Publications:

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Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study.

Medical Sciences (Basel, Switzerland)

A Chuluun-Erdene, O Sengeragchaa, TA Altangerel, P Sanjmyatav, B Dagdan, S Battulga, L Enkhbat, N Byambasuren, M Malchinkhuu, M Janlav

Publication Date: 2020-09-02

Variant appearance in text: APOA5: Gly185Cys

PubMed Link: 32887252

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic and functional studies of the LMF1 gene in Thai patients with severe hypertriglyceridemia.

Molecular Genetics And Metabolism Reports

W Plengpanich, S Muanpetch, S Charoen, A Kiateprungvej, W Khovidhunkit

Publication Date: 2020-06

Variant appearance in text: APOA5: Gly185Cys

PubMed Link: 32190547

Variant Present in the following documents:

• Main text

View BVdb publication page

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Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations.

Scientific Reports

PT Williams

Publication Date: 2020-03-11

Variant appearance in text: APOA5: Gly185Cys

PubMed Link: 32161301

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genome-wide association study of metabolic syndrome in Korean populations.

Plos One

SW Oh, JE Lee, E Shin, H Kwon, EK Choe, SY Choi, H Rhee, SH Choi

Publication Date: 2020

Variant appearance in text: rs2075291

PubMed Link: 31910446

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification and functional characterization of mutations in LPL gene causing severe hypertriglyceridaemia and acute pancreatitis.

Journal Of Cellular And Molecular Medicine

P Han, G Wei, K Cai, X Xiang, WP Deng, YB Li, S Kuang, Z Dong, T Zheng, Y Luo, J Liu, Y Guan, C Li, SK Dey, Z Liao, S Banerjee

Publication Date: 2020-01

Variant appearance in text: APOA5: 553G>T; Gly185Cys

PubMed Link: 31901151

Variant Present in the following documents:

• Main text

View BVdb publication page

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The transferability of lipid loci across African, Asian and European cohorts.

Nature Communications

K Kuchenbaecker, N Telkar, T Reiker, RG Walters, K Lin, A Eriksson, D Gurdasani, A Gilly, L Southam, E Tsafantakis, M Karaleftheri, J Seeley, A Kamali, G Asiki, IY Millwood, M Holmes, H Du, Y Guo, M Kumari, G Dedoussis, L Li, Z Chen, MS Sandhu, E Zeggini,

Publication Date: 2019-09-24

Variant appearance in text: rs2075291

PubMed Link: 31551420

Variant Present in the following documents:

• 41467_2019_12026_MOESM1_ESM.pdf

View BVdb publication page

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Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females.

Bmc Medical Genetics

S Kong, YS Cho

Publication Date: 2019-06-06

Variant appearance in text: rs2075291

PubMed Link: 31170924

Variant Present in the following documents:

• Main text

View BVdb publication page

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Association of BUD13-ZNF259-APOA5-APOA1-SIK3 cluster polymorphism in 11q23.3 and structure of APOA5 with increased plasma triglyceride levels in a Korean population.

Scientific Reports

HK Kim, MA Anwar, S Choi

Publication Date: 2019-06-05

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 31165758

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.

Scientific Reports

S Moon, YJ Kim, S Han, MY Hwang, DM Shin, MY Park, Y Lu, K Yoon, HM Jang, YK Kim, TJ Park, DS Song, JK Park, JE Lee, BJ Kim

Publication Date: 2019-02-04

Variant appearance in text: rs2075291

PubMed Link: 30718733

Variant Present in the following documents:

