Variant ID: 11-116662407-G-C

NM_001166598.1(APOA5):c.56C>G;(p.Ser19Trp)

This variant was identified in 204 publications




Publications:


Association of c.56C > G (rs3135506) Apolipoprotein A5 Gene Polymorphism with Coronary Artery Disease in Moroccan Subjects: A Case-Control Study and an Updated Meta-Analysis.

Cardiology Research And Practice
I Morjane, H Charoute, S Ouatou, L Elkhattabi, H Benrahma, R Saile, H Rouba, A Barakat
Publication Date: 2020

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 32832146
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetically Mediated Lipid Metabolism and Risk of Insulin Resistance: Insights from Mendelian Randomization Studies.

Journal Of Lipid And Atherosclerosis
SY Bu
Publication Date: 2019-09

Variant appearance in text: rs3135506
PubMed Link: 32821703
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa.

Bioscience Reports
M Hechmi, H Dallali, M Gharbi, H Jmel, M Fassatoui, Y Ben Halima, S Bahri, A Bahlous, A Abid, H Jamoussi, A Barakat, R Kefi
Publication Date: 2020-08-28

Variant appearance in text: rs3135506
PubMed Link: 32725151
Variant Present in the following documents:
  • Main text
View BVdb publication page



Verification of Underlying Genetic Cause in a Cohort of Russian Patients with Familial Hypercholesterolemia Using Targeted Next Generation Sequencing.

Journal Of Cardiovascular Development And Disease
AE Semenova, IV Sergienko, D García-Giustiniani, L Monserrat, AB Popova, DN Nozadze, MV Ezhov
Publication Date: 2020-05-14

Variant appearance in text: APOA5: Ser19Trp
PubMed Link: 32423031
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genes and Eating Preferences, Their Roles in Personalized Nutrition.

Genes
A Vesnina, A Prosekov, O Kozlova, V Atuchin
Publication Date: 2020-03-27

Variant appearance in text: rs3135506
PubMed Link: 32230794
Variant Present in the following documents:
  • Main text
View BVdb publication page



Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study.

Plos Genetics
Y Hu, M Graff, J Haessler, S Buyske, SA Bien, R Tao, HM Highland, KK Nishimura, N Zubair, Y Lu, M Verbanck, AT Hilliard, D Klarin, SM Damrauer, YL Ho, , PWF Wilson, KM Chang, PS Tsao, K Cho, CJ O'Donnell, TL Assimes, LE Petty, JE Below, O Dikilitas, DJ Schaid, ML Kosel, IJ Kullo, LJ Rasmussen-Torvik, GP Jarvik, Q Feng, WQ Wei, EB Larson, FD Mentch, B Almoguera, PM Sleiman, LM Raffield, A Correa, LW Martin, M Daviglus, TC Matise, JL Ambite, CS Carlson, R Do, RJF Loos, LR Wilkens, L Le Marchand, C Haiman, DO Stram, LA Hindorff, KE North, C Kooperberg, I Cheng, U Peters
Publication Date: 2020-03

Variant appearance in text: APOA5: Ser19Trp; rs3135506
PubMed Link: 32226016
Variant Present in the following documents:
  • Main text
View BVdb publication page



Quantile-dependent expressivity of postprandial lipemia.

Plos One
PT Williams
Publication Date: 2020

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 32101585
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of single nucleotide polymorphisms with dyslipidemia in antiretroviral exposed HIV patients in a Ghanaian population: A case-control study.

Plos One
C Obirikorang, E Acheampong, L Quaye, J Yorke, EK Amos-Abanyie, PA Akyaw, EO Anto, SB Bani, EA Asamoah, EN Batu
Publication Date: 2020

Variant appearance in text: APOA5: S19W
PubMed Link: 31929604
Variant Present in the following documents:
  • Main text
View BVdb publication page



Population History and Gene Divergence in Native Mexicans Inferred from 76 Human Exomes.

Molecular Biology And Evolution
MC Ávila-Arcos, KF McManus, K Sandoval, JE Rodríguez-Rodríguez, V Villa-Islas, AR Martin, P Luisi, RI Peñaloza-Espinosa, C Eng, S Huntsman, EG Burchard, CR Gignoux, CD Bustamante, A Moreno-Estrada
Publication Date: 2020-04-01

Variant appearance in text: rs3135506
PubMed Link: 31848607
Variant Present in the following documents:
  • Main text
View BVdb publication page



Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study.

Nutrients
I San Mauro Martín, E Garicano Vilar, S Sanz Rojo, L Collado Yurrita, E Pérez Arruche, E Arce Delgado, JA Blumenfeld Olivares
Publication Date: 2019-10-21

Variant appearance in text: APOA5: Ser19Trp; rs3135506
PubMed Link: 31640222
Variant Present in the following documents:
  • Main text
  • nutrients-11-02538.pdf
View BVdb publication page



Genetic architecture of human plasma lipidome and its link to cardiovascular disease.

