Publications:

Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation.

Elife

Kuenze, Georg G; Vanoye, Carlos G CG; Desai, Reshma R RR; Adusumilli, Sneha S; Brewer, Kathryn R KR; Woods, Hope H; McDonald, Eli F EF; Sanders, Charles R CR; George, Alfred L AL; Meiler, Jens J

Publication Date: 2020-10-23

Variant appearance in text: KCNQ1: I274A

PubMed Link: 33095155

Variant Present in the following documents:

• Main text
• elife-57680.pdf

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Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activation.

Nature Communications

Hou, Panpan P; Kang, Po Wei PW; Kongmeneck, Audrey Deyawe AD; Yang, Nien-Du ND; Liu, Yongfeng Y; Shi, Jingyi J; Xu, Xianjin X; White, Kelli McFarland KM; Zaydman, Mark A MA; Kasimova, Marina A MA; Seebohm, Guiscard G; Zhong, Ling L; Zou, Xiaoqin X; Tarek, Mounir M; Cui, Jianmin J

Publication Date: 2020-02-03

Variant appearance in text: KCNQ1: I274A

PubMed Link: 32015334

Variant Present in the following documents:

• 41467_2020_14406_MOESM1_ESM.pdf

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KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting.

Nature Communications

Wrobel, Eva E; Rothenberg, Ina I; Krisp, Christoph C; Hundt, Franziska F; Fraenzel, Benjamin B; Eckey, Karina K; Linders, Joannes T M JT; Gallacher, David J DJ; Towart, Rob R; Pott, Lutz L; Pusch, Michael M; Yang, Tao T; Roden, Dan M DM; Kurata, Harley T HT; Schulze-Bahr, Eric E; Strutz-Seebohm, Nathalie N; Wolters, Dirk D; Seebohm, Guiscard G

Publication Date: 2016-10-12

Variant appearance in text: Kv7.1: I274A

PubMed Link: 27731317

Variant Present in the following documents:

• Main text
• ncomms12795.pdf

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Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.

Biophysical Journal

Ma, Li-Juan LJ; Ohmert, Iris I; Vardanyan, Vitya V

Publication Date: 2011-02-16

Variant appearance in text: KCNQ1: I274A

PubMed Link: 21320432

Variant Present in the following documents:

• Main text

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