• Main text

View BVdb publication page

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Nature Communications

TO Kilpeläinen, AR Bentley, R Noordam, YJ Sung, K Schwander, TW Winkler, H Jakupović, DI Chasman, A Manning, I Ntalla, H Aschard, MR Brown, L de Las Fuentes, N Franceschini, X Guo, D Vojinovic, S Aslibekyan, MF Feitosa, M Kho, SK Musani, M Richard, H Wang, Z Wang, TM Bartz, LF Bielak, A Campbell, R Dorajoo, V Fisher, FP Hartwig, ARVR Horimoto, C Li, KK Lohman, J Marten, X Sim, AV Smith, SM Tajuddin, M Alver, M Amini, M Boissel, JF Chai, X Chen, J Divers, E Evangelou, C Gao, M Graff, SE Harris, M He, FC Hsu, AU Jackson, JH Zhao, AT Kraja, B Kühnel, F Laguzzi, LP Lyytikäinen, IM Nolte, R Rauramaa, M Riaz, A Robino, R Rueedi, HM Stringham, F Takeuchi, PJ van der Most, TV Varga, N Verweij, EB Ware, W Wen, X Li, LR Yanek, N Amin, DK Arnett, E Boerwinkle, M Brumat, B Cade, M Canouil, YI Chen, MP Concas, J Connell, R de Mutsert, HJ de Silva, PS de Vries, A Demirkan, J Ding, CB Eaton, JD Faul, Y Friedlander, KP Gabriel, M Ghanbari, F Giulianini, CC Gu, D Gu, TB Harris, J He, S Heikkinen, CK Heng, SC Hunt, MA Ikram, JB Jonas, WP Koh, P Komulainen, JE Krieger, SB Kritchevsky, Z Kutalik, J Kuusisto, CD Langefeld, C Langenberg, LJ Launer, K Leander, RN Lemaitre, CE Lewis, J Liang, , J Liu, R Mägi, A Manichaikul, T Meitinger, A Metspalu, Y Milaneschi, KL Mohlke, TH Mosley, AD Murray, MA Nalls, EK Nang, CP Nelson, S Nona, JM Norris, CV Nwuba, J O'Connell, ND Palmer, GJ Papanicolau, R Pazoki, NL Pedersen, A Peters, PA Peyser, O Polasek, DJ Porteous, A Poveda, OT Raitakari, SS Rich, N Risch, JG Robinson, LM Rose, I Rudan, PJ Schreiner, RA Scott, SS Sidney, M Sims, JA Smith, H Snieder, T Sofer, JM Starr, B Sternfeld, K Strauch, H Tang, KD Taylor, MY Tsai, J Tuomilehto, AG Uitterlinden, MY van der Ende, D van Heemst, T Voortman, M Waldenberger, P Wennberg, G Wilson, YB Xiang, J Yao, C Yu, JM Yuan, W Zhao, AB Zonderman, DM Becker, M Boehnke, DW Bowden, U de Faire, IJ Deary, P Elliott, T Esko, BI Freedman, P Froguel, P Gasparini, C Gieger, N Kato, M Laakso, TA Lakka, T Lehtimäki, PKE Magnusson, AJ Oldehinkel, BWJH Penninx, NJ Samani, XO Shu, P van der Harst, JV Van Vliet-Ostaptchouk, P Vollenweider, LE Wagenknecht, YX Wang, NJ Wareham, DR Weir, T Wu, W Zheng, X Zhu, MK Evans, PW Franks, V Gudnason, C Hayward, BL Horta, TN Kelly, Y Liu, KE North, AC Pereira, PM Ridker, ES Tai, RM van Dam, ER Fox, SLR Kardia, CT Liu, DO Mook-Kanamori, MA Province, S Redline, CM van Duijn, JI Rotter, CB Kooperberg, WJ Gauderman, BM Psaty, K Rice, PB Munroe, M Fornage, LA Cupples, CN Rotimi, AC Morrison, DC Rao, RJF Loos

Publication Date: 2019-01-22

Variant appearance in text: rs2075291

PubMed Link: 30670697

Variant Present in the following documents:

• 41467_2018_8008_MOESM10_ESM.xlsx
• 41467_2018_8008_MOESM12_ESM.xlsx
• 41467_2018_8008_MOESM7_ESM.xlsx
• 41467_2018_8008_MOESM9_ESM.xlsx

View BVdb publication page

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A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug.

Bmc Cardiovascular Disorders

NM Bogari, A Aljohani, AA Amin, FA Al-Allaf, A Dannoun, MM Taher, A Elsayed, DI Rednah, O Elkhatee, M Porqueddu, F Alamanni, SAA Khogeer, A Fawzy

Publication Date: 2019-01-03

Variant appearance in text: APOA5: 553G>T; rs2075291

PubMed Link: 30606120

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.

International Journal Of Endocrinology And Metabolism

MS Daneshpour, M Hedayati, B Sedaghati-Khayat, K Guity, M Zarkesh, M Akbarzadeh, N Javanrooh, A Zadeh-Vakili, F Azizi

Publication Date: 2018-10

Variant appearance in text: rs2075291

PubMed Link: 30584432

Variant Present in the following documents:

• Main text

View BVdb publication page

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Intensive genetic analysis for Chinese patients with very high triglyceride levels: Relations of mutations to triglyceride levels and acute pancreatitis.

Ebiomedicine

JL Jin, D Sun, YX Cao, HW Zhang, YL Guo, NQ Wu, CG Zhu, Y Gao, QT Dong, G Liu, Q Dong, JJ Li

Publication Date: 2018-12

Variant appearance in text: APOA5: Gly185Cys

PubMed Link: 30420299

Variant Present in the following documents:

• Main text
• mmc1.pdf

View BVdb publication page

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Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia.

International Journal Of Molecular Medicine

Y Yamada, K Kato, M Oguri, H Horibe, T Fujimaki, Y Yasukochi, I Takeuchi, J Sakuma

Publication Date: 2019-01

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 30365130

Variant Present in the following documents:

• Main text

View BVdb publication page

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Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk.

Journal Of Lipid Research

Y Zhou, R Mägi, L Milani, VM Lauschke

Publication Date: 2018-10

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 30076208

Variant Present in the following documents:

• Main text

View BVdb publication page

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New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients.

Lipids In Health And Disease

X Su, Y Kong, DQ Peng

Publication Date: 2018-07-27

Variant appearance in text: APOA5: 553G>T

PubMed Link: 30053818

Variant Present in the following documents:

• Main text

View BVdb publication page

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Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease.

