FADS2 c.318+253C>T

Variant ID: 11-61605613-C-T

NM_004265.3(FADS2):c.318+253C>T

This variant was identified in 27 publications

View GRCh38 version.




Publications:


Novel Interactions of Myristic Acid and FADS3 Variants Predict Atopic Dermatitis among Indonesian Infants.

Nutrients
Tanjung, Conny C; Harris, Carla P CP; Demmelmair, Hans H; Dwitya, Sarah S; Munasir, Zakiudin Z; Sudoyo, Herawati H; Standl, Marie M; Sjarif, Damayanti Rusli DR; Koletzko, Berthold B
Publication Date: 2022-11-04

Variant appearance in text: rs174579
PubMed Link: 36364938
Variant Present in the following documents:
  • nutrients-14-04676.pdf
View BVdb publication page



Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study.

Nutrition & Metabolism
Li, Ping P; Chen, Yuhui Y; Song, Jieyun J; Yan, Lailai L; Tang, Tiantian T; Wang, Rui R; Fan, Xiuqin X; Zhao, Yurong Y; Qi, Kemin K
Publication Date: 2022-07-23

Variant appearance in text: rs174579
PubMed Link: 35871074
Variant Present in the following documents:
  • Main text
  • 12986_2022_Article_683.pdf
View BVdb publication page



Nutrigenetics, omega-3 and plasma lipids/lipoproteins/apolipoproteins with evidence evaluation using the GRADE approach: a systematic review.

Bmj Open
Keathley, Justine J; Garneau, Véronique V; Marcil, Valérie V; Mutch, David M DM; Robitaille, Julie J; Rudkowska, Iwona I; Sofian, Gabriela Magdalena GM; Desroches, Sophie S; Vohl, Marie-Claude MC
Publication Date: 2022-02-22

Variant appearance in text: rs174579
PubMed Link: 35193914
Variant Present in the following documents:
  • bmjopen-2021-054417.draft_revisions.pdf
  • bmjopen-2021-054417supp001.pdf
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Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms are Associated with Children's Processing Speed up to Age 9 Years.

Nutrients
Campoy, Cristina C; Azaryah, Hatim H; Torres-Espínola, Francisco J FJ; Martínez-Zaldívar, Cristina C; García-Santos, José Antonio JA; Demmelmair, Hans H; Haile, Gudrun G; Györei, Eszter E; Ramírez-Tortosa, María Del Carmen MDC; Reischl, Eva E; Rzehak, Peter P; Molloy, Anne M AM; Décsi, Tamas T; Luna, Juan de Dios JD; Koletzko, Berthold B; Pérez-García, Miguel M
Publication Date: 2020-12-31

Variant appearance in text: rs174579
PubMed Link: 33396458
Variant Present in the following documents:
  • nutrients-13-00131-s001.pdf
View BVdb publication page



Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.

Nutrition Reviews
Conway, Marie C MC; McSorley, Emeir M EM; Mulhern, Maria S MS; Strain, J J JJ; van Wijngaarden, Edwin E; Yeates, Alison J AJ
Publication Date: 2020-08-01

Variant appearance in text: rs174579
PubMed Link: 31943072
Variant Present in the following documents:
  • Main text
View BVdb publication page



Determinants of Plasma Docosahexaenoic Acid Levels and Their Relationship to Neurological and Cognitive Functions in PKU Patients: A Double Blind Randomized Supplementation Study.

Nutrients
Demmelmair, Hans H; MacDonald, Anita A; Kotzaeridou, Urania U; Burgard, Peter P; Gonzalez-Lamuno, Domingo D; Verduci, Elvira E; Ersoy, Melike M; Gokcay, Gulden G; Alyanak, Behiye B; Reischl, Eva E; Müller-Felber, Wolfgang W; Faber, Fabienne Lara FL; Handel, Uschi U; Paci, Sabrina S; Koletzko, Berthold B
Publication Date: 2018-12-07

Variant appearance in text: rs174579
PubMed Link: 30544518
Variant Present in the following documents:
  • Main text
View BVdb publication page



The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants.

