Publications:

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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Nature Communications

Shi, Jianxin J; Shiraishi, Kouya K; Choi, Jiyeon J; Matsuo, Keitaro K; Chen, Tzu-Yu TY; Dai, Juncheng J; Hung, Rayjean J RJ; Chen, Kexin K; Shu, Xiao-Ou XO; Kim, Young Tae YT; Landi, Maria Teresa MT; Lin, Dongxin D; Zheng, Wei W; Yin, Zhihua Z; Zhou, Baosen B; Song, Bao B; Wang, Jiucun J; Seow, Wei Jie WJ; Song, Lei L; Chang, I-Shou IS; Hu, Wei W; Chien, Li-Hsin LH; Cai, Qiuyin Q; Hong, Yun-Chul YC; Kim, Hee Nam HN; Wu, Yi-Long YL; Wong, Maria Pik MP; Richardson, Brian Douglas BD; Funderburk, Karen M KM; Li, Shilan S; Zhang, Tongwu T; Breeze, Charles C; Wang, Zhaoming Z; Blechter, Batel B; Bassig, Bryan A BA; Kim, Jin Hee JH; Albanes, Demetrius D; Wong, Jason Y Y JYY; Shin, Min-Ho MH; Chung, Lap Ping LP; Yang, Yang Y; An, She-Juan SJ; Zheng, Hong H; Yatabe, Yasushi Y; Zhang, Xu-Chao XC; Kim, Young-Chul YC; Caporaso, Neil E NE; Chang, Jiang J; Ho, James Chung Man JCM; Kubo, Michiaki M; Daigo, Yataro Y; Song, Minsun M; Momozawa, Yukihide Y; Kamatani, Yoichiro Y; Kobayashi, Masashi M; Okubo, Kenichi K; Honda, Takayuki T; Hosgood, Dean H DH; Kunitoh, Hideo H; Patel, Harsh H; Watanabe, Shun-Ichi SI; Miyagi, Yohei Y; Nakayama, Haruhiko H; Matsumoto, Shingo S; Horinouchi, Hidehito H; Tsuboi, Masahiro M; Hamamoto, Ryuji R; Goto, Koichi K; Ohe, Yuichiro Y; Takahashi, Atsushi A; Goto, Akiteru A; Minamiya, Yoshihiro Y; Hara, Megumi M; Nishida, Yuichiro Y; Takeuchi, Kenji K; Wakai, Kenji K; Matsuda, Koichi K; Murakami, Yoshinori Y; Shimizu, Kimihiro K; Suzuki, Hiroyuki H; Saito, Motonobu M; Ohtaki, Yoichi Y; Tanaka, Kazumi K; Wu, Tangchun T; Wei, Fusheng F; Dai, Hongji H; Machiela, Mitchell J MJ; Su, Jian J; Kim, Yeul Hong YH; Oh, In-Jae IJ; Lee, Victor Ho Fun VHF; Chang, Gee-Chen GC; Tsai, Ying-Huang YH; Chen, Kuan-Yu KY; Huang, Ming-Shyan MS; Su, Wu-Chou WC; Chen, Yuh-Min YM; Seow, Adeline A; Park, Jae Yong JY; Kweon, Sun-Seog SS; Chen, Kun-Chieh KC; Gao, Yu-Tang YT; Qian, Biyun B; Wu, Chen C; Lu, Daru D; Liu, Jianjun J; Schwartz, Ann G AG; Houlston, Richard R; Spitz, Margaret R MR; Gorlov, Ivan P IP; Wu, Xifeng X; Yang, Ping P; Lam, Stephen S; Tardon, Adonina A; Chen, Chu C; Bojesen, Stig E SE; Johansson, Mattias M; Risch, Angela A; Bickeböller, Heike H; Ji, Bu-Tian BT; Wichmann, H-Erich HE; Christiani, David C DC; Rennert, Gadi G; Arnold, Susanne S; Brennan, Paul P; McKay, James J; Field, John K JK; Shete, Sanjay S SS; Le Marchand, Loic L; Liu, Geoffrey G; Andrew, Angeline A; Kiemeney, Lambertus A LA; Zienolddiny-Narui, Shan S; Grankvist, Kjell K; Johansson, Mikael M; Cox, Angela A; Taylor, Fiona F; Yuan, Jian-Min JM; Lazarus, Philip P; Schabath, Matthew B MB; Aldrich, Melinda C MC; Jeon, Hyo-Sung HS; Jiang, Shih Sheng SS; Sung, Jae Sook JS; Chen, Chung-Hsing CH; Hsiao, Chin-Fu CF; Jung, Yoo Jin YJ; Guo, Huan H; Hu, Zhibin Z; Burdett, Laurie L; Yeager, Meredith M; Hutchinson, Amy A; Hicks, Belynda B; Liu, Jia J; Zhu, Bin B; Berndt, Sonja I SI; Wu, Wei W; Wang, Junwen J; Li, Yuqing Y; Choi, Jin Eun JE; Park, Kyong Hwa KH; Sung, Sook Whan SW; Liu, Li L; Kang, Chang Hyun CH; Wang, Wen-Chang WC; Xu, Jun J; Guan, Peng P; Tan, Wen W; Yu, Chong-Jen CJ; Yang, Gong G; Sihoe, Alan Dart Loon ADL; Chen, Ying Y; Choi, Yi Young YY; Kim, Jun Suk JS; Yoon, Ho-Il HI; Park, In Kyu IK; Xu, Ping P; He, Qincheng Q; Wang, Chih-Liang CL; Hung, Hsiao-Han HH; Vermeulen, Roel C H RCH; Cheng, Iona I; Wu, Junjie J; Lim, Wei-Yen WY; Tsai, Fang-Yu FY; Chan, John K C JKC; Li, Jihua J; Chen, Hongyan H; Lin, Hsien-Chih HC; Jin, Li L; Liu, Jie J; Sawada, Norie N; Yamaji, Taiki T; Wyatt, Kathleen K; Li, Shengchao A SA; Ma, Hongxia H; Zhu, Meng M; Wang, Zhehai Z; Cheng, Sensen S; Li, Xuelian X; Ren, Yangwu Y; Chao, Ann A; Iwasaki, Motoki M; Zhu, Junjie J; Jiang, Gening G; Fei, Ke K; Wu, Guoping G; Chen, Chih-Yi CY; Chen, Chien-Jen CJ; Yang, Pan-Chyr PC; Yu, Jinming J; Stevens, Victoria L VL; Fraumeni, Joseph F JF; Chatterjee, Nilanjan N; Gorlova, Olga Y OY; Hsiung, Chao Agnes CA; Amos, Christopher I CI; Shen, Hongbing H; Chanock, Stephen J SJ; Rothman, Nathaniel N; Kohno, Takashi T; Lan, Qing Q