Journal Of The American College Of Cardiology

A Saeed, EV Feofanova, B Yu, W Sun, SS Virani, V Nambi, J Coresh, CS Guild, E Boerwinkle, CM Ballantyne, RC Hoogeveen

Publication Date: 2018-07-10

Variant appearance in text: rs2075291

PubMed Link: 29976289

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of four genes as novel susceptibility loci for early-onset type 2 diabetes mellitus, metabolic syndrome, or hyperuricemia.

Biomedical Reports

Y Yamada, K Kato, M Oguri, H Horibe, T Fujimaki, Y Yasukochi, I Takeuchi, J Sakuma

Publication Date: 2018-07

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 29930802

Variant Present in the following documents:

• Main text

View BVdb publication page

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Effects of polymorphisms in APOA5 on the plasma levels of triglycerides and risk of coronary heart disease in Jilin, northeast China: a case-control study.

Bmj Open

Y You, YH Wu, Y Zhang, L Zhang, Y Song, W Bai, Y Li, Y Yu, C Kou

Publication Date: 2018-06-04

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 29866721

Variant Present in the following documents:

• Main text
• bmjopen-2017-020016.draft_revisions.pdf
• bmjopen-2017-020016.reviewer_comments.pdf

View BVdb publication page

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The SNPcurator: literature mining of enriched SNP-disease associations.

Database : The Journal Of Biological Databases And Curation

NS Tawfik, MR Spruit

Publication Date: 2018-01-01

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 29688369

Variant Present in the following documents:

• Main text

View BVdb publication page

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Magnolol-mediated regulation of plasma triglyceride through affecting lipoprotein lipase activity in apolipoprotein A5 knock-in mice.

Plos One

CK Chang, XR Lin, YL Lin, WH Fang, SW Lin, SY Chang, JT Kao

Publication Date: 2018

Variant appearance in text: APOA5: 553G>T; G185C; rs2075291

PubMed Link: 29425239

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.

Scientific Reports

Y Han, R Dorajoo, X Chang, L Wang, CC Khor, X Sim, CY Cheng, Y Shi, YC Tham, W Zhao, ML Chee, C Sabanayagam, ML Chee, N Tan, TY Wong, ES Tai, J Liu, DYT Goh, JM Yuan, WP Koh, RM van Dam, AF Low, MY Chan, Y Friedlander, CK Heng

Publication Date: 2017-12-20

Variant appearance in text: rs2075291

PubMed Link: 29263402

Variant Present in the following documents:

• 41598_2017_18214_MOESM1_ESM.doc
• aaaaaMain text

View BVdb publication page

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Variants of Lipolysis-Related Genes in Korean Patients with Very High Triglycerides.

Yonsei Medical Journal

CJ Lee, CY Oum, Y Lee, S Park, SM Kang, D Choi, Y Jang, JH Lee, SH Lee

Publication Date: 2018-01

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 29214790

Variant Present in the following documents:

• Main text

View BVdb publication page

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A promoter variant of the APOA5 gene increases atherogenic LDL levels and arterial stiffness in hypertriglyceridemic patients.

Plos One

M Kim, M Kim, HJ Yoo, E Lee, JS Chae, SH Lee, JH Lee

Publication Date: 2017

Variant appearance in text: APOA5: 553G>T; rs2075291

PubMed Link: 29211729

Variant Present in the following documents:

• Main text

View BVdb publication page

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Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.

Nature Genetics

X Lu, GM Peloso, DJ Liu, Y Wu, H Zhang, W Zhou, J Li, CS Tang, R Dorajoo, H Li, J Long, X Guo, M Xu, CN Spracklen, Y Chen, X Liu, Y Zhang, CC Khor, J Liu, L Sun, L Wang, YT Gao, Y Hu, K Yu, Y Wang, CYY Cheung, F Wang, J Huang, Q Fan, Q Cai, S Chen, J Shi, X Yang, W Zhao, WH Sheu, SS Cherny, M He, AB Feranil, LS Adair, P Gordon-Larsen, S Du, R Varma, YI Chen, XO Shu, KSL Lam, TY Wong, SK Ganesh, Z Mo, K Hveem, LG Fritsche, JB Nielsen, HF Tse, Y Huo, CY Cheng, YE Chen, W Zheng, ES Tai, W Gao, X Lin, W Huang, G Abecasis, , S Kathiresan, KL Mohlke, T Wu, PC Sham, D Gu, CJ Willer

Publication Date: 2017-12

Variant appearance in text: rs2075291

PubMed Link: 29083407

Variant Present in the following documents:

• Main text
• NIHMS909133-supplement-1.docx
• NIHMS909133-supplement-2.xlsx

View BVdb publication page

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Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies.

Oncotarget

Y Yamada, J Sakuma, I Takeuchi, Y Yasukochi, K Kato, M Oguri, T Fujimaki, H Horibe, M Muramatsu, M Sawabe, Y Fujiwara, Y Taniguchi, S Obuchi, H Kawai, S Shinkai, S Mori, T Arai, M Tanaka

Publication Date: 2017-06-13

Variant appearance in text: rs2075291

PubMed Link: 28473662

Variant Present in the following documents:

• Main text
• oncotarget-08-38950-s002.docx
• oncotarget-08-38950-s012.docx
• oncotarget-08-38950-s013.docx
• oncotarget-08-38950-s015.docx
• oncotarget-08-38950-s016.docx
• oncotarget-08-38950-s018.docx
• oncotarget-08-38950-s019.docx

View BVdb publication page

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Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.

