Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.
Nature Genetics
Schlosser, Pascal P; Scherer, Nora N; Grundner-Culemann, Franziska F; Monteiro-Martins, Sara S; Haug, Stefan S; Steinbrenner, Inga I; Uluvar, Burulça B; Wuttke, Matthias M; Cheng, Yurong Y; Ekici, Arif B AB; Gyimesi, Gergely G; Karoly, Edward D ED; Kotsis, Fruzsina F; Mielke, Johanna J; Gomez, Maria F MF; Yu, Bing B; Grams, Morgan E ME; Coresh, Josef J; Boerwinkle, Eric E; Köttgen, Michael M; Kronenberg, Florian F; Meiselbach, Heike H; Mohney, Robert P RP; Akilesh, Shreeram S; , ; Schmidts, Miriam M; Hediger, Matthias A MA; Schultheiss, Ulla T UT; Eckardt, Kai-Uwe KU; Oefner, Peter J PJ; Sekula, Peggy P; Li, Yong Y; Köttgen, Anna A
Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis.
Jama Psychiatry
Gong, Weiming W; Guo, Ping P; Li, Yuanming Y; Liu, Lu L; Yan, Ran R; Liu, Shuai S; Wang, Shukang S; Xue, Fuzhong F; Zhou, Xiang X; Yuan, Zhongshang Z
JAK-STAT signaling in inflammatory breast cancer enables chemotherapy-resistant cell states.
Cancer Research
Stevens, Laura E LE; Peluffo, Guillermo G; Qiu, Xintao X; Temko, Daniel D; Fassl, Anne A; Li, Zheqi Z; Trinh, Anne A; Seehawer, Marco M; Jovanovic, Bojana B; Aleckovic, Masa M; Wilde, Callahan M CM; Geck, Renee C RC; Shu, Shaokun S; Kingston, Natalie L NL; Harper, Nicholas W NW; Almendro, Vanessa V; Pyke, Alanna L AL; Egri, Shawn B SB; Papanastasiou, Malvina M; Clement, Kendell K; Zhou, Ningxuan N; Walker, Sarah S; Salas, Jacqueline J; Park, So Yeon SY; Frank, David A DA; Meissner, Alexander A; Jaffe, Jacob D JD; Sicinski, Piotr P; Toker, Alex A; Michor, Franziska F; Long, Henry W HW; Overmoyer, Beth A BA; Polyak, Kornelia K
Publication Date: 2022-11-21
Variant appearance in text: TMEM258: 113+162A>G; rs102275
Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants.
Bmc Medicine
Borges, Maria Carolina MC; Haycock, Philip C PC; Zheng, Jie J; Hemani, Gibran G; Holmes, Michael V MV; Davey Smith, George G; Hingorani, Aroon D AD; Lawlor, Deborah A DA
Using Genetic Variants to Evaluate the Causal Effect of Plasma Phospholipid Fatty Acids on Breast Cancer and Prostate Cancer: A Mendelian Randomization Study.
Frontiers In Genetics
Yang, Ze Z; Li, Jingjia J; Sun, Yandi Y; Qu, Zihao Z; Lin, Yindan Y; Zhang, Lihong L; He, Qian Q; Jia, Xueyao X; Ahmad, Mashaal M; Zhang, Xueyun X; Luo, Yan Y
Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders.
Human Molecular Genetics
van Duijvenboden, Stefan S; Ramírez, Julia J; Young, William J WJ; Orini, Michele M; Mifsud, Borbala B; Tinker, Andrew A; Lambiase, Pier D PD; Munroe, Patricia B PB
Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules.
Network And Systems Medicine
Gillenwater, Lucas A LA; Pratte, Katherine A KA; Hobbs, Brian D BD; Cho, Michael H MH; Zhuang, Yonghua Y; Halper-Stromberg, Eitan E; Cruickshank-Quinn, Charmion C; Reisdorph, Nichole N; Petrache, Irina I; Labaki, Wassim W WW; O'Neal, Wanda K WK; Ortega, Victor E VE; Jones, Dean P DP; Uppal, Karan K; Jacobson, Sean S; Michelotti, Gregory G; Wendt, Christine H CH; Kechris, Katerina J KJ; Bowler, Russell P RP
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.
