Variant ID: 11-116660686-G-A

NM_001166598.1(APOA5):c.*158C>T

This variant was identified in 90 publications




Publications:


Quantile-dependent expressivity of postprandial lipemia.

Plos One
PT Williams
Publication Date: 2020

Variant appearance in text: rs2266788
PubMed Link: 32101585
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association study of metabolic syndrome in Korean populations.

Plos One
SW Oh, JE Lee, E Shin, H Kwon, EK Choe, SY Choi, H Rhee, SH Choi
Publication Date: 2020

Variant appearance in text: rs2266788
PubMed Link: 31910446
Variant Present in the following documents:
  • Main text
View BVdb publication page



A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context.

Nature Communications
A Gallois, J Mefford, A Ko, A Vaysse, H Julienne, M Ala-Korpela, M Laakso, N Zaitlen, P Pajukanta, H Aschard
Publication Date: 2019-10-21

Variant appearance in text: rs2266788
PubMed Link: 31636271
Variant Present in the following documents:
  • 41467_2019_12703_MOESM11_ESM.xlsx
  • 41467_2019_12703_MOESM3_ESM.xlsx
  • 41467_2019_12703_MOESM4_ESM.xlsx
  • 41467_2019_12703_MOESM6_ESM.xlsx
  • 41467_2019_12703_MOESM7_ESM.xlsx
  • 41467_2019_12703_MOESM8_ESM.xlsx
  • 41467_2019_Article_12703.pdf
  • aaaaaMain text
View BVdb publication page



Introducing the first whole genomes of nationals from the United Arab Emirates.

Scientific Reports
HS AlSafar, M Al-Ali, GD Elbait, MH Al-Maini, D Ruta, B Peramo, A Henschel, GK Tay
Publication Date: 2019-10-11

Variant appearance in text: rs2266788
PubMed Link: 31604968
Variant Present in the following documents:
  • 41598_2019_50876_MOESM1_ESM.xlsx
View BVdb publication page



Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology.

Nature Communications
Y Tanigawa, J Li, JM Justesen, H Horn, M Aguirre, C DeBoever, C Chang, B Narasimhan, K Lage, T Hastie, CY Park, G Bejerano, E Ingelsson, MA Rivas
Publication Date: 2019-09-06

Variant appearance in text: rs2266788
PubMed Link: 31492854
Variant Present in the following documents:
  • 41467_2019_11953_MOESM6_ESM.xlsx
View BVdb publication page



Evolutionary history of disease-susceptibility loci identified in longitudinal exome-wide association studies.

Molecular Genetics & Genomic Medicine
Y Yasukochi, J Sakuma, I Takeuchi, K Kato, M Oguri, T Fujimaki, H Horibe, Y Yamada
Publication Date: 2019-09

Variant appearance in text: rs2266788
PubMed Link: 31402603
Variant Present in the following documents:
  • MGG3-7-e925-s001.pdf
View BVdb publication page



Evaluation of the appropriate predictive contributor and diagnostic threshold for the cardio-metabolic syndrome in Chinese Uyghur adults.

Bmc Public Health
Z Zhang, S Fan, Z Xue, J Yuan, Z Zhou, T Wang, J Liu, A Bawudun, N Nurmamat, Y Wang, Z Yang
Publication Date: 2019-05-21

Variant appearance in text: rs2266788
PubMed Link: 31113427
Variant Present in the following documents:
  • Main text
View BVdb publication page



Metabolic Syndrome Prediction Using Machine Learning Models with Genetic and Clinical Information from a Nonobese Healthy Population.

Genomics & Informatics
EK Choe, H Rhee, S Lee, E Shin, SW Oh, JE Lee, SH Choi
Publication Date: 2018-12

Variant appearance in text: rs2266788
PubMed Link: 30602092
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia.

International Journal Of Molecular Medicine
Y Yamada, K Kato, M Oguri, H Horibe, T Fujimaki, Y Yasukochi, I Takeuchi, J Sakuma
Publication Date: 2019-01

Variant appearance in text: rs2266788
PubMed Link: 30365130
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of genetic and environmental factors in DNA methylation of lipid metabolism.

Genes & Diseases
Z He, R Zhang, F Jiang, W Hou, C Hu
Publication Date: 2018-03

Variant appearance in text: rs2266788
PubMed Link: 30258929
Variant Present in the following documents:
  • Main text
View BVdb publication page



Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk.

Journal Of Lipid Research
Y Zhou, R Mägi, L Milani, VM Lauschke
Publication Date: 2018-10

Variant appearance in text: rs2266788
PubMed Link: 30076208
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach.

Frontiers In Cardiovascular Medicine
B Vilne, H Schunkert
Publication Date: 2018

Variant appearance in text: rs2266788
PubMed Link: 30065929
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influence of APOA5 Locus on the Treatment Efficacy of Three Statins: Evidence From a Randomized Pilot Study in Chinese Subjects.

Frontiers In Pharmacology
S Hua, C Ma, J Zhang, J Li, W Wu, N Xu, G Luo, J Zhao
Publication Date: 2018

Variant appearance in text: rs2266788
PubMed Link: 29695967
Variant Present in the following documents:
  • Main text
View BVdb publication page



Sequence Analysis of APOA5 Among the Kuwaiti Population Identifies Association of rs2072560, rs2266788, and rs662799 With TG and VLDL Levels.

