The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect.
The Journal Of Biological Chemistry
Hornos, Felipe F; Feng, Han-Zhong HZ; Rizzuti, Bruno B; Palomino-Schätzlein, Martina M; Wieczorek, David D; Neira, José L JL; Jin, J-P JP
Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response.
Frontiers In Physiology
Chowdhury, Shamim A K SAK; Warren, Chad M CM; Simon, Jillian N JN; Ryba, David M DM; Batra, Ashley A; Varga, Peter P; Kranias, Evangelia G EG; Tardiff, Jil C JC; Solaro, R John RJ; Wolska, Beata M BM