Human Molecular Genetics

N Zubair, M Graff, J Luis Ambite, WS Bush, G Kichaev, Y Lu, A Manichaikul, WH Sheu, D Absher, TL Assimes, SJ Bielinski, EP Bottinger, P Buzkova, LM Chuang, RH Chung, B Cochran, L Dumitrescu, O Gottesman, JW Haessler, C Haiman, G Heiss, CA Hsiung, YJ Hung, CM Hwu, JJ Juang, L Le Marchand, IT Lee, WJ Lee, LA Lin, D Lin, SY Lin, RH Mackey, LW Martin, B Pasaniuc, U Peters, I Predazzi, T Quertermous, AP Reiner, J Robinson, JI Rotter, KK Ryckman, PJ Schreiner, E Stahl, R Tao, MY Tsai, LL Waite, TD Wang, S Buyske, YD Ida Chen, I Cheng, DC Crawford, RJF Loos, SS Rich, M Fornage, KE North, C Kooperberg, CL Carty

Publication Date: 2016-12-15

Variant appearance in text: rs2075291

PubMed Link: 28426890

Variant Present in the following documents:

• ddw358_supp.docx

View BVdb publication page

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Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

Human Molecular Genetics

CN Spracklen, P Chen, YJ Kim, X Wang, H Cai, S Li, J Long, Y Wu, YX Wang, F Takeuchi, JY Wu, KJ Jung, C Hu, K Akiyama, Y Zhang, S Moon, TA Johnson, H Li, R Dorajoo, M He, ME Cannon, TS Roman, E Salfati, KH Lin, X Guo, WHH Sheu, D Absher, LS Adair, TL Assimes, T Aung, Q Cai, LC Chang, CH Chen, LH Chien, LM Chuang, SC Chuang, S Du, Q Fan, CSJ Fann, AB Feranil, Y Friedlander, P Gordon-Larsen, D Gu, L Gui, Z Guo, CK Heng, J Hixson, X Hou, CA Hsiung, Y Hu, MY Hwang, CM Hwu, M Isono, JJ Juang, CC Khor, YK Kim, WP Koh, M Kubo, IT Lee, SJ Lee, WJ Lee, KW Liang, B Lim, SH Lim, J Liu, T Nabika, WH Pan, H Peng, T Quertermous, C Sabanayagam, K Sandow, J Shi, L Sun, PC Tan, SP Tan, KD Taylor, YY Teo, SA Toh, T Tsunoda, RM van Dam, A Wang, F Wang, J Wang, WB Wei, YB Xiang, J Yao, JM Yuan, R Zhang, W Zhao, YI Chen, SS Rich, JI Rotter, TD Wang, T Wu, X Lin, BG Han, T Tanaka, YS Cho, T Katsuya, W Jia, SH Jee, YT Chen, N Kato, JB Jonas, CY Cheng, XO Shu, J He, W Zheng, TY Wong, W Huang, BJ Kim, ES Tai, KL Mohlke, X Sim

Publication Date: 2017-05-01

Variant appearance in text: APOA5: Gly185Cys; rs2075291

PubMed Link: 28334899

Variant Present in the following documents:

• Main text

View BVdb publication page

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Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis.

Scientific Reports

Z Liu, S Burgess, Z Wang, W Deng, X Chu, J Cai, Y Zhu, J Shi, X Xie, Y Wang, L Jin, X Wang

Publication Date: 2017-01-30

Variant appearance in text: APOA5: 553G>T; G185C; rs2075291

PubMed Link: 28134330

Variant Present in the following documents:

• Main text

View BVdb publication page

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Single Nucleotide Polymorphisms in Cellular Drug Transporters Are Associated with Intolerance to Antiretroviral Therapy in Brazilian HIV-1 Positive Individuals.

Plos One

MB Arruda, F Campagnari, TB de Almeida, JC Couto-Fernandez, A Tanuri, CC Cardoso

Publication Date: 2016

Variant appearance in text: rs2075291

PubMed Link: 27648838

Variant Present in the following documents:

• pone.0163170.s001.xlsx

View BVdb publication page

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Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology.

Gene

JA Hubacek

Publication Date: 2016-10-30

Variant appearance in text: rs2075291

PubMed Link: 27496343

Variant Present in the following documents:

• Main text

View BVdb publication page

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Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India.

Plos One

R Pranav Chand, AS Kumar, K Anuj, S Vishnupriya, B Mohan Reddy

Publication Date: 2016

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 27257688

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Contribution of GWAS Loci in Familial Dyslipidemias.

Plos Genetics

P Ripatti, JT Rämö, S Söderlund, I Surakka, N Matikainen, M Pirinen, P Pajukanta, AP Sarin, SK Service, PP Laurila, C Ehnholm, V Salomaa, RK Wilson, A Palotie, NB Freimer, MR Taskinen, S Ripatti

Publication Date: 2016-05

Variant appearance in text: rs2075291

PubMed Link: 27227539

Variant Present in the following documents:

• pgen.1006078.s008.pdf

View BVdb publication page

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Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients.