Communications Biology
Bell, Steven S; Rigas, Andreas S AS; Magnusson, Magnus K MK; Ferkingstad, Egil E; Allara, Elias E; Bjornsdottir, Gyda G; Ramond, Anna A; Sørensen, Erik E; Halldorsson, Gisli H GH; Paul, Dirk S DS; Burgdorf, Kristoffer S KS; Eggertsson, Hannes P HP; Howson, Joanna M M JMM; Thørner, Lise W LW; Kristmundsdottir, Snaedis S; Astle, William J WJ; Erikstrup, Christian C; Sigurdsson, Jon K JK; Vuckovic, Dragana D; Dinh, Khoa M KM; Tragante, Vinicius V; Surendran, Praveen P; Pedersen, Ole B OB; Vidarsson, Brynjar B; Jiang, Tao T; Paarup, Helene M HM; Onundarson, Pall T PT; Akbari, Parsa P; Nielsen, Kaspar R KR; Lund, Sigrun H SH; Juliusson, Kristinn K; Magnusson, Magnus I MI; Frigge, Michael L ML; Oddsson, Asmundur A; Olafsson, Isleifur I; Kaptoge, Stephen S; Hjalgrim, Henrik H; Runarsson, Gudmundur G; Wood, Angela M AM; Jonsdottir, Ingileif I; Hansen, Thomas F TF; Sigurdardottir, Olof O; Stefansson, Hreinn H; Rye, David D; , ; Peters, James E JE; Westergaard, David D; Holm, Hilma H; Soranzo, Nicole N; Banasik, Karina K; Thorleifsson, Gudmar G; Ouwehand, Willem H WH; Thorsteinsdottir, Unnur U; Roberts, David J DJ; Sulem, Patrick P; Butterworth, Adam S AS; Gudbjartsson, Daniel F DF; Danesh, John J; Brunak, Søren S; Di Angelantonio, Emanuele E; Ullum, Henrik H; Stefansson, Kari K
Maternal and child fatty acid desaturase genotype as determinants of cord blood long-chain PUFA (LCPUFA) concentrations in the Seychelles Child Development Study.
The British Journal Of Nutrition
Conway, Marie C MC; McSorley, Emeir M EM; Mulhern, Maria S MS; Spence, Toni T; Weslowska, Maria M; Strain, J J JJ; van Wijngaarden, Edwin E; Davidson, Phil W PW; Myers, Gary J GJ; Wahlberg, Karin E KE; Shamlaye, Conrad F CF; Cobice, Diego F DF; Hyland, Barry W BW; Pineda, Daniela D; Broberg, Karin K; Yeates, Alison J AJ
Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population.
Journal Of The American Heart Association
Palmu, Joonatan J; Watrous, Jeramie D JD; Mercader, Kysha K; Havulinna, Aki S AS; Lagerborg, Kim A KA; Salosensaari, Aaro A; Inouye, Mike M; Larson, Martin G MG; Rong, Jian J; Vasan, Ramachandran S RS; Lahti, Leo L; Andres, Allen A; Cheng, Susan S; Jousilahti, Pekka P; Salomaa, Veikko V; Jain, Mohit M; Niiranen, Teemu J TJ
Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.
Nutrients
Coltell, Oscar O; Sorlí, Jose V JV; Asensio, Eva M EM; Barragán, Rocío R; González, José I JI; Giménez-Alba, Ignacio M IM; Zanón-Moreno, Vicente V; Estruch, Ramon R; Ramírez-Sabio, Judith B JB; Pascual, Eva C EC; Ortega-Azorín, Carolina C; Ordovas, Jose M JM; Corella, Dolores D
Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.
Nutrition Reviews
Conway, Marie C MC; McSorley, Emeir M EM; Mulhern, Maria S MS; Strain, J J JJ; van Wijngaarden, Edwin E; Yeates, Alison J AJ
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context.
Nature Communications
Gallois, Apolline A; Mefford, Joel J; Ko, Arthur A; Vaysse, Amaury A; Julienne, Hanna H; Ala-Korpela, Mika M; Laakso, Markku M; Zaitlen, Noah N; Pajukanta, Päivi P; Aschard, Hugues H
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.
Circulation. Genomic And Precision Medicine
Bihlmeyer, Nathan A NA; Brody, Jennifer A JA; Smith, Albert Vernon AV; Warren, Helen R HR; Lin, Honghuang H; Isaacs, Aaron A; Liu, Ching-Ti CT; Marten, Jonathan J; Radmanesh, Farid F; Hall, Leanne M LM; Grarup, Niels N; Mei, Hao H; Müller-Nurasyid, Martina M; Huffman, Jennifer E JE; Verweij, Niek N; Guo, Xiuqing X; Yao, Jie J; Li-Gao, Ruifang R; van den Berg, Marten M; Weiss, Stefan S; Prins, Bram P BP; van Setten, Jessica J; Haessler, Jeffrey J; Lyytikäinen, Leo-Pekka LP; Li, Man M; Alonso, Alvaro A; Soliman, Elsayed Z EZ; Bis, Joshua C JC; Austin, Tom T; Chen, Yii-Der Ida YI; Psaty, Bruce M BM; Harrris, Tamara B TB; Launer, Lenore J LJ; Padmanabhan, Sandosh S; Dominiczak, Anna A; Huang, Paul L PL; Xie, Zhijun Z; Ellinor, Patrick T PT; Kors, Jan A JA; Campbell, Archie A; Murray, Alison D AD; Nelson, Christopher P CP; Tobin, Martin D MD; Bork-Jensen, Jette J; Hansen, Torben T; Pedersen, Oluf O; Linneberg, Allan A; Sinner, Moritz F MF; Peters, Annette A; Waldenberger, Melanie M; Meitinger, Thomas T; Perz, Siegfried S; Kolcic, Ivana I; Rudan, Igor I; de Boer, Rudolf A RA; van der Meer, Peter P; Lin, Henry J HJ; Taylor, Kent D KD; de Mutsert, Renée R; Trompet, Stella S; Jukema, J Wouter JW; Maan, Arie C AC; Stricker, Bruno H C BHC; Rivadeneira, Fernando F; Uitterlinden, André A; Völker, Uwe U; Homuth, Georg G; Völzke, Henry H; Felix, Stephan B SB; Mangino, Massimo M; Spector, Timothy D TD; Bots, Michiel L ML; Perez, Marco M; Raitakari, Olli T OT; Kähönen, Mika M; Mononen, Nina N; Gudnason, Vilmundur V; Munroe, Patricia B PB; Lubitz, Steven A SA; van Duijn, Cornelia M CM; Newton-Cheh, Christopher H CH; Hayward, Caroline C; Rosand, Jonathan J; Samani, Nilesh J NJ; Kanters, Jørgen K JK; Wilson, James G JG; Kääb, Stefan S; Polasek, Ozren O; van der Harst, Pim P; Heckbert, Susan R SR; Rotter, Jerome I JI; Mook-Kanamori, Dennis O DO; Eijgelsheim, Mark M; Dörr, Marcus M; Jamshidi, Yalda Y; Asselbergs, Folkert W FW; Kooperberg, Charles C; Lehtimäki, Terho T; Arking, Dan E DE; Sotoodehnia, Nona N
DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.
Annals Of The Rheumatic Diseases
Imgenberg-Kreuz, Juliana J; Carlsson Almlöf, Jonas J; Leonard, Dag D; Alexsson, Andrei A; Nordmark, Gunnel G; Eloranta, Maija-Leena ML; Rantapää-Dahlqvist, Solbritt S; Bengtsson, Anders A AA; Jönsen, Andreas A; Padyukov, Leonid L; Gunnarsson, Iva I; Svenungsson, Elisabet E; Sjöwall, Christopher C; Rönnblom, Lars L; Syvänen, Ann-Christine AC; Sandling, Johanna K JK
Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.
European Journal Of Cancer (Oxford, England : 1990)
May-Wilson, Sebastian S; Sud, Amit A; Law, Philip J PJ; Palin, Kimmo K; Tuupanen, Sari S; Gylfe, Alexandra A; Hänninen, Ulrika A UA; Cajuso, Tatiana T; Tanskanen, Tomas T; Kondelin, Johanna J; Kaasinen, Eevi E; Sarin, Antti-Pekka AP; Eriksson, Johan G JG; Rissanen, Harri H; Knekt, Paul P; Pukkala, Eero E; Jousilahti, Pekka P; Salomaa, Veikko V; Ripatti, Samuli S; Palotie, Aarno A; Renkonen-Sinisalo, Laura L; Lepistö, Anna A; Böhm, Jan J; Mecklin, Jukka-Pekka JP; Al-Tassan, Nada A NA; Palles, Claire C; Farrington, Susan M SM; Timofeeva, Maria N MN; Meyer, Brian F BF; Wakil, Salma M SM; Campbell, Harry H; Smith, Christopher G CG; Idziaszczyk, Shelley S; Maughan, Timothy S TS; Fisher, David D; Kerr, Rachel R; Kerr, David D; Passarelli, Michael N MN; Figueiredo, Jane C JC; Buchanan, Daniel D DD; Win, Aung K AK; Hopper, John L JL; Jenkins, Mark A MA; Lindor, Noralane M NM; Newcomb, Polly A PA; Gallinger, Steven S; Conti, David D; Schumacher, Fred F; Casey, Graham G; Aaltonen, Lauri A LA; Cheadle, Jeremy P JP; Tomlinson, Ian P IP; Dunlop, Malcolm G MG; Houlston, Richard S RS
Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations.