Frontiers In Genetics
AA Jasim, SA Al-Bustan, W Al-Kandari, A Al-Serri, H AlAskar
Publication Date: 2018

Variant appearance in text: rs2266788
PubMed Link: 29686695
Variant Present in the following documents:
  • Main text
  • Table2.pdf
View BVdb publication page



Genetic variants in mRNA untranslated regions.

Wiley Interdisciplinary Reviews. Rna
M Steri, ML Idda, MB Whalen, V Orrù
Publication Date: 2018-07

Variant appearance in text: rs2266788
PubMed Link: 29582564
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population.

Physiological Genomics
Y Yasukochi, J Sakuma, I Takeuchi, K Kato, M Oguri, T Fujimaki, H Horibe, Y Yamada
Publication Date: 2018-03-01

Variant appearance in text: rs2266788
PubMed Link: 29341862
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.

Scientific Reports
Y Han, R Dorajoo, X Chang, L Wang, CC Khor, X Sim, CY Cheng, Y Shi, YC Tham, W Zhao, ML Chee, C Sabanayagam, ML Chee, N Tan, TY Wong, ES Tai, J Liu, DYT Goh, JM Yuan, WP Koh, RM van Dam, AF Low, MY Chan, Y Friedlander, CK Heng
Publication Date: 2017-12-20

Variant appearance in text: rs2266788
PubMed Link: 29263402
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by an APOC3 Founder Mutation.

Circulation. Cardiovascular Genetics
WC Hsueh, AK Nair, S Kobes, P Chen, HHH Göring, TI Pollin, A Malhotra, WC Knowler, LJ Baier, RL Hanson
Publication Date: 2017-12

Variant appearance in text: rs2266788
PubMed Link: 29237685
Variant Present in the following documents:
  • Main text
  • NIHMS917321-supplement-001809_-_Supplemental_material.pdf
View BVdb publication page



Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

Plos Genetics
JP Davis, JR Huyghe, AE Locke, AU Jackson, X Sim, HM Stringham, TM Teslovich, RP Welch, C Fuchsberger, N Narisu, PS Chines, AJ Kangas, P Soininen, M Ala-Korpela, J Kuusisto, FS Collins, M Laakso, M Boehnke, KL Mohlke
Publication Date: 2017-10

Variant appearance in text: rs2266788
PubMed Link: 29084231
Variant Present in the following documents:
  • pgen.1007079.s010.xlsx
View BVdb publication page



Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.

Nature Genetics
X Lu, GM Peloso, DJ Liu, Y Wu, H Zhang, W Zhou, J Li, CS Tang, R Dorajoo, H Li, J Long, X Guo, M Xu, CN Spracklen, Y Chen, X Liu, Y Zhang, CC Khor, J Liu, L Sun, L Wang, YT Gao, Y Hu, K Yu, Y Wang, CYY Cheung, F Wang, J Huang, Q Fan, Q Cai, S Chen, J Shi, X Yang, W Zhao, WH Sheu, SS Cherny, M He, AB Feranil, LS Adair, P Gordon-Larsen, S Du, R Varma, YI Chen, XO Shu, KSL Lam, TY Wong, SK Ganesh, Z Mo, K Hveem, LG Fritsche, JB Nielsen, HF Tse, Y Huo, CY Cheng, YE Chen, W Zheng, ES Tai, W Gao, X Lin, W Huang, G Abecasis, , S Kathiresan, KL Mohlke, T Wu, PC Sham, D Gu, CJ Willer
Publication Date: 2017-12

Variant appearance in text: rs2266788
PubMed Link: 29083407
Variant Present in the following documents:
  • NIHMS909133-supplement-1.docx
View BVdb publication page



Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

Plos One
LC Pilling, JL Atkins, MO Duff, RN Beaumont, SE Jones, J Tyrrell, CL Kuo, KS Ruth, MA Tuke, H Yaghootkar, AR Wood, A Murray, MN Weedon, LW Harries, GA Kuchel, L Ferrucci, TM Frayling, D Melzer
Publication Date: 2017

Variant appearance in text: rs2266788
PubMed Link: 28957414
Variant Present in the following documents:
  • pone.0185083.s004.xlsx
View BVdb publication page



Evaluating the Causal Relation of ApoA-IV with Disease-Related Traits - A Bidirectional Two-sample Mendelian Randomization Study.

Scientific Reports
S Mack, S Coassin, J Vaucher, F Kronenberg, C Lamina,
Publication Date: 2017-08-18

Variant appearance in text: rs2266788
PubMed Link: 28821713
Variant Present in the following documents:
  • Main text
View BVdb publication page



A GDF15 3' UTR variant, rs1054564, results in allele-specific translational repression of GDF15 by hsa-miR-1233-3p.

Plos One
MS Teng, LA Hsu, SH Juan, WC Lin, MC Lee, CW Su, S Wu, YL Ko
Publication Date: 2017

Variant appearance in text: rs2266788
PubMed Link: 28806401
Variant Present in the following documents:
  • Main text
View BVdb publication page



The association between apolipoprotein A1-C3-A5 gene cluster promoter polymorphisms and risk of ischemic stroke in the northern Chinese Han population.

