Variant ID: 11-116662407-G-A

NM_001166598.1(APOA5):c.56C>T;(p.Ser19Leu)

This variant was identified in 117 publications




Publications:


Genetically Mediated Lipid Metabolism and Risk of Insulin Resistance: Insights from Mendelian Randomization Studies.

Journal Of Lipid And Atherosclerosis
SY Bu
Publication Date: 2019-09

Variant appearance in text: rs3135506
PubMed Link: 32821703
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa.

Bioscience Reports
M Hechmi, H Dallali, M Gharbi, H Jmel, M Fassatoui, Y Ben Halima, S Bahri, A Bahlous, A Abid, H Jamoussi, A Barakat, R Kefi
Publication Date: 2020-08-28

Variant appearance in text: rs3135506
PubMed Link: 32725151
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genes and Eating Preferences, Their Roles in Personalized Nutrition.

Genes
A Vesnina, A Prosekov, O Kozlova, V Atuchin
Publication Date: 2020-03-27

Variant appearance in text: rs3135506
PubMed Link: 32230794
Variant Present in the following documents:
  • Main text
View BVdb publication page



Population History and Gene Divergence in Native Mexicans Inferred from 76 Human Exomes.

Molecular Biology And Evolution
MC Ávila-Arcos, KF McManus, K Sandoval, JE Rodríguez-Rodríguez, V Villa-Islas, AR Martin, P Luisi, RI Peñaloza-Espinosa, C Eng, S Huntsman, EG Burchard, CR Gignoux, CD Bustamante, A Moreno-Estrada
Publication Date: 2020-04-01

Variant appearance in text: rs3135506
PubMed Link: 31848607
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic architecture of human plasma lipidome and its link to cardiovascular disease.

Nature Communications
R Tabassum, JT Rämö, P Ripatti, JT Koskela, M Kurki, J Karjalainen, P Palta, S Hassan, J Nunez-Fontarnau, TTJ Kiiskinen, S Söderlund, N Matikainen, MJ Gerl, MA Surma, C Klose, NO Stitziel, H Laivuori, AS Havulinna, SK Service, V Salomaa, M Pirinen, , M Jauhiainen, MJ Daly, NB Freimer, A Palotie, MR Taskinen, K Simons, S Ripatti
Publication Date: 2019-09-24

Variant appearance in text: rs3135506
PubMed Link: 31551469
Variant Present in the following documents:
  • 41467_2019_11954_MOESM13_ESM.xlsx
  • 41467_2019_11954_MOESM14_ESM.xlsx
View BVdb publication page



Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology.

Nature Communications
Y Tanigawa, J Li, JM Justesen, H Horn, M Aguirre, C DeBoever, C Chang, B Narasimhan, K Lage, T Hastie, CY Park, G Bejerano, E Ingelsson, MA Rivas
Publication Date: 2019-09-06

Variant appearance in text: rs3135506
PubMed Link: 31492854
Variant Present in the following documents:
  • 41467_2019_11953_MOESM6_ESM.xlsx
View BVdb publication page



Exome sequencing of Finnish isolates enhances rare-variant association power.

Nature
AE Locke, KM Steinberg, CWK Chiang, SK Service, AS Havulinna, L Stell, M Pirinen, HJ Abel, CC Chiang, RS Fulton, AU Jackson, CJ Kang, KL Kanchi, DC Koboldt, DE Larson, J Nelson, TJ Nicholas, A Pietilä, V Ramensky, D Ray, LJ Scott, HM Stringham, J Vangipurapu, R Welch, P Yajnik, X Yin, JG Eriksson, M Ala-Korpela, MR Järvelin, M Männikkö, H Laivuori, , SK Dutcher, NO Stitziel, RK Wilson, IM Hall, C Sabatti, A Palotie, V Salomaa, M Laakso, S Ripatti, M Boehnke, NB Freimer
Publication Date: 2019-08

Variant appearance in text: rs3135506
PubMed Link: 31367044
Variant Present in the following documents:
  • EMS83607-supplement-Supplementary_Tables.xlsx
View BVdb publication page



A 3-SNP gene risk score and a metabolic risk score both predict hypertriglyceridemia and cardiovascular disease risk.

Journal Of Clinical Lipidology
R Verbeek, F Oldoni, RP Surendran, AH Zwinderman, KT Khaw, ESG Stroes, NJ Wareham, SM Boekholdt, GM Dallinga-Thie
Publication Date: 2019

Variant appearance in text: rs3135506
PubMed Link: 30910668
Variant Present in the following documents:
  • Main text
View BVdb publication page



A sleep apneic's gene: perspectives for development of diabetes.

Polish Archives Of Internal Medicine
P Singh
Publication Date: 2019-01-31

Variant appearance in text: rs3135506
PubMed Link: 30702652
Variant Present in the following documents:
  • Main text
  • nihms-1026704.pdf
View BVdb publication page



Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease.

Jama
BA Ference, JJP Kastelein, KK Ray, HN Ginsberg, MJ Chapman, CJ Packard, U Laufs, C Oliver-Williams, AM Wood, AS Butterworth, E Di Angelantonio, J Danesh, SJ Nicholls, DL Bhatt, MS Sabatine, AL Catapano
Publication Date: 2019-01-29

Variant appearance in text: rs3135506
PubMed Link: 30694319
Variant Present in the following documents:
  • jama-321-364-s001.pdf
View BVdb publication page



Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.