Publication Date: 2023-05-26

Variant appearance in text: rs174557

PubMed Link: 37236969

Variant Present in the following documents:

• Main text
• 41467_2023_Article_38196.pdf

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Interpreting Clinical Trials With Omega-3 Supplements in the Context of Ancestry and FADS Genetic Variation.

Frontiers In Nutrition

Chilton, Floyd H FH; Manichaikul, Ani A; Yang, Chaojie C; O'Connor, Timothy D TD; Johnstone, Laurel M LM; Blomquist, Sarah S; Schembre, Susan M SM; Sergeant, Susan S; Zec, Manja M; Tsai, Michael Y MY; Rich, Stephen S SS; Bridgewater, Susan J SJ; Mathias, Rasika A RA; Hallmark, Brian B

Publication Date: 2021

Variant appearance in text: rs174557

PubMed Link: 35211495

Variant Present in the following documents:

• Main text
• fnut-08-808054.pdf

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Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism.

Plos One

Kirk, L Madison LM; Waits, Charlotte Mae K CMK; Bashore, Alexander C AC; Dosso, Beverly B; Meyers, Allison K AK; Renaldo, Antonio C AC; DePalma, Thomas J TJ; Simms, Kelli N KN; Hauser, Nathaniel N; Chuang Key, Chia-Chi CC; McCall, Charles E CE; Parks, John S JS; Sergeant, Susan S; Langefeld, Carl D CD; Skardal, Aleksander A; Rahbar, Elaheh E

Publication Date: 2022

Variant appearance in text: rs174557

PubMed Link: 35051193

Variant Present in the following documents:

• Main text
• pone.0262173.pdf

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Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism.

Plos One

Kirk, L Madison LM; Waits, Charlotte Mae K CMK; Bashore, Alexander C AC; Dosso, Beverly B; Meyers, Allison K AK; Renaldo, Antonio C AC; DePalma, Thomas J TJ; Simms, Kelli N KN; Hauser, Nathaniel N; Chuang Key, Chia-Chi CC; McCall, Charles E CE; Parks, John S JS; Sergeant, Susan S; Langefeld, Carl D CD; Skardal, Aleksander A; Rahbar, Elaheh E

Publication Date: 2022

Variant appearance in text: rs174557

PubMed Link: 35051193

Variant Present in the following documents:

• Main text
• pone.0262173.pdf

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Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations.

Communications Biology

Yang, Chaojie C; Hallmark, Brian B; Chai, Jin Choul JC; O'Connor, Timothy D TD; Reynolds, Lindsay M LM; Wood, Alexis C AC; Seeds, Michael M; Chen, Yii-Der Ida YI; Steffen, Lyn M LM; Tsai, Michael Y MY; Kaplan, Robert C RC; Daviglus, Martha L ML; Mandarino, Lawrence J LJ; Fretts, Amanda M AM; Lemaitre, Rozenn N RN; Coletta, Dawn K DK; Blomquist, Sarah A SA; Johnstone, Laurel M LM; Tontsch, Chandra C; Qi, Qibin Q; Ruczinski, Ingo I; Rich, Stephen S SS; Mathias, Rasika A RA; Chilton, Floyd H FH; Manichaikul, Ani A

Publication Date: 2021-07-28

Variant appearance in text: rs174557

PubMed Link: 34321601

Variant Present in the following documents:

• Main text
• 42003_2021_2431_MOESM1_ESM.pdf
• 42003_2021_Article_2431.pdf

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Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs.

