Publications:

Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements.

Frontiers In Physiology

Chen, Lei L; Peng, Gary G; Comollo, Thomas W TW; Zou, Xinle X; Sampson, Kevin J KJ; Larsson, H Peter HP; Kass, Robert S RS

Publication Date: 2022

Variant appearance in text: KCNQ1: R243Q

PubMed Link: 35957984

Variant Present in the following documents:

• Main text
• fphys-13-903050.pdf

View BVdb publication page

Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments.

Biophysical Journal

Xu, Yu Y; Wang, Yuhong Y; Zhang, Mei M; Jiang, Min M; Rosenhouse-Dantsker, Avia A; Wassenaar, Tsjerk T; Tseng, Gea-Ny GN

Publication Date: 2015-01-06

Variant appearance in text: KCNQ1: R243Q

PubMed Link: 25564853

Variant Present in the following documents:

• Main text

View BVdb publication page

Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel.

Elife

Zaydman, Mark A MA; Kasimova, Marina A MA; McFarland, Kelli K; Beller, Zachary Z; Hou, Panpan P; Kinser, Holly E HE; Liang, Hongwu H; Zhang, Guohui G; Shi, Jingyi J; Tarek, Mounir M; Cui, Jianmin J

Publication Date: 2014-12-23

Variant appearance in text: KCNQ1: R243Q

PubMed Link: 25535795

Variant Present in the following documents:

• Main text
• elife03606.pdf

View BVdb publication page

Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Zaydman, Mark A MA; Silva, Jonathan R JR; Delaloye, Kelli K; Li, Yang Y; Liang, Hongwu H; Larsson, H Peter HP; Shi, Jingyi J; Cui, Jianmin J

Publication Date: 2013-08-06

Variant appearance in text: Kv7.1: R243Q

PubMed Link: 23861489

Variant Present in the following documents:

• Main text

View BVdb publication page

Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Osteen, Jeremiah D JD; Barro-Soria, Rene R; Robey, Seth S; Sampson, Kevin J KJ; Kass, Robert S RS; Larsson, H Peter HP

Publication Date: 2012-05-01

Variant appearance in text: KCNQ1: R243Q

PubMed Link: 22509038

Variant Present in the following documents:

• Main text

View BVdb publication page