Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.
Biological Psychiatry
Alex, Ann M AM; Buss, Claudia C; Davis, Elysia Poggi EP; Campos, Gustavo de Los GL; Donald, Kirsten A KA; Fair, Damien A DA; Gaab, Nadine N; Gao, Wei W; Gilmore, John H JH; Girault, Jessica B JB; Grewen, Karen K; Groenewold, Nynke A NA; Hankin, Benjamin L BL; Ipser, Jonathan J; Kapoor, Shreya S; Kim, Pilyoung P; Lin, Weili W; Luo, Shan S; Norton, Elizabeth S ES; O'Connor, Thomas G TG; Piven, Joseph J; Qiu, Anqi A; Rasmussen, Jerod M JM; Skeide, Michael A MA; Stein, Dan J DJ; Styner, Martin A MA; Thompson, Paul M PM; Wakschlag, Laurie L; Knickmeyer, Rebecca R; ,
Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts.
Research Square
Yang, Chaojie C; Veenstra, Jenna J; Bartz, Traci T; Pahl, Matthew M; Hallmark, Brian B; Chen, Yii-Der Ida YI; Westra, Jason J; Steffen, Lyn L; Brown, Christopher C; Siscovick, David D; Tsai, Michael M; Wood, Alexis A; Rich, Stephen S; Smith, Caren C; O'Connor, Timothy T; Mozaffarian, Dariush D; Grant, Struan S; Chilton, Floyd F; Tintle, Nathan N; Lemaitre, Rozenn R; Manichaikul, Ani A
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia.
Jama Network Open
Yang, Wenjian W; Karol, Seth E SE; Hoshitsuki, Keito K; Lee, Shawn S; Larsen, Eric C EC; Winick, Naomi N; Carroll, William L WL; Loh, Mignon L ML; Raetz, Elizabeth A EA; Hunger, Stephen P SP; Winter, Stuart S SS; Dunsmore, Kimberly P KP; Devidas, Meenakshi M; Relling, Mary V MV; Yang, Jun J JJ
Novel Interactions of Myristic Acid and FADS3 Variants Predict Atopic Dermatitis among Indonesian Infants.
Nutrients
Tanjung, Conny C; Harris, Carla P CP; Demmelmair, Hans H; Dwitya, Sarah S; Munasir, Zakiudin Z; Sudoyo, Herawati H; Standl, Marie M; Sjarif, Damayanti Rusli DR; Koletzko, Berthold B
Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study.
The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study.
Human Molecular Genetics
Borges, Maria-Carolina MC; Haycock, Phillip P; Zheng, Jie J; Hemani, Gibran G; Howe, Laurence J LJ; Schmidt, A Floriaan AF; Staley, James R JR; Lumbers, R Thomas RT; Henry, Albert A; Lemaitre, Rozenn N RN; Gaunt, Tom R TR; Holmes, Michael V MV; Davey Smith, George G; Hingorani, Aroon D AD; Lawlor, Deborah A DA
Altered Cerebral Curvature in Preterm Infants Is Associated with the Common Genetic Variation Related to Autism Spectrum Disorder and Lipid Metabolism.
Journal Of Clinical Medicine
Kim, Hyuna H; Ahn, Ja-Hye JH; Lee, Joo Young JY; Jang, Yong Hun YH; Kim, Young-Eun YE; Kim, Johanna Inhyang JI; Kim, Bung-Nyun BN; Lee, Hyun Ju HJ
Shared genetic loci between depression and cardiometabolic traits.
Plos Genetics
Torgersen, Kristin K; Rahman, Zillur Z; Bahrami, Shahram S; Hindley, Guy Frederick Lanyon GFL; Parker, Nadine N; Frei, Oleksandr O; Shadrin, Alexey A; O'Connell, Kevin S KS; Tesli, Martin M; Smeland, Olav B OB; Munkhaugen, John J; Djurovic, Srdjan S; Dammen, Toril T; Andreassen, Ole A OA
Disentangling Signatures of Selection Before and After European Colonization in Latin Americans.