The Journal Of International Medical Research
Y Wang, F Liu, L Li, S Deng, Z He
Publication Date: 2017-12

Variant appearance in text: rs2266788
PubMed Link: 28635360
Variant Present in the following documents:
  • Main text
View BVdb publication page



Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.

Nature Communications
L Southam, A Gilly, D Süveges, AE Farmaki, J Schwartzentruber, I Tachmazidou, A Matchan, NW Rayner, E Tsafantakis, M Karaleftheri, Y Xue, G Dedoussis, E Zeggini
Publication Date: 2017-05-26

Variant appearance in text: rs2266788
PubMed Link: 28548082
Variant Present in the following documents:
  • ncomms15606-s1.pdf
View BVdb publication page



Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies.

Oncotarget
Y Yamada, J Sakuma, I Takeuchi, Y Yasukochi, K Kato, M Oguri, T Fujimaki, H Horibe, M Muramatsu, M Sawabe, Y Fujiwara, Y Taniguchi, S Obuchi, H Kawai, S Shinkai, S Mori, T Arai, M Tanaka
Publication Date: 2017-06-13

Variant appearance in text: rs2266788
PubMed Link: 28473662
Variant Present in the following documents:
  • Main text
  • oncotarget-08-38950-s002.docx
  • oncotarget-08-38950-s012.docx
  • oncotarget-08-38950-s013.docx
  • oncotarget-08-38950-s015.docx
  • oncotarget-08-38950-s016.docx
  • oncotarget-08-38950-s018.docx
  • oncotarget-08-38950-s019.docx
View BVdb publication page



Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study.

Bmj (Clinical Research Ed.)
M Benn, BG Nordestgaard, R Frikke-Schmidt, A Tybjærg-Hansen
Publication Date: 2017-04-24

Variant appearance in text: rs2266788
PubMed Link: 28438747
Variant Present in the following documents:
  • benm033277.ww1.pdf
View BVdb publication page



Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.

Human Molecular Genetics
N Zubair, M Graff, J Luis Ambite, WS Bush, G Kichaev, Y Lu, A Manichaikul, WH Sheu, D Absher, TL Assimes, SJ Bielinski, EP Bottinger, P Buzkova, LM Chuang, RH Chung, B Cochran, L Dumitrescu, O Gottesman, JW Haessler, C Haiman, G Heiss, CA Hsiung, YJ Hung, CM Hwu, JJ Juang, L Le Marchand, IT Lee, WJ Lee, LA Lin, D Lin, SY Lin, RH Mackey, LW Martin, B Pasaniuc, U Peters, I Predazzi, T Quertermous, AP Reiner, J Robinson, JI Rotter, KK Ryckman, PJ Schreiner, E Stahl, R Tao, MY Tsai, LL Waite, TD Wang, S Buyske, YD Ida Chen, I Cheng, DC Crawford, RJF Loos, SS Rich, M Fornage, KE North, C Kooperberg, CL Carty
Publication Date: 2016-12-15

Variant appearance in text: rs2266788
PubMed Link: 28426890
Variant Present in the following documents:
  • ddw358_supp.docx
View BVdb publication page



SNPs in microRNA target sites and their potential role in human disease.

Open Biology
A Moszyńska, M Gebert, JF Collawn, R Bartoszewski
Publication Date: 2017-04

Variant appearance in text: rs2266788
PubMed Link: 28381629
Variant Present in the following documents:
  • Main text
View BVdb publication page



Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.

Journal Of Cellular And Molecular Medicine
Y Zhu, D Zhang, D Zhou, Z Li, Z Li, L Fang, M Yang, Z Shan, H Li, J Chen, X Zhou, W Ye, S Yu, H Li, L Cai, C Liu, J Zhang, L Wang, Y Lai, L Ruan, Z Sun, S Zhang, H Wang, Y Liu, Y Xu, J Ling, C Xu, Y Zhang, D Lv, Z Yuan, J Zhang, Y Zhang, Y Shi, M Lai
Publication Date: 2017-06

Variant appearance in text: rs2266788
PubMed Link: 28371326
Variant Present in the following documents:
  • Main text
  • JCMM-21-1106-s002.xlsx
View BVdb publication page



Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.

Plos One
EJ Parra, A Mazurek, CR Gignoux, A Sockell, M Agostino, AP Morris, LE Petty, CL Hanis, NJ Cox, A Valladares-Salgado, JE Below, M Cruz
Publication Date: 2017

Variant appearance in text: rs2266788
PubMed Link: 28245265
Variant Present in the following documents:
  • pone.0172880.s002.xlsx
View BVdb publication page



Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis.

Scientific Reports
Z Liu, S Burgess, Z Wang, W Deng, X Chu, J Cai, Y Zhu, J Shi, X Xie, Y Wang, L Jin, X Wang
Publication Date: 2017-01-30

Variant appearance in text: rs2266788
PubMed Link: 28134330
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-Wide Association Study Reveals Four Loci for Lipid Ratios in the Korean Population and the Constitutional Subgroup.

Plos One
T Kim, AY Park, Y Baek, S Cha
Publication Date: 2017

Variant appearance in text: rs2266788
PubMed Link: 28046027
Variant Present in the following documents:
  • Main text
View BVdb publication page



Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.