Nature Communications
R Tabassum, JT Rämö, P Ripatti, JT Koskela, M Kurki, J Karjalainen, P Palta, S Hassan, J Nunez-Fontarnau, TTJ Kiiskinen, S Söderlund, N Matikainen, MJ Gerl, MA Surma, C Klose, NO Stitziel, H Laivuori, AS Havulinna, SK Service, V Salomaa, M Pirinen, , M Jauhiainen, MJ Daly, NB Freimer, A Palotie, MR Taskinen, K Simons, S Ripatti
Publication Date: 2019-09-24

Variant appearance in text: rs3135506
PubMed Link: 31551469
Variant Present in the following documents:
  • 41467_2019_11954_MOESM13_ESM.xlsx
  • 41467_2019_11954_MOESM14_ESM.xlsx
View BVdb publication page



The transferability of lipid loci across African, Asian and European cohorts.

Nature Communications
K Kuchenbaecker, N Telkar, T Reiker, RG Walters, K Lin, A Eriksson, D Gurdasani, A Gilly, L Southam, E Tsafantakis, M Karaleftheri, J Seeley, A Kamali, G Asiki, IY Millwood, M Holmes, H Du, Y Guo, M Kumari, G Dedoussis, L Li, Z Chen, MS Sandhu, E Zeggini,
Publication Date: 2019-09-24

Variant appearance in text: APOA5: Ser19Trp; rs3135506
PubMed Link: 31551420
Variant Present in the following documents:
  • 41467_2019_12026_MOESM2_ESM.pdf
View BVdb publication page



Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology.

Nature Communications
Y Tanigawa, J Li, JM Justesen, H Horn, M Aguirre, C DeBoever, C Chang, B Narasimhan, K Lage, T Hastie, CY Park, G Bejerano, E Ingelsson, MA Rivas
Publication Date: 2019-09-06

Variant appearance in text: rs3135506
PubMed Link: 31492854
Variant Present in the following documents:
  • 41467_2019_11953_MOESM6_ESM.xlsx
View BVdb publication page



Phenotypic severity in a family with MEND syndrome is directly associated with the accumulation of potentially functional variants of cholesterol homeostasis genes.

Molecular Genetics & Genomic Medicine
MC Barboza-Cerda, O Barboza-Quintana, G Martínez-Aldape, R Garza-Guajardo, MA Déctor
Publication Date: 2019-09

Variant appearance in text: APOA5: 56C>G; Ser19Trp; rs3135506
PubMed Link: 31397093
Variant Present in the following documents:
  • Main text
View BVdb publication page



Exome sequencing of Finnish isolates enhances rare-variant association power.

Nature
AE Locke, KM Steinberg, CWK Chiang, SK Service, AS Havulinna, L Stell, M Pirinen, HJ Abel, CC Chiang, RS Fulton, AU Jackson, CJ Kang, KL Kanchi, DC Koboldt, DE Larson, J Nelson, TJ Nicholas, A Pietilä, V Ramensky, D Ray, LJ Scott, HM Stringham, J Vangipurapu, R Welch, P Yajnik, X Yin, JG Eriksson, M Ala-Korpela, MR Järvelin, M Männikkö, H Laivuori, , SK Dutcher, NO Stitziel, RK Wilson, IM Hall, C Sabatti, A Palotie, V Salomaa, M Laakso, S Ripatti, M Boehnke, NB Freimer
Publication Date: 2019-08

Variant appearance in text: rs3135506
PubMed Link: 31367044
Variant Present in the following documents:
  • EMS83607-supplement-Supplementary_Tables.xlsx
View BVdb publication page



Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.

Annals Of Pediatric Cardiology
I San Mauro Martín, S Sanz Rojo, E Garicano Vilar, L Collado Yurrita, JA Blumenfeld Olivares
Publication Date: 2019

Variant appearance in text: APOA5: Ser19Trp; rs3135506
PubMed Link: 31143031
Variant Present in the following documents:
  • Main text
View BVdb publication page



A 3-SNP gene risk score and a metabolic risk score both predict hypertriglyceridemia and cardiovascular disease risk.

Journal Of Clinical Lipidology
R Verbeek, F Oldoni, RP Surendran, AH Zwinderman, KT Khaw, ESG Stroes, NJ Wareham, SM Boekholdt, GM Dallinga-Thie
Publication Date: 2019

Variant appearance in text: rs3135506
PubMed Link: 30910668
Variant Present in the following documents:
  • Main text
View BVdb publication page



A sleep apneic's gene: perspectives for development of diabetes.

Polish Archives Of Internal Medicine
P Singh
Publication Date: 2019-01-31

Variant appearance in text: rs3135506
PubMed Link: 30702652
Variant Present in the following documents:
  • Main text
  • nihms-1026704.pdf
View BVdb publication page



Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease.

Jama
BA Ference, JJP Kastelein, KK Ray, HN Ginsberg, MJ Chapman, CJ Packard, U Laufs, C Oliver-Williams, AM Wood, AS Butterworth, E Di Angelantonio, J Danesh, SJ Nicholls, DL Bhatt, MS Sabatine, AL Catapano
Publication Date: 2019-01-29

Variant appearance in text: rs3135506
PubMed Link: 30694319
Variant Present in the following documents:
  • jama-321-364-s001.pdf
View BVdb publication page



A genetic variant c.553G > T (rs2075291) in the apolipoprotein A5 gene is associated with altered triglycerides levels in coronary artery disease (CAD) patients with lipid lowering drug.