The American Journal Of Clinical Nutrition
Tanjung, Conny C; Rzehak, Peter P; Sudoyo, Herawati H; Mansyur, Muchtaruddin M; Munasir, Zakiudin Z; Immanuel, Suzanna S; Irawan, Roedi R; Reischl, Eva E; Demmelmair, Hans H; Hadinegoro, Sri Rezeki SR; Sjarif, Damayanti Rusli DR; Koletzko, Berthold B
Publication Date: 2018-11-01

Variant appearance in text: rs174579
PubMed Link: 30475958
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membranes.

Nutrients
Lankinen, Maria M; Uusitupa, Matti M; Schwab, Ursula U
Publication Date: 2018-11-16

Variant appearance in text: rs174579
PubMed Link: 30453550
Variant Present in the following documents:
  • Main text
  • nutrients-10-01785.pdf
View BVdb publication page



Genetic Evidence Supporting the Role of the Calcium Channel, CACNA1S, in Tooth Cusp and Root Patterning.

Frontiers In Physiology
Laugel-Haushalter, Virginie V; Morkmued, Supawich S; Stoetzel, Corinne C; Geoffroy, Véronique V; Muller, Jean J; Boland, Anne A; Deleuze, Jean-François JF; Chennen, Kirsley K; Pitiphat, Waranuch W; Dollfus, Hélène H; Niederreither, Karen K; Bloch-Zupan, Agnès A; Pungchanchaikul, Patimaporn P
Publication Date: 2018

Variant appearance in text: FADS2: 318+253C>T; rs174579
PubMed Link: 30319441
Variant Present in the following documents:
  • Table_5.xlsx, sheet 1
View BVdb publication page



FADS Polymorphism, Omega-3 Fatty Acids and Diabetes Risk: A Systematic Review.

Nutrients
Brayner, Bárbara B; Kaur, Gunveen G; Keske, Michelle A MA; Livingstone, Katherine M KM
Publication Date: 2018-06-13

Variant appearance in text: rs174579
PubMed Link: 29899246
Variant Present in the following documents:
  • Main text
  • nutrients-10-00758.pdf
View BVdb publication page



Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study.

Bmj (Clinical Research Ed.)
Benn, Marianne M; Nordestgaard, Børge G BG; Frikke-Schmidt, Ruth R; Tybjærg-Hansen, Anne A
Publication Date: 2017-04-24

Variant appearance in text: rs174579
PubMed Link: 28438747
Variant Present in the following documents:
  • benm033277.ww1.pdf
View BVdb publication page



Study protocol to investigate the environmental and genetic aetiology of atopic dermatitis: the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI).

Bmj Open
Tanjung, Conny C; Rzehak, Peter P; Mansyur, Muchtaruddin M; Munasir, Zakiudin Z; Sudoyo, Herawati H; Immanuel, Suzanna S; Irawan, Roedi R; Reischl, Eva E; Demmelmair, Hans H; Koletzko, Berthold B; Hadinegoro, Sri Rezeki SR; Sjarif, Damayanti Rusli DR
Publication Date: 2017-03-03

Variant appearance in text: rs174579
PubMed Link: 28259851
Variant Present in the following documents:
  • Main text
  • bmjopen-2016-012475.pdf
View BVdb publication page



Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight.

The American Journal Of Clinical Nutrition
Gonzalez-Casanova, Ines I; Rzehak, Peter P; Stein, Aryeh D AD; Garcia Feregrino, Raquel R; Rivera Dommarco, Juan A JA; Barraza-Villarreal, Albino A; Demmelmair, Hans H; Romieu, Isabelle I; Villalpando, Salvador S; Martorell, Reynaldo R; Koletzko, Berthold B; Ramakrishnan, Usha U
Publication Date: 2016-04

Variant appearance in text: rs174579
PubMed Link: 26912491
Variant Present in the following documents:
  • Main text
View BVdb publication page



Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study.