International Journal Of Endocrinology And Metabolism
MS Daneshpour, M Hedayati, B Sedaghati-Khayat, K Guity, M Zarkesh, M Akbarzadeh, N Javanrooh, A Zadeh-Vakili, F Azizi
Publication Date: 2018-10

Variant appearance in text: rs3135506
PubMed Link: 30584432
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review.

Omics : A Journal Of Integrative Biology
JJ Noubiap, EPM Mato, M Guewo-Fokeng, AD Kaze, H Boulenouar, A Wonkam
Publication Date: 2018-12

Variant appearance in text: rs3135506
PubMed Link: 30571611
Variant Present in the following documents:
  • Main text
View BVdb publication page



Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

Scientific Reports
SE John, D Antony, M Eaaswarkhanth, P Hebbar, AM Channanath, D Thomas, S Devarajan, J Tuomilehto, F Al-Mulla, O Alsmadi, TA Thanaraj
Publication Date: 2018-11-08

Variant appearance in text: rs3135506
PubMed Link: 30409984
Variant Present in the following documents:
  • Main text
View BVdb publication page



Population Pharmacokinetics of Tacrolimus in Transplant Recipients: What Did We Learn About Sources of Interindividual Variabilities?

Journal Of Clinical Pharmacology
O Campagne, DE Mager, KM Tornatore
Publication Date: 2019-03

Variant appearance in text: rs3135506
PubMed Link: 30371942
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

Nature Communications
C Yao, G Chen, C Song, J Keefe, M Mendelson, T Huan, BB Sun, A Laser, JC Maranville, H Wu, JE Ho, P Courchesne, A Lyass, MG Larson, C Gieger, J Graumann, AD Johnson, J Danesh, H Runz, SJ Hwang, C Liu, AS Butterworth, K Suhre, D Levy
Publication Date: 2018-08-15

Variant appearance in text: rs3135506
PubMed Link: 30111768
Variant Present in the following documents:
  • 41467_2018_5512_MOESM11_ESM.xlsx
  • 41467_2018_5512_MOESM7_ESM.xlsx
  • 41467_2018_5512_MOESM8_ESM.xlsx
View BVdb publication page



Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease.

Journal Of The American College Of Cardiology
A Saeed, EV Feofanova, B Yu, W Sun, SS Virani, V Nambi, J Coresh, CS Guild, E Boerwinkle, CM Ballantyne, RC Hoogeveen
Publication Date: 2018-07-10

Variant appearance in text: rs3135506
PubMed Link: 29976289
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influence of APOA5 Locus on the Treatment Efficacy of Three Statins: Evidence From a Randomized Pilot Study in Chinese Subjects.

Frontiers In Pharmacology
S Hua, C Ma, J Zhang, J Li, W Wu, N Xu, G Luo, J Zhao
Publication Date: 2018

Variant appearance in text: rs3135506
PubMed Link: 29695967
Variant Present in the following documents:
  • Main text
View BVdb publication page



The SNPcurator: literature mining of enriched SNP-disease associations.

Database : The Journal Of Biological Databases And Curation
NS Tawfik, MR Spruit
Publication Date: 2018-01-01

Variant appearance in text: rs3135506
PubMed Link: 29688369
Variant Present in the following documents:
  • Main text
View BVdb publication page



An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort.

Journal Of Lipid Research
X Geng, MR Irvin, B Hidalgo, S Aslibekyan, V Srinivasasainagendra, P An, AC Frazier-Wood, HK Tiwari, T Dave, K Ryan, JM Ordovas, RJ Straka, MF Feitosa, PN Hopkins, I Borecki, MA Province, BD Mitchell, DK Arnett, D Zhi
Publication Date: 2018-04

Variant appearance in text: rs3135506
PubMed Link: 29463568
Variant Present in the following documents:
  • Main text
View BVdb publication page



Apolipoprotein A5 3'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey.

Nutrition Research And Practice
OY Kim, J Moon, G Jo, SY Kwak, JY Kim, MJ Shin
Publication Date: 2018-02

Variant appearance in text: rs3135506
PubMed Link: 29399298
Variant Present in the following documents:
  • Main text
View BVdb publication page



Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

Plos Genetics
JP Davis, JR Huyghe, AE Locke, AU Jackson, X Sim, HM Stringham, TM Teslovich, RP Welch, C Fuchsberger, N Narisu, PS Chines, AJ Kangas, P Soininen, M Ala-Korpela, J Kuusisto, FS Collins, M Laakso, M Boehnke, KL Mohlke
Publication Date: 2017-10

Variant appearance in text: rs3135506
PubMed Link: 29084231
Variant Present in the following documents:
  • pgen.1007079.s010.xlsx
View BVdb publication page



Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.

