The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population.
Diabetologia
Wedekind, Lauren E LE; Mahajan, Anubha A; Hsueh, Wen-Chi WC; Chen, Peng P; Olaiya, Muideen T MT; Kobes, Sayuko S; Sinha, Madhumita M; Baier, Leslie J LJ; Knowler, William C WC; McCarthy, Mark I MI; Hanson, Robert L RL
Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians.
Cells
Nair, Anup K AK; Traurig, Michael M; Sutherland, Jeff R JR; Muller, Yunhua L YL; Grellinger, Emma D ED; Saporito, Lucas L; Nelson, Robert G RG; Bogardus, Clifton C; Baier, Leslie J LJ
A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.
Communications Biology
Schreiber, Julian A JA; Möller, Melina M; Zaydman, Mark M; Zhao, Lu L; Beller, Zachary Z; Becker, Sebastian S; Ritter, Nadine N; Hou, Panpan P; Shi, Jingyi J; Silva, Jon J; Wrobel, Eva E; Strutz-Seebohm, Nathalie N; Decher, Niels N; Schmitt, Nicole N; Meuth, Sven G SG; Düfer, Martina M; Wünsch, Bernhard B; Cui, Jianmin J; Seebohm, Guiscard G
Impact of Genetic Risk Score and Dietary Protein Intake on Vitamin D Status in Young Adults from Brazil.
Nutrients
Alathari, Buthaina E BE; Cruvinel, Nathália Teixeira NT; da Silva, Nara Rubia NR; Chandrabose, Mathurra M; Lovegrove, Julie A JA; Horst, Maria A MA; Vimaleswaran, Karani S KS
Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis.
Journal Of The National Cancer Institute
Murphy, Neil N; Song, Mingyang M; Papadimitriou, Nikos N; Carreras-Torres, Robert R; Langenberg, Claudia C; Martin, Richard M RM; Tsilidis, Konstantinos K KK; Barroso, Inês I; Chen, Ji J; Frayling, Timothy M TM; Bull, Caroline J CJ; Vincent, Emma E EE; Cotterchio, Michelle M; Gruber, Stephen B SB; Pai, Rish K RK; Newcomb, Polly A PA; Perez-Cornago, Aurora A; van Duijnhoven, Franzel J B FJB; Van Guelpen, Bethany B; Vodicka, Pavel P; Wolk, Alicja A; Wu, Anna H AH; Peters, Ulrike U; Chan, Andrew T AT; Gunter, Marc J MJ
Celebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels Kv 7.1 and Kv 11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes.
Acta Physiologica (Oxford, England)
Lubberding, Anniek F AF; Juhl, Christian R CR; Skovhøj, Emil Z EZ; Kanters, Jørgen K JK; Mandrup-Poulsen, Thomas T; Torekov, Signe S SS
Associations of Polygenetic Variants at the 11q23 Locus and Their Interactions with Macronutrient Intake for the Risk of 3GO, a Combination of Hypertension, Hyperglycemia, and Dyslipidemia.
Methylation status of vault RNA 2-1 promoter is a predictor of glycemic response to glucagon-like peptide-1 analog therapy in type 2 diabetes mellitus.
Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women.
Nutrients
Alathari, Buthaina E BE; Aji, Arif Sabta AS; Ariyasra, Utami U; Sari, Sri R SR; Tasrif, Nabila N; Yani, Finny F FF; Sudji, Ikhwan R IR; Lovegrove, Julie A JA; Lipoeto, Nur I NI; Vimaleswaran, Karani S KS
Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study.
International Journal Of Endocrinology
Khan, Vasiuddin V; Verma, Amit Kumar AK; Bhatt, Deepti D; Khan, Shahbaz S; Hasan, Rameez R; Goyal, Yamini Y; Ramachandran, Sowmya S; Alsahli, Mohammed A MA; Rahmani, Arshad Husain AH; Almatroudi, Ahmad A; Shareef, M Y MY; Meena, Babita B; Dev, Kapil K
Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian.
Genes & Nutrition
Alsulami, Sooad S; Aji, A S AS; Ariyasra, U U; Sari, S R SR; Tasrif, N N; Yani, F F FF; Lovegrove, J A JA; Sudji, I R IR; Lipoeto, N I NI; Vimaleswaran, K S KS
Pharmacogenetics of hypoglycemia associated with sulfonylurea therapy in usual clinical care.
The Pharmacogenomics Journal
Mitchell, Sabrina L SL; Leon, Daniel A Carranza DAC; Chaugai, Sandip S; Kawai, Vivian K VK; Levinson, Rebecca T RT; Wei, Wei-Qi WQ; Stein, C Michael CM
Classification of Type 2 Diabetes Genetic Variants and a Novel Genetic Risk Score Association With Insulin Clearance.
The Journal Of Clinical Endocrinology And Metabolism
Goodarzi, Mark O MO; Palmer, Nicholette D ND; Cui, Jinrui J; Guo, Xiuqing X; Chen, Yii-Der I YI; Taylor, Kent D KD; Raffel, Leslie J LJ; Wagenknecht, Lynne E LE; Buchanan, Thomas A TA; Hsueh, Willa A WA; Rotter, Jerome I JI
Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk.
Scientific Reports
Christodoulou, Maria-Ioanna MI; Avgeris, Margaritis M; Kokkinopoulou, Ioanna I; Maratou, Eirini E; Mitrou, Panayota P; Kontos, Christos K CK; Pappas, Efthimios E; Boutati, Eleni E; Scorilas, Andreas A; Fragoulis, Emmanuel G EG
Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation.
Diabetes Research And Clinical Practice
Shah, Ushma J UJ; Xie, Weijia W; Flyvbjerg, Allan A; Nolan, John J JJ; Højlund, Kurt K; Walker, Mark M; Relton, Caroline L CL; Elliott, Hannah R HR; ,