Bmj Open

DP Chan, MP Lee, NS Wong, RK Leung, CM Naftalin, SS Lee

Publication Date: 2016-04-11

Variant appearance in text: APOA5: 553G>T; rs2075291

PubMed Link: 27067897

Variant Present in the following documents:

• Main text

View BVdb publication page

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Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

Journal Of Medical Genetics

EM van Leeuwen, A Sabo, JC Bis, JE Huffman, A Manichaikul, AV Smith, MF Feitosa, S Demissie, PK Joshi, Q Duan, J Marten, JB van Klinken, I Surakka, IM Nolte, W Zhang, H Mbarek, R Li-Gao, S Trompet, N Verweij, E Evangelou, LP Lyytikäinen, BO Tayo, J Deelen, PJ van der Most, SW van der Laan, DE Arking, A Morrison, A Dehghan, OH Franco, A Hofman, F Rivadeneira, EJ Sijbrands, AG Uitterlinden, JC Mychaleckyj, A Campbell, LJ Hocking, S Padmanabhan, JA Brody, KM Rice, CC White, T Harris, A Isaacs, H Campbell, LA Lange, I Rudan, I Kolcic, P Navarro, T Zemunik, V Salomaa, , AS Kooner, JS Kooner, B Lehne, WR Scott, ST Tan, EJ de Geus, Y Milaneschi, BW Penninx, G Willemsen, R de Mutsert, I Ford, RT Gansevoort, MP Segura-Lepe, OT Raitakari, JS Viikari, K Nikus, T Forrester, CA McKenzie, AJ de Craen, HM de Ruijter, , G Pasterkamp, H Snieder, AJ Oldehinkel, PE Slagboom, RS Cooper, M Kähönen, T Lehtimäki, P Elliott, P van der Harst, JW Jukema, DO Mook-Kanamori, DI Boomsma, JC Chambers, M Swertz, S Ripatti, K Willems van Dijk, V Vitart, O Polasek, C Hayward, JG Wilson, JF Wilson, V Gudnason, SS Rich, BM Psaty, IB Borecki, E Boerwinkle, JI Rotter, LA Cupples, CM van Duijn

Publication Date: 2016-07

Variant appearance in text: rs2075291

PubMed Link: 27036123

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetics of Coronary Artery Disease in Taiwan: A Cardiometabochip Study by the Taichi Consortium.

Plos One

TL Assimes, IT Lee, JM Juang, X Guo, TD Wang, ET Kim, WJ Lee, D Absher, YF Chiu, CC Hsu, LM Chuang, T Quertermous, CA Hsiung, JI Rotter, WH Sheu, YD Chen, KD Taylor

Publication Date: 2016

Variant appearance in text: rs2075291

PubMed Link: 26982883

Variant Present in the following documents:

• pone.0138014.s004.xlsx

View BVdb publication page

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Nutrigenomics: A controversy.

Applied & Translational Genomics

C Pavlidis, GP Patrinos, T Katsila

Publication Date: 2015-03

Variant appearance in text: rs2075291

PubMed Link: 26937350

Variant Present in the following documents:

• Main text

View BVdb publication page

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Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome.

Plos One

Y Wu, Y Yu, T Zhao, S Wang, Y Fu, Y Qi, G Yang, W Yao, Y Su, Y Ma, J Shi, J Jiang, C Kou

Publication Date: 2016

Variant appearance in text: rs2075291

PubMed Link: 26824674

Variant Present in the following documents:

• Main text

View BVdb publication page

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Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.

Nature Communications

CS Tang, H Zhang, CY Cheung, M Xu, JC Ho, W Zhou, SS Cherny, Y Zhang, O Holmen, KW Au, H Yu, L Xu, J Jia, RM Porsch, L Sun, W Xu, H Zheng, LY Wong, Y Mu, J Dou, CH Fong, S Wang, X Hong, L Dong, Y Liao, J Wang, LS Lam, X Su, H Yan, ML Yang, J Chen, CW Siu, G Xie, YC Woo, Y Wu, KC Tan, K Hveem, BM Cheung, S Zöllner, A Xu, Y Eugene Chen, CQ Jiang, Y Zhang, TH Lam, SK Ganesh, Y Huo, PC Sham, KS Lam, CJ Willer, HF Tse, W Gao

Publication Date: 2015-12-22

Variant appearance in text: APOA5: Gly185Cys; rs2075291

PubMed Link: 26690388

Variant Present in the following documents:

• Main text
• ncomms10206-s1.pdf
• ncomms10206-s2.xlsx

View BVdb publication page

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Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.

Journal Of Biomedical Research

TM Forte, V Sharma, RO Ryan

Publication Date: 2016-03

Variant appearance in text: APOA5: 553G>T; rs2075291

PubMed Link: 26679785

Variant Present in the following documents:

• Main text

View BVdb publication page

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Multiple susceptibility loci at chromosome 11q23.3 are associated with plasma triglyceride in East Asians.