International Journal Of Epidemiology
TV Varga, A Kurbasic, M Aine, P Eriksson, A Ali, G Hindy, S Gustafsson, J Luan, D Shungin, Y Chen, CA Schulz, PM Nilsson, G Hallmans, I Barroso, P Deloukas, C Langenberg, RA Scott, NJ Wareham, L Lind, E Ingelsson, O Melander, M Orho-Melander, F Renström, PW Franks
Publication Date: 2017-08-01

Variant appearance in text: rs2266788
PubMed Link: 27864399
Variant Present in the following documents:
  • dyw245_supplementary_method_2.docx
  • dyw245_supplementary_table_7.xlsx
View BVdb publication page



Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population.

Scientific Reports
E Lin, PH Kuo, YL Liu, AC Yang, CF Kao, SJ Tsai
Publication Date: 2016-11-09

Variant appearance in text: rs2266788
PubMed Link: 27827461
Variant Present in the following documents:
  • srep36830-s1.pdf
View BVdb publication page



The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia.

Journal Of Hypertension
LC Thomsen, NS McCarthy, PE Melton, G Cadby, R Austgulen, OK Nygård, MP Johnson, S Brennecke, EK Moses, L Bjørge, AC Iversen
Publication Date: 2017-01

Variant appearance in text: rs2266788
PubMed Link: 27755385
Variant Present in the following documents:
  • jhype-35-132-s001.docx
View BVdb publication page



Single Nucleotide Polymorphisms in Cellular Drug Transporters Are Associated with Intolerance to Antiretroviral Therapy in Brazilian HIV-1 Positive Individuals.

Plos One
MB Arruda, F Campagnari, TB de Almeida, JC Couto-Fernandez, A Tanuri, CC Cardoso
Publication Date: 2016

Variant appearance in text: rs2266788
PubMed Link: 27648838
Variant Present in the following documents:
  • pone.0163170.s001.xlsx
View BVdb publication page



Analysis with the exome array identifies multiple new independent variants in lipid loci.

Human Molecular Genetics
S Kanoni, NG Masca, KE Stirrups, TV Varga, HR Warren, RA Scott, L Southam, W Zhang, H Yaghootkar, M Müller-Nurasyid, A Couto Alves, RJ Strawbridge, L Lataniotis, N An Hashim, C Besse, A Boland, PS Braund, JM Connell, A Dominiczak, AE Farmaki, S Franks, H Grallert, JH Jansson, M Karaleftheri, S Keinänen-Kiukaanniemi, A Matchan, D Pasko, A Peters, N Poulter, NW Rayner, F Renström, O Rolandsson, M Sabater-Lleal, B Sennblad, P Sever, D Shields, A Silveira, AV Stanton, K Strauch, M Tomaszewski, E Tsafantakis, M Waldenberger, AI Blakemore, G Dedoussis, SA Escher, JS Kooner, MI McCarthy, CN Palmer, , A Hamsten, MJ Caulfield, TM Frayling, MD Tobin, MR Jarvelin, E Zeggini, C Gieger, JC Chambers, NJ Wareham, PB Munroe, PW Franks, NJ Samani, P Deloukas
Publication Date: 2016-09-15

Variant appearance in text: rs2266788
PubMed Link: 27466198
Variant Present in the following documents:
  • Main text
View BVdb publication page



Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015.

Bmc Genomics
.
Publication Date: 2016-07-20

Variant appearance in text: rs2266788
PubMed Link: 27454254
Variant Present in the following documents:
  • Main text
View BVdb publication page



Two-stage association study to identify the genetic susceptibility of a novel common variant of rs2075290 in ZPR1 to type 2 diabetes.

Scientific Reports
F Guan, Y Niu, T Zhang, S Liu, L Ma, T Qi, J Feng, H Zuo, G Li, X Liu, S Wang
Publication Date: 2016-07-14

Variant appearance in text: rs2266788
PubMed Link: 27411854
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits.

Plos One
P Volkov, AH Olsson, L Gillberg, SW Jørgensen, C Brøns, KF Eriksson, L Groop, PA Jansson, E Nilsson, T Rönn, A Vaag, C Ling
Publication Date: 2016

Variant appearance in text: rs2266788
PubMed Link: 27322064
Variant Present in the following documents:
  • pone.0157776.s004.xlsx
View BVdb publication page



Genetics of Insulin Resistance and the Metabolic Syndrome.

Current Cardiology Reports
AE Brown, M Walker
Publication Date: 2016-08

Variant appearance in text: rs2266788
PubMed Link: 27312935
Variant Present in the following documents:
  • Main text
View BVdb publication page



Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India.

Plos One
R Pranav Chand, AS Kumar, K Anuj, S Vishnupriya, B Mohan Reddy
Publication Date: 2016

Variant appearance in text: rs2266788
PubMed Link: 27257688
Variant Present in the following documents:
  • pone.0153720.s002.docx
  • pone.0153720.s003.xlsx
View BVdb publication page



The Contribution of GWAS Loci in Familial Dyslipidemias.

Plos Genetics
P Ripatti, JT Rämö, S Söderlund, I Surakka, N Matikainen, M Pirinen, P Pajukanta, AP Sarin, SK Service, PP Laurila, C Ehnholm, V Salomaa, RK Wilson, A Palotie, NB Freimer, MR Taskinen, S Ripatti
Publication Date: 2016-05

Variant appearance in text: rs2266788
PubMed Link: 27227539
Variant Present in the following documents:
  • pgen.1006078.s008.pdf
  • pgen.1006078.s009.pdf
View BVdb publication page



Nutrigenomics: A controversy.