Nature Genetics
X Lu, GM Peloso, DJ Liu, Y Wu, H Zhang, W Zhou, J Li, CS Tang, R Dorajoo, H Li, J Long, X Guo, M Xu, CN Spracklen, Y Chen, X Liu, Y Zhang, CC Khor, J Liu, L Sun, L Wang, YT Gao, Y Hu, K Yu, Y Wang, CYY Cheung, F Wang, J Huang, Q Fan, Q Cai, S Chen, J Shi, X Yang, W Zhao, WH Sheu, SS Cherny, M He, AB Feranil, LS Adair, P Gordon-Larsen, S Du, R Varma, YI Chen, XO Shu, KSL Lam, TY Wong, SK Ganesh, Z Mo, K Hveem, LG Fritsche, JB Nielsen, HF Tse, Y Huo, CY Cheng, YE Chen, W Zheng, ES Tai, W Gao, X Lin, W Huang, G Abecasis, , S Kathiresan, KL Mohlke, T Wu, PC Sham, D Gu, CJ Willer
Publication Date: 2017-12

Variant appearance in text: rs3135506
PubMed Link: 29083407
Variant Present in the following documents:
  • NIHMS909133-supplement-2.xlsx
View BVdb publication page



The impact of rare and low-frequency genetic variants in common disease.

Genome Biology
L Bomba, K Walter, N Soranzo
Publication Date: 2017-04-27

Variant appearance in text: rs3135506
PubMed Link: 28449691
Variant Present in the following documents:
  • 13059_2017_1212_MOESM1_ESM.xlsx
View BVdb publication page



Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci.

Nature Genetics
S Stender, J Kozlitina, BG Nordestgaard, A Tybjærg-Hansen, HH Hobbs, JC Cohen
Publication Date: 2017-06

Variant appearance in text: rs3135506
PubMed Link: 28436986
Variant Present in the following documents:
  • NIHMS864885-supplement-1.pdf
View BVdb publication page



Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.

Human Molecular Genetics
N Zubair, M Graff, J Luis Ambite, WS Bush, G Kichaev, Y Lu, A Manichaikul, WH Sheu, D Absher, TL Assimes, SJ Bielinski, EP Bottinger, P Buzkova, LM Chuang, RH Chung, B Cochran, L Dumitrescu, O Gottesman, JW Haessler, C Haiman, G Heiss, CA Hsiung, YJ Hung, CM Hwu, JJ Juang, L Le Marchand, IT Lee, WJ Lee, LA Lin, D Lin, SY Lin, RH Mackey, LW Martin, B Pasaniuc, U Peters, I Predazzi, T Quertermous, AP Reiner, J Robinson, JI Rotter, KK Ryckman, PJ Schreiner, E Stahl, R Tao, MY Tsai, LL Waite, TD Wang, S Buyske, YD Ida Chen, I Cheng, DC Crawford, RJF Loos, SS Rich, M Fornage, KE North, C Kooperberg, CL Carty
Publication Date: 2016-12-15

Variant appearance in text: rs3135506
PubMed Link: 28426890
Variant Present in the following documents:
  • Main text
  • ddw358_supp.docx
View BVdb publication page



Genetic associations with lipoprotein subfraction measures differ by ethnicity in the multi-ethnic study of atherosclerosis (MESA).

Human Genetics
Z Wang, A Manichukal, DC Goff, S Mora, JM Ordovas, NM Pajewski, WS Post, JI Rotter, MM Sale, SA Santorico, D Siscovick, MY Tsai, DK Arnett, S Rich, AC Frazier-Wood
Publication Date: 2017-06

Variant appearance in text: rs3135506
PubMed Link: 28352986
Variant Present in the following documents:
  • 439_2017_1782_MOESM1_ESM.docx
View BVdb publication page



Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.

Plos One
EJ Parra, A Mazurek, CR Gignoux, A Sockell, M Agostino, AP Morris, LE Petty, CL Hanis, NJ Cox, A Valladares-Salgado, JE Below, M Cruz
Publication Date: 2017

Variant appearance in text: rs3135506
PubMed Link: 28245265
Variant Present in the following documents:
  • Main text
View BVdb publication page



IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients.

Acta Pharmacologica Sinica
MZ Liu, HY He, YL Zhang, YF Hu, FZ He, JQ Luo, ZY Luo, XP Chen, ZQ Liu, HH Zhou, MJ Shao, YZ Ming, HW Xin, W Zhang
Publication Date: 2017-03

Variant appearance in text: rs3135506
PubMed Link: 28112181
Variant Present in the following documents:
  • aps2016153x11.doc
View BVdb publication page



Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program.

Circulation. Cardiovascular Genetics
TV Varga, AH Winters, KA Jablonski, ES Horton, P Khare-Ranade, WC Knowler, SM Marcovina, F Renström, KE Watson, R Goldberg, JC Florez, TI Pollin, PW Franks
Publication Date: 2016-12

Variant appearance in text: rs3135506
PubMed Link: 27784733
Variant Present in the following documents:
  • NIHMS825913-supplement-001457_-_Supplemental_Material.pdf
View BVdb publication page



Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.

Cardiovascular Diabetology
KS Weber, B Knebel, K Strassburger, J Kotzka, P Stehle, J Szendroedi, K Müssig, AE Buyken, M Roden,
Publication Date: 2016-09-27

Variant appearance in text: rs3135506
PubMed Link: 27677442
Variant Present in the following documents:
  • 12933_2016_455_MOESM1_ESM.docx
  • aaaaaMain text
View BVdb publication page



Single Nucleotide Polymorphisms in Cellular Drug Transporters Are Associated with Intolerance to Antiretroviral Therapy in Brazilian HIV-1 Positive Individuals.

Plos One
MB Arruda, F Campagnari, TB de Almeida, JC Couto-Fernandez, A Tanuri, CC Cardoso
Publication Date: 2016

Variant appearance in text: rs3135506
PubMed Link: 27648838
Variant Present in the following documents:
  • pone.0163170.s001.xlsx
View BVdb publication page



Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology.