Journal Of Lipid Research

B Gombojav, SJ Lee, M Kho, YM Song, K Lee, J Sung

Publication Date: 2016-02

Variant appearance in text: rs2075291

PubMed Link: 26634697

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic Variants Associated with Gestational Hypertriglyceridemia and Pancreatitis.

Plos One

SL Xie, TZ Chen, XL Huang, C Chen, R Jin, ZM Huang, MT Zhou

Publication Date: 2015

Variant appearance in text: APOA5: 553G>T; G185C; rs2075291

PubMed Link: 26079787

Variant Present in the following documents:

• Main text

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Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism.

Current Drug Targets

TM Forte, RO Ryan

Publication Date: 2015

Variant appearance in text: APOA5: 553G>T; G185C

PubMed Link: 26028042

Variant Present in the following documents:

• Main text

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Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome.

Journal Of Diabetes And Metabolic Disorders

M Ajjemami, S Ouatou, H Charoute, M Fakiri, H Rhaissi, H Benrahma, H Rouba, A Barakat

Publication Date: 2015

Variant appearance in text: APOA5: 553G>T; G185C; rs2075291

PubMed Link: 25909077

Variant Present in the following documents:

• Main text

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Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study.

Plos One

M Nakatochi, Y Ushida, Y Yasuda, Y Yoshida, S Kawai, R Kato, T Nakashima, M Iwata, Y Kuwatsuka, M Ando, N Hamajima, T Kondo, H Oda, M Hayashi, S Kato, M Yamaguchi, S Maruyama, S Matsuo, H Honda

Publication Date: 2015

Variant appearance in text: APOA5: Gly185Cys; rs2075291

PubMed Link: 25646961

Variant Present in the following documents:

• pone.0117591.s001.docx
• pone.0117591.s002.xlsx
• pone.0117591.s003.xlsx
• pone.0117591.s004.xlsx

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Influences of APOA5 variants on plasma triglyceride levels in Uyghur population.

Plos One

S Li, B Hu, Y Wang, D Wu, L Jin, X Wang

Publication Date: 2014

Variant appearance in text: APOA5: 553G>T; G185C; rs2075291

PubMed Link: 25313938

Variant Present in the following documents:

• Main text
• pone.0110258.s001.docx

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Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study.

Lipids In Health And Disease

A Hishida, K Wakai, M Naito, S Suma, T Sasakabe, N Hamajima, S Hosono, M Horita, TC Turin, S Suzuki, TS Kairupan, H Mikami, K Ohnaka, I Watanabe, H Uemura, M Kubo, H Tanaka,

Publication Date: 2014-10-14

Variant appearance in text: rs2075291

PubMed Link: 25311932

Variant Present in the following documents:

• Main text

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Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291).

Arteriosclerosis, Thrombosis, And Vascular Biology

V Sharma, A Witkowski, HE Witkowska, A Dykstra, JB Simonsen, L Nelbach, JA Beckstead, CR Pullinger, JP Kane, MJ Malloy, G Watson, TM Forte, RO Ryan

Publication Date: 2014-10

Variant appearance in text: APOA5: 553G>T; Gly185Cys; rs2075291

PubMed Link: 25127531

Variant Present in the following documents:

• Main text

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Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients.

Lipids In Health And Disease

S Ouatou, M Ajjemami, H Charoute, H Sefri, N Ghalim, H Rhaissi, H Benrahma, A Barakat, H Rouba

Publication Date: 2014-04-01

Variant appearance in text: APOA5: 553G>T; rs2075291

PubMed Link: 24684850

Variant Present in the following documents:

• Main text

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Genetic polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects.

Plos One

YW Yin, QQ Sun, PJ Wang, L Qiao, AM Hu, HL Liu, Q Wang, ZZ Hou

Publication Date: 2014

Variant appearance in text: APOA5: G185C

PubMed Link: 24586566

Variant Present in the following documents:

• Main text

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Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.

Journal Of Lipid Research

Y Wu, AF Marvelle, J Li, DC Croteau-Chonka, AB Feranil, CW Kuzawa, Y Li, LS Adair, KL Mohlke

Publication Date: 2013-11

Variant appearance in text: APOA5: Gly185Cys; rs2075291

PubMed Link: 24023260

Variant Present in the following documents:

• Main text

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Apolipoprotein A5 gene variants and the risk of coronary heart disease: a case‑control study and meta‑analysis.

Molecular Medicine Reports

J Zhou, L Xu, RS Huang, Y Huang, Y Le, D Jiang, X Yang, W Xu, X Huang, C Dong, M Ye, J Lian, S Duan

Publication Date: 2013-10

Variant appearance in text: rs2075291

PubMed Link: 23970179

Variant Present in the following documents:

• Main text

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The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study.

Bmc Cancer

MC Hsu, KT Lee, WC Hsiao, CH Wu, HY Sun, IL Lin, KC Young

Publication Date: 2013-07-05

Variant appearance in text: rs2075291

PubMed Link: 23829168

Variant Present in the following documents:

• 1471-2407-13-330-S1.doc
• 1471-2407-13-330-S3.doc
• aaaaaMain text

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Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.

