Publications:

Structural Basis of β2 Integrin Inside-Out Activation.

Cells

Wen, Lai L; Lyu, Qingkang Q; Ley, Klaus K; Goult, Benjamin T BT

Publication Date: 2022-09-28

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PubMed Link: 36231001

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• cells-11-03039.pdf

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The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells.

Frontiers In Cell And Developmental Biology

Sun, Hao H; Lagarrigue, Frederic F; Ginsberg, Mark H MH

Publication Date: 2022

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PubMed Link: 35721481

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Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins.

The Journal Of Biological Chemistry

Liao, Zhongji Z; Gingras, Alexandre R AR; Lagarrigue, Frederic F; Ginsberg, Mark H MH; Shattil, Sanford J SJ

Publication Date: 2021

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PubMed Link: 33865854

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• main.pdf

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Talin-1 is the principal platelet Rap1 effector of integrin activation.

Blood

Lagarrigue, Frederic F; Paul, David S DS; Gingras, Alexandre R AR; Valadez, Andrew J AJ; Sun, Hao H; Lin, Jenny J; Cuevas, Monica N MN; Ablack, Jailal N JN; Lopez-Ramirez, Miguel Alejandro MA; Bergmeier, Wolfgang W; Ginsberg, Mark H MH

Publication Date: 2020-09-03

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PubMed Link: 32518959

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Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem.

The Journal Of Cell Biology

Gingras, Alexandre R AR; Lagarrigue, Frederic F; Cuevas, Monica N MN; Valadez, Andrew J AJ; Zorovich, Marcus M; McLaughlin, Wilma W; Lopez-Ramirez, Miguel Alejandro MA; Seban, Nicolas N; Ley, Klaus K; Kiosses, William B WB; Ginsberg, Mark H MH

Publication Date: 2019-06-03

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PubMed Link: 30988001

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• JCB_201810061.pdf

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