Bmc Cardiovascular Disorders
NM Bogari, A Aljohani, AA Amin, FA Al-Allaf, A Dannoun, MM Taher, A Elsayed, DI Rednah, O Elkhatee, M Porqueddu, F Alamanni, SAA Khogeer, A Fawzy
Publication Date: 2019-01-03

Variant appearance in text: APOA5: 56C>G
PubMed Link: 30606120
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.

International Journal Of Endocrinology And Metabolism
MS Daneshpour, M Hedayati, B Sedaghati-Khayat, K Guity, M Zarkesh, M Akbarzadeh, N Javanrooh, A Zadeh-Vakili, F Azizi
Publication Date: 2018-10

Variant appearance in text: rs3135506
PubMed Link: 30584432
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review.

Omics : A Journal Of Integrative Biology
JJ Noubiap, EPM Mato, M Guewo-Fokeng, AD Kaze, H Boulenouar, A Wonkam
Publication Date: 2018-12

Variant appearance in text: rs3135506
PubMed Link: 30571611
Variant Present in the following documents:
  • Main text
View BVdb publication page



Vitamin E Metabolic Effects and Genetic Variants: A Challenge for Precision Nutrition in Obesity and Associated Disturbances.

Nutrients
S Galmés, F Serra, A Palou
Publication Date: 2018-12-04

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 30518135
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of APOA5 and APOC3 Genetic Polymorphisms With Severity of Hypertriglyceridemia in Patients With Cutaneous T-Cell Lymphoma Treated With Bexarotene.

Jama Dermatology
I Cabello, P Alia, X Pintó, C Muniesa, R Fernandez-de-Misa, Y Peñate, M Morillo, A Perez-Farriols, T Estrach, R Izu, F Gallardo, C Román, I Cervigón, A Ortiz-Brugues, PL Ortiz-Romero, O Servitje
Publication Date: 2018-12-01

Variant appearance in text: APOA5: 56C>G; rs3135506
PubMed Link: 30422238
Variant Present in the following documents:
  • Main text
View BVdb publication page



Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

Scientific Reports
SE John, D Antony, M Eaaswarkhanth, P Hebbar, AM Channanath, D Thomas, S Devarajan, J Tuomilehto, F Al-Mulla, O Alsmadi, TA Thanaraj
Publication Date: 2018-11-08

Variant appearance in text: APOA5: Ser19Trp; rs3135506
PubMed Link: 30409984
Variant Present in the following documents:
  • Main text
View BVdb publication page



Population Pharmacokinetics of Tacrolimus in Transplant Recipients: What Did We Learn About Sources of Interindividual Variabilities?

Journal Of Clinical Pharmacology
O Campagne, DE Mager, KM Tornatore
Publication Date: 2019-03

Variant appearance in text: rs3135506
PubMed Link: 30371942
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

Nature Genetics
D Klarin, SM Damrauer, K Cho, YV Sun, TM Teslovich, J Honerlaw, DR Gagnon, SL DuVall, J Li, GM Peloso, M Chaffin, AM Small, J Huang, H Tang, JA Lynch, YL Ho, DJ Liu, CA Emdin, AH Li, JE Huffman, JS Lee, P Natarajan, R Chowdhury, D Saleheen, M Vujkovic, A Baras, S Pyarajan, E Di Angelantonio, BM Neale, A Naheed, AV Khera, J Danesh, KM Chang, G Abecasis, C Willer, FE Dewey, DJ Carey, , , , , J Concato, JM Gaziano, CJ O'Donnell, PS Tsao, S Kathiresan, DJ Rader, PWF Wilson, TL Assimes
Publication Date: 2018-11

Variant appearance in text: APOA5: Ser19Trp
PubMed Link: 30275531
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

Nature Communications
C Yao, G Chen, C Song, J Keefe, M Mendelson, T Huan, BB Sun, A Laser, JC Maranville, H Wu, JE Ho, P Courchesne, A Lyass, MG Larson, C Gieger, J Graumann, AD Johnson, J Danesh, H Runz, SJ Hwang, C Liu, AS Butterworth, K Suhre, D Levy
Publication Date: 2018-08-15

Variant appearance in text: rs3135506
PubMed Link: 30111768
Variant Present in the following documents:
  • 41467_2018_5512_MOESM11_ESM.xlsx
  • 41467_2018_5512_MOESM7_ESM.xlsx
  • 41467_2018_5512_MOESM8_ESM.xlsx
View BVdb publication page



Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk.

Journal Of Lipid Research
Y Zhou, R Mägi, L Milani, VM Lauschke
Publication Date: 2018-10

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 30076208
Variant Present in the following documents:
  • Main text
View BVdb publication page



Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease.

Journal Of The American College Of Cardiology
A Saeed, EV Feofanova, B Yu, W Sun, SS Virani, V Nambi, J Coresh, CS Guild, E Boerwinkle, CM Ballantyne, RC Hoogeveen
Publication Date: 2018-07-10

Variant appearance in text: rs3135506
PubMed Link: 29976289
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of polymorphisms in APOA5 on the plasma levels of triglycerides and risk of coronary heart disease in Jilin, northeast China: a case-control study.