Gene
JA Hubacek
Publication Date: 2016-10-30

Variant appearance in text: rs3135506
PubMed Link: 27496343
Variant Present in the following documents:
  • Main text
View BVdb publication page



Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India.

Plos One
R Pranav Chand, AS Kumar, K Anuj, S Vishnupriya, B Mohan Reddy
Publication Date: 2016

Variant appearance in text: rs3135506
PubMed Link: 27257688
Variant Present in the following documents:
  • pone.0153720.s002.docx
  • pone.0153720.s003.xlsx
View BVdb publication page



The Contribution of GWAS Loci in Familial Dyslipidemias.

Plos Genetics
P Ripatti, JT Rämö, S Söderlund, I Surakka, N Matikainen, M Pirinen, P Pajukanta, AP Sarin, SK Service, PP Laurila, C Ehnholm, V Salomaa, RK Wilson, A Palotie, NB Freimer, MR Taskinen, S Ripatti
Publication Date: 2016-05

Variant appearance in text: rs3135506
PubMed Link: 27227539
Variant Present in the following documents:
  • Main text
  • pgen.1006078.s005.pdf
  • pgen.1006078.s008.pdf
  • pgen.1006078.s009.pdf
View BVdb publication page



Frequency of rare mutations and common genetic variations in severe hypertriglyceridemia in the general population of Spain.

Lipids In Health And Disease
I Lamiquiz-Moneo, C Blanco-Torrecilla, AM Bea, R Mateo-Gallego, S Pérez-Calahorra, L Baila-Rueda, A Cenarro, F Civeira, I de Castro-Orós
Publication Date: 2016-04-23

Variant appearance in text: APOA5: 56C>T
PubMed Link: 27108409
Variant Present in the following documents:
  • Main text
View BVdb publication page



Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

Journal Of Medical Genetics
EM van Leeuwen, A Sabo, JC Bis, JE Huffman, A Manichaikul, AV Smith, MF Feitosa, S Demissie, PK Joshi, Q Duan, J Marten, JB van Klinken, I Surakka, IM Nolte, W Zhang, H Mbarek, R Li-Gao, S Trompet, N Verweij, E Evangelou, LP Lyytikäinen, BO Tayo, J Deelen, PJ van der Most, SW van der Laan, DE Arking, A Morrison, A Dehghan, OH Franco, A Hofman, F Rivadeneira, EJ Sijbrands, AG Uitterlinden, JC Mychaleckyj, A Campbell, LJ Hocking, S Padmanabhan, JA Brody, KM Rice, CC White, T Harris, A Isaacs, H Campbell, LA Lange, I Rudan, I Kolcic, P Navarro, T Zemunik, V Salomaa, , AS Kooner, JS Kooner, B Lehne, WR Scott, ST Tan, EJ de Geus, Y Milaneschi, BW Penninx, G Willemsen, R de Mutsert, I Ford, RT Gansevoort, MP Segura-Lepe, OT Raitakari, JS Viikari, K Nikus, T Forrester, CA McKenzie, AJ de Craen, HM de Ruijter, , G Pasterkamp, H Snieder, AJ Oldehinkel, PE Slagboom, RS Cooper, M Kähönen, T Lehtimäki, P Elliott, P van der Harst, JW Jukema, DO Mook-Kanamori, DI Boomsma, JC Chambers, M Swertz, S Ripatti, K Willems van Dijk, V Vitart, O Polasek, C Hayward, JG Wilson, JF Wilson, V Gudnason, SS Rich, BM Psaty, IB Borecki, E Boerwinkle, JI Rotter, LA Cupples, CM van Duijn
Publication Date: 2016-07

Variant appearance in text: rs3135506
PubMed Link: 27036123
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nutrigenomics: A controversy.

Applied & Translational Genomics
C Pavlidis, GP Patrinos, T Katsila
Publication Date: 2015-03

Variant appearance in text: rs3135506
PubMed Link: 26937350
Variant Present in the following documents:
  • Main text
View BVdb publication page



Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.

Scientific Reports
JE Below, EJ Parra, ER Gamazon, J Torres, S Krithika, S Candille, Y Lu, A Manichakul, J Peralta-Romero, Q Duan, Y Li, AP Morris, O Gottesman, E Bottinger, XQ Wang, KD Taylor, YD Ida Chen, JI Rotter, SS Rich, RJ Loos, H Tang, NJ Cox, M Cruz, CL Hanis, A Valladares-Salgado
Publication Date: 2016-01-19

Variant appearance in text: rs3135506
PubMed Link: 26780889
Variant Present in the following documents:
  • srep19429-s3.xls
View BVdb publication page



Lipid levels in HIV-positive men receiving anti-retroviral therapy are not associated with copy number variation of reverse cholesterol transport pathway genes.

Bmc Research Notes
RB Marino, LA Kingsley, SK Hussain, JH Bream, S Penogonda, P Duggal, JJ Martinson
Publication Date: 2015-11-21

Variant appearance in text: rs3135506
PubMed Link: 26590594
Variant Present in the following documents:
  • Main text
View BVdb publication page



Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis.