Jci Insight

Chen, Xiao-Feng XF; Guo, Ming-Rui MR; Duan, Yuan-Yuan YY; Jiang, Feng F; Wu, Hao H; Dong, Shan-Shan SS; Zhou, Xiao-Rong XR; Thynn, Hlaing Nwe HN; Liu, Cong-Cong CC; Zhang, Lin L; Guo, Yan Y; Yang, Tie-Lin TL

Publication Date: 2020-09-03

Variant appearance in text: rs174557

PubMed Link: 32879140

Variant Present in the following documents:

• jciinsight-5-136477-s105.xlsx, sheet 5

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rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression.

Iscience

Pan, Gang G; Cavalli, Marco M; Carlsson, Björn B; Skrtic, Stanko S; Kumar, Chanchal C; Wadelius, Claes C

Publication Date: 2020-02-21

Variant appearance in text: rs174557

PubMed Link: 31928966

Variant Present in the following documents:

• main.pdf

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FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.

Clinical Epigenetics

He, Zhen Z; Zhang, Rong R; Jiang, Feng F; Zhang, Hong H; Zhao, Aihua A; Xu, Bo B; Jin, Li L; Wang, Tao T; Jia, Wei W; Jia, Weiping W; Hu, Cheng C

Publication Date: 2018-08-29

Variant appearance in text: rs174557

PubMed Link: 30157936

Variant Present in the following documents:

• Main text
• 13148_2018_Article_545.pdf

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Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.

Plos One

Reynolds, Lindsay M LM; Howard, Timothy D TD; Ruczinski, Ingo I; Kanchan, Kanika K; Seeds, Michael C MC; Mathias, Rasika A RA; Chilton, Floyd H FH

Publication Date: 2018

Variant appearance in text: rs174557

PubMed Link: 29590160

Variant Present in the following documents:

• Main text

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Multiplex genomewide association analysis of breast milk fatty acid composition extends the phenotypic association and potential selection of FADS1 variants to arachidonic acid, a critical infant micronutrient.

Journal Of Medical Genetics

Mychaleckyj, Josyf C JC; Nayak, Uma U; Colgate, E Ross ER; Zhang, Dadong D; Carstensen, Tommy T; Ahmed, Shahnawaz S; Ahmed, Tahmeed T; Mentzer, Alexander J AJ; Alam, Masud M; Kirkpatrick, Beth D BD; Haque, Rashidul R; Faruque, Abu Syed Golam ASG; Petri, William A WA

Publication Date: 2018-07

Variant appearance in text: rs174557

PubMed Link: 29514873

Variant Present in the following documents:

• Main text
• jmedgenet-2017-105134.pdf

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Dietary adaptation of FADS genes in Europe varied across time and geography.

Nature Ecology & Evolution

Ye, Kaixiong K; Gao, Feng F; Wang, David D; Bar-Yosef, Ofer O; Keinan, Alon A

Publication Date: 2017-05-26

Variant appearance in text: rs174557

PubMed Link: 29094686

Variant Present in the following documents:

• Main text
• nihms869521.pdf
• NIHMS869521-supplement-2.pdf

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Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.

Scientific Reports

Jäger, Susanne S; Wahl, Simone S; Kröger, Janine J; Sharma, Sapna S; Hoffmann, Per P; Floegel, Anna A; Pischon, Tobias T; Prehn, Cornelia C; Adamski, Jerzy J; Müller-Nurasyid, Martina M; Waldenberger, Melanie M; Strauch, Konstantin K; Peters, Annette A; Gieger, Christian C; Suhre, Karsten K; Grallert, Harald H; Boeing, Heiner H; Schulze, Matthias B MB; Meidtner, Karina K

Publication Date: 2017-07-20

Variant appearance in text: rs174557

PubMed Link: 28729637

Variant Present in the following documents:

• Main text
• 41598_2017_Article_6158.pdf

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Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes.

Molecular Biology And Evolution

Buckley, Matthew T MT; Racimo, Fernando F; Allentoft, Morten E ME; Jensen, Majken K MK; Jonsson, Anna A; Huang, Hongyan H; Hormozdiari, Farhad F; Sikora, Martin M; Marnetto, Davide D; Eskin, Eleazar E; Jørgensen, Marit E ME; Grarup, Niels N; Pedersen, Oluf O; Hansen, Torben T; Kraft, Peter P; Willerslev, Eske E; Nielsen, Rasmus R

Publication Date: 2017-06-01

Variant appearance in text: rs174557

PubMed Link: 28333262

Variant Present in the following documents:

• Main text
• msx103.pdf

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PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c.

Nucleic Acids Research

Pan, Gang G; Ameur, Adam A; Enroth, Stefan S; Bysani, Madhusudhan M; Nord, Helena H; Cavalli, Marco M; Essand, Magnus M; Gyllensten, Ulf U; Wadelius, Claes C

Publication Date: 2017-03-17

Variant appearance in text: rs174557

PubMed Link: 27932482

Variant Present in the following documents:

• Main text

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