake, J Klovins
Publication Date: 2013

Variant appearance in text: rs6589566
PubMed Link: 23675527
Variant Present in the following documents:
  • Main text
  • pone.0064191.s002.docx
View BVdb publication page



Improvement in prediction of coronary heart disease risk over conventional risk factors using SNPs identified in genome-wide association studies.

Plos One
JL Bolton, MC Stewart, JF Wilson, N Anderson, JF Price
Publication Date: 2013

Variant appearance in text: rs6589566
PubMed Link: 23468967
Variant Present in the following documents:
  • pone.0057310.s005.pdf
View BVdb publication page



Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.

Cardiovascular Diabetology
CM Povel, JM Boer, NC Onland-Moret, ME Dollé, EJ Feskens, YT van der Schouw
Publication Date: 2012-10-29

Variant appearance in text: rs6589566
PubMed Link: 23101478
Variant Present in the following documents:
  • Main text
View BVdb publication page



Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

American Journal Of Human Genetics
FW Asselbergs, Y Guo, EP van Iperen, S Sivapalaratnam, V Tragante, MB Lanktree, LA Lange, B Almoguera, YE Appelman, J Barnard, J Baumert, AL Beitelshees, TR Bhangale, YD Chen, TR Gaunt, Y Gong, JC Hopewell, T Johnson, ME Kleber, TY Langaee, M Li, YR Li, K Liu, CW McDonough, MF Meijs, RP Middelberg, K Musunuru, CP Nelson, JR O'Connell, S Padmanabhan, JS Pankow, N Pankratz, S Rafelt, R Rajagopalan, SP Romaine, NJ Schork, J Shaffer, H Shen, EN Smith, SE Tischfield, PJ van der Most, JV van Vliet-Ostaptchouk, N Verweij, KA Volcik, L Zhang, KR Bailey, KM Bailey, F Bauer, JM Boer, PS Braund, A Burt, PR Burton, SG Buxbaum, W Chen, RM Cooper-Dehoff, LA Cupples, JS deJong, C Delles, D Duggan, M Fornage, CE Furlong, N Glazer, JG Gums, C Hastie, MV Holmes, T Illig, SA Kirkland, M Kivimaki, R Klein, BE Klein, C Kooperberg, K Kottke-Marchant, M Kumari, AZ LaCroix, L Mallela, G Murugesan, J Ordovas, WH Ouwehand, WS Post, R Saxena, H Scharnagl, PJ Schreiner, T Shah, DC Shields, D Shimbo, SR Srinivasan, RP Stolk, DI Swerdlow, HA Taylor, EJ Topol, E Toskala, JL van Pelt, J van Setten, S Yusuf, JC Whittaker, AH Zwinderman, , SS Anand, AJ Balmforth, GS Berenson, CR Bezzina, BO Boehm, E Boerwinkle, JP Casas, MJ Caulfield, R Clarke, JM Connell, KJ Cruickshanks, KW Davidson, IN Day, PI de Bakker, PA Doevendans, AF Dominiczak, AS Hall, CA Hartman, C Hengstenberg, HL Hillege, MH Hofker, SE Humphries, GP Jarvik, JA Johnson, BM Kaess, S Kathiresan, W Koenig, DA Lawlor, W März, O Melander, BD Mitchell, GW Montgomery, PB Munroe, SS Murray, SJ Newhouse, NC Onland-Moret, N Poulter, B Psaty, S Redline, SS Rich, JI Rotter, H Schunkert, P Sever, AR Shuldiner, RL Silverstein, A Stanton, B Thorand, MD Trip, MY Tsai, P van der Harst, E van der Schoot, YT van der Schouw, WM Verschuren, H Watkins, AA Wilde, BH Wolffenbuttel, JB Whitfield, GK Hovingh, CM Ballantyne, C Wijmenga, MP Reilly, NG Martin, JG Wilson, DJ Rader, NJ Samani, AP Reiner, RA Hegele, JJ Kastelein, AD Hingorani, PJ Talmud, H Hakonarson, CC Elbers, BJ Keating, F Drenos
Publication Date: 2012-11-02

Variant appearance in text: rs6589566
PubMed Link: 23063622
Variant Present in the following documents:
  • mmc4.xls
View BVdb publication page



Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals.