Applied & Translational Genomics
C Pavlidis, GP Patrinos, T Katsila
Publication Date: 2015-03

Variant appearance in text: rs2266788
PubMed Link: 26937350
Variant Present in the following documents:
  • Main text
View BVdb publication page



Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.

Scientific Reports
JE Below, EJ Parra, ER Gamazon, J Torres, S Krithika, S Candille, Y Lu, A Manichakul, J Peralta-Romero, Q Duan, Y Li, AP Morris, O Gottesman, E Bottinger, XQ Wang, KD Taylor, YD Ida Chen, JI Rotter, SS Rich, RJ Loos, H Tang, NJ Cox, M Cruz, CL Hanis, A Valladares-Salgado
Publication Date: 2016-01-19

Variant appearance in text: rs2266788
PubMed Link: 26780889
Variant Present in the following documents:
  • srep19429-s5.xls
View BVdb publication page



INTEGRATING CLINICAL LABORATORY MEASURES AND ICD-9 CODE DIAGNOSES IN PHENOME-WIDE ASSOCIATION STUDIES.

Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing
A Verma, JB Leader, SS Verma, A Frase, J Wallace, S Dudek, DR Lavage, CV Van Hout, FE Dewey, J Penn, A Lopez, JD Overton, DJ Carey, DH Ledbetter, HL Kirchner, MD Ritchie, SA Pendergrass
Publication Date: 2016

Variant appearance in text: rs2266788
PubMed Link: 26776183
Variant Present in the following documents:
  • NIHMS742521-supplement-2.pdf
View BVdb publication page



Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.

Molecular Genetics And Metabolism
F Tekola-Ayele, AP Doumatey, D Shriner, AR Bentley, G Chen, J Zhou, O Fasanmade, T Johnson, J Oli, G Okafor, BA Eghan, K Agyenim-Boateng, C Adebamowo, A Amoah, J Acheampong, A Adeyemo, CN Rotimi
Publication Date: 2015-12

Variant appearance in text: rs2266788
PubMed Link: 26507551
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.

Plos One
Q Fu, X Tang, J Chen, L Su, M Zhang, L Wang, J Jing, L Zhou
Publication Date: 2015

Variant appearance in text: rs2266788
PubMed Link: 26397108
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.

Lipids In Health And Disease
KY Son, HY Son, J Chae, J Hwang, S Jang, JM Yun, B Cho, JH Park, JI Kim
Publication Date: 2015-09-13

Variant appearance in text: rs2266788
PubMed Link: 26365620
Variant Present in the following documents:
  • 12944_2015_111_MOESM1_ESM.docx
  • aaaaaMain text
View BVdb publication page



Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis.

Plos One
H Ye, A Zhou, Q Hong, L Tang, X Xu, Y Xin, D Jiang, D Dai, Y Li, DW Wang, S Duan
Publication Date: 2015

Variant appearance in text: rs2266788
PubMed Link: 26309253
Variant Present in the following documents:
  • pone.0135683.s004.doc
View BVdb publication page



Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.

Arteriosclerosis, Thrombosis, And Vascular Biology
I Brænne, M Civelek, B Vilne, A Di Narzo, AD Johnson, Y Zhao, B Reiz, V Codoni, TR Webb, H Foroughi Asl, SE Hamby, L Zeng, DA Trégouët, K Hao, EJ Topol, EE Schadt, X Yang, NJ Samani, JL Björkegren, J Erdmann, H Schunkert, AJ Lusis,
Publication Date: 2015-10

Variant appearance in text: rs2266788
PubMed Link: 26293461
Variant Present in the following documents:
  • Main text
  • NIHMS714198-supplement-6.xlsx
View BVdb publication page



Non-coding genetic variants in human disease.

Human Molecular Genetics
F Zhang, JR Lupski
Publication Date: 2015-10-15

Variant appearance in text: rs2266788
PubMed Link: 26152199
Variant Present in the following documents:
  • Main text
View BVdb publication page



Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome.

Journal Of Diabetes And Metabolic Disorders
M Ajjemami, S Ouatou, H Charoute, M Fakiri, H Rhaissi, H Benrahma, H Rouba, A Barakat
Publication Date: 2015

Variant appearance in text: rs2266788
PubMed Link: 25909077
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association study of metabolic syndrome in koreans.

Genomics & Informatics
SW Jeong, M Chung, SJ Park, SB Cho, KW Hong
Publication Date: 2014-12

Variant appearance in text: rs2266788
PubMed Link: 25705157
Variant Present in the following documents:
  • gni-12-187-s001.pdf
View BVdb publication page



GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb.

Atherosclerosis
M den Hoed, RJ Strawbridge, P Almgren, S Gustafsson, T Axelsson, G Engström, U de Faire, B Hedblad, SE Humphries, CM Lindgren, AP Morris, G Östling, AC Syvänen, E Tremoli, A Hamsten, E Ingelsson, O Melander, L Lind
Publication Date: 2015-04

Variant appearance in text: rs2266788
PubMed Link: 25682028
Variant Present in the following documents:
  • NIHMS73492-supplement-Supplement.pdf
View BVdb publication page



Burden of disease variants in participants of the Long Life Family Study.