Genomics Data
SE John, G Thareja, P Hebbar, K Behbehani, TA Thanaraj, O Alsmadi
Publication Date: 2015-03

Variant appearance in text: rs3135506
PubMed Link: 26484159
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mendelian randomization studies of biomarkers and type 2 diabetes.

Endocrine Connections
A Abbasi
Publication Date: 2015-12

Variant appearance in text: rs3135506
PubMed Link: 26446360
Variant Present in the following documents:
  • Main text
View BVdb publication page



Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects.

Lipids In Health And Disease
T Domínguez-Reyes, CC Astudillo-López, L Salgado-Goytia, JF Muñoz-Valle, AB Salgado-Bernabé, IP Guzmán-Guzmán, N Castro-Alarcón, ME Moreno-Godínez, I Parra-Rojas
Publication Date: 2015-09-13

Variant appearance in text: rs3135506
PubMed Link: 26365669
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.

Lipids In Health And Disease
KY Son, HY Son, J Chae, J Hwang, S Jang, JM Yun, B Cho, JH Park, JI Kim
Publication Date: 2015-09-13

Variant appearance in text: rs3135506
PubMed Link: 26365620
Variant Present in the following documents:
  • Main text
View BVdb publication page



Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis.

Plos One
H Ye, A Zhou, Q Hong, L Tang, X Xu, Y Xin, D Jiang, D Dai, Y Li, DW Wang, S Duan
Publication Date: 2015

Variant appearance in text: rs3135506
PubMed Link: 26309253
Variant Present in the following documents:
  • Main text
  • pone.0135683.s001.doc
  • pone.0135683.s004.doc
View BVdb publication page



Apolipoprotein E and protection against hepatitis E viral infection in American non-Hispanic blacks.

Hepatology (Baltimore, Md.)
L Zhang, A Yesupriya, MH Chang, E Teshale, CG Teo
Publication Date: 2015-11

Variant appearance in text: rs3135506
PubMed Link: 26096528
Variant Present in the following documents:
  • NIHMS1043972-supplement-Supplemental.pdf
View BVdb publication page



Evidence for Clinical Implementation of Pharmacogenomics in Cardiac Drugs.

Mayo Clinic Proceedings
AL Kaufman, J Spitz, M Jacobs, M Sorrentino, S Yuen, K Danahey, D Saner, TE Klein, RB Altman, MJ Ratain, PH O'Donnell
Publication Date: 2015-06

Variant appearance in text: rs3135506
PubMed Link: 26046407
Variant Present in the following documents:
  • NIHMS676556-supplement-4.pdf
View BVdb publication page



Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.

Jama Neurology
PL Auer, M Nalls, JF Meschia, BB Worrall, WT Longstreth, S Seshadri, C Kooperberg, KM Burger, CS Carlson, CL Carty, WM Chen, LA Cupples, AL DeStefano, M Fornage, J Hardy, L Hsu, RD Jackson, GP Jarvik, DS Kim, K Lakshminarayan, LA Lange, A Manichaikul, AR Quinlan, AB Singleton, TA Thornton, DA Nickerson, U Peters, SS Rich,
Publication Date: 2015-07

Variant appearance in text: rs3135506
PubMed Link: 25961151
Variant Present in the following documents:
  • NIHMS740326-supplement-Supplement.pdf
View BVdb publication page



USF-1 genetic polymorphisms confer a high risk of nonalcoholic fatty liver disease in Chinese population.

International Journal Of Clinical And Experimental Medicine
Y Wang, BF Wang, J Tong, B Chang, BY Wang
Publication Date: 2015

Variant appearance in text: rs3135506
PubMed Link: 25932200
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population.

Meta Gene
I Radovica, D Fridmanis, I Silamikelis, L Nikitina-Zake, J Klovins
Publication Date: 2014-12

Variant appearance in text: rs3135506
PubMed Link: 25606439
Variant Present in the following documents:
  • mmc1.docx
View BVdb publication page



Association of apolipoprotein A5 genetic polymorphisms with steroid-induced osteonecrosis of femoral head in a Chinese Han population.

Diagnostic Pathology
Y Cui, A Kaisaierjiang, P Cao, ZY Wu, Q Lv
Publication Date: 2014-12-17

Variant appearance in text: rs3135506
PubMed Link: 25515090
Variant Present in the following documents:
  • Main text
View BVdb publication page



Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study.

Plos Genetics
MA Hall, A Verma, KD Brown-Gentry, R Goodloe, J Boston, S Wilson, B McClellan, C Sutcliffe, HH Dilks, NB Gillani, H Jin, P Mayo, M Allen, N Schnetz-Boutaud, DC Crawford, MD Ritchie, SA Pendergrass
Publication Date: 2014-12

Variant appearance in text: rs3135506
PubMed Link: 25474351
Variant Present in the following documents:
  • Main text
  • pgen.1004678.s007.xlsx
  • pgen.1004678.s011.xlsx
View BVdb publication page



Association between lipid genetic and immunological status in chronically HIV-infected patients.

Journal Of The International Aids Society
P Echeverría, M Guardiola, M González, JC Vallvé, J Puig, A Bonjoch, B Clotet, J Ribalta, E Negredo
Publication Date: 2014

Variant appearance in text: rs3135506
PubMed Link: 25394062
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influences of APOA5 variants on plasma triglyceride levels in Uyghur population.

Plos One
S Li, B Hu, Y Wang, D Wu, L Jin, X Wang
Publication Date: 2014

Variant appearance in text: rs3135506
PubMed Link: 25313938
Variant Present in the following documents:
  • pone.0110258.s001.docx
View BVdb publication page



VAS: a convenient web portal for efficient integration of genomic features with millions of genetic variants.

Bmc Genomics
ED Ho, Q Cao, SD Lee, KY Yip
Publication Date: 2014-10-11

Variant appearance in text: rs3135506
PubMed Link: 25306238
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between the PNPLA3 I148M polymorphism and non-alcoholic fatty liver disease in the Uygur and Han ethnic groups of northwestern China.

Plos One
Y Zhang, W Cai, J Song, L Miao, B Zhang, Q Xu, L Zhang, H Yao
Publication Date: 2014

Variant appearance in text: rs3135506
PubMed Link: 25290313
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels.

Circulation. Cardiovascular Genetics
H Rasheed, K Hughes, TJ Flynn, TR Merriman
Publication Date: 2014-12

Variant appearance in text: rs3135506
PubMed Link: 25249548
Variant Present in the following documents:
  • Main text
  • NIHMS633494-supplement-000556_-_PAP.pdf
View BVdb publication page



Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study.

Investigative Ophthalmology & Visual Science
NA Restrepo, KL Spencer, R Goodloe, TA Garrett, G Heiss, P Bůžková, N Jorgensen, RA Jensen, TC Matise, LA Hindorff, BE Klein, R Klein, TY Wong, CY Cheng, BK Cornes, ES Tai, MD Ritchie, JL Haines, DC Crawford
Publication Date: 2014-09-09

Variant appearance in text: rs3135506
PubMed Link: 25205864
Variant Present in the following documents:
  • Main text
View BVdb publication page



Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.

Circulation. Cardiovascular Genetics
CL Carty, S Bhattacharjee, J Haessler, I Cheng, LA Hindorff, V Aroda, CS Carlson, CN Hsu, L Wilkens, S Liu, E Selvin, R Jackson, KE North, U Peters, JS Pankow, N Chatterjee, C Kooperberg
Publication Date: 2014-08

Variant appearance in text: rs3135506
PubMed Link: 25023634
Variant Present in the following documents:
  • Main text
  • NIHMS614064-supplement-000386_-_PAP.pdf
View BVdb publication page



Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study.

Cardiovascular Diabetology
JN Adams, LM Raffield, BI Freedman, CD Langefeld, MC Ng, JJ Carr, AJ Cox, DW Bowden
Publication Date: 2014-04-12

Variant appearance in text: rs3135506
PubMed Link: 24725463
Variant Present in the following documents:
  • 1475-2840-13-77-S1.xls
  • aaaaaMain text
View BVdb publication page



Sex-specific association of the zinc finger protein 259 rs2075290 polymorphism and serum lipid levels.

International Journal Of Medical Sciences
LH Aung, RX Yin, DF Wu, W Wang, JZ Wu, CW Liu
Publication Date: 2014

Variant appearance in text: rs3135506
PubMed Link: 24688311
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.

Circulation. Cardiovascular Genetics
JM Kocarnik, SA Pendergrass, CL Carty, JS Pankow, FR Schumacher, I Cheng, P Durda, JL Ambite, E Deelman, NR Cook, S Liu, J Wactawski-Wende, C Hutter, K Brown-Gentry, S Wilson, LG Best, N Pankratz, CP Hong, SA Cole, VS Voruganti, P Bůžkova, NW Jorgensen, NS Jenny, LR Wilkens, CA Haiman, LN Kolonel, A Lacroix, K North, R Jackson, L Le Marchand, LA Hindorff, DC Crawford, M Gross, U Peters
Publication Date: 2014-04

Variant appearance in text: rs3135506
PubMed Link: 24622110
Variant Present in the following documents:
  • NIHMS575195-supplement-000173_-_Supplemental_Material.pdf
View BVdb publication page



Effects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans.

Lipids In Health And Disease
S Cha, H Yu, AY Park, KH Song
Publication Date: 2014-03-12

Variant appearance in text: rs3135506
PubMed Link: 24618354
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

American Journal Of Human Genetics
GM Peloso, PL Auer, JC Bis, A Voorman, AC Morrison, NO Stitziel, JA Brody, SA Khetarpal, JR Crosby, M Fornage, A Isaacs, J Jakobsdottir, MF Feitosa, G Davies, JE Huffman, A Manichaikul, B Davis, K Lohman, AY Joon, AV Smith, ML Grove, P Zanoni, V Redon, S Demissie, K Lawson, U Peters, C Carlson, RD Jackson, KK Ryckman, RH Mackey, JG Robinson, DS Siscovick, PJ Schreiner, JC Mychaleckyj, JS Pankow, A Hofman, AG Uitterlinden, TB Harris, KD Taylor, JM Stafford, LM Reynolds, RE Marioni, A Dehghan, OH Franco, AP Patel, Y Lu, G Hindy, O Gottesman, EP Bottinger, O Melander, M Orho-Melander, RJ Loos, S Duga, PA Merlini, M Farrall, A Goel, R Asselta, D Girelli, N Martinelli, SH Shah, WE Kraus, M Li, DJ Rader, MP Reilly, R McPherson, H Watkins, D Ardissino, , Q Zhang, J Wang, MY Tsai, HA Taylor, A Correa, ME Griswold, LA Lange, JM Starr, I Rudan, G Eiriksdottir, LJ Launer, JM Ordovas, D Levy, YD Chen, AP Reiner, C Hayward, O Polasek, IJ Deary, IB Borecki, Y Liu, V Gudnason, JG Wilson, CM van Duijn, C Kooperberg, SS Rich, BM Psaty, JI Rotter, CJ O'Donnell, K Rice, E Boerwinkle, S Kathiresan, LA Cupples
Publication Date: 2014-02-06

Variant appearance in text: rs3135506
PubMed Link: 24507774
Variant Present in the following documents:
  • Main text
View BVdb publication page



Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.