Bmj Open
Y You, YH Wu, Y Zhang, L Zhang, Y Song, W Bai, Y Li, Y Yu, C Kou
Publication Date: 2018-06-04

Variant appearance in text: APOA5: S19W
PubMed Link: 29866721
Variant Present in the following documents:
  • Main text
  • bmjopen-2017-020016.draft_revisions.pdf
  • bmjopen-2017-020016.reviewer_comments.pdf
View BVdb publication page



Influence of APOA5 Locus on the Treatment Efficacy of Three Statins: Evidence From a Randomized Pilot Study in Chinese Subjects.

Frontiers In Pharmacology
S Hua, C Ma, J Zhang, J Li, W Wu, N Xu, G Luo, J Zhao
Publication Date: 2018

Variant appearance in text: rs3135506
PubMed Link: 29695967
Variant Present in the following documents:
  • Main text
View BVdb publication page



The SNPcurator: literature mining of enriched SNP-disease associations.

Database : The Journal Of Biological Databases And Curation
NS Tawfik, MR Spruit
Publication Date: 2018-01-01

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 29688369
Variant Present in the following documents:
  • Main text
View BVdb publication page



Sequence Analysis of APOA5 Among the Kuwaiti Population Identifies Association of rs2072560, rs2266788, and rs662799 With TG and VLDL Levels.

Frontiers In Genetics
AA Jasim, SA Al-Bustan, W Al-Kandari, A Al-Serri, H AlAskar
Publication Date: 2018

Variant appearance in text: APOA5: 56C>G; S19W; rs3135506
PubMed Link: 29686695
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment.

Diseases (Basel, Switzerland)
I San Mauro Martín, JA Blumenfeld Olivares, E Pérez Arruche, E Arce Delgado, MJ Ciudad Cabañas, E Garicano Vilar, L Collado Yurrita
Publication Date: 2018-04-03

Variant appearance in text: APOA5: Ser19Trp; rs3135506
PubMed Link: 29614023
Variant Present in the following documents:
  • Main text
View BVdb publication page



An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort.

Journal Of Lipid Research
X Geng, MR Irvin, B Hidalgo, S Aslibekyan, V Srinivasasainagendra, P An, AC Frazier-Wood, HK Tiwari, T Dave, K Ryan, JM Ordovas, RJ Straka, MF Feitosa, PN Hopkins, I Borecki, MA Province, BD Mitchell, DK Arnett, D Zhi
Publication Date: 2018-04

Variant appearance in text: rs3135506
PubMed Link: 29463568
Variant Present in the following documents:
  • Main text
View BVdb publication page



Apolipoprotein A5 3'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey.

Nutrition Research And Practice
OY Kim, J Moon, G Jo, SY Kwak, JY Kim, MJ Shin
Publication Date: 2018-02

Variant appearance in text: rs3135506
PubMed Link: 29399298
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by an APOC3 Founder Mutation.

Circulation. Cardiovascular Genetics
WC Hsueh, AK Nair, S Kobes, P Chen, HHH Göring, TI Pollin, A Malhotra, WC Knowler, LJ Baier, RL Hanson
Publication Date: 2017-12

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 29237685
Variant Present in the following documents:
  • Main text
  • NIHMS917321-supplement-001809_-_Supplemental_material.pdf
View BVdb publication page



Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.

Plos Genetics
JP Davis, JR Huyghe, AE Locke, AU Jackson, X Sim, HM Stringham, TM Teslovich, RP Welch, C Fuchsberger, N Narisu, PS Chines, AJ Kangas, P Soininen, M Ala-Korpela, J Kuusisto, FS Collins, M Laakso, M Boehnke, KL Mohlke
Publication Date: 2017-10

Variant appearance in text: rs3135506
PubMed Link: 29084231
Variant Present in the following documents:
  • pgen.1007079.s010.xlsx
View BVdb publication page



Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.

Nature Genetics
X Lu, GM Peloso, DJ Liu, Y Wu, H Zhang, W Zhou, J Li, CS Tang, R Dorajoo, H Li, J Long, X Guo, M Xu, CN Spracklen, Y Chen, X Liu, Y Zhang, CC Khor, J Liu, L Sun, L Wang, YT Gao, Y Hu, K Yu, Y Wang, CYY Cheung, F Wang, J Huang, Q Fan, Q Cai, S Chen, J Shi, X Yang, W Zhao, WH Sheu, SS Cherny, M He, AB Feranil, LS Adair, P Gordon-Larsen, S Du, R Varma, YI Chen, XO Shu, KSL Lam, TY Wong, SK Ganesh, Z Mo, K Hveem, LG Fritsche, JB Nielsen, HF Tse, Y Huo, CY Cheng, YE Chen, W Zheng, ES Tai, W Gao, X Lin, W Huang, G Abecasis, , S Kathiresan, KL Mohlke, T Wu, PC Sham, D Gu, CJ Willer
Publication Date: 2017-12

Variant appearance in text: rs3135506
PubMed Link: 29083407
Variant Present in the following documents:
  • NIHMS909133-supplement-2.xlsx
View BVdb publication page



The impact of rare and low-frequency genetic variants in common disease.