Journal Of Lipid Research
Hu, Yao Y; Tanaka, Toshiko T; Zhu, Jingwen J; Guan, Weihua W; Wu, Jason H Y JHY; Psaty, Bruce M BM; McKnight, Barbara B; King, Irena B IB; Sun, Qi Q; Richard, Melissa M; Manichaikul, Ani A; Frazier-Wood, Alexis C AC; Kabagambe, Edmond K EK; Hopkins, Paul N PN; Ordovas, Jose M JM; Ferrucci, Luigi L; Bandinelli, Stefania S; Arnett, Donna K DK; Chen, Yii-Der I YI; Liang, Shuang S; Siscovick, David S DS; Tsai, Michael Y MY; Rich, Stephen S SS; Fornage, Myriam M; Hu, Frank B FB; Rimm, Eric B EB; Jensen, Majken K MK; Lemaitre, Rozenn N RN; Mozaffarian, Dariush D; Steffen, Lyn M LM; Morris, Andrew P AP; Li, Huaixing H; Lin, Xu X
Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci.
Clinical And Translational Gastroenterology
Di Narzo, Antonio F AF; Peters, Lauren A LA; Argmann, Carmen C; Stojmirovic, Aleksandar A; Perrigoue, Jacqueline J; Li, Katherine K; Telesco, Shannon S; Kidd, Brian B; Walker, Jennifer J; Dudley, Joel J; Cho, Judy J; Schadt, Eric E EE; Kasarskis, Andrew A; Curran, Mark M; Dobrin, Radu R; Hao, Ke K
Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2.
American Journal Of Human Genetics
Simon, Lukas M LM; Chen, Edward S ES; Edelstein, Leonard C LC; Kong, Xianguo X; Bhatlekar, Seema S; Rigoutsos, Isidore I; Bray, Paul F PF; Shaw, Chad A CA
Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease.
Plos Genetics
Peters, James E JE; Lyons, Paul A PA; Lee, James C JC; Richard, Arianne C AC; Fortune, Mary D MD; Newcombe, Paul J PJ; Richardson, Sylvia S; Smith, Kenneth G C KG
Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians.
European Journal Of Nutrition
Zhu, Jingwen J; Manichaikul, Ani A; Hu, Yao Y; Chen, Yii-Der I YI; Liang, Shuang S; Steffen, Lyn M LM; Rich, Stephen S SS; Tsai, Michael M; Siscovick, David S DS; Lemaitre, Rozenn N RN; Li, Huaixing H; Lin, Xu X
Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).
Nutrients
Barman, Malin M; Nilsson, Staffan S; Torinsson Naluai, Åsa Å; Sandin, Anna A; Wold, Agnes E AE; Sandberg, Ann-Sofie AS
Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.
Carcinogenesis
Khalili, Hamed H; Gong, Jian J; Brenner, Hermann H; Austin, Thomas R TR; Hutter, Carolyn M CM; Baba, Yoshifumi Y; Baron, John A JA; Berndt, Sonja I SI; Bézieau, Stéphane S; Caan, Bette B; Campbell, Peter T PT; Chang-Claude, Jenny J; Chanock, Stephen J SJ; Chen, Constance C; Hsu, Li L; Jiao, Shuo S; Conti, David V DV; Duggan, David D; Fuchs, Charles S CS; Gala, Manish M; Gallinger, Steven S; Haile, Robert W RW; Harrison, Tabitha A TA; Hayes, Richard R; Hazra, Aditi A; Henderson, Brian B; Haiman, Chris C; Hoffmeister, Michael M; Hopper, John L JL; Jenkins, Mark A MA; Kolonel, Laurence N LN; Küry, Sébastien S; LaCroix, Andrea A; Marchand, Loic Le LL; Lemire, Mathieu M; Lindor, Noralane M NM; Ma, Jing J; Manson, JoAnn E JE; Morikawa, Teppei T; Nan, Hongmei H; Ng, Kimmie K; Newcomb, Polly A PA; Nishihara, Reiko R; Potter, John D JD; Qu, Conghui C; Schoen, Robert E RE; Schumacher, Fredrick R FR; Seminara, Daniela D; Taverna, Darin D; Thibodeau, Stephen S; Wactawski-Wende, Jean J; White, Emily E; Wu, Kana K; Zanke, Brent W BW; Casey, Graham G; Hudson, Thomas J TJ; Kraft, Peter P; Peters, Ulrike U; Slattery, Martha L ML; Ogino, Shuji S; Chan, Andrew T AT; ,
Serum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure.
