Omega-3 mechanism of action in inflammation and endoplasmic reticulum stress in mononuclear cells from overweight non-alcoholic fatty liver disease participants: study protocol for the "Brazilian Omega Study" (BROS)-a randomized controlled trial.
Trials
Batista, Ellencristina Silva ES; da Silva Rios, Thaiane T; Muñoz, Vitor Rosetto VR; Jesus, Joyce Santos JS; Vasconcelos, Marcel Monteiro MM; da Cunha, Diogo Thimóteo DT; Marques-Rocha, Jose Luis JL; Nakandakari, Susana Castelo Branco Ramos SCBR; Lara, Roberta R; da Silva, Adelino Sanchez Ramos ASR; Pauli, José Rodrigo JR; Ropelle, Eduardo Rochete ER; Mekary, Rania Angelina RA; de Moura, Leandro Pereira LP; Camargo, Enilton Aparecido EA; Cintra, Dennys Esper DE
CD200 promotes immunosuppression in the pancreatic tumor microenvironment.
Journal For Immunotherapy Of Cancer
Choueiry, Fouad F; Torok, Molly M; Shakya, Reena R; Agrawal, Kriti K; Deems, Anna A; Benner, Brooke B; Hinton, Alice A; Shaffer, Jami J; Blaser, Bradley W BW; Noonan, Anne M AM; Williams, Terence M TM; Dillhoff, Mary M; Conwell, Darwin L DL; Hart, Phil A PA; Cruz-Monserrate, Zobeida Z; Bai, Xue-Feng XF; Carson, William E WE; Mace, Thomas A TA
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.
Cell Death And Differentiation
Patel, Snahel S; Webster, Joshua D JD; Varfolomeev, Eugene E; Kwon, Youngsu C YC; Cheng, Jason H JH; Zhang, Juan J; Dugger, Debra L DL; Wickliffe, Kate E KE; Maltzman, Allie A; Sujatha-Bhaskar, Swathi S; Bir Kohli, Pawan P; Ramaswamy, Sreema S; Deshmukh, Gauri G; Liederer, Bianca M BM; Fong, Rina R; Hamilton, Greg G; Lupardus, Patrick P; Caplazi, Patrick P; Lee, Wyne P WP; van Lookeren Campagne, Menno M; Johnson, Adam A; McKenzie, Brent S BS; Junttila, Melissa R MR; Newton, Kim K; Vucic, Domagoj D
The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression.
Molecular Cancer Therapeutics
Wallez, Yann Y; Dunlop, Charles R CR; Johnson, Timothy Isaac TI; Koh, Siang-Boon SB; Fornari, Chiara C; Yates, James W T JWT; Bernaldo de Quirós Fernández, Sandra S; Lau, Alan A; Richards, Frances M FM; Jodrell, Duncan I DI
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Nature Communications
Schütte, Moritz M; Risch, Thomas T; Abdavi-Azar, Nilofar N; Boehnke, Karsten K; Schumacher, Dirk D; Keil, Marlen M; Yildiriman, Reha R; Jandrasits, Christine C; Borodina, Tatiana T; Amstislavskiy, Vyacheslav V; Worth, Catherine L CL; Schweiger, Caroline C; Liebs, Sandra S; Lange, Martin M; Warnatz, Hans-Jörg HJ; Butcher, Lee M LM; Barrett, James E JE; Sultan, Marc M; Wierling, Christoph C; Golob-Schwarzl, Nicole N; Lax, Sigurd S; Uranitsch, Stefan S; Becker, Michael M; Welte, Yvonne Y; Regan, Joseph Lewis JL; Silvestrov, Maxine M; Kehler, Inge I; Fusi, Alberto A; Kessler, Thomas T; Herwig, Ralf R; Landegren, Ulf U; Wienke, Dirk D; Nilsson, Mats M; Velasco, Juan A JA; Garin-Chesa, Pilar P; Reinhard, Christoph C; Beck, Stephan S; Schäfer, Reinhold R; Regenbrecht, Christian R A CR; Henderson, David D; Lange, Bodo B; Haybaeck, Johannes J; Keilholz, Ulrich U; Hoffmann, Jens J; Lehrach, Hans H; Yaspo, Marie-Laure ML
Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Catenacci, Daniel V T DV; Junttila, Melissa R MR; Karrison, Theodore T; Bahary, Nathan N; Horiba, Margit N MN; Nattam, Sreenivasa R SR; Marsh, Robert R; Wallace, James J; Kozloff, Mark M; Rajdev, Lakshmi L; Cohen, Deirdre D; Wade, James J; Sleckman, Bethany B; Lenz, Heinz-Josef HJ; Stiff, Patrick P; Kumar, Pankaj P; Xu, Peng P; Henderson, Les L; Takebe, Naoko N; Salgia, Ravi R; Wang, Xi X; Stadler, Walter M WM; de Sauvage, Frederic J FJ; Kindler, Hedy L HL
Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer.
Scientific Reports
Chatterjee, Moumita M; Ben-Josef, Edgar E; Thomas, Dafydd G DG; Morgan, Meredith A MA; Zalupski, Mark M MM; Khan, Gazala G; Andrew Robinson, Charles C; Griffith, Kent A KA; Chen, Ching-Shih CS; Ludwig, Thomas T; Bekaii-Saab, Tanios T; Chakravarti, Arnab A; Williams, Terence M TM
Naguib, Adam A; Bencze, Gyula G; Engle, Dannielle D DD; Chio, Iok I C II; Herzka, Tali T; Watrud, Kaitlin K; Bencze, Szilvia S; Tuveson, David A DA; Pappin, Darryl J DJ; Trotman, Lloyd C LC
A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.
Cancer Discovery
Collisson, Eric A EA; Trejo, Christy L CL; Silva, Jillian M JM; Gu, Shenda S; Korkola, James E JE; Heiser, Laura M LM; Charles, Roch-Philