Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.
Nature Genetics
Schlosser, Pascal P; Scherer, Nora N; Grundner-Culemann, Franziska F; Monteiro-Martins, Sara S; Haug, Stefan S; Steinbrenner, Inga I; Uluvar, Burulça B; Wuttke, Matthias M; Cheng, Yurong Y; Ekici, Arif B AB; Gyimesi, Gergely G; Karoly, Edward D ED; Kotsis, Fruzsina F; Mielke, Johanna J; Gomez, Maria F MF; Yu, Bing B; Grams, Morgan E ME; Coresh, Josef J; Boerwinkle, Eric E; Köttgen, Michael M; Kronenberg, Florian F; Meiselbach, Heike H; Mohney, Robert P RP; Akilesh, Shreeram S; , ; Schmidts, Miriam M; Hediger, Matthias A MA; Schultheiss, Ulla T UT; Eckardt, Kai-Uwe KU; Oefner, Peter J PJ; Sekula, Peggy P; Li, Yong Y; Köttgen, Anna A
Genome-wide analysis of oxylipins and oxylipin profiles in a pediatric population.
Frontiers In Nutrition
Buckner, Teresa T; Johnson, Randi K RK; Vanderlinden, Lauren A LA; Carry, Patrick M PM; Romero, Alex A; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Kim, Soojeong S; Fiehn, Oliver O; Frohnert, Brigitte I BI; Crume, Tessa T; Perng, Wei W; Kechris, Katerina K; Rewers, Marian M; Norris, Jill M JM
Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts.
Research Square
Yang, Chaojie C; Veenstra, Jenna J; Bartz, Traci T; Pahl, Matthew M; Hallmark, Brian B; Chen, Yii-Der Ida YI; Westra, Jason J; Steffen, Lyn L; Brown, Christopher C; Siscovick, David D; Tsai, Michael M; Wood, Alexis A; Rich, Stephen S; Smith, Caren C; O'Connor, Timothy T; Mozaffarian, Dariush D; Grant, Struan S; Chilton, Floyd F; Tintle, Nathan N; Lemaitre, Rozenn R; Manichaikul, Ani A
Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations.
Genome Medicine
Xin, Junyi J; Du, Mulong M; Gu, Dongying D; Jiang, Kewei K; Wang, Mengyun M; Jin, Mingjuan M; Hu, Yeting Y; Ben, Shuai S; Chen, Silu S; Shao, Wei W; Li, Shuwei S; Chu, Haiyan H; Zhu, Linjun L; Li, Chen C; Chen, Kun K; Ding, Kefeng K; Zhang, Zhengdong Z; Shen, Hongbing H; Wang, Meilin M
Genetics, genomics, and diet interactions in obesity in the Latin American environment.
Frontiers In Nutrition
Guevara-Ramírez, Patricia P; Cadena-Ullauri, Santiago S; Ruiz-Pozo, Viviana A VA; Tamayo-Trujillo, Rafael R; Paz-Cruz, Elius E; Simancas-Racines, Daniel D; Zambrano, Ana Karina AK
Kiani, Aysha Karim AK; Bonetti, Gabriele G; Donato, Kevin K; Kaftalli, Jurgen J; Herbst, Karen L KL; Stuppia, Liborio L; Fioretti, Francesco F; Nodari, Savina S; Perrone, Marco M; Chiurazzi, Pietro P; Bellinato, Francesco F; Gisondi, Paolo P; Bertelli, Matteo M
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.
Nature Communications
Young, William J WJ; Lahrouchi, Najim N; Isaacs, Aaron A; Duong, ThuyVy T; Foco, Luisa L; Ahmed, Farah F; Brody, Jennifer A JA; Salman, Reem R; Noordam, Raymond R; Benjamins, Jan-Walter JW; Haessler, Jeffrey J; Lyytikäinen, Leo-Pekka LP; Repetto, Linda L; Concas, Maria Pina MP; van den Berg, Marten E ME; Weiss, Stefan S; Baldassari, Antoine R AR; Bartz, Traci M TM; Cook, James P JP; Evans, Daniel S DS; Freudling, Rebecca R; Hines, Oliver O; Isaksen, Jonas L JL; Lin, Honghuang H; Mei, Hao H; Moscati, Arden A; Müller-Nurasyid, Martina M; Nursyifa, Casia C; Qian, Yong Y; Richmond, Anne A; Roselli, Carolina C; Ryan, Kathleen A KA; Tarazona-Santos, Eduardo E; Thériault, Sébastien S; van Duijvenboden, Stefan S; Warren, Helen R HR; Yao, Jie J; Raza, Dania D; Aeschbacher, Stefanie S; Ahlberg, Gustav G; Alonso, Alvaro A; Andreasen, Laura L; Bis, Joshua C JC; Boerwinkle, Eric E; Campbell, Archie A; Catamo, Eulalia E; Cocca, Massimiliano M; Cutler, Michael J MJ; Darbar, Dawood D; De Grandi, Alessandro A; De Luca, Antonio A; Ding, Jun J; Ellervik, Christina C; Ellinor, Patrick T PT; Felix, Stephan B SB; Froguel, Philippe P; Fuchsberger, Christian C; Gögele, Martin M; Graff, Claus C; Graff, Mariaelisa M; Guo, Xiuqing X; Hansen, Torben T; Heckbert, Susan R SR; Huang, Paul L PL; Huikuri, Heikki V HV; Hutri-Kähönen, Nina N; Ikram, M Arfan MA; Jackson, Rebecca D RD; Junttila, Juhani J; Kavousi, Maryam M; Kors, Jan A JA; Leal, Thiago P TP; Lemaitre, Rozenn N RN; Lin, Henry J HJ; Lind, Lars L; Linneberg, Allan A; Liu, Simin S; MacFarlane, Peter W PW; Mangino, Massimo M; Meitinger, Thomas T; Mezzavilla, Massimo M; Mishra, Pashupati P PP; Mitchell, Rebecca N RN; Mononen, Nina N; Montasser, May E ME; Morrison, Alanna C AC; Nauck, Matthias M; Nauffal, Victor V; Navarro, Pau P; Nikus, Kjell K; Pare, Guillaume G; Patton, Kristen K KK; Pelliccione, Giulia G; Pittman, Alan A; Porteous, David J DJ; Pramstaller, Peter P PP; Preuss, Michael H MH; Raitakari, Olli T OT; Reiner, Alexander P AP; Ribeiro, Antonio Luiz P ALP; Rice, Kenneth M KM; Risch, Lorenz L; Schlessinger, David D; Schotten, Ulrich U; Schurmann, Claudia C; Shen, Xia X; Shoemaker, M Benjamin MB; Sinagra, Gianfranco G; Sinner, Moritz F MF; Soliman, Elsayed Z EZ; Stoll, Monika M; Strauch, Konstantin K; Tarasov, Kirill K; Taylor, Kent D KD; Tinker, Andrew A; Trompet, Stella S; Uitterlinden, André A; Völker, Uwe U; Völzke, Henry H; Waldenberger, Melanie M; Weng, Lu-Chen LC; Whitsel, Eric A EA; Wilson, James G JG; Avery, Christy L CL; Conen, David D; Correa, Adolfo A; Cucca, Francesco F; Dörr, Marcus M; Gharib, Sina A SA; Girotto, Giorgia G; Grarup, Niels N; Hayward, Caroline C; Jamshidi, Yalda Y; Järvelin, Marjo-Riitta MR; Jukema, J Wouter JW; Kääb, Stefan S; Kähönen, Mika M; Kanters, Jørgen K JK; Kooperberg, Charles C; Lehtimäki, Terho T; Lima-Costa, Maria Fernanda MF; Liu, Yongmei Y; Loos, Ruth J F RJF; Lubitz, Steven A SA; Mook-Kanamori, Dennis O DO; Morris, Andrew P AP; O'Connell, Jeffrey R JR; Olesen, Morten Salling MS; Orini, Michele M; Padmanabhan, Sandosh S; Pattaro, Cristian C; Peters, Annette A; Psaty, Bruce M BM; Rotter, Jerome I JI; Stricker, Bruno B; van der Harst, Pim P; van Duijn, Cornelia M CM; Verweij, Niek N; Wilson, James F JF; Arking, Dan E DE; Ramirez, Julia J; Lambiase, Pier D PD; Sotoodehnia, Nona N; Mifsud, Borbala B; Newton-Cheh, Christopher C; Munroe, Patricia B PB
Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening.
Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Arnau-Collell, Coral C; Díez-Villanueva, Anna A; Bellosillo, Beatriz B; Augé, Josep M JM; Muñoz, Jenifer J; Guinó, Elisabet E; Moreira, Leticia L; Serradesanferm, Anna A; Pozo, Àngels À; Torà-Rocamora, Isabel I; Bonjoch, Laia L; Ibañez-Sanz, Gemma G; Obon-Santacana, Mireia M; Moratalla-Navarro, Ferran F; Sanz-Pamplona, Rebeca R; Márquez Márquez, Carmen C; Rueda Miret, Rebeca R; Pérez Berbegal, Rocio R; Piquer Velasco, Gabriel G; Hernández Rodríguez, Cristina C; Grau, Jaume J; Castells, Antoni A; Borràs, Josep M JM; Bessa, Xavier X; Moreno, Victor V; Castellví-Bel, Sergi S
Interpreting Clinical Trials With Omega-3 Supplements in the Context of Ancestry and FADS Genetic Variation.
Frontiers In Nutrition
Chilton, Floyd H FH; Manichaikul, Ani A; Yang, Chaojie C; O'Connor, Timothy D TD; Johnstone, Laurel M LM; Blomquist, Sarah S; Schembre, Susan M SM; Sergeant, Susan S; Zec, Manja M; Tsai, Michael Y MY; Rich, Stephen S SS; Bridgewater, Susan J SJ; Mathias, Rasika A RA; Hallmark, Brian B
Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism.
Plos One
Kirk, L Madison LM; Waits, Charlotte Mae K CMK; Bashore, Alexander C AC; Dosso, Beverly B; Meyers, Allison K AK; Renaldo, Antonio C AC; DePalma, Thomas J TJ; Simms, Kelli N KN; Hauser, Nathaniel N; Chuang Key, Chia-Chi CC; McCall, Charles E CE; Parks, John S JS; Sergeant, Susan S; Langefeld, Carl D CD; Skardal, Aleksander A; Rahbar, Elaheh E
Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism.
Plos One
Kirk, L Madison LM; Waits, Charlotte Mae K CMK; Bashore, Alexander C AC; Dosso, Beverly B; Meyers, Allison K AK; Renaldo, Antonio C AC; DePalma, Thomas J TJ; Simms, Kelli N KN; Hauser, Nathaniel N; Chuang Key, Chia-Chi CC; McCall, Charles E CE; Parks, John S JS; Sergeant, Susan S; Langefeld, Carl D CD; Skardal, Aleksander A; Rahbar, Elaheh E
Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms.
Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations.
Communications Biology
Yang, Chaojie C; Hallmark, Brian B; Chai, Jin Choul JC; O'Connor, Timothy D TD; Reynolds, Lindsay M LM; Wood, Alexis C AC; Seeds, Michael M; Chen, Yii-Der Ida YI; Steffen, Lyn M LM; Tsai, Michael Y MY; Kaplan, Robert C RC; Daviglus, Martha L ML; Mandarino, Lawrence J LJ; Fretts, Amanda M AM; Lemaitre, Rozenn N RN; Coletta, Dawn K DK; Blomquist, Sarah A SA; Johnstone, Laurel M LM; Tontsch, Chandra C; Qi, Qibin Q; Ruczinski, Ingo I; Rich, Stephen S SS; Mathias, Rasika A RA; Chilton, Floyd H FH; Manichaikul, Ani A
Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort.
