Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.
Annals Of Neurology
Kia, Demis A DA; Noyce, Alastair J AJ; White, Jon J; Speed, Doug D; Nicolas, Aude A; , ; Burgess, Stephen S; Lawlor, Debbie A DA; Davey Smith, George G; Singleton, Andrew A; Nalls, Mike A MA; Sofat, Reecha R; Wood, Nicholas W NW
Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability.
Nature Genetics
Hysi, Pirro G PG; Valdes, Ana M AM; Liu, Fan F; Furlotte, Nicholas A NA; Evans, David M DM; Bataille, Veronique V; Visconti, Alessia A; Hemani, Gibran G; McMahon, George G; Ring, Susan M SM; Smith, George Davey GD; Duffy, David L DL; Zhu, Gu G; Gordon, Scott D SD; Medland, Sarah E SE; Lin, Bochao D BD; Willemsen, Gonneke G; Jan Hottenga, Jouke J; Vuckovic, Dragana D; Girotto, Giorgia G; Gandin, Ilaria I; Sala, Cinzia C; Concas, Maria Pina MP; Brumat, Marco M; Gasparini, Paolo P; Toniolo, Daniela D; Cocca, Massimiliano M; Robino, Antonietta A; Yazar, Seyhan S; Hewitt, Alex W AW; Chen, Yan Y; Zeng, Changqing C; Uitterlinden, Andre G AG; Ikram, M Arfan MA; Hamer, Merel A MA; van Duijn, Cornelia M CM; Nijsten, Tamar T; Mackey, David A DA; Falchi, Mario M; Boomsma, Dorret I DI; Martin, Nicholas G NG; , ; Hinds, David A DA; Kayser, Manfred M; Spector, Timothy D TD
MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.
Annals Of The Rheumatic Diseases
Li, Xue X; Meng, Xiangrui X; Spiliopoulou, Athina A; Timofeeva, Maria M; Wei, Wei-Qi WQ; Gifford, Aliya A; Shen, Xia X; He, Yazhou Y; Varley, Tim T; McKeigue, Paul P; Tzoulaki, Ioanna I; Wright, Alan F AF; Joshi, Peter P; Denny, Joshua C JC; Campbell, Harry H; Theodoratou, Evropi E
Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.
The Lancet. Diabetes & Endocrinology
White, Jon J; Sofat, Reecha R; Hemani, Gibran G; Shah, Tina T; Engmann, Jorgen J; Dale, Caroline C; Shah, Sonia S; Kruger, Felix A FA; Giambartolomei, Claudia C; Swerdlow, Daniel I DI; Palmer, Tom T; McLachlan, Stela S; Langenberg, Claudia C; Zabaneh, Delilah D; Lovering, Ruth R; Cavadino, Alana A; Jefferis, Barbara B; Finan, Chris C; Wong, Andrew A; Amuzu, Antoinette A; Ong, Ken K; Gaunt, Tom R TR; Warren, Helen H; Davies, Teri-Louise TL; Drenos, Fotios F; Cooper, Jackie J; Ebrahim, Shah S; Lawlor, Debbie A DA; Talmud, Philippa J PJ; Humphries, Steve E SE; Power, Christine C; Hypponen, Elina E; Richards, Marcus M; Hardy, Rebecca R; Kuh, Diana D; Wareham, Nicholas N; Ben-Shlomo, Yoav Y; Day, Ian N IN; Whincup, Peter P; Morris, Richard R; Strachan, Mark W J MW; Price, Jacqueline J; Kumari, Meena M; Kivimaki, Mika M; Plagnol, Vincent V; Whittaker, John C JC; , ; Smith, George Davey GD; Dudbridge, Frank F; Casas, Juan P JP; Holmes, Michael V MV; Hingorani, Aroon D AD; ,
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.
Hypertension (Dallas, Tex. : 1979)
Andreassen, Ole A OA; McEvoy, Linda K LK; Thompson, Wesley K WK; Wang, Yunpeng Y; Reppe, Sjur S; Schork, Andrew J AJ; Zuber, Verena V; Barrett-Connor, Elizabeth E; Gautvik, Kaare K; Aukrust, Pål P; Karlsen, Tom H TH; Djurovic, Srdjan S; Desikan, Rahul S RS; Dale, Anders M AM; ,
Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects.