Molecular Biology And Evolution
Mendoza-Revilla, Javier J; Chacón-Duque, J Camilo JC; Fuentes-Guajardo, Macarena M; Ormond, Louise L; Wang, Ke K; Hurtado, Malena M; Villegas, Valeria V; Granja, Vanessa V; Acuña-Alonzo, Victor V; Jaramillo, Claudia C; Arias, William W; Barquera, Rodrigo R; Gómez-Valdés, Jorge J; Villamil-Ramírez, Hugo H; Silva de Cerqueira, Caio C CC; Badillo Rivera, Keyla M KM; Nieves-Colón, Maria A MA; Gignoux, Christopher R CR; Wojcik, Genevieve L GL; Moreno-Estrada, Andrés A; Hünemeier, Tábita T; Ramallo, Virginia V; Schuler-Faccini, Lavinia L; Gonzalez-José, Rolando R; Bortolini, Maria-Cátira MC; Canizales-Quinteros, Samuel S; Gallo, Carla C; Poletti, Giovanni G; Bedoya, Gabriel G; Rothhammer, Francisco F; Balding, David D; Fumagalli, Matteo M; Adhikari, Kaustubh K; Ruiz-Linares, Andrés A; Hellenthal, Garrett G
A multi-omics study of circulating phospholipid markers of blood pressure.
Scientific Reports
Liu, Jun J; de Vries, Paul S PS; Del Greco M, Fabiola F; Johansson, Åsa Å; Schraut, Katharina E KE; Hayward, Caroline C; van Dijk, Ko Willems KW; Franco, Oscar H OH; Hicks, Andrew A AA; Vitart, Veronique V; Rudan, Igor I; Campbell, Harry H; Polašek, Ozren O; Pramstaller, Peter P PP; Wilson, James F JF; Gyllensten, Ulf U; van Duijn, Cornelia M CM; Dehghan, Abbas A; Demirkan, Ayşe A
A multi-omics study of circulating phospholipid markers of blood pressure.
Scientific Reports
Liu, Jun J; de Vries, Paul S PS; Del Greco M, Fabiola F; Johansson, Åsa Å; Schraut, Katharina E KE; Hayward, Caroline C; van Dijk, Ko Willems KW; Franco, Oscar H OH; Hicks, Andrew A AA; Vitart, Veronique V; Rudan, Igor I; Campbell, Harry H; Polašek, Ozren O; Pramstaller, Peter P PP; Wilson, James F JF; Gyllensten, Ulf U; van Duijn, Cornelia M CM; Dehghan, Abbas A; Demirkan, Ayşe A
Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?
Nutrients
Zec, Manja M MM; Krga, Irena I; Stojković, Ljiljana L; Živković, Maja M; Pokimica, Biljana B; Stanković, Aleksandra A; Glibetic, Maria M
Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms are Associated with Children's Processing Speed up to Age 9 Years.
Nutrients
Campoy, Cristina C; Azaryah, Hatim H; Torres-Espínola, Francisco J FJ; Martínez-Zaldívar, Cristina C; García-Santos, José Antonio JA; Demmelmair, Hans H; Haile, Gudrun G; Györei, Eszter E; Ramírez-Tortosa, María Del Carmen MDC; Reischl, Eva E; Rzehak, Peter P; Molloy, Anne M AM; Décsi, Tamas T; Luna, Juan de Dios JD; Koletzko, Berthold B; Pérez-García, Miguel M
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nature Communications
Nielsen, Jonas B JB; Rom, Oren O; Surakka, Ida I; Graham, Sarah E SE; Zhou, Wei W; Roychowdhury, Tanmoy T; Fritsche, Lars G LG; Gagliano Taliun, Sarah A SA; Sidore, Carlo C; Liu, Yuhao Y; Gabrielsen, Maiken E ME; Skogholt, Anne Heidi AH; Wolford, Brooke B; Overton, William W; Zhao, Ying Y; Chen, Jin J; Zhang, He H; Hornsby, Whitney E WE; Acheampong, Akua A; Grooms, Austen A; Schaefer, Amanda A; Zajac, Gregory J M GJM; Villacorta, Luis L; Zhang, Jifeng J; Brumpton, Ben B; Løset, Mari M; Rai, Vivek V; Lundegaard, Pia R PR; Olesen, Morten S MS; Taylor, Kent D KD; Palmer, Nicholette D ND; Chen, Yii-Der YD; Choi, Seung H SH; Lubitz, Steven A SA; Ellinor, Patrick T PT; Barnes, Kathleen C KC; Daya, Michelle