Plos Genetics
SK Service, TM Teslovich, C Fuchsberger, V Ramensky, P Yajnik, DC Koboldt, DE Larson, Q Zhang, L Lin, R Welch, L Ding, MD McLellan, M O'Laughlin, C Fronick, LL Fulton, V Magrini, A Swift, P Elliott, MR Jarvelin, M Kaakinen, MI McCarthy, L Peltonen, A Pouta, LL Bonnycastle, FS Collins, N Narisu, HM Stringham, J Tuomilehto, S Ripatti, RS Fulton, C Sabatti, RK Wilson, M Boehnke, NB Freimer
Publication Date: 2014-01

Variant appearance in text: rs3135506
PubMed Link: 24497850
Variant Present in the following documents:
  • Main text
  • pgen.1004147.s004.pdf
View BVdb publication page



The association between APOA5 haplotypes and plasma lipids is not modified by energy or fat intake: the Czech HAPIEE study.

Nutrition, Metabolism, And Cardiovascular Diseases : Nmcd
JA Hubacek, A Peasey, R Kubinova, H Pikhart, M Bobak
Publication Date: 2014-03

Variant appearance in text: rs3135506
PubMed Link: 24462044
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data.

Plos One
JD Mosley, SL Van Driest, EK Larkin, PE Weeke, JS Witte, QS Wells, JH Karnes, Y Guo, L Bastarache, LM Olson, CA McCarty, JA Pacheco, GP Jarvik, DS Carrell, EB Larson, DR Crosslin, IJ Kullo, G Tromp, H Kuivaniemi, DJ Carey, MD Ritchie, JC Denny, DM Roden
Publication Date: 2013

Variant appearance in text: rs3135506
PubMed Link: 24349080
Variant Present in the following documents:
  • pone.0081503.s006.xlsx
View BVdb publication page



Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.

American Journal Of Human Genetics
EA Rosenthal, J Ranchalis, DR Crosslin, A Burt, JD Brunzell, AG Motulsky, DA Nickerson, , EM Wijsman, GP Jarvik
Publication Date: 2013-12-05

Variant appearance in text: rs3135506
PubMed Link: 24268658
Variant Present in the following documents:
  • Main text
View BVdb publication page



No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.

Human Genetics
L Dumitrescu, CL Carty, N Franceschini, LA Hindorff, SA Cole, P Bůžková, FR Schumacher, CB Eaton, RJ Goodloe, DJ Duggan, J Haessler, B Cochran, BE Henderson, I Cheng, KC Johnson, CS Carlson, SA Love, K Brown-Gentry, AQ Nato, M Quibrera, RV Shohet, JL Ambite, LR Wilkens, L Le Marchand, CA Haiman, S Buyske, C Kooperberg, KE North, M Fornage, DC Crawford
Publication Date: 2013-12

Variant appearance in text: rs3135506
PubMed Link: 24100633
Variant Present in the following documents:
  • NIHMS530028-supplement-439_2013_1375_MOESM1_ESM.docx
View BVdb publication page



Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study.

Plos Biology
CS Carlson, TC Matise, KE North, CA Haiman, MD Fesinmeyer, S Buyske, FR Schumacher, U Peters, N Franceschini, MD Ritchie, DJ Duggan, KL Spencer, L Dumitrescu, CB Eaton, F Thomas, A Young, C Carty, G Heiss, L Le Marchand, DC Crawford, LA Hindorff, CL Kooperberg,
Publication Date: 2013-09

Variant appearance in text: rs3135506
PubMed Link: 24068893
Variant Present in the following documents:
  • pbio.1001661.s003.xlsx
  • pbio.1001661.s004.xlsx
View BVdb publication page



Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.

Journal Of Lipid Research
Y Wu, AF Marvelle, J Li, DC Croteau-Chonka, AB Feranil, CW Kuzawa, Y Li, LS Adair, KL Mohlke
Publication Date: 2013-11

Variant appearance in text: rs3135506
PubMed Link: 24023260
Variant Present in the following documents:
  • Main text
View BVdb publication page



The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.

Plos One
I Radovica, D Fridmanis, I Vaivade, L Nikitina-Zake, J Klovins
Publication Date: 2013

Variant appearance in text: rs3135506
PubMed Link: 23675527
Variant Present in the following documents:
  • pone.0064191.s002.docx
View BVdb publication page



Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults.

Lipids In Health And Disease
AJ Clifford, G Rincon, JE Owens, JF Medrano, AJ Moshfegh, DJ Baer, JA Novotny
Publication Date: 2013-05-08

Variant appearance in text: rs3135506
PubMed Link: 23656756
Variant Present in the following documents:
  • Main text
View BVdb publication page



Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study.

