FADS2 c.208-2013C>T

Variant ID: 11-61603237-C-T

NM_004265.3(FADS2):c.208-2013C>T

This variant was identified in 27 publications

View GRCh38 version.




Publications:


Interaction among dietary n-3 and n-6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low-density lipoprotein cholesterol levels in type 2 diabetes patients.

Journal Of Diabetes Investigation
Huang, Pei-Chi PC; Cheng, Hsuan H; Su, Yu-Ting YT; Huang, Meng-Chuan MC; Hsu, Chih-Cheng CC; Hwang, Shang-Jyh SJ; Shin, Shyi-Jang SJ; Chang, Wen-Tsan WT
Publication Date: 2022-11-22

Variant appearance in text: rs2727270
PubMed Link: 36412559
Variant Present in the following documents:
  • Main text
  • JDI-14-297.pdf
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Nutrigenomics of Dietary Lipids.

Antioxidants (Basel, Switzerland)
Bordoni, Laura L; Petracci, Irene I; Zhao, Fanrui F; Min, Weihong W; Pierella, Elisa E; Assmann, Taís Silveira TS; Martinez, J Alfredo JA; Gabbianelli, Rosita R
Publication Date: 2021-06-22

Variant appearance in text: rs2727270
PubMed Link: 34206632
Variant Present in the following documents:
  • Main text
  • antioxidants-10-00994.pdf
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Nutrition, genetic variation and male fertility.

Translational Andrology And Urology
Vanderhout, Shelley M SM; Rastegar Panah, Matineh M; Garcia-Bailo, Bibiana B; Grace-Farfaglia, Patricia P; Samsel, Konrad K; Dockray, Judith J; Jarvi, Keith K; El-Sohemy, Ahmed A
Publication Date: 2021-03

Variant appearance in text: rs2727270
PubMed Link: 33850777
Variant Present in the following documents:
  • Main text
  • tau-10-03-1410.pdf
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Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population.

Journal Of The American Heart Association
Palmu, Joonatan J; Watrous, Jeramie D JD; Mercader, Kysha K; Havulinna, Aki S AS; Lagerborg, Kim A KA; Salosensaari, Aaro A; Inouye, Mike M; Larson, Martin G MG; Rong, Jian J; Vasan, Ramachandran S RS; Lahti, Leo L; Andres, Allen A; Cheng, Susan S; Jousilahti, Pekka P; Salomaa, Veikko V; Jain, Mohit M; Niiranen, Teemu J TJ
Publication Date: 2020-10-20

Variant appearance in text: rs2727270
PubMed Link: 32975162
Variant Present in the following documents:
  • JAH3-9-e017598.pdf
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Mitochondrial pathways in human health and aging.

Mitochondrion
Bornstein, Rebecca R; Gonzalez, Brenda B; Johnson, Simon C SC
Publication Date: 2020-09

Variant appearance in text: rs2727270
PubMed Link: 32738358
Variant Present in the following documents:
  • Main text
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A Scoping Review of Interactions between Omega-3 Long-Chain Polyunsaturated Fatty Acids and Genetic Variation in Relation to Cancer Risk.

Nutrients
Yurko-Mauro, Karin K; Van Elswyk, Mary M; Teo, Lynn L
Publication Date: 2020-06-02

Variant appearance in text: rs2727270
PubMed Link: 32498320
Variant Present in the following documents:
  • Main text
  • nutrients-12-01647.pdf
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Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk.

Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Khankari, Nikhil K NK; Banbury, Barbara L BL; Borges, Maria C MC; Haycock, Philip P; Albanes, Demetrius D; Arndt, Volker V; Berndt, Sonja I SI; Bézieau, Stéphane S; Brenner, Hermann H; Campbell, Peter T PT; Casey, Graham G; Chan, Andrew T AT; Chang-Claude, Jenny J; Conti, David V DV; Cotterchio, Michelle M; English, Dallas R DR; Figueiredo, Jane C JC; Giles, Graham G GG; Giovannucci, Edward L EL; Gunter, Marc J MJ; Hampe, Jochen J; Hoffmeister, Michael M; Hopper, John L JL; Jenkins, Mark A MA; Joshi, Amit D AD; Marchand, Loic Le LL; Lemire, Mathieu M; Li, Christopher I CI; Li, Li L; Lindblom, Annika A; Martín, Vicente V; Moreno, Victor V; Newcomb, Polly A PA; Offit, Kenneth K; Pharoah, Paul D P PDP; Rennert, Gad G; Sakoda, Lori C LC; Schafmayer, Clemens C; Schmit, Stephanie L SL; Slattery, Martha L ML; Song, Mingyang M; Thibodeau, Stephen N SN; Ulrich, Cornelia M CM; Weinstein, Stephanie J SJ; White, Emily E; Win, Aung Ko AK; Wolk, Alicja A; Woods, Michael O MO; Wu, Anna H AH; Cai, Qiuyin Q; Denny, Joshua C JC; Edwards, Todd L TL; Murff, Harvey J HJ; Gruber, Stephen B SB; Peters, Ulrike U; Zheng, Wei W
Publication Date: 2020-04

Variant appearance in text: rs2727270
PubMed Link: 32051193
Variant Present in the following documents:
  • Main text
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Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease.

Nutrients
Czumaj, Aleksandra A; Śledziński, Tomasz T
Publication Date: 2020-01-29

Variant appearance in text: rs2727270
PubMed Link: 32013225
Variant Present in the following documents:
  • Main text
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Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.

Nutrients
Coltell, Oscar O; Sorlí, Jose V JV; Asensio, Eva M EM; Barragán, Rocío R; González, José I JI; Giménez-Alba, Ignacio M IM; Zanón-Moreno, Vicente V; Estruch, Ramon R; Ramírez-Sabio, Judith B JB; Pascual, Eva C EC; Ortega-Azorín, Carolina C; Ordovas, Jose M JM; Corella, Dolores D
Publication Date: 2020-01-24

Variant appearance in text: rs2727270
PubMed Link: 31991592
Variant Present in the following documents:
  • Main text
  • nutrients-12-00310-s001.pdf
  • nutrients-12-00310.pdf
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Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.

Nutrition Reviews
Conway, Marie C MC; McSorley, Emeir M EM; Mulhern, Maria S MS; Strain, J J JJ; van Wijngaarden, Edwin E; Yeates, Alison J AJ
Publication Date: 2020-08-01

Variant appearance in text: rs2727270
PubMed Link: 31943072
Variant Present in the following documents:
  • Main text
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Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membranes.

Nutrients
Lankinen, Maria M; Uusitupa, Matti M; Schwab, Ursula U
Publication Date: 2018-11-16

Variant appearance in text: rs2727270
PubMed Link: 30453550
Variant Present in the following documents:
  • Main text
  • nutrients-10-01785.pdf
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FADS Polymorphism, Omega-3 Fatty Acids and Diabetes Risk: A Systematic Review.

Nutrients
Brayner, Bárbara B; Kaur, Gunveen G; Keske, Michelle A MA; Livingstone, Katherine M KM
Publication Date: 2018-06-13

Variant appearance in text: rs2727270
PubMed Link: 29899246
Variant Present in the following documents:
  • Main text
  • nutrients-10-00758.pdf
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Long-chain polyunsaturated fatty acids, gestation duration, and birth size: a Mendelian randomization study using fatty acid desaturase variants.

The American Journal Of Clinical Nutrition
Bernard, Jonathan Y JY; Pan, Hong H; Aris, Izzuddin M IM; Moreno-Betancur, Margarita M; Soh, Shu-E SE; Yap, Fabian F; Tan, Kok Hian KH; Shek, Lynette P LP; Chong, Yap-Seng YS; Gluckman, Peter D PD; Calder, Philip C PC; Godfrey, Keith M KM; Chong, Mary Foong-Fong MF; Kramer, Michael S MS; Karnani, Neerja N; Lee, Yung Seng YS
Publication Date: 2018-07-01

Variant appearance in text: rs2727270
PubMed Link: 29878044
Variant Present in the following documents:
  • Main text
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The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden: the GLACIER Study.

International Journal Of Obesity (2005)
Chen, Yan Y; Estampador, Angela C AC; Keller, Maria M; Poveda, Alaitz A; Dalla-Riva, Jonathan J; Johansson, Ingegerd I; Renström, Frida F; Kurbasic, Azra A; Franks, Paul W PW; Varga, Tibor V TV
Publication Date: 2019-04

Variant appearance in text: rs2727270
PubMed Link: 29795460
Variant Present in the following documents:
  • NIHMS77016-supplement-S2_Text.pdf
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Dietary adaptation of FADS genes in Europe varied across time and geography.

Nature Ecology & Evolution
Ye, Kaixiong K; Gao, Feng F; Wang, David D; Bar-Yosef, Ofer O; Keinan, Alon A
Publication Date: 2017-05-26

Variant appearance in text: rs2727270
PubMed Link: 29094686
Variant Present in the following documents:
  • NIHMS869521-supplement-2.pdf
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FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.

International Journal Of Environmental Research And Public Health
Huang, Meng-Chuan MC; Chang, Wen-Tsan WT; Chang, Hsin-Yu HY; Chung, Hsin-Fang HF; Chen, Fang-Pei FP; Huang, Ya-Fang YF; Hsu, Chih-Cheng CC; Hwang, Shang-Jyh SJ
Publication Date: 2017-05-28

Variant appearance in text: rs2727270
PubMed Link: 28555039
Variant Present in the following documents:
  • Main text
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Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study.

Bmj (Clinical Research Ed.)
Benn, Marianne M; Nordestgaard, Børge G BG; Frikke-Schmidt, Ruth R; Tybjærg-Hansen, Anne A
Publication Date: 2017-04-24

Variant appearance in text: rs2727270
PubMed Link: 28438747
Variant Present in the following documents:
  • benm033277.ww1.pdf
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Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium.

British Journal Of Cancer
Khankari, Nikhil K NK; Murff, Harvey J HJ; Zeng, Chenjie C; Wen, Wanqing W; Eeles, Rosalind A RA; Easton, Douglas F DF; Kote-Jarai, Zsofia Z; Al Olama, Ali Amin AA; Benlloch, Sara S; Muir, Kenneth K; Giles, Graham G GG; Wiklund, Fredrik F; Gronberg, Henrik H; Haiman, Christopher A CA; Schleutker, Johanna J; Nordestgaard, Børge G BG; Travis, Ruth C RC; Donovan, Jenny L JL; Pashayan, Nora N; Khaw, Kay-Tee KT; Stanford, Janet L JL; Blot, William J WJ; Thibodeau, Stephen N SN; Maier, Christiane C; Kibel, Adam S AS; Cybulski, Cezary C; Cannon-Albright, Lisa L; Brenner, Hermann H; Park, Jong J; Kaneva, Radka R; Batra, Jyotsna J; Teixeira, Manuel R MR; Pandha, Hardev H; Zheng, Wei W; ,
Publication Date: 2016-08-23

Variant appearance in text: rs2727270
PubMed Link: 27490808
Variant Present in the following documents:
  • Main text
  • bjc2016228a.pdf
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Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid.

Molecular Biology And Evolution
Kothapalli, Kumar S D KS; Ye, Kaixiong K; Gadgil, Maithili S MS; Carlson, Susan E SE; O'Brien, Kimberly O KO; Zhang, Ji Yao JY; Park, Hui Gyu HG; Ojukwu, Kinsley K; Zou, James J; Hyon, Stephanie S SS; Joshi, Kalpana S KS; Gu, Zhenglong Z; Keinan, Alon A; Brenna, J Thomas JT
Publication Date: 2016-07

Variant appearance in text: rs2727270
PubMed Link: 27188529
Variant Present in the following documents:
  • Main text
  • msw049.pdf
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Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype.