Journal Of The American Heart Association
Huang, Neil K NK; Bůžková, Petra P; Matthan, Nirupa R NR; Djoussé, Luc L; Hirsch, Calvin H CH; Kizer, Jorge R JR; Longstreth, W T WT; Mukamal, Kenneth J KJ; Lichtenstein, Alice H AH
Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.
Adipocyte
Wang, Chenxuan C; Murphy, Jessica J; Delaney, Kerri Z KZ; Khor, Natalie N; Morais, José A JA; Tsoukas, Michael A MA; Lowry, Dana E DE; Mutch, David M DM; Santosa, Sylvia S
Maternal and child fatty acid desaturase genotype as determinants of cord blood long-chain PUFA (LCPUFA) concentrations in the Seychelles Child Development Study.
The British Journal Of Nutrition
Conway, Marie C MC; McSorley, Emeir M EM; Mulhern, Maria S MS; Spence, Toni T; Weslowska, Maria M; Strain, J J JJ; van Wijngaarden, Edwin E; Davidson, Phil W PW; Myers, Gary J GJ; Wahlberg, Karin E KE; Shamlaye, Conrad F CF; Cobice, Diego F DF; Hyland, Barry W BW; Pineda, Daniela D; Broberg, Karin K; Yeates, Alison J AJ
Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance.
International Journal Of Cancer
He, Yazhou Y; Timofeeva, Maria M; Zhang, Xiaomeng X; Xu, Wei W; Li, Xue X; Din, Farhat V N FVN; Svinti, Victoria V; Farrington, Susan M SM; Campbell, Harry H; Dunlop, Malcolm G MG; Theodoratou, Evropi E
Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19✰,✰✰,★,★★.
Prostaglandins, Leukotrienes, And Essential Fatty Acids
Kothapalli, Kumar S D KSD; Park, Hui Gyu HG; Brenna, J Thomas JT
Impact of rs174537 on Critically Ill Patients with Acute Lung Injury: A Secondary Analysis of the OMEGA Randomized Clinical Trial.
Current Developments In Nutrition
Dosso, Beverly B; Waits, Charlotte Mae K CMK; Simms, Kelli N KN; Sergeant, Susan S; Files, D Clark DC; Howard, Timothy D TD; Langefeld, Carl D CD; Chilton, Floyd H FH; Rahbar, Elaheh E
The influence of fish consumption on serum n-3 polyunsaturated fatty acid (PUFA) concentrations in women of childbearing age: a randomised controlled trial (the iFish Study).
European Journal Of Nutrition
Conway, Marie C MC; McSorley, Emeir M EM; Mulhern, Maria S MS; Spence, Toni T; Wijngaarden, Edwin van EV; Watson, Gene E GE; Wahlberg, Karin K; Pineda, Daniela D; Broberg, Karin K; Hyland, Barry W BW; Cobice, Diego F DF; Strain, J J JJ; Yeates, Alison J AJ
Maternal Long-Chain Polyunsaturated Fatty Acid Status, Methylmercury Exposure, and Birth Outcomes in a High-Fish-Eating Mother-Child Cohort.
The Journal Of Nutrition
Yeates, Alison Jayne AJ; Zavez, Alexis A; Thurston, Sally W SW; McSorley, Emeir M EM; Mulhern, Maria S MS; Alhamdow, Ayman A; Engström, Karin K; Wahlberg, Karin K; Strain, J J JJ; Watson, Gene E GE; Myers, Gary J GJ; Davidson, Philip W PW; Shamlaye, Conrad F CF; Broberg, Karin K; van Wijngaarden, Edwin E