Plos One
F Takeuchi, M Isono, T Katsuya, M Yokota, K Yamamoto, T Nabika, K Shimokawa, E Nakashima, T Sugiyama, H Rakugi, S Yamaguchi, T Ogihara, Y Yamori, N Kato
Publication Date: 2012

Variant appearance in text: rs6589566
PubMed Link: 23050023
Variant Present in the following documents:
  • pone.0046385.s002.xls
View BVdb publication page



TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans.

Translational Psychiatry
HM Ollila, S Utge, E Kronholm, V Aho, W Van Leeuwen, K Silander, T Partonen, M Perola, J Kaprio, V Salomaa, M Sallinen, M Härmä, T Porkka-Heiskanen, T Paunio
Publication Date: 2012-03-20

Variant appearance in text: rs6589566
PubMed Link: 22832862
Variant Present in the following documents:
  • tp201220x1.pdf
View BVdb publication page



Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.

Lancet (London, England)
BF Voight, GM Peloso, M Orho-Melander, R Frikke-Schmidt, M Barbalic, MK Jensen, G Hindy, H Hólm, EL Ding, T Johnson, H Schunkert, NJ Samani, R Clarke, JC Hopewell, JF Thompson, M Li, G Thorleifsson, C Newton-Cheh, K Musunuru, JP Pirruccello, D Saleheen, L Chen, A Stewart, A Schillert, U Thorsteinsdottir, G Thorgeirsson, S Anand, JC Engert, T Morgan, J Spertus, M Stoll, K Berger, N Martinelli, D Girelli, PP McKeown, CC Patterson, SE Epstein, J Devaney, MS Burnett, V Mooser, S Ripatti, I Surakka, MS Nieminen, J Sinisalo, ML Lokki, M Perola, A Havulinna, U de Faire, B Gigante, E Ingelsson, T Zeller, P Wild, PI de Bakker, OH Klungel, AH Maitland-van der Zee, BJ Peters, A de Boer, DE Grobbee, PW Kamphuisen, VH Deneer, CC Elbers, NC Onland-Moret, MH Hofker, C Wijmenga, WM Verschuren, JM Boer, YT van der Schouw, A Rasheed, P Frossard, S Demissie, C Willer, R Do, JM Ordovas, GR Abecasis, M Boehnke, KL Mohlke, MJ Daly, C Guiducci, NP Burtt, A Surti, E Gonzalez, S Purcell, S Gabriel, J Marrugat, J Peden, J Erdmann, P Diemert, C Willenborg, IR König, M Fischer, C Hengstenberg, A Ziegler, I Buysschaert, D Lambrechts, F Van de Werf, KA Fox, NE El Mokhtari, D Rubin, J Schrezenmeir, S Schreiber, A Schäfer, J Danesh, S Blankenberg, R Roberts, R McPherson, H Watkins, AS Hall, K Overvad, E Rimm, E Boerwinkle, A Tybjaerg-Hansen, LA Cupples, MP Reilly, O Melander, PM Mannucci, D Ardissino, D Siscovick, R Elosua, K Stefansson, CJ O'Donnell, V Salomaa, DJ Rader, L Peltonen, SM Schwartz, D Altshuler, S Kathiresan
Publication Date: 2012-08-11

Variant appearance in text: rs6589566
PubMed Link: 22607825
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.