Neurobiology Of Aging
Warstadt, Nicholus M NM; Dennis, Emily L EL; Jahanshad, Neda N; Kohannim, Omid O; Nir, Talia M TM; McMahon, Katie L KL; de Zubicaray, Greig I GI; Montgomery, Grant W GW; Henders, Anjali K AK; Martin, Nicholas G NG; Whitfield, John B JB; Jack, Clifford R CR; Bernstein, Matt A MA; Weiner, Michael W MW; Toga, Arthur W AW; Wright, Margaret J MJ; Thompson, Paul M PM; ,
Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants.
Plos One
Narahara, Maiko M; Higasa, Koichiro K; Nakamura, Seiji S; Tabara, Yasuharu Y; Kawaguchi, Takahisa T; Ishii, Miho M; Matsubara, Kenichi K; Matsuda, Fumihiko F; Yamada, Ryo R
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
Circulation. Cardiovascular Genetics
Guan, Weihua W; Steffen, Brian T BT; Lemaitre, Rozenn N RN; Wu, Jason H Y JHY; Tanaka, Toshiko T; Manichaikul, Ani A; Foy, Millennia M; Rich, Stephen S SS; Wang, Lu L; Nettleton, Jennifer A JA; Tang, Weihong W; Gu, Xiangjun X; Bandinelli, Stafania S; King, Irena B IB; McKnight, Barbara B; Psaty, Bruce M BM; Siscovick, David D; Djousse, Luc L; Chen, Yii-Der Ida YI; Ferrucci, Luigi L; Fornage, Myriam M; Mozafarrian, Dariush D; Tsai, Michael Y MY; Steffen, Lyn M LM
GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease.
American Journal Of Human Genetics
Liu, Yun Y; Li, Xin X; Aryee, Martin J MJ; Ekström, Tomas J TJ; Padyukov, Leonid L; Klareskog, Lars L; Vandiver, Amy A; Moore, Ann Zenobia AZ; Tanaka, Toshiko T; Ferrucci, Luigi L; Fallin, M Daniele MD; Feinberg, Andrew P AP
Nalls, Mike A MA; Saad, Mohamad M; Noyce, Alastair J AJ; Keller, Margaux F MF; Schrag, Anette A; Bestwick, Jonathan P JP; Traynor, Bryan J BJ; Gibbs, J Raphael JR; Hernandez, Dena G DG; Cookson, Mark R MR; Morris, Huw R HR; Williams, Nigel N; Gasser, Thomas T; Heutink, Peter P; Wood, Nick N; Hardy, John J; Martinez, Maria M; Singleton, Andrew B AB; , ; , ; , ; ,
FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.
Plos One
Rizzi, Thais S TS; van der Sluis, Sophie S; Derom, Catherine C; Thiery, Evert E; van Kesteren, Ronald E RE; Jacobs, Nele N; Van Gestel, Sofie S; Vlietinck, Robert R; Verhage, Matthijs M; Heutink, Peter P; Posthuma, Danielle D
A genome-wide association study of the human metabolome in a community-based cohort.
Cell Metabolism
Rhee, Eugene P EP; Ho, Jennifer E JE; Chen, Ming-Huei MH; Shen, Dongxiao D; Cheng, Susan S; Larson, Martin G MG; Ghorbani, Anahita A; Shi, Xu X; Helenius, Iiro T IT; O'Donnell, Christopher J CJ; Souza, Amanda L AL; Deik, Amy A; Pierce, Kerry A KA; Bullock, Kevin K; Walford, Geoffrey A GA; Vasan, Ramachandran S RS; Florez, Jose C JC; Clish, Clary C; Yeh, J-R Joanna JR; Wang, Thomas J TJ; Gerszten, Robert E RE