Genome Biology
L Bomba, K Walter, N Soranzo
Publication Date: 2017-04-27

Variant appearance in text: rs3135506
PubMed Link: 28449691
Variant Present in the following documents:
  • 13059_2017_1212_MOESM1_ESM.xlsx
View BVdb publication page



Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci.

Nature Genetics
S Stender, J Kozlitina, BG Nordestgaard, A Tybjærg-Hansen, HH Hobbs, JC Cohen
Publication Date: 2017-06

Variant appearance in text: rs3135506
PubMed Link: 28436986
Variant Present in the following documents:
  • NIHMS864885-supplement-1.pdf
View BVdb publication page



Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.

Human Molecular Genetics
N Zubair, M Graff, J Luis Ambite, WS Bush, G Kichaev, Y Lu, A Manichaikul, WH Sheu, D Absher, TL Assimes, SJ Bielinski, EP Bottinger, P Buzkova, LM Chuang, RH Chung, B Cochran, L Dumitrescu, O Gottesman, JW Haessler, C Haiman, G Heiss, CA Hsiung, YJ Hung, CM Hwu, JJ Juang, L Le Marchand, IT Lee, WJ Lee, LA Lin, D Lin, SY Lin, RH Mackey, LW Martin, B Pasaniuc, U Peters, I Predazzi, T Quertermous, AP Reiner, J Robinson, JI Rotter, KK Ryckman, PJ Schreiner, E Stahl, R Tao, MY Tsai, LL Waite, TD Wang, S Buyske, YD Ida Chen, I Cheng, DC Crawford, RJF Loos, SS Rich, M Fornage, KE North, C Kooperberg, CL Carty
Publication Date: 2016-12-15

Variant appearance in text: rs3135506
PubMed Link: 28426890
Variant Present in the following documents:
  • Main text
  • ddw358_supp.docx
View BVdb publication page



Genetic associations with lipoprotein subfraction measures differ by ethnicity in the multi-ethnic study of atherosclerosis (MESA).

Human Genetics
Z Wang, A Manichukal, DC Goff, S Mora, JM Ordovas, NM Pajewski, WS Post, JI Rotter, MM Sale, SA Santorico, D Siscovick, MY Tsai, DK Arnett, S Rich, AC Frazier-Wood
Publication Date: 2017-06

Variant appearance in text: rs3135506
PubMed Link: 28352986
Variant Present in the following documents:
  • 439_2017_1782_MOESM1_ESM.docx
View BVdb publication page



Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal.

Plos One
EJ Parra, A Mazurek, CR Gignoux, A Sockell, M Agostino, AP Morris, LE Petty, CL Hanis, NJ Cox, A Valladares-Salgado, JE Below, M Cruz
Publication Date: 2017

Variant appearance in text: rs3135506
PubMed Link: 28245265
Variant Present in the following documents:
  • Main text
View BVdb publication page



Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis.

Scientific Reports
Z Liu, S Burgess, Z Wang, W Deng, X Chu, J Cai, Y Zhu, J Shi, X Xie, Y Wang, L Jin, X Wang
Publication Date: 2017-01-30

Variant appearance in text: APOA5: 56C>G; S19W; rs3135506
PubMed Link: 28134330
Variant Present in the following documents:
  • Main text
View BVdb publication page



IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients.

Acta Pharmacologica Sinica
MZ Liu, HY He, YL Zhang, YF Hu, FZ He, JQ Luo, ZY Luo, XP Chen, ZQ Liu, HH Zhou, MJ Shao, YZ Ming, HW Xin, W Zhang
Publication Date: 2017-03

Variant appearance in text: rs3135506
PubMed Link: 28112181
Variant Present in the following documents:
  • aps2016153x11.doc
View BVdb publication page



Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program.

Circulation. Cardiovascular Genetics
TV Varga, AH Winters, KA Jablonski, ES Horton, P Khare-Ranade, WC Knowler, SM Marcovina, F Renström, KE Watson, R Goldberg, JC Florez, TI Pollin, PW Franks
Publication Date: 2016-12

Variant appearance in text: rs3135506
PubMed Link: 27784733
Variant Present in the following documents:
  • NIHMS825913-supplement-001457_-_Supplemental_Material.pdf
View BVdb publication page



Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge.

Journal Of Lipid Research
CQ Lai, MK Wojczynski, LD Parnell, BA Hidalgo, MR Irvin, S Aslibekyan, MA Province, DM Absher, DK Arnett, JM Ordovás
Publication Date: 2016-12

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 27777315
Variant Present in the following documents:
  • Main text
View BVdb publication page



Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.

