Publications:

Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements.

Frontiers In Physiology

Chen, Lei L; Peng, Gary G; Comollo, Thomas W TW; Zou, Xinle X; Sampson, Kevin J KJ; Larsson, H Peter HP; Kass, Robert S RS

Publication Date: 2022

Variant appearance in text: KCNQ1: G272C

PubMed Link: 35957984

Variant Present in the following documents:

• Main text
• fphys-13-903050.pdf

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Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.

Nature Communications

Willegems, Katrien K; Eldstrom, Jodene J; Kyriakis, Efthimios E; Ataei, Fariba F; Sahakyan, Harutyun H; Dou, Ying Y; Russo, Sophia S; Van Petegem, Filip F; Fedida, David D

Publication Date: 2022-06-29

Variant appearance in text: KCNQ1: G272C

PubMed Link: 35768468

Variant Present in the following documents:

• Main text
• 41467_2022_31526_MOESM1_ESM.pdf
• 41467_2022_31526_MOESM2_ESM.pdf
• 41467_2022_Article_31526.pdf

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ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state.

The Journal Of General Physiology

Eldstrom, Jodene J; McAfee, Donald A DA; Dou, Ying Y; Wang, Yundi Y; Fedida, David D

Publication Date: 2021-12-06

Variant appearance in text: KCNQ1: G272C

PubMed Link: 34636894

Variant Present in the following documents:

• Main text

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Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels.

The Journal Of Physiology

Seebohm, Guiscard G; Sanguinetti, Michael C MC; Pusch, Michael M

Publication Date: 2003-10-15

Variant appearance in text: KCNQ1: G272C

PubMed Link: 14561821

Variant Present in the following documents:

• Main text

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