Plos Genetics

Y Wu, LL Waite, AU Jackson, WH Sheu, S Buyske, D Absher, DK Arnett, E Boerwinkle, LL Bonnycastle, CL Carty, I Cheng, B Cochran, DC Croteau-Chonka, L Dumitrescu, CB Eaton, N Franceschini, X Guo, BE Henderson, LA Hindorff, E Kim, L Kinnunen, P Komulainen, WJ Lee, L Le Marchand, Y Lin, J Lindström, O Lingaas-Holmen, SL Mitchell, N Narisu, JG Robinson, F Schumacher, A Stančáková, J Sundvall, YJ Sung, AJ Swift, WC Wang, L Wilkens, T Wilsgaard, AM Young, LS Adair, CM Ballantyne, P Bůžková, A Chakravarti, FS Collins, D Duggan, AB Feranil, LT Ho, YJ Hung, SC Hunt, K Hveem, JM Juang, AY Kesäniemi, J Kuusisto, M Laakso, TA Lakka, IT Lee, MF Leppert, TC Matise, L Moilanen, I Njølstad, U Peters, T Quertermous, R Rauramaa, JI Rotter, J Saramies, J Tuomilehto, M Uusitupa, TD Wang, M Boehnke, CA Haiman, YD Chen, C Kooperberg, TL Assimes, DC Crawford, CA Hsiung, KE North, KL Mohlke

Publication Date: 2013-03

Variant appearance in text: APOA5: G185C; rs2075291

PubMed Link: 23555291

Variant Present in the following documents:

• Main text

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Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population.

Nutrition & Metabolism

I Rudkowska, C Ouellette, E Dewailly, RA Hegele, V Boiteau, A Dubé-Linteau, B Abdous, F Proust, Y Giguère, P Julien, ML Château-Degat, MC Vohl

Publication Date: 2013-03-12

Variant appearance in text: APOA5: Gly185Cys; rs2075291

PubMed Link: 23497168

Variant Present in the following documents:

• Main text

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Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.

Nutrition & Diabetes

MC Hsu, CS Chang, KT Lee, HY Sun, YS Tsai, PH Kuo, KC Young, CH Wu

Publication Date: 2013-03-04

Variant appearance in text: rs2075291

PubMed Link: 23459084

Variant Present in the following documents:

• Main text

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Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia.

Journal Of Lipid Research

E Mendoza-Barberá, J Julve, SK Nilsson, A Lookene, JM Martín-Campos, R Roig, AM Lechuga-Sancho, JH Sloan, P Fuentes-Prior, F Blanco-Vaca

Publication Date: 2013-03

Variant appearance in text: APOA5: Gly185Cys

PubMed Link: 23307945

Variant Present in the following documents:

• Main text

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Influence of apolipoprotein A-V on the metabolic fate of triacylglycerol.

Current Opinion In Lipidology

V Sharma, TM Forte, RO Ryan

Publication Date: 2013-04

Variant appearance in text: APOA5: 553G>T

PubMed Link: 23241513

Variant Present in the following documents:

• Main text

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Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.

Plos One

CC Elbers, Y Guo, V Tragante, EP van Iperen, MB Lanktree, BA Castillo, F Chen, LR Yanek, MK Wojczynski, YR Li, B Ferwerda, CM Ballantyne, SG Buxbaum, YD Chen, WM Chen, LA Cupples, M Cushman, Y Duan, D Duggan, MK Evans, JK Fernandes, M Fornage, M Garcia, WT Garvey, N Glazer, F Gomez, TB Harris, I Halder, VJ Howard, MF Keller, MI Kamboh, C Kooperberg, SB Kritchevsky, A LaCroix, K Liu, Y Liu, K Musunuru, AB Newman, NC Onland-Moret, J Ordovas, I Peter, W Post, S Redline, SE Reis, R Saxena, PJ Schreiner, KA Volcik, X Wang, S Yusuf, AB Zonderland, SS Anand, DM Becker, B Psaty, DJ Rader, AP Reiner, SS Rich, JI Rotter, MM Sale, MY Tsai, IB Borecki, RA Hegele, S Kathiresan, MA Nalls, HA Taylor, H Hakonarson, S Sivapalaratnam, FW Asselbergs, F Drenos, JG Wilson, BJ Keating

Publication Date: 2012

Variant appearance in text: rs2075291

PubMed Link: 23236364

Variant Present in the following documents:

• pone.0050198.s002.pdf
• pone.0050198.s008.xlsx

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Associations of polymorphisms in the apolipoprotein APOA1-C3-A5 gene cluster with acute coronary syndrome.

Journal Of Biomedicine & Biotechnology

Y Ding, MA Zhu, ZX Wang, J Zhu, JB Feng, DS Li

Publication Date: 2012

Variant appearance in text: APOA5: 553G>T

PubMed Link: 22675253

Variant Present in the following documents:

• Main text

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Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians.

Journal Of Community Genetics

AA Bhanushali, BR Das

Publication Date: 2010-09

Variant appearance in text: APOA5: 553G>T; G185C

PubMed Link: 22460246

Variant Present in the following documents:

• Main text

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Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels.