Arthritis Research & Therapy
Flynn, Tanya J TJ; Phipps-Green, Amanda A; Hollis-Moffatt, Jade E JE; Merriman, Marilyn E ME; Topless, Ruth R; Montgomery, Grant G; Chapman, Brett B; Stamp, Lisa K LK; Dalbeth, Nicola N; Merriman, Tony R TR
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Nature Genetics
Köttgen, Anna A; Albrecht, Eva E; Teumer, Alexander A; Vitart, Veronique V; Krumsiek, Jan J; Hundertmark, Claudia C; Pistis, Giorgio G; Ruggiero, Daniela D; O'Seaghdha, Conall M CM; Haller, Toomas T; Yang, Qiong Q; Tanaka, Toshiko T; Johnson, Andrew D AD; Kutalik, Zoltán Z; Smith, Albert V AV; Shi, Julia J; Struchalin, Maksim M; Middelberg, Rita P S RP; Brown, Morris J MJ; Gaffo, Angelo L AL; Pirastu, Nicola N; Li, Guo G; Hayward, Caroline C; Zemunik, Tatijana T; Huffman, Jennifer J; Yengo, Loic L; Zhao, Jing Hua JH; Demirkan, Ayse A; Feitosa, Mary F MF; Liu, Xuan X; Malerba, Giovanni G; Lopez, Lorna M LM; van der Harst, Pim P; Li, Xinzhong X; Kleber, Marcus E ME; Hicks, Andrew A AA; Nolte, Ilja M IM; Johansson, Asa A; Murgia, Federico F; Wild, Sarah H SH; Bakker, Stephan J L SJ; Peden, John F JF; Dehghan, Abbas A; Steri, Maristella M; Tenesa, Albert A; Lagou, Vasiliki V; Salo, Perttu P; Mangino, Massimo M; Rose, Lynda M LM; Lehtimäki, Terho T; Woodward, Owen M OM; Okada, Yukinori Y; Tin, Adrienne A; Müller, Christian C; Oldmeadow, Christopher C; Putku, Margus M; Czamara, Darina D; Kraft, Peter P; Frogheri, Laura L; Thun, Gian Andri GA; Grotevendt, Anne A; Gislason, Gauti Kjartan GK; Harris, Tamara B TB; Launer, Lenore J LJ; McArdle, Patrick P; Shuldiner, Alan R AR; Boerwinkle, Eric E; Coresh, Josef J; Schmidt, Helena H; Schallert, Michael M; Martin, Nicholas G NG; Montgomery, Grant W GW; Kubo, Michiaki M; Nakamura, Yusuke Y; Tanaka, Toshihiro T; Munroe, Patricia B PB; Samani, Nilesh J NJ; Jacobs, David R DR; Liu, Kiang K; D'Adamo, Pio P; Ulivi, Sheila S; Rotter, Jerome I JI; Psaty, Bruce M BM; Vollenweider, Peter P; Waeber, Gerard G; Campbell, Susan S; Devuyst, Olivier O; Navarro, Pau P; Kolcic, Ivana I; Hastie, Nicholas N; Balkau, Beverley B; Froguel, Philippe P; Esko, Tõnu T; Salumets, Andres A; Khaw, Kay Tee KT; Langenberg, Claudia C; Wareham, Nicholas J NJ; Isaacs, Aaron A; Kraja, Aldi A; Zhang, Qunyuan Q; Wild, Philipp S PS; Scott, Rodney J RJ; Holliday, Elizabeth G EG; Org, Elin E; Viigimaa, Margus M; Bandinelli, Stefania S; Metter, Jeffrey E JE; Lupo, Antonio A; Trabetti, Elisabetta E; Sorice, Rossella R; Döring, Angela A; Lattka, Eva E; Strauch, Konstantin K; Theis, Fabian F; Waldenberger, Melanie M; Wichmann, H-Erich HE; Davies, Gail G; Gow, Alan J AJ; Bruinenberg, Marcel M; , ; Stolk, Ronald P RP; Kooner, Jaspal S JS; Zhang, Weihua W; Winkelmann, Bernhard R BR; Boehm, Bernhard O BO; Lucae, Susanne S; Penninx, Brenda W BW; Smit, Johannes H JH; Curhan, Gary G; Mudgal, Poorva P; Plenge, Robert M RM; Portas, Laura L; Persico, Ivana I; Kirin, Mirna M; Wilson, James F JF; Mateo Leach, Irene I; van Gilst, Wiek H WH; Goel, Anuj A; Ongen, Halit H; Hofman, Albert A; Rivadeneira, Fernando F; Uitterlinden, Andre G AG; Imboden, Medea M; von Eckardstein, Arnold A; Cucca, Francesco F; Nagaraja, Ramaiah R; Piras, Maria Grazia MG; Nauck, Matthias M; Schurmann, Claudia C; Budde, Kathrin K; Ernst, Florian F; Farrington, Susan M SM; Theodoratou, Evropi E; Prokopenko, Inga I; Stumvoll, Michael M; Jula, Antti A; Perola, Markus M; Salomaa, Veikko V; Shin, So-Youn SY; Spector, Tim D TD; Sala, Cinzia C; Ridker, Paul M PM; Kähönen, Mika M; Viikari, Jorma J; Hengstenberg, Christian C; Nelson, Christopher P CP; , ; , ; , ; , ; Meschia, James F JF; Nalls, Michael A MA; Sharma, Pankaj P; Singleton, Andrew B AB; Kamatani, Naoyuki N; Zeller, Tanja T; Burnier, Michel M; Attia, John J; Laan, Maris M; Klopp, Norman N; Hillege, Hans L HL; Kloiber, Stefan S; Choi, Hyon H; Pirastu, Mario M; Tore, Silvia S; Probst-Hensch, Nicole M NM; Völzke, Henry H; Gudnason, Vilmundur V; Parsa, Afshin A; Schmidt, Reinhold R; Whitfield, John B JB; Fornage, Myriam M; Gasparini, Paolo P; Siscovick, David S DS; Polašek, Ozren O; Campbell, Harry H; Rudan, Igor I; Bouatia-Naji, Nabila N; Metspalu, Andres A; Loos, Ruth J F RJ; van Duijn, Cornelia M CM; Borecki, Ingrid B IB; Ferrucci, Luigi L; Gambaro, Giovanni G; Deary, Ian J IJ; Wolffenbuttel, Bruce H R BH; Chambers, John C JC; März, Winfried W; Pramstaller, Peter P PP; Snieder, Harold H; Gyllensten, Ulf U; Wright, Alan F AF; Navis, Gerjan G; Watkins, Hugh H; Witteman, Jacqueline C M JC; Sanna, Serena S; Schipf, Sabine S; Dunlop, Malcolm G MG; Tönjes, Anke A; Ripatti, Samuli S; Soranzo, Nicole N; Toniolo, Daniela D; Chasman, Daniel I DI; Raitakari, Olli O; Kao, W H Linda WH; Ciullo, Marina M; Fox, Caroline S CS; Caulfield, Mark M; Bochud, Murielle M; Gieger, Christian C