Cardiovascular Diabetology
KS Weber, B Knebel, K Strassburger, J Kotzka, P Stehle, J Szendroedi, K Müssig, AE Buyken, M Roden,
Publication Date: 2016-09-27

Variant appearance in text: rs3135506
PubMed Link: 27677442
Variant Present in the following documents:
  • 12933_2016_455_MOESM1_ESM.docx
  • aaaaaMain text
View BVdb publication page



Single Nucleotide Polymorphisms in Cellular Drug Transporters Are Associated with Intolerance to Antiretroviral Therapy in Brazilian HIV-1 Positive Individuals.

Plos One
MB Arruda, F Campagnari, TB de Almeida, JC Couto-Fernandez, A Tanuri, CC Cardoso
Publication Date: 2016

Variant appearance in text: rs3135506
PubMed Link: 27648838
Variant Present in the following documents:
  • pone.0163170.s001.xlsx
View BVdb publication page



Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology.

Gene
JA Hubacek
Publication Date: 2016-10-30

Variant appearance in text: rs3135506
PubMed Link: 27496343
Variant Present in the following documents:
  • Main text
View BVdb publication page



An exome array study of the plasma metabolome.

Nature Communications
EP Rhee, Q Yang, B Yu, X Liu, S Cheng, A Deik, KA Pierce, K Bullock, JE Ho, D Levy, JC Florez, S Kathiresan, MG Larson, RS Vasan, CB Clish, TJ Wang, E Boerwinkle, CJ O'Donnell, RE Gerszten
Publication Date: 2016-07-25

Variant appearance in text: APOA5: Ser19Trp; rs3135506
PubMed Link: 27453504
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multidimensional regulation of lipoprotein lipase: impact on biochemical and cardiovascular phenotypes.

Journal Of Lipid Research
RA Hegele
Publication Date: 2016-09

Variant appearance in text: APOA5: S19W
PubMed Link: 27412676
Variant Present in the following documents:
  • Main text
View BVdb publication page



Erratum: Question Marks Left Over a Quantitative Assessment of Apolipoprotein C3 Gene Polymorphisms.

Aging And Disease
PG Sand
Publication Date: 2016-05

Variant appearance in text: APOA5: S19W
PubMed Link: 27329227
Variant Present in the following documents:
  • Main text
View BVdb publication page



Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India.

Plos One
R Pranav Chand, AS Kumar, K Anuj, S Vishnupriya, B Mohan Reddy
Publication Date: 2016

Variant appearance in text: rs3135506
PubMed Link: 27257688
Variant Present in the following documents:
  • Main text
  • pone.0153720.s002.docx
  • pone.0153720.s003.xlsx
View BVdb publication page



The Contribution of GWAS Loci in Familial Dyslipidemias.

Plos Genetics
P Ripatti, JT Rämö, S Söderlund, I Surakka, N Matikainen, M Pirinen, P Pajukanta, AP Sarin, SK Service, PP Laurila, C Ehnholm, V Salomaa, RK Wilson, A Palotie, NB Freimer, MR Taskinen, S Ripatti
Publication Date: 2016-05

Variant appearance in text: rs3135506
PubMed Link: 27227539
Variant Present in the following documents:
  • Main text
  • pgen.1006078.s005.pdf
  • pgen.1006078.s008.pdf
  • pgen.1006078.s009.pdf
View BVdb publication page



Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution.

Atherosclerosis
AP Patel, GM Peloso, JP Pirruccello, CT Johansen, JB Dubé, DB Larach, MR Ban, GM Dallinge-Thie, N Gupta, M Boehnke, GR Abecasis, JJ Kastelein, GK Hovingh, RA Hegele, DJ Rader, S Kathiresan
Publication Date: 2016-07

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 27182959
Variant Present in the following documents:
  • Main text
View BVdb publication page



Frequency of rare mutations and common genetic variations in severe hypertriglyceridemia in the general population of Spain.

Lipids In Health And Disease
I Lamiquiz-Moneo, C Blanco-Torrecilla, AM Bea, R Mateo-Gallego, S Pérez-Calahorra, L Baila-Rueda, A Cenarro, F Civeira, I de Castro-Orós
Publication Date: 2016-04-23

Variant appearance in text: APOA5: Ser19Trp
PubMed Link: 27108409
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients.

Bmj Open
DP Chan, MP Lee, NS Wong, RK Leung, CM Naftalin, SS Lee
Publication Date: 2016-04-11

Variant appearance in text: APOA5: 56C>G; S19W; rs3135506
PubMed Link: 27067897
Variant Present in the following documents:
  • Main text
  • bmjopen-2015-010998aupp_tables.pdf
View BVdb publication page



Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

Journal Of Medical Genetics
EM van Leeuwen, A Sabo, JC Bis, JE Huffman, A Manichaikul, AV Smith, MF Feitosa, S Demissie, PK Joshi, Q Duan, J Marten, JB van Klinken, I Surakka, IM Nolte, W Zhang, H Mbarek, R Li-Gao, S Trompet, N Verweij, E Evangelou, LP Lyytikäinen, BO Tayo, J Deelen, PJ van der Most, SW van der Laan, DE Arking, A Morrison, A Dehghan, OH Franco, A Hofman, F Rivadeneira, EJ Sijbrands, AG Uitterlinden, JC Mychaleckyj, A Campbell, LJ Hocking, S Padmanabhan, JA Brody, KM Rice, CC White, T Harris, A Isaacs, H Campbell, LA Lange, I Rudan, I Kolcic, P Navarro, T Zemunik, V Salomaa, , AS Kooner, JS Kooner, B Lehne, WR Scott, ST Tan, EJ de Geus, Y Milaneschi, BW Penninx, G Willemsen, R de Mutsert, I Ford, RT Gansevoort, MP Segura-Lepe, OT Raitakari, JS Viikari, K Nikus, T Forrester, CA McKenzie, AJ de Craen, HM de Ruijter, , G Pasterkamp, H Snieder, AJ Oldehinkel, PE Slagboom, RS Cooper, M Kähönen, T Lehtimäki, P Elliott, P van der Harst, JW Jukema, DO Mook-Kanamori, DI Boomsma, JC Chambers, M Swertz, S Ripatti, K Willems van Dijk, V Vitart, O Polasek, C Hayward, JG Wilson, JF Wilson, V Gudnason, SS Rich, BM Psaty, IB Borecki, E Boerwinkle, JI Rotter, LA Cupples, CM van Duijn
Publication Date: 2016-07

Variant appearance in text: rs3135506
PubMed Link: 27036123
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nutrigenomics: A controversy.

Applied & Translational Genomics
C Pavlidis, GP Patrinos, T Katsila
Publication Date: 2015-03

Variant appearance in text: rs3135506
PubMed Link: 26937350
Variant Present in the following documents:
  • Main text
View BVdb publication page



Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.

Scientific Reports
JE Below, EJ Parra, ER Gamazon, J Torres, S Krithika, S Candille, Y Lu, A Manichakul, J Peralta-Romero, Q Duan, Y Li, AP Morris, O Gottesman, E Bottinger, XQ Wang, KD Taylor, YD Ida Chen, JI Rotter, SS Rich, RJ Loos, H Tang, NJ Cox, M Cruz, CL Hanis, A Valladares-Salgado
Publication Date: 2016-01-19

Variant appearance in text: rs3135506
PubMed Link: 26780889
Variant Present in the following documents:
  • srep19429-s3.xls
View BVdb publication page



Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.

Journal Of Biomedical Research
TM Forte, V Sharma, RO Ryan
Publication Date: 2016-03

Variant appearance in text: APOA5: 56C>G; Ser19Trp; rs3135506
PubMed Link: 26679785
Variant Present in the following documents:
  • Main text
View BVdb publication page



Lipid levels in HIV-positive men receiving anti-retroviral therapy are not associated with copy number variation of reverse cholesterol transport pathway genes.

Bmc Research Notes
RB Marino, LA Kingsley, SK Hussain, JH Bream, S Penogonda, P Duggal, JJ Martinson
Publication Date: 2015-11-21

Variant appearance in text: rs3135506
PubMed Link: 26590594
Variant Present in the following documents:
  • Main text
View BVdb publication page



Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis.

Genomics Data
SE John, G Thareja, P Hebbar, K Behbehani, TA Thanaraj, O Alsmadi
Publication Date: 2015-03

Variant appearance in text: rs3135506
PubMed Link: 26484159
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mendelian randomization studies of biomarkers and type 2 diabetes.

Endocrine Connections
A Abbasi
Publication Date: 2015-12

Variant appearance in text: rs3135506
PubMed Link: 26446360
Variant Present in the following documents:
  • Main text
View BVdb publication page



Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects.

Lipids In Health And Disease
T Domínguez-Reyes, CC Astudillo-López, L Salgado-Goytia, JF Muñoz-Valle, AB Salgado-Bernabé, IP Guzmán-Guzmán, N Castro-Alarcón, ME Moreno-Godínez, I Parra-Rojas
Publication Date: 2015-09-13

Variant appearance in text: rs3135506
PubMed Link: 26365669
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.

Lipids In Health And Disease
KY Son, HY Son, J Chae, J Hwang, S Jang, JM Yun, B Cho, JH Park, JI Kim
Publication Date: 2015-09-13

Variant appearance in text: rs3135506
PubMed Link: 26365620
Variant Present in the following documents:
  • Main text
View BVdb publication page



Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis.

Plos One
H Ye, A Zhou, Q Hong, L Tang, X Xu, Y Xin, D Jiang, D Dai, Y Li, DW Wang, S Duan
Publication Date: 2015

Variant appearance in text: rs3135506
PubMed Link: 26309253
Variant Present in the following documents:
  • Main text
  • pone.0135683.s001.doc
  • pone.0135683.s004.doc
View BVdb publication page



Apolipoprotein E and protection against hepatitis E viral infection in American non-Hispanic blacks.

Hepatology (Baltimore, Md.)
L Zhang, A Yesupriya, MH Chang, E Teshale, CG Teo
Publication Date: 2015-11

Variant appearance in text: rs3135506
PubMed Link: 26096528
Variant Present in the following documents:
  • NIHMS1043972-supplement-Supplemental.pdf
View BVdb publication page



Genetic Variants Associated with Gestational Hypertriglyceridemia and Pancreatitis.

