Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Nature Immunology
Johnson, Andy L AL; Aravind, L L; Shulzhenko, Natalia N; Morgun, Andre A; Choi, See-Young SY; Crockford, Tanya L TL; Lambe, Teresa T; Domaschenz, Heather H; Kucharska, Edyta M EM; Zheng, Lixin L; Vinuesa, Carola G CG; Lenardo, Michael J MJ; Goodnow, Christopher C CC; Cornall, Richard J RJ; Schwartz, Ronald H RH
CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus.
The Journal Of Experimental Medicine
Vratsanos, G S GS; Jung, S S; Park, Y M YM; Craft, J J