Lipids In Health And Disease

RX Yin, YY Li, CQ Lai

Publication Date: 2011-08-19

Variant appearance in text: rs2075291

PubMed Link: 21854571

Variant Present in the following documents:

• Main text

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Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

Journal Of Epidemiology

K Wakai, N Hamajima, R Okada, M Naito, E Morita, A Hishida, S Kawai, K Nishio, G Yin, Y Asai, K Matsuo, S Hosono, H Ito, M Watanabe, T Kawase, T Suzuki, K Tajima, K Tanaka, Y Higaki, M Hara, T Imaizumi, N Taguchi, K Nakamura, H Nanri, T Sakamoto, M Horita, K Shinchi, Y Kita, TC Turin, N Rumana, K Matsui, K Miura, H Ueshima, N Takashima, Y Nakamura, S Suzuki, R Ando, A Hosono, N Imaeda, K Shibata, C Goto, N Hattori, M Fukatsu, T Yamada, S Tokudome, T Takezaki, H Niimura, K Hirasada, A Nakamura, M Tatebo, S Ogawa, N Tsunematsu, S Chiba, H Mikami, S Kono, K Ohnaka, R Takayanagi, Y Watanabe, E Ozaki, M Shigeta, N Kuriyama, A Yoshikawa, D Matsui, I Watanabe, K Inoue, K Ozasa, S Mitani, K Arisawa, H Uemura, M Hiyoshi, H Takami, M Yamaguchi, M Nakamoto, H Takeda, M Kubo, H Tanaka,

Publication Date: 2011

Variant appearance in text: APOA5: Gly185Cys; rs2075291

PubMed Link: 21467728

Variant Present in the following documents:

• Main text

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Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels.

Plos One

RX Yin, YY Li, WY Liu, L Zhang, JZ Wu

Publication Date: 2011-03-14

Variant appearance in text: rs2075291

PubMed Link: 21423763

Variant Present in the following documents:

• Main text

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Genetic determinants of plasma triglycerides.

Journal Of Lipid Research

CT Johansen, S Kathiresan, RA Hegele

Publication Date: 2011-02

Variant appearance in text: APOA5: G185C

PubMed Link: 21041806

Variant Present in the following documents:

• Main text

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Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.

Nature Genetics

CT Johansen, J Wang, MB Lanktree, H Cao, AD McIntyre, MR Ban, RA Martins, BA Kennedy, RG Hassell, ME Visser, SM Schwartz, BF Voight, R Elosua, V Salomaa, CJ O'Donnell, GM Dallinga-Thie, SS Anand, S Yusuf, MW Huff, S Kathiresan, RA Hegele

Publication Date: 2010-08

Variant appearance in text: APOA5: G185C

PubMed Link: 20657596

Variant Present in the following documents:

• NIHMS260054-supplement-Supplemental_Data.pdf

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A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese.

European Journal Of Human Genetics : Ejhg

CQ Jiang, B Liu, BM Cheung, TH Lam, JM Lin, Y Li Jin, XJ Yue, KL Ong, S Tam, KS Wong, B Tomlinson, KS Lam, GN Thomas

Publication Date: 2010-11

Variant appearance in text: rs2075291

PubMed Link: 20571505

Variant Present in the following documents:

• Main text

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Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

Experimental Gerontology

E Boes, S Coassin, B Kollerits, IM Heid, F Kronenberg

Publication Date: 2009-03

Variant appearance in text: APOA5: Gly185Cys; rs2075291

PubMed Link: 19041386

Variant Present in the following documents:

• Main text

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Clinical significance of apolipoprotein A5.

Current Opinion In Lipidology

ES Tai, JM Ordovas

Publication Date: 2008-08

Variant appearance in text: APOA5: Gly185Cys

PubMed Link: 18607181

Variant Present in the following documents:

• Main text

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An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.

Journal Of Lipid Research

CR Pullinger, BE Aouizerat, I Movsesyan, V Durlach, EJ Sijbrands, K Nakajima, A Poon, GM Dallinga-Thie, H Hattori, LL Green, PY Kwok, RJ Havel, PH Frost, MJ Malloy, JP Kane

Publication Date: 2008-08

Variant appearance in text: APOA5: 553G>T; rs2075291

PubMed Link: 18441017

Variant Present in the following documents:

• Main text

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Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11.

Genomics

M Olivier, X Wang, R Cole, B Gau, J Kim, EM Rubin, LA Pennacchio

Publication Date: 2004-05

Variant appearance in text: rs2075291

PubMed Link: 15081120

Variant Present in the following documents:

• Main text

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000227665.4	c.553G>T	p.Gly185Cys	missense_variant	3/3	-
ENST00000542499.1	c.553G>T	p.Gly185Cys	missense_variant	4/4	-
NM_001166598.2	c.553G>T	p.Gly185Cys	missense_variant	4/4	-
NM_001371904.1	c.553G>T	p.Gly185Cys	missense_variant	3/3	-
NM_052968.5	c.553G>T	p.Gly185Cys	missense_variant	4/4	-