Plos One
SL Xie, TZ Chen, XL Huang, C Chen, R Jin, ZM Huang, MT Zhou
Publication Date: 2015

Variant appearance in text: APOA5: S19W
PubMed Link: 26079787
Variant Present in the following documents:
  • Main text
View BVdb publication page



Evidence for Clinical Implementation of Pharmacogenomics in Cardiac Drugs.

Mayo Clinic Proceedings
AL Kaufman, J Spitz, M Jacobs, M Sorrentino, S Yuen, K Danahey, D Saner, TE Klein, RB Altman, MJ Ratain, PH O'Donnell
Publication Date: 2015-06

Variant appearance in text: rs3135506
PubMed Link: 26046407
Variant Present in the following documents:
  • NIHMS676556-supplement-4.pdf
View BVdb publication page



Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism.

Current Drug Targets
TM Forte, RO Ryan
Publication Date: 2015

Variant appearance in text: APOA5: 56C>G; S19W
PubMed Link: 26028042
Variant Present in the following documents:
  • Main text
View BVdb publication page



Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.

Jama Neurology
PL Auer, M Nalls, JF Meschia, BB Worrall, WT Longstreth, S Seshadri, C Kooperberg, KM Burger, CS Carlson, CL Carty, WM Chen, LA Cupples, AL DeStefano, M Fornage, J Hardy, L Hsu, RD Jackson, GP Jarvik, DS Kim, K Lakshminarayan, LA Lange, A Manichaikul, AR Quinlan, AB Singleton, TA Thornton, DA Nickerson, U Peters, SS Rich,
Publication Date: 2015-07

Variant appearance in text: rs3135506
PubMed Link: 25961151
Variant Present in the following documents:
  • NIHMS740326-supplement-Supplement.pdf
View BVdb publication page



USF-1 genetic polymorphisms confer a high risk of nonalcoholic fatty liver disease in Chinese population.

International Journal Of Clinical And Experimental Medicine
Y Wang, BF Wang, J Tong, B Chang, BY Wang
Publication Date: 2015

Variant appearance in text: rs3135506
PubMed Link: 25932200
Variant Present in the following documents:
  • Main text
View BVdb publication page



Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome.

Journal Of Diabetes And Metabolic Disorders
M Ajjemami, S Ouatou, H Charoute, M Fakiri, H Rhaissi, H Benrahma, H Rouba, A Barakat
Publication Date: 2015

Variant appearance in text: APOA5: 56C>G; Ser19Trp; rs3135506
PubMed Link: 25909077
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study.

Plos One
M Nakatochi, Y Ushida, Y Yasuda, Y Yoshida, S Kawai, R Kato, T Nakashima, M Iwata, Y Kuwatsuka, M Ando, N Hamajima, T Kondo, H Oda, M Hayashi, S Kato, M Yamaguchi, S Maruyama, S Matsuo, H Honda
Publication Date: 2015

Variant appearance in text: APOA5: S19W
PubMed Link: 25646961
Variant Present in the following documents:
  • pone.0117591.s001.docx
View BVdb publication page



Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population.

Meta Gene
I Radovica, D Fridmanis, I Silamikelis, L Nikitina-Zake, J Klovins
Publication Date: 2014-12

Variant appearance in text: rs3135506
PubMed Link: 25606439
Variant Present in the following documents:
  • mmc1.docx
View BVdb publication page



Association of polymorphisms of genes involved in lipid metabolism with blood pressure and lipid values in mexican hypertensive individuals.

Disease Markers
BE Ríos-González, B Ibarra-Cortés, G Ramírez-López, J Sánchez-Corona, MT Magaña-Torres
Publication Date: 2014

Variant appearance in text: APOA5: S19W; rs3135506
PubMed Link: 25587205
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of apolipoprotein A5 genetic polymorphisms with steroid-induced osteonecrosis of femoral head in a Chinese Han population.

Diagnostic Pathology
Y Cui, A Kaisaierjiang, P Cao, ZY Wu, Q Lv
Publication Date: 2014-12-17

Variant appearance in text: rs3135506
PubMed Link: 25515090
Variant Present in the following documents:
  • Main text
View BVdb publication page



Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study.

Plos Genetics
MA Hall, A Verma, KD Brown-Gentry, R Goodloe, J Boston, S Wilson, B McClellan, C Sutcliffe, HH Dilks, NB Gillani, H Jin, P Mayo, M Allen, N Schnetz-Boutaud, DC Crawford, MD Ritchie, SA Pendergrass
Publication Date: 2014-12

Variant appearance in text: rs3135506
PubMed Link: 25474351
Variant Present in the following documents:
  • pgen.1004678.s011.xlsx
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000227665.4 c.56C>G p.Ser19Trp missense_variant 2/3 -
ENST00000433069.1 c.56C>G p.Ser19Trp missense_variant 3/4 -
ENST00000542499.1 c.56C>G p.Ser19Trp missense_variant 3/4 -
NM_001166598.2 c.56C>G p.Ser19Trp missense_variant 3/4 -
NM_001371904.1 c.56C>G p.Ser19Trp missense_variant 2/3 -
NM_052968.5 c.56C>G p.Ser19Trp missense_variant 3/4 -