Nutrition & Metabolism
Abdelmagid, Salma A SA; Clarke, Shannon E SE; Roke, Kaitlin K; Nielsen, Daiva E DE; Badawi, Alaa A; El-Sohemy, Ahmed A; Mutch, David M DM; Ma, David Wl DW
Publication Date: 2015

Variant appearance in text: rs174579
PubMed Link: 25914723
Variant Present in the following documents:
  • Main text
  • 12986_2015_Article_10.pdf
View BVdb publication page



Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

The American Journal Of Clinical Nutrition
Mozaffarian, Dariush D; Kabagambe, Edmond K EK; Johnson, Catherine O CO; Lemaitre, Rozenn N RN; Manichaikul, Ani A; Sun, Qi Q; Foy, Millennia M; Wang, Lu L; Wiener, Howard H; Irvin, Marguerite R MR; Rich, Stephen S SS; Wu, Hongyu H; Jensen, Majken K MK; Chasman, Daniel I DI; Chu, Audrey Y AY; Fornage, Myriam M; Steffen, Lyn L; King, Irena B IB; McKnight, Barbara B; Psaty, Bruce M BM; Djoussé, Luc L; Chen, Ida Y-D IY; Wu, Jason H Y JH; Siscovick, David S DS; Ridker, Paul M PM; Tsai, Michael Y MY; Rimm, Eric B EB; Hu, Frank B FB; Arnett, Donna K DK
Publication Date: 2015-02

Variant appearance in text: rs174579
PubMed Link: 25646338
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation.

Genes & Nutrition
Cormier, Hubert H; Rudkowska, Iwona I; Lemieux, Simone S; Couture, Patrick P; Julien, Pierre P; Vohl, Marie-Claude MC
Publication Date: 2014-11

Variant appearance in text: rs174579
PubMed Link: 25367143
Variant Present in the following documents:
  • Main text
  • 12263_2014_Article_437.pdf
View BVdb publication page



Polymorphisms in Fatty Acid Desaturase (FADS) Gene Cluster: Effects on Glycemic Controls Following an Omega-3 Polyunsaturated Fatty Acids (PUFA) Supplementation.

Genes
Cormier, Hubert H; Rudkowska, Iwona I; Thifault, Elisabeth E; Lemieux, Simone S; Couture, Patrick P; Vohl, Marie-Claude MC
Publication Date: 2013-09-10

Variant appearance in text: rs174579
PubMed Link: 24705214
Variant Present in the following documents:
  • Main text
  • genes-04-00485.pdf
View BVdb publication page



Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age.

The American Journal Of Clinical Nutrition
Steer, Colin D CD; Lattka, Eva E; Koletzko, Berthold B; Golding, Jean J; Hibbeln, Joseph R JR
Publication Date: 2013-12

Variant appearance in text: rs174579
PubMed Link: 24067669
Variant Present in the following documents:
  • Main text
View BVdb publication page



FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.

Plos One
Rizzi, Thais S TS; van der Sluis, Sophie S; Derom, Catherine C; Thiery, Evert E; van Kesteren, Ronald E RE; Jacobs, Nele N; Van Gestel, Sofie S; Vlietinck, Robert R; Verhage, Matthijs M; Heutink, Peter P; Posthuma, Danielle D
Publication Date: 2013

Variant appearance in text: rs174579
PubMed Link: 23826354
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation.

Nutrients
Cormier, Hubert H; Rudkowska, Iwona I; Paradis, Ann-Marie AM; Thifault, Elisabeth E; Garneau, Véronique V; Lemieux, Simone S; Couture, Patrick P; Vohl, Marie-Claude MC
Publication Date: 2012-08

Variant appearance in text: rs174579
PubMed Link: 23016130
Variant Present in the following documents:
  • Main text
  • nutrients-04-01026.pdf
View BVdb publication page



Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC).