Journal Of Clinical Medicine
Lenihan-Geels, Georgia G; Bishop, Karen S KS; Ferguson, Lynnette R LR
Publication Date: 2016-02-15

Variant appearance in text: rs2727270
PubMed Link: 26891335
Variant Present in the following documents:
  • Main text
  • jcm-05-00025.pdf
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Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

Circulation. Cardiovascular Genetics
Guan, Weihua W; Steffen, Brian T BT; Lemaitre, Rozenn N RN; Wu, Jason H Y JHY; Tanaka, Toshiko T; Manichaikul, Ani A; Foy, Millennia M; Rich, Stephen S SS; Wang, Lu L; Nettleton, Jennifer A JA; Tang, Weihong W; Gu, Xiangjun X; Bandinelli, Stafania S; King, Irena B IB; McKnight, Barbara B; Psaty, Bruce M BM; Siscovick, David D; Djousse, Luc L; Chen, Yii-Der Ida YI; Ferrucci, Luigi L; Fornage, Myriam M; Mozafarrian, Dariush D; Tsai, Michael Y MY; Steffen, Lyn M LM
Publication Date: 2014-06

Variant appearance in text: rs2727270
PubMed Link: 24823311
Variant Present in the following documents:
  • Main text
View BVdb publication page



Polymorphisms in Fatty Acid Desaturase (FADS) Gene Cluster: Effects on Glycemic Controls Following an Omega-3 Polyunsaturated Fatty Acids (PUFA) Supplementation.

Genes
Cormier, Hubert H; Rudkowska, Iwona I; Thifault, Elisabeth E; Lemieux, Simone S; Couture, Patrick P; Vohl, Marie-Claude MC
Publication Date: 2013-09-10

Variant appearance in text: rs2727270
PubMed Link: 24705214
Variant Present in the following documents:
  • Main text
  • genes-04-00485.pdf
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FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.

Plos One
Rizzi, Thais S TS; van der Sluis, Sophie S; Derom, Catherine C; Thiery, Evert E; van Kesteren, Ronald E RE; Jacobs, Nele N; Van Gestel, Sofie S; Vlietinck, Robert R; Verhage, Matthijs M; Heutink, Peter P; Posthuma, Danielle D
Publication Date: 2013

Variant appearance in text: rs2727270
PubMed Link: 23826354
Variant Present in the following documents:
  • Main text
  • pone.0068000.pdf
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Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men.

Clinical Interventions In Aging
Hong, Seul Hee SH; Kwak, Jung Hyun JH; Paik, Jean Kyung JK; Chae, Jey Sook JS; Lee, Jong Ho JH
Publication Date: 2013

Variant appearance in text: rs2727270
PubMed Link: 23818766
Variant Present in the following documents:
  • Main text
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Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study.

Investigative Ophthalmology & Visual Science
Meyers, Kristin J KJ; Johnson, Elizabeth J EJ; Bernstein, Paul S PS; Iyengar, Sudha K SK; Engelman, Corinne D CD; Karki, Chitra K CK; Liu, Zhe Z; Igo, Robert P RP; Truitt, Barbara B; Klein, Michael L ML; Snodderly, D Max DM; Blodi, Barbara A BA; Gehrs, Karen M KM; Sarto, Gloria E GE; Wallace, Robert B RB; Robinson, Jennifer J; LeBlanc, Erin S ES; Hageman, Gregory G; Tinker, Lesley L; Mares, Julie A JA
Publication Date: 2013-03-28

Variant appearance in text: rs2727270
PubMed Link: 23404124
Variant Present in the following documents:
  • Main text
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Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.

Prostaglandins, Leukotrienes, And Essential Fatty Acids
Reardon, Holly T HT; Zhang, Jimmy J; Kothapalli, Kumar S D KS; Kim, Andrea J AJ; Park, Woo Jung WJ; Brenna, J Thomas JT
Publication Date: 2012-07

Variant appearance in text: rs2727270
PubMed Link: 22748975
Variant Present in the following documents:
  • Main text
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Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.

Nutrition & Metabolism
Kim, Oh Yoen OY; Lim, Hyo Hee HH; Yang, Long In LI; Chae, Jey Sook JS; Lee, Jong Ho JH
Publication Date: 2011-04-23

Variant appearance in text: rs2727270
PubMed Link: 21513558
Variant Present in the following documents:
  • Main text
  • 1743-7075-8-24.pdf
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