Neurobiology Of Disease
DG Hernandez, MA Nalls, M Moore, S Chong, A Dillman, D Trabzuni, JR Gibbs, M Ryten, S Arepalli, ME Weale, AB Zonderman, J Troncoso, R O'Brien, R Walker, C Smith, S Bandinelli, BJ Traynor, J Hardy, AB Singleton, MR Cookson
Publication Date: 2012-07

Variant appearance in text: rs6589566
PubMed Link: 22433082
Variant Present in the following documents:
  • mmc1.xls
View BVdb publication page



Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

Nature Genetics
J Kettunen, T Tukiainen, AP Sarin, A Ortega-Alonso, E Tikkanen, LP Lyytikäinen, AJ Kangas, P Soininen, P Würtz, K Silander, DM Dick, RJ Rose, MJ Savolainen, J Viikari, M Kähönen, T Lehtimäki, KH Pietiläinen, M Inouye, MI McCarthy, A Jula, J Eriksson, OT Raitakari, V Salomaa, J Kaprio, MR Järvelin, L Peltonen, M Perola, NB Freimer, M Ala-Korpela, A Palotie, S Ripatti
Publication Date: 2012-01-29

Variant appearance in text: rs6589566
PubMed Link: 22286219
Variant Present in the following documents:
  • NIHMS444574-supplement-supplementary_table_2.xlsx
View BVdb publication page



A genome-wide scan for common variants affecting the rate of age-related cognitive decline.

Neurobiology Of Aging
PL De Jager, JM Shulman, LB Chibnik, BT Keenan, T Raj, RS Wilson, L Yu, SE Leurgans, D Tran, C Aubin, CD Anderson, A Biffi, JJ Corneveaux, MJ Huentelman, , J Rosand, MJ Daly, AJ Myers, EM Reiman, DA Bennett, DA Evans
Publication Date: 2012-05

Variant appearance in text: rs6589566
PubMed Link: 22054870
Variant Present in the following documents:
  • NIHMS328602-supplement-01.doc
View BVdb publication page



Implications of discoveries from genome-wide association studies in current cardiovascular practice.

World Journal Of Cardiology
P Jeemon, K Pettigrew, C Sainsbury, D Prabhakaran, S Padmanabhan
Publication Date: 2011-07-26

Variant appearance in text: rs6589566
PubMed Link: 21860704
Variant Present in the following documents:
  • Main text
View BVdb publication page



Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

Plos Genetics
RS Fehrmann, RC Jansen, JH Veldink, HJ Westra, D Arends, MJ Bonder, J Fu, P Deelen, HJ Groen, A Smolonska, RK Weersma, RM Hofstra, WA Buurman, S Rensen, MG Wolfs, M Platteel, A Zhernakova, CC Elbers, EM Festen, G Trynka, MH Hofker, CG Saris, RA Ophoff, LH van den Berg, DA van Heel, C Wijmenga, GJ Te Meerman, L Franke
Publication Date: 2011-08

Variant appearance in text: rs6589566
PubMed Link: 21829388
Variant Present in the following documents:
  • pgen.1002197.s016.xls
View BVdb publication page



Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

European Heart Journal
A Angelakopoulou, T Shah, R Sofat, S Shah, DJ Berry, J Cooper, J Palmen, I Tzoulaki, A Wong, BJ Jefferis, N Maniatis, F Drenos, B Gigante, R Hardy, RC Laxton, K Leander, A Motterle, IA Simpson, L Smeeth, A Thomson, C Verzilli, D Kuh, H Ireland, J Deanfield, M Caulfield, C Wallace, N Samani, PB Munroe, M Lathrop, FG Fowkes, M Marmot, PH Whincup, JC Whittaker, U de Faire, M Kivimaki, M Kumari, E Hypponen, C Power, SE Humphries, PJ Talmud, J Price, RW Morris, S Ye, JP Casas, AD Hingorani
Publication Date: 2012-02

Variant appearance in text: rs6589566
PubMed Link: 21804106
Variant Present in the following documents:
  • Main text
View BVdb publication page



A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium.