The British Journal Of Nutrition
Lattka, Eva E; Koletzko, Berthold B; Zeilinger, Sonja S; Hibbeln, Joseph R JR; Klopp, Norman N; Ring, Susan M SM; Steer, Colin D CD
Publication Date: 2013-04-14

Variant appearance in text: rs174579
PubMed Link: 22877655
Variant Present in the following documents:
  • Main text
View BVdb publication page



Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.

Prostaglandins, Leukotrienes, And Essential Fatty Acids
Reardon, Holly T HT; Zhang, Jimmy J; Kothapalli, Kumar S D KS; Kim, Andrea J AJ; Park, Woo Jung WJ; Brenna, J Thomas JT
Publication Date: 2012-07

Variant appearance in text: rs174579
PubMed Link: 22748975
Variant Present in the following documents:
  • Main text
View BVdb publication page



Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos.

Frontiers In Genetics
Voruganti, V Saroja VS; Higgins, Paul B PB; Ebbesson, Sven O E SO; Kennish, John J; Göring, Harald H H HH; Haack, Karin K; Laston, Sandra S; Drigalenko, Eugene E; Wenger, Charlotte R CR; Harris, William S WS; Fabsitz, Richard R RR; Devereux, Richard B RB; Maccluer, Jean W JW; Curran, Joanne E JE; Carless, Melanie A MA; Johnson, Matthew P MP; Moses, Eric K EK; Blangero, John J; Umans, Jason G JG; Howard, Barbara V BV; Cole, Shelley A SA; Comuzzie, Anthony Gean AG
Publication Date: 2012

Variant appearance in text: rs174579
PubMed Link: 22701466
Variant Present in the following documents:
  • Main text
View BVdb publication page



Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.

The British Journal Of Nutrition
Sergeant, Susan S; Hugenschmidt, Christina E CE; Rudock, Megan E ME; Ziegler, Julie T JT; Ivester, Priscilla P; Ainsworth, Hannah C HC; Vaidya, Dhananjay D; Case, L Douglas LD; Langefeld, Carl D CD; Freedman, Barry I BI; Bowden, Donald W DW; Mathias, Rasika A RA; Chilton, Floyd H FH
Publication Date: 2012-02

Variant appearance in text: rs174579
PubMed Link: 21733300
Variant Present in the following documents:
  • Main text
View BVdb publication page



The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans.

Bmc Genetics
Mathias, Rasika A RA; Sergeant, Susan S; Ruczinski, Ingo I; Torgerson, Dara G DG; Hugenschmidt, Christina E CE; Kubala, Meghan M; Vaidya, Dhananjay D; Suktitipat, Bhoom B; Ziegler, Julie T JT; Ivester, Priscilla P; Case, Douglas D; Yanek, Lisa R LR; Freedman, Barry I BI; Rudock, Megan E ME; Barnes, Kathleen C KC; Langefeld, Carl D CD; Becker, Lewis C LC; Bowden, Donald W DW; Becker, Diane M DM; Chilton, Floyd H FH
Publication Date: 2011-05-20

Variant appearance in text: rs174579
PubMed Link: 21599946
Variant Present in the following documents:
  • Main text
  • 1471-2156-12-50.pdf
View BVdb publication page



Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease.

Bmc Medical Genetics
Ding, Keyue K; Kullo, Iftikhar J IJ
Publication Date: 2011-04-20

Variant appearance in text: rs174579
PubMed Link: 21507254
Variant Present in the following documents:
  • Main text
  • 1471-2350-12-55.pdf
View BVdb publication page



Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health.

Maternal & Child Nutrition
Glaser, Claudia C; Lattka, Eva E; Rzehak, Peter P; Steer, Colin C; Koletzko, Berthold B
Publication Date: 2011-04

Variant appearance in text: rs174579
PubMed Link: 21366865
Variant Present in the following documents:
  • Main text
View BVdb publication page