Aging
M Stevenson, H Bae, N Schupf, S Andersen, Q Zhang, T Perls, P Sebastiani
Publication Date: 2015-02

Variant appearance in text: rs2266788
PubMed Link: 25664523
Variant Present in the following documents:
  • aging-07-0123-s001.docx
View BVdb publication page



A comparative encyclopedia of DNA elements in the mouse genome.

Nature
F Yue, Y Cheng, A Breschi, J Vierstra, W Wu, T Ryba, R Sandstrom, Z Ma, C Davis, BD Pope, Y Shen, DD Pervouchine, S Djebali, RE Thurman, R Kaul, E Rynes, A Kirilusha, GK Marinov, BA Williams, D Trout, H Amrhein, K Fisher-Aylor, I Antoshechkin, G DeSalvo, LH See, M Fastuca, J Drenkow, C Zaleski, A Dobin, P Prieto, J Lagarde, G Bussotti, A Tanzer, O Denas, K Li, MA Bender, M Zhang, R Byron, MT Groudine, D McCleary, L Pham, Z Ye, S Kuan, L Edsall, YC Wu, MD Rasmussen, MS Bansal, M Kellis, CA Keller, CS Morrissey, T Mishra, D Jain, N Dogan, RS Harris, P Cayting, T Kawli, AP Boyle, G Euskirchen, A Kundaje, S Lin, Y Lin, C Jansen, VS Malladi, MS Cline, DT Erickson, VM Kirkup, K Learned, CA Sloan, KR Rosenbloom, B Lacerda de Sousa, K Beal, M Pignatelli, P Flicek, J Lian, T Kahveci, D Lee, WJ Kent, M Ramalho Santos, J Herrero, C Notredame, A Johnson, S Vong, K Lee, D Bates, F Neri, M Diegel, T Canfield, PJ Sabo, MS Wilken, TA Reh, E Giste, A Shafer, T Kutyavin, E Haugen, D Dunn, AP Reynolds, S Neph, R Humbert, RS Hansen, M De Bruijn, L Selleri, A Rudensky, S Josefowicz, R Samstein, EE Eichler, SH Orkin, D Levasseur, T Papayannopoulou, KH Chang, A Skoultchi, S Gosh, C Disteche, P Treuting, Y Wang, MJ Weiss, GA Blobel, X Cao, S Zhong, T Wang, PJ Good, RF Lowdon, LB Adams, XQ Zhou, MJ Pazin, EA Feingold, B Wold, J Taylor, A Mortazavi, SM Weissman, JA Stamatoyannopoulos, MP Snyder, R Guigo, TR Gingeras, DM Gilbert, RC Hardison, MA Beer, B Ren,
Publication Date: 2014-11-20

Variant appearance in text: rs2266788
PubMed Link: 25409824
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influences of APOA5 variants on plasma triglyceride levels in Uyghur population.

Plos One
S Li, B Hu, Y Wang, D Wu, L Jin, X Wang
Publication Date: 2014

Variant appearance in text: rs2266788
PubMed Link: 25313938
Variant Present in the following documents:
  • Main text
  • pone.0110258.s001.docx
View BVdb publication page



Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study.

Lipids In Health And Disease
A Hishida, K Wakai, M Naito, S Suma, T Sasakabe, N Hamajima, S Hosono, M Horita, TC Turin, S Suzuki, TS Kairupan, H Mikami, K Ohnaka, I Watanabe, H Uemura, M Kubo, H Tanaka,
Publication Date: 2014-10-14

Variant appearance in text: rs2266788
PubMed Link: 25311932
Variant Present in the following documents:
  • 12944_2014_1143_MOESM1_ESM.doc
  • aaaaaMain text
View BVdb publication page



Association between the MLX interacting protein-like, BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels.

Scientific Reports
LH Aung, RX Yin, JZ Wu, DF Wu, W Wang, H Li
Publication Date: 2014-07-03

Variant appearance in text: rs2266788
PubMed Link: 24989072
Variant Present in the following documents:
  • Main text
View BVdb publication page



Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents.

Lipids In Health And Disease
WF Zhu, CL Wang, L Liang, Z Shen, JF Fu, PN Liu, LQ Lv, YM Zhu
Publication Date: 2014-06-05

Variant appearance in text: rs2266788
PubMed Link: 24903888
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans.