M; Rafaels, Nicholas N; Weiss, Scott T ST; Lasky-Su, Jessica J; Tracy, Russell P RP; Vasan, Ramachandran S RS; Cupples, L Adrienne LA; Mathias, Rasika A RA; Yanek, Lisa R LR; Becker, Lewis C LC; Peyser, Patricia A PA; Bielak, Lawrence F LF; Smith, Jennifer A JA; Aslibekyan, Stella S; Hidalgo, Bertha A BA; Arnett, Donna K DK; Irvin, Marguerite R MR; Wilson, James G JG; Musani, Solomon K SK; Correa, Adolfo A; Rich, Stephen S SS; Guo, Xiuqing X; Rotter, Jerome I JI; Konkle, Barbara A BA; Johnsen, Jill M JM; Ashley-Koch, Allison E AE; Telen, Marilyn J MJ; Sheehan, Vivien A VA; Blangero, John J; Curran, Joanne E JE; Peralta, Juan M JM; Montgomery, Courtney C; Sheu, Wayne H-H WH; Chung, Ren-Hua RH; Schwander, Karen K; Nouraie, Seyed M SM; Gordeuk, Victor R VR; Zhang, Yingze Y; Kooperberg, Charles C; Reiner, Alexander P AP; Jackson, Rebecca D RD; Bleecker, Eugene R ER; Meyers, Deborah A DA; Li, Xingnan X; Das, Sayantan S; Yu, Ketian K; LeFaive, Jonathon J; Smith, Albert A; Blackwell, Tom T; Taliun, Daniel D; Zollner, Sebastian S; Forer, Lukas L; Schoenherr, Sebastian S; Fuchsberger, Christian C; Pandit, Anita A; Zawistowski, Matthew M; Kheterpal, Sachin S; Brummett, Chad M CM; Natarajan, Pradeep P; Schlessinger, David D; Lee, Seunggeun S; Kang, Hyun Min HM; Cucca, Francesco F; Holmen, Oddgeir L OL; Åsvold, Bjørn O BO; Boehnke, Michael M; Kathiresan, Sekar S; Abecasis, Goncalo R GR; Chen, Y Eugene YE; Willer, Cristen J CJ; Hveem, Kristian K
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.
The Journal Of Clinical Endocrinology And Metabolism
Deshmukh, Harshal A HA; Madsen, Anne Lundager AL; Viñuela, Ana A; Have, Christian Theil CT; Grarup, Niels N; Tura, Andrea A; Mahajan, Anubha A; Heggie, Alison J AJ; Koivula, Robert W RW; De Masi, Federico F; Tsirigos, Konstantinos K KK; Linneberg, Allan A; Drivsholm, Thomas T; Pedersen, Oluf O; Sørensen, Thorkild I A TIA; Astrup, Arne A; Gjesing, Anette A P AAP; Pavo, Imre I; Wood, Andrew R AR; Ruetten, Hartmut H; Jones, Angus G AG; Koopman, Anitra D M ADM; Cederberg, Henna H; Rutters, Femke F; Ridderstrale, Martin M; Laakso, Markku M; McCarthy, Mark I MI; Frayling, Tim M TM; Ferrannini, Ele E; Franks, Paul W PW; Pearson, Ewan R ER; Mari, Andrea A; Hansen, Torben T; Walker, Mark M
FADS1 (Fatty Acid Desaturase 1) Genotype Associates With Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification.
Circulation. Genomic And Precision Medicine
Plunde, Oscar O; Larsson, Susanna C SC; Artiach, Gonzalo G; Thanassoulis, George G; Carracedo, Miguel M; Franco-Cereceda, Anders A; Eriksson, Per P; Bäck, Magnus M
Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.
Nutrients
Coltell, Oscar O; Sorlí, Jose V JV; Asensio, Eva M EM; Barragán, Rocío R; González, José I JI; Giménez-Alba, Ignacio M IM; Zanón-Moreno, Vicente V; Estruch, Ramon R; Ramírez-Sabio, Judith B JB; Pascual, Eva C EC; Ortega-Azorín, Carolina C; Ordovas, Jose M JM; Corella, Dolores D
Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.
Nutrition Reviews
Conway, Marie C MC; McSorley, Emeir M EM; Mulhern, Maria S MS; Strain, J J JJ; van Wijngaarden, Edwin E; Yeates, Alison J AJ
Long-chain polyunsaturated fatty acids, gestation duration, and birth size: a Mendelian randomization study using fatty acid desaturase variants.