Bmc Genetics
KC Taylor, CL Carty, L Dumitrescu, P Bůžková, SA Cole, L Hindorff, FR Schumacher, LR Wilkens, RV Shohet, PM Quibrera, KC Johnson, BE Henderson, J Haessler, N Franceschini, CB Eaton, DJ Duggan, B Cochran, I Cheng, CS Carlson, K Brown-Gentry, G Anderson, JL Ambite, C Haiman, L Le Marchand, C Kooperberg, DC Crawford, S Buyske, KE North, M Fornage,
Publication Date: 2013-05-01

Variant appearance in text: rs3135506
PubMed Link: 23634756
Variant Present in the following documents:
  • 1471-2156-14-33-S1.pdf
  • aaaaaMain text
View BVdb publication page



Rare APOA5 promoter variants associated with paradoxical HDL cholesterol decrease in response to fenofibric acid therapy.

Journal Of Lipid Research
A Brautbar, M Barbalic, F Chen, J Belmont, SS Virani, S Scherer, RA Hegele, CM Ballantyne
Publication Date: 2013-07

Variant appearance in text: rs3135506
PubMed Link: 23633496
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic variants from lipid-related pathways and risk for incident myocardial infarction.

Plos One
C Song, NL Pedersen, CA Reynolds, M Sabater-Lleal, S Kanoni, C Willenborg, , AC Syvänen, H Watkins, A Hamsten, JA Prince, E Ingelsson
Publication Date: 2013

Variant appearance in text: rs3135506
PubMed Link: 23555974
Variant Present in the following documents:
  • pone.0060454.s001.pdf
View BVdb publication page



Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.

Plos Genetics
Y Wu, LL Waite, AU Jackson, WH Sheu, S Buyske, D Absher, DK Arnett, E Boerwinkle, LL Bonnycastle, CL Carty, I Cheng, B Cochran, DC Croteau-Chonka, L Dumitrescu, CB Eaton, N Franceschini, X Guo, BE Henderson, LA Hindorff, E Kim, L Kinnunen, P Komulainen, WJ Lee, L Le Marchand, Y Lin, J Lindström, O Lingaas-Holmen, SL Mitchell, N Narisu, JG Robinson, F Schumacher, A Stančáková, J Sundvall, YJ Sung, AJ Swift, WC Wang, L Wilkens, T Wilsgaard, AM Young, LS Adair, CM Ballantyne, P Bůžková, A Chakravarti, FS Collins, D Duggan, AB Feranil, LT Ho, YJ Hung, SC Hunt, K Hveem, JM Juang, AY Kesäniemi, J Kuusisto, M Laakso, TA Lakka, IT Lee, MF Leppert, TC Matise, L Moilanen, I Njølstad, U Peters, T Quertermous, R Rauramaa, JI Rotter, J Saramies, J Tuomilehto, M Uusitupa, TD Wang, M Boehnke, CA Haiman, YD Chen, C Kooperberg, TL Assimes, DC Crawford, CA Hsiung, KE North, KL Mohlke
Publication Date: 2013-03

Variant appearance in text: rs3135506
PubMed Link: 23555291
Variant Present in the following documents:
  • pgen.1003379.s009.pdf
View BVdb publication page



Pharmacogenomics of high-density lipoprotein-cholesterol-raising therapies.

Expert Review Of Cardiovascular Therapy
S Aslibekyan, RJ Straka, MR Irvin, SA Claas, DK Arnett
Publication Date: 2013-03

Variant appearance in text: rs3135506
PubMed Link: 23469915
Variant Present in the following documents:
  • Main text
View BVdb publication page



Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.

Nutrition & Diabetes
MC Hsu, CS Chang, KT Lee, HY Sun, YS Tsai, PH Kuo, KC Young, CH Wu
Publication Date: 2013-03-04

Variant appearance in text: rs3135506
PubMed Link: 23459084
Variant Present in the following documents:
  • Main text
View BVdb publication page



Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network.

Plos Genetics
SA Pendergrass, K Brown-Gentry, S Dudek, A Frase, ES Torstenson, R Goodloe, JL Ambite, CL Avery, S Buyske, P Bůžková, E Deelman, MD Fesinmeyer, CA Haiman, G Heiss, LA Hindorff, CN Hsu, RD Jackson, C Kooperberg, L Le Marchand, Y Lin, TC Matise, KR Monroe, L Moreland, SL Park, A Reiner, R Wallace, LR Wilkens, DC Crawford, MD Ritchie
Publication Date: 2013

Variant appearance in text: rs3135506
PubMed Link: 23382687
Variant Present in the following documents:
  • pgen.1003087.s001.xlsx
View BVdb publication page



APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial.

The American Journal Of Clinical Nutrition
X Zhang, Q Qi, GA Bray, FB Hu, FM Sacks, L Qi
Publication Date: 2012-10

Variant appearance in text: rs3135506
PubMed Link: 22914552
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000227665.4 c.56C>T p.Ser19Leu missense_variant 2/3 -
ENST00000433069.1 c.56C>T p.Ser19Leu missense_variant 3/4 -
ENST00000542499.1 c.56C>T p.Ser19Leu missense_variant 3/4 -
NM_001166598.2 c.56C>T p.Ser19Leu missense_variant 3/4 -
NM_001371904.1 c.56C>T p.Ser19Leu missense_variant 2/3 -
NM_052968.5 c.56C>T p.Ser19Leu missense_variant 3/4 -