Lipids In Health And Disease
S Cha, H Yu, AY Park, KH Song
Publication Date: 2014-03-12

Variant appearance in text: rs2266788
PubMed Link: 24618354
Variant Present in the following documents:
  • 1476-511X-13-45-S2.xls
  • aaaaaMain text
View BVdb publication page



Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

American Journal Of Human Genetics
GM Peloso, PL Auer, JC Bis, A Voorman, AC Morrison, NO Stitziel, JA Brody, SA Khetarpal, JR Crosby, M Fornage, A Isaacs, J Jakobsdottir, MF Feitosa, G Davies, JE Huffman, A Manichaikul, B Davis, K Lohman, AY Joon, AV Smith, ML Grove, P Zanoni, V Redon, S Demissie, K Lawson, U Peters, C Carlson, RD Jackson, KK Ryckman, RH Mackey, JG Robinson, DS Siscovick, PJ Schreiner, JC Mychaleckyj, JS Pankow, A Hofman, AG Uitterlinden, TB Harris, KD Taylor, JM Stafford, LM Reynolds, RE Marioni, A Dehghan, OH Franco, AP Patel, Y Lu, G Hindy, O Gottesman, EP Bottinger, O Melander, M Orho-Melander, RJ Loos, S Duga, PA Merlini, M Farrall, A Goel, R Asselta, D Girelli, N Martinelli, SH Shah, WE Kraus, M Li, DJ Rader, MP Reilly, R McPherson, H Watkins, D Ardissino, , Q Zhang, J Wang, MY Tsai, HA Taylor, A Correa, ME Griswold, LA Lange, JM Starr, I Rudan, G Eiriksdottir, LJ Launer, JM Ordovas, D Levy, YD Chen, AP Reiner, C Hayward, O Polasek, IJ Deary, IB Borecki, Y Liu, V Gudnason, JG Wilson, CM van Duijn, C Kooperberg, SS Rich, BM Psaty, JI Rotter, CJ O'Donnell, K Rice, E Boerwinkle, S Kathiresan, LA Cupples
Publication Date: 2014-02-06

Variant appearance in text: rs2266788
PubMed Link: 24507774
Variant Present in the following documents:
  • Main text
View BVdb publication page



Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.

Plos Genetics
SK Service, TM Teslovich, C Fuchsberger, V Ramensky, P Yajnik, DC Koboldt, DE Larson, Q Zhang, L Lin, R Welch, L Ding, MD McLellan, M O'Laughlin, C Fronick, LL Fulton, V Magrini, A Swift, P Elliott, MR Jarvelin, M Kaakinen, MI McCarthy, L Peltonen, A Pouta, LL Bonnycastle, FS Collins, N Narisu, HM Stringham, J Tuomilehto, S Ripatti, RS Fulton, C Sabatti, RK Wilson, M Boehnke, NB Freimer
Publication Date: 2014-01

Variant appearance in text: rs2266788
PubMed Link: 24497850
Variant Present in the following documents:
  • Main text
View BVdb publication page



An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.

American Journal Of Human Genetics
C Caussy, S Charrière, C Marçais, M Di Filippo, A Sassolas, M Delay, V Euthine, A Jalabert, E Lefai, S Rome, P Moulin
Publication Date: 2014-01-02

Variant appearance in text: rs2266788
PubMed Link: 24387992
Variant Present in the following documents:
  • Main text
View BVdb publication page



Biobanking across the phenome - at the center of chronic disease research.

Bmc Public Health
M Imboden, NM Probst-Hensch
Publication Date: 2013-11-25

Variant appearance in text: rs2266788
PubMed Link: 24274136
Variant Present in the following documents:
  • 1471-2458-13-1094-S2.xlsx
View BVdb publication page



ChIP-seq in steatohepatitis and normal liver tissue identifies candidate disease mechanisms related to progression to cancer.

Bmc Medical Genomics
M Bysani, O Wallerman, S Bornelöv, K Zatloukal, J Komorowski, C Wadelius
Publication Date: 2013-11-08

Variant appearance in text: rs2266788
PubMed Link: 24206787
Variant Present in the following documents:
  • 1755-8794-6-50-S2.docx
View BVdb publication page



Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis.

Plos One
C Xu, R Bai, D Zhang, Z Li, H Zhu, M Lai, Y Zhu
Publication Date: 2013

Variant appearance in text: rs2266788
PubMed Link: 23468858
Variant Present in the following documents:
  • Main text
View BVdb publication page



Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

Plos One
AG Comuzzie, SA Cole, SL Laston, VS Voruganti, K Haack, RA Gibbs, NF Butte
Publication Date: 2012

Variant appearance in text: rs2266788
PubMed Link: 23251661
Variant Present in the following documents:
  • Main text
View BVdb publication page



Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.

Plos One
CC Elbers, Y Guo, V Tragante, EP van Iperen, MB Lanktree, BA Castillo, F Chen, LR Yanek, MK Wojczynski, YR Li, B Ferwerda, CM Ballantyne, SG Buxbaum, YD Chen, WM Chen, LA Cupples, M Cushman, Y Duan, D Duggan, MK Evans, JK Fernandes, M Fornage, M Garcia, WT Garvey, N Glazer, F Gomez, TB Harris, I Halder, VJ Howard, MF Keller, MI Kamboh, C Kooperberg, SB Kritchevsky, A LaCroix, K Liu, Y Liu, K Musunuru, AB Newman, NC Onland-Moret, J Ordovas, I Peter, W Post, S Redline, SE Reis, R Saxena, PJ Schreiner, KA Volcik, X Wang, S Yusuf, AB Zonderland, SS Anand, DM Becker, B Psaty, DJ Rader, AP Reiner, SS Rich, JI Rotter, MM Sale, MY Tsai, IB Borecki, RA Hegele, S Kathiresan, MA Nalls, HA Taylor, H Hakonarson, S Sivapalaratnam, FW Asselbergs, F Drenos, JG Wilson, BJ Keating
Publication Date: 2012