The American Journal Of Clinical Nutrition
Bernard, Jonathan Y JY; Pan, Hong H; Aris, Izzuddin M IM; Moreno-Betancur, Margarita M; Soh, Shu-E SE; Yap, Fabian F; Tan, Kok Hian KH; Shek, Lynette P LP; Chong, Yap-Seng YS; Gluckman, Peter D PD; Calder, Philip C PC; Godfrey, Keith M KM; Chong, Mary Foong-Fong MF; Kramer, Michael S MS; Karnani, Neerja N; Lee, Yung Seng YS
Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations.
Journal Of Lipid Research
Hu, Yao Y; Tanaka, Toshiko T; Zhu, Jingwen J; Guan, Weihua W; Wu, Jason H Y JHY; Psaty, Bruce M BM; McKnight, Barbara B; King, Irena B IB; Sun, Qi Q; Richard, Melissa M; Manichaikul, Ani A; Frazier-Wood, Alexis C AC; Kabagambe, Edmond K EK; Hopkins, Paul N PN; Ordovas, Jose M JM; Ferrucci, Luigi L; Bandinelli, Stefania S; Arnett, Donna K DK; Chen, Yii-Der I YI; Liang, Shuang S; Siscovick, David S DS; Tsai, Michael Y MY; Rich, Stephen S SS; Fornage, Myriam M; Hu, Frank B FB; Rimm, Eric B EB; Jensen, Majken K MK; Lemaitre, Rozenn N RN; Mozaffarian, Dariush D; Steffen, Lyn M LM; Morris, Andrew P AP; Li, Huaixing H; Lin, Xu X
Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?
Antioxidants & Redox Signaling
Tricò, Domenico D; Di Sessa, Anna A; Caprio, Sonia S; Chalasani, Naga N; Liu, Wanqing W; Liang, Tiebing T; Graf, Joerg J; Herzog, Raimund I RI; Johnson, Casey D CD; Umano, Giuseppina Rosaria GR; Feldstein, Ariel E AE; Santoro, Nicola N
Study protocol to investigate the environmental and genetic aetiology of atopic dermatitis: the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI).
Bmj Open
Tanjung, Conny C; Rzehak, Peter P; Mansyur, Muchtaruddin M; Munasir, Zakiudin Z; Sudoyo, Herawati H; Immanuel, Suzanna S; Irawan, Roedi R; Reischl, Eva E; Demmelmair, Hans H; Koletzko, Berthold B; Hadinegoro, Sri Rezeki SR; Sjarif, Damayanti Rusli DR
A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.
Molecular Psychiatry
Ikeda, M M; Takahashi, A A; Kamatani, Y Y; Okahisa, Y Y; Kunugi, H H; Mori, N N; Sasaki, T T; Ohmori, T T; Okamoto, Y Y; Kawasaki, H H; Shimodera, S S; Kato, T T; Yoneda, H H; Yoshimura, R R; Iyo, M M; Matsuda, K K; Akiyama, M M; Ashikawa, K K; Kashiwase, K K; Tokunaga, K K; Kondo, K K; Saito, T T; Shimasaki, A A; Kawase, K K; Kitajima, T T; Matsuo, K K; Itokawa, M M; Someya, T T; Inada, T T; Hashimoto, R R; Inoue, T T; Akiyama, K K; Tanii, H H; Arai, H H; Kanba, S S; Ozaki, N N; Kusumi, I I; Yoshikawa, T T; Kubo, M M; Iwata, N N
Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2.
American Journal Of Human Genetics
Simon, Lukas M LM; Chen, Edward S ES; Edelstein, Leonard C LC; Kong, Xianguo X; Bhatlekar, Seema S; Rigoutsos, Isidore I; Bray, Paul F PF; Shaw, Chad A CA
Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight.
The American Journal Of Clinical Nutrition
Gonzalez-Casanova, Ines I; Rzehak, Peter P; Stein, Aryeh D AD; Garcia Feregrino, Raquel R; Rivera Dommarco, Juan A JA; Barraza-Villarreal, Albino A; Demmelmair, Hans H; Romieu, Isabelle I; Villalpando, Salvador S; Martorell, Reynaldo R; Koletzko, Berthold B; Ramakrishnan, Usha U
A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.