Human Molecular Genetics
KC Taylor, LA Lange, D Zabaneh, E Lange, BJ Keating, W Tang, NL Smith, JA Delaney, M Kumari, A Hingorani, KE North, M Kivimaki, RP Tracy, CJ O'Donnell, AR Folsom, D Green, SE Humphries, AP Reiner
Publication Date: 2011-09-01

Variant appearance in text: rs6589566
PubMed Link: 21676895
Variant Present in the following documents:
  • Main text
View BVdb publication page



Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Nature Genetics
H Schunkert, IR König, S Kathiresan, MP Reilly, TL Assimes, H Holm, M Preuss, AF Stewart, M Barbalic, C Gieger, D Absher, Z Aherrahrou, H Allayee, D Altshuler, SS Anand, K Andersen, JL Anderson, D Ardissino, SG Ball, AJ Balmforth, TA Barnes, DM Becker, LC Becker, K Berger, JC Bis, SM Boekholdt, E Boerwinkle, PS Braund, MJ Brown, MS Burnett, I Buysschaert, , JF Carlquist, L Chen, S Cichon, V Codd, RW Davies, G Dedoussis, A Dehghan, S Demissie, JM Devaney, P Diemert, R Do, A Doering, S Eifert, NE Mokhtari, SG Ellis, R Elosua, JC Engert, SE Epstein, U de Faire, M Fischer, AR Folsom, J Freyer, B Gigante, D Girelli, S Gretarsdottir, V Gudnason, JR Gulcher, E Halperin, N Hammond, SL Hazen, A Hofman, BD Horne, T Illig, C Iribarren, GT Jones, JW Jukema, MA Kaiser, LM Kaplan, JJ Kastelein, KT Khaw, JW Knowles, G Kolovou, A Kong, R Laaksonen, D Lambrechts, K Leander, G Lettre, M Li, W Lieb, C Loley, AJ Lotery, PM Mannucci, S Maouche, N Martinelli, PP McKeown, C Meisinger, T Meitinger, O Melander, PA Merlini, V Mooser, T Morgan, TW Mühleisen, JB Muhlestein, T Münzel, K Musunuru, J Nahrstaedt, CP Nelson, MM Nöthen, O Olivieri, RS Patel, CC Patterson, A Peters, F Peyvandi, L Qu, AA Quyyumi, DJ Rader, LS Rallidis, C Rice, FR Rosendaal, D Rubin, V Salomaa, ML Sampietro, MS Sandhu, E Schadt, A Schäfer, A Schillert, S Schreiber, J Schrezenmeir, SM Schwartz, DS Siscovick, M Sivananthan, S Sivapalaratnam, A Smith, TB Smith, JD Snoep, N Soranzo, JA Spertus, K Stark, K Stirrups, M Stoll, WH Tang, S Tennstedt, G Thorgeirsson, G Thorleifsson, M Tomaszewski, AG Uitterlinden, AM van Rij, BF Voight, NJ Wareham, GA Wells, HE Wichmann, PS Wild, C Willenborg, JC Witteman, BJ Wright, S Ye, T Zeller, A Ziegler, F Cambien, AH Goodall, LA Cupples, T Quertermous, W März, C Hengstenberg, S Blankenberg, WH Ouwehand, AS Hall, P Deloukas, JR Thompson, K Stefansson, R Roberts, U Thorsteinsdottir, CJ O'Donnell, R McPherson, J Erdmann, , NJ Samani
Publication Date: 2011-03-06

Variant appearance in text: rs6589566
PubMed Link: 21378990
Variant Present in the following documents:
  • NIHMS287053-supplement-01.pdf
View BVdb publication page



Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

Plos Genetics
G Lettre, CD Palmer, T Young, KG Ejebe, H Allayee, EJ Benjamin, F Bennett, DW Bowden, A Chakravarti, A Dreisbach, DN Farlow, AR Folsom, M Fornage, T Forrester, E Fox, CA Haiman, J Hartiala, TB Harris, SL Hazen, SR Heckbert, BE Henderson, JN Hirschhorn, BJ Keating, SB Kritchevsky, E Larkin, M Li, ME Rudock, CA McKenzie, JB Meigs, YA Meng, TH Mosley, AB Newman, CH Newton-Cheh, DN Paltoo, GJ Papanicolaou, N Patterson, WS Post, BM Psaty, AN Qasim, L Qu, DJ Rader, S Redline, MP Reilly, AP Reiner, SS Rich, JI Rotter, Y Liu, P Shrader, DS Siscovick, WH Tang, HA Taylor, RP Tracy, RS Vasan, KM Waters, R Wilks, JG Wilson, RR Fabsitz, SB Gabriel, S Kathiresan, E Boerwinkle
Publication Date: 2011-02-10

Variant appearance in text: rs6589566
PubMed Link: 21347282
Variant Present in the following documents:
  • pgen.1001300.s016.doc
  • pgen.1001300.s017.doc
View BVdb publication page



Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids.