Variant appearance in text: rs2266788
PubMed Link: 23236364
Variant Present in the following documents:
  • pone.0050198.s002.pdf
View BVdb publication page



Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

American Journal Of Human Genetics
FW Asselbergs, Y Guo, EP van Iperen, S Sivapalaratnam, V Tragante, MB Lanktree, LA Lange, B Almoguera, YE Appelman, J Barnard, J Baumert, AL Beitelshees, TR Bhangale, YD Chen, TR Gaunt, Y Gong, JC Hopewell, T Johnson, ME Kleber, TY Langaee, M Li, YR Li, K Liu, CW McDonough, MF Meijs, RP Middelberg, K Musunuru, CP Nelson, JR O'Connell, S Padmanabhan, JS Pankow, N Pankratz, S Rafelt, R Rajagopalan, SP Romaine, NJ Schork, J Shaffer, H Shen, EN Smith, SE Tischfield, PJ van der Most, JV van Vliet-Ostaptchouk, N Verweij, KA Volcik, L Zhang, KR Bailey, KM Bailey, F Bauer, JM Boer, PS Braund, A Burt, PR Burton, SG Buxbaum, W Chen, RM Cooper-Dehoff, LA Cupples, JS deJong, C Delles, D Duggan, M Fornage, CE Furlong, N Glazer, JG Gums, C Hastie, MV Holmes, T Illig, SA Kirkland, M Kivimaki, R Klein, BE Klein, C Kooperberg, K Kottke-Marchant, M Kumari, AZ LaCroix, L Mallela, G Murugesan, J Ordovas, WH Ouwehand, WS Post, R Saxena, H Scharnagl, PJ Schreiner, T Shah, DC Shields, D Shimbo, SR Srinivasan, RP Stolk, DI Swerdlow, HA Taylor, EJ Topol, E Toskala, JL van Pelt, J van Setten, S Yusuf, JC Whittaker, AH Zwinderman, , SS Anand, AJ Balmforth, GS Berenson, CR Bezzina, BO Boehm, E Boerwinkle, JP Casas, MJ Caulfield, R Clarke, JM Connell, KJ Cruickshanks, KW Davidson, IN Day, PI de Bakker, PA Doevendans, AF Dominiczak, AS Hall, CA Hartman, C Hengstenberg, HL Hillege, MH Hofker, SE Humphries, GP Jarvik, JA Johnson, BM Kaess, S Kathiresan, W Koenig, DA Lawlor, W März, O Melander, BD Mitchell, GW Montgomery, PB Munroe, SS Murray, SJ Newhouse, NC Onland-Moret, N Poulter, B Psaty, S Redline, SS Rich, JI Rotter, H Schunkert, P Sever, AR Shuldiner, RL Silverstein, A Stanton, B Thorand, MD Trip, MY Tsai, P van der Harst, E van der Schoot, YT van der Schouw, WM Verschuren, H Watkins, AA Wilde, BH Wolffenbuttel, JB Whitfield, GK Hovingh, CM Ballantyne, C Wijmenga, MP Reilly, NG Martin, JG Wilson, DJ Rader, NJ Samani, AP Reiner, RA Hegele, JJ Kastelein, AD Hingorani, PJ Talmud, H Hakonarson, CC Elbers, BJ Keating, F Drenos
Publication Date: 2012-11-02

Variant appearance in text: rs2266788
PubMed Link: 23063622
Variant Present in the following documents:
  • mmc4.xls
  • mmc7.xls
View BVdb publication page



Detailed analysis of Japanese population substructure with a focus on the southwest islands of Japan.

Plos One
T Nishiyama, H Kishino, S Suzuki, R Ando, H Niimura, H Uemura, M Horita, K Ohnaka, N Kuriyama, H Mikami, N Takashima, K Mastuo, Y Guang, K Wakai, N Hamajima, H Tanaka,
Publication Date: 2012

Variant appearance in text: rs2266788
PubMed Link: 22509376
Variant Present in the following documents:
  • pone.0035000.s006.doc
View BVdb publication page



Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.

Circulation. Cardiovascular Genetics
K Kristiansson, M Perola, E Tikkanen, J Kettunen, I Surakka, AS Havulinna, A Stancáková, C Barnes, E Widen, E Kajantie, JG Eriksson, J Viikari, M Kähönen, T Lehtimäki, OT Raitakari, AL Hartikainen, A Ruokonen, A Pouta, A Jula, AJ Kangas, P Soininen, M Ala-Korpela, S Männistö, P Jousilahti, LL Bonnycastle, MR Järvelin, J Kuusisto, FS Collins, M Laakso, ME Hurles, A Palotie, L Peltonen, S Ripatti, V Salomaa
Publication Date: 2012-04-01

Variant appearance in text: rs2266788
PubMed Link: 22399527
Variant Present in the following documents:
  • NIHMS47601-supplement-supp_data.pdf
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000227665.4 c.*158C>T - 3_prime_UTR_variant 3/3 -
ENST00000542499.1 c.*158C>T - 3_prime_UTR_variant 4/4 -
NM_001166598.2 c.*158C>T - 3_prime_UTR_variant 4/4 -
NM_001371904.1 c.*158C>T - 3_prime_UTR_variant 3/3 -
NM_052968.5 c.*158C>T - 3_prime_UTR_variant 4/4 -