Nature Communications
Ahmad, Omar S OS; Morris, John A JA; Mujammami, Muhammad M; Forgetta, Vincenzo V; Leong, Aaron A; Li, Rui R; Turgeon, Maxime M; Greenwood, Celia M T CM; Thanassoulis, George G; Meigs, James B JB; Sladek, Robert R; Richards, J Brent JB
Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study.
Nutrition & Metabolism
Abdelmagid, Salma A SA; Clarke, Shannon E SE; Roke, Kaitlin K; Nielsen, Daiva E DE; Badawi, Alaa A; El-Sohemy, Ahmed A; Mutch, David M DM; Ma, David Wl DW
FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.
Plos One
Rizzi, Thais S TS; van der Sluis, Sophie S; Derom, Catherine C; Thiery, Evert E; van Kesteren, Ronald E RE; Jacobs, Nele N; Van Gestel, Sofie S; Vlietinck, Robert R; Verhage, Matthijs M; Heutink, Peter P; Posthuma, Danielle D
A genome-wide association study of the human metabolome in a community-based cohort.
Cell Metabolism
Rhee, Eugene P EP; Ho, Jennifer E JE; Chen, Ming-Huei MH; Shen, Dongxiao D; Cheng, Susan S; Larson, Martin G MG; Ghorbani, Anahita A; Shi, Xu X; Helenius, Iiro T IT; O'Donnell, Christopher J CJ; Souza, Amanda L AL; Deik, Amy A; Pierce, Kerry A KA; Bullock, Kevin K; Walford, Geoffrey A GA; Vasan, Ramachandran S RS; Florez, Jose C JC; Clish, Clary C; Yeh, J-R Joanna JR; Wang, Thomas J TJ; Gerszten, Robert E RE
Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men.
Clinical Interventions In Aging
Hong, Seul Hee SH; Kwak, Jung Hyun JH; Paik, Jean Kyung JK; Chae, Jey Sook JS; Lee, Jong Ho JH
Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC).
The British Journal Of Nutrition
Lattka, Eva E; Koletzko, Berthold B; Zeilinger, Sonja S; Hibbeln, Joseph R JR; Klopp, Norman N; Ring, Susan M SM; Steer, Colin D CD
Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.
Prostaglandins, Leukotrienes, And Essential Fatty Acids
Reardon, Holly T HT; Zhang, Jimmy J; Kothapalli, Kumar S D KS; Kim, Andrea J AJ; Park, Woo Jung WJ; Brenna, J Thomas JT
Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos.
Frontiers In Genetics
Voruganti, V Saroja VS; Higgins, Paul B PB; Ebbesson, Sven O E SO; Kennish, John J; Göring, Harald H H HH; Haack, Karin K; Laston, Sandra S; Drigalenko, Eugene E; Wenger, Charlotte R CR; Harris, William S WS; Fabsitz, Richard R RR; Devereux, Richard B RB; Maccluer, Jean W JW; Curran, Joanne E JE; Carless, Melanie A MA; Johnson, Matthew P MP; Moses, Eric K EK; Blangero, John J; Umans, Jason G JG; Howard, Barbara V BV; Cole, Shelley A SA; Comuzzie, Anthony Gean AG
Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.
The British Journal Of Nutrition
Sergeant, Susan S; Hugenschmidt, Christina E CE; Rudock, Megan E ME; Ziegler, Julie T JT; Ivester, Priscilla P; Ainsworth, Hannah C HC; Vaidya, Dhananjay D; Case, L Douglas LD; Langefeld, Carl D CD; Freedman, Barry I BI; Bowden, Donald W DW; Mathias, Rasika A RA; Chilton, Floyd H FH
The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans.
Bmc Genetics
Mathias, Rasika A RA; Sergeant, Susan S; Ruczinski, Ingo I; Torgerson, Dara G DG; Hugenschmidt, Christina E CE; Kubala, Meghan M; Vaidya, Dhananjay D; Suktitipat, Bhoom B; Ziegler, Julie T JT; Ivester, Priscilla P; Case, Douglas D; Yanek, Lisa R LR; Freedman, Barry I BI; Rudock, Megan E ME; Barnes, Kathleen C KC; Langefeld, Carl D CD; Becker, Lewis C LC; Bowden, Donald W DW; Becker, Diane M DM; Chilton, Floyd H FH