KCNQ1 c.1084_1085delinsGC ;(p.K362A)

Variant ID: 11-2606493-AA-GC

NM_000218.2(KCNQ1):c.1084_1085delinsGC;(p.K362A)

This variant was identified in 6 publications

View GRCh38 version.




Publications:


Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation.

Elife
Kuenze, Georg G; Vanoye, Carlos G CG; Desai, Reshma R RR; Adusumilli, Sneha S; Brewer, Kathryn R KR; Woods, Hope H; McDonald, Eli F EF; Sanders, Charles R CR; George, Alfred L AL; Meiler, Jens J
Publication Date: 2020-10-23

Variant appearance in text: KCNQ1: K362A
PubMed Link: 33095155
Variant Present in the following documents:
  • Main text
  • elife-57680-fig5-data1.xlsx, sheet 2
  • elife-57680.pdf
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A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂.

Pflugers Archiv : European Journal Of Physiology
Telezhkin, Vsevolod V; Thomas, Alison M AM; Harmer, Stephen C SC; Tinker, Andrew A; Brown, David A DA
Publication Date: 2013-07

Variant appearance in text: Kv7.1: K362A
PubMed Link: 23291709
Variant Present in the following documents:
  • Main text
  • 424_2012_Article_1199.pdf
View BVdb publication page



An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.

Molecular Pharmacology
Yang, Tao T; Smith, Jarrod A JA; Leake, Brenda F BF; Sanders, Charles R CR; Meiler, Jens J; Roden, Dan M DM
Publication Date: 2013-02

Variant appearance in text: KCNQ1: K362A
PubMed Link: 23193163
Variant Present in the following documents:
  • Main text
View BVdb publication page



Ginsenoside Rg3 enhances large conductance Ca2+-activated potassium channel currents: a role of Tyr360 residue.

Molecules And Cells
Choi, Sun-Hye SH; Shin, Tae-Joon TJ; Lee, Byung-Hwan BH; Hwang, Sung Hee SH; Lee, Sang-Mok SM; Lee, Byung-Cheol BC; Park, Cheol-Seung CS; Ha, Tal Soo TS; Nah, Seung-Yeol SY
Publication Date: 2011-02

Variant appearance in text: KCNQ1: K362A
PubMed Link: 21191818
Variant Present in the following documents:
  • Main text
View BVdb publication page



Characterization of a binding site for anionic phospholipids on KCNQ1.

The Journal Of Biological Chemistry
Thomas, Alison M AM; Harmer, Stephen C SC; Khambra, Tapsi T; Tinker, Andrew A
Publication Date: 2011-01-21

Variant appearance in text: KCNQ1: K362A
PubMed Link: 21084310
Variant Present in the following documents:
  • Main text
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Role of the S6 C-terminus in KCNQ1 channel gating.

The Journal Of Physiology
Boulet, Inge R IR; Labro, Alain J AJ; Raes, Adam L AL; Snyders, Dirk J DJ
Publication Date: 2007-12-01

Variant appearance in text: KCNQ1: K362A
PubMed Link: 17932138
Variant Present in the following documents:
  • Main text
View BVdb publication page