Atherosclerosis
CG Walker, RJ Loos, AD Olson, GS Frost, BA Griffin, JA Lovegrove, TA Sanders, SA Jebb
Publication Date: 2011-04

Variant appearance in text: rs6589566
PubMed Link: 21292264
Variant Present in the following documents:
  • mmc2.pdf
  • mmc3.doc
  • mmc4.pdf
  • mmc5.pdf
View BVdb publication page



Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

American Journal Of Epidemiology
OA Panagiotou, E Evangelou, JP Ioannidis
Publication Date: 2010-10-15

Variant appearance in text: rs6589566
PubMed Link: 20876667
Variant Present in the following documents:
  • Main text
View BVdb publication page



The genetics of obesity and the metabolic syndrome.

Endocrine, Metabolic & Immune Disorders Drug Targets
KL Monda, KE North, SC Hunt, DC Rao, MA Province, AT Kraja
Publication Date: 2010-06

Variant appearance in text: rs6589566
PubMed Link: 20406164
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association of lipid-lowering response to statins in combined study populations.

Plos One
MJ Barber, LM Mangravite, CL Hyde, DI Chasman, JD Smith, CA McCarty, X Li, RA Wilke, MJ Rieder, PT Williams, PM Ridker, A Chatterjee, JI Rotter, DA Nickerson, M Stephens, RM Krauss
Publication Date: 2010-03-22

Variant appearance in text: rs6589566
PubMed Link: 20339536
Variant Present in the following documents:
  • pone.0009763.s008.xls
View BVdb publication page



Association between a literature-based genetic risk score and cardiovascular events in women.

Jama
NP Paynter, DI Chasman, G Paré, JE Buring, NR Cook, JP Miletich, PM Ridker
Publication Date: 2010-02-17

Variant appearance in text: rs6589566
PubMed Link: 20159871
Variant Present in the following documents:
  • NIHMS173546-supplement-supplement_1.pdf
View BVdb publication page



Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results.

Bmc Proceedings
YJ Yoo, D Pinnaduwage, D Waggott, SB Bull, L Sun
Publication Date: 2009-12-15

Variant appearance in text: rs6589566
PubMed Link: 20017967
Variant Present in the following documents:
  • Main text
View BVdb publication page



A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

Human Molecular Genetics
RA Hegele, MR Ban, N Hsueh, BA Kennedy, H Cao, GY Zou, S Anand, S Yusuf, MW Huff, J Wang
Publication Date: 2009-11-01

Variant appearance in text: rs6589566
PubMed Link: 19656773
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

Human Molecular Genetics
F Drenos, PJ Talmud, JP Casas, L Smeeth, J Palmen, SE Humphries, AD Hingorani
Publication Date: 2009-06-15

Variant appearance in text: rs6589566
PubMed Link: 19336475
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

American Journal Of Human Genetics
C Wallace, SJ Newhouse, P Braund, F Zhang, M Tobin, M Falchi, K Ahmadi, RJ Dobson, AC Marçano, C Hajat, P Burton, P Deloukas, M Brown, JM Connell, A Dominiczak, GM Lathrop, J Webster, M Farrall, T Spector, NJ Samani, MJ Caulfield, PB Munroe
Publication Date: 2008-01

Variant appearance in text: rs6589566
PubMed Link: 18179892
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000227322.3 c.1179+451C>G - intron_variant - 12/13
ENST00000429220.1 c.958+451C>G - intron_variant - 10/11
ENST00000444935.1 c.1091+1212C>G - intron_variant - 11/12
NM_001317086.2 c.1017+451C>G - intron_variant - 11/12
NM_003904.5 c.1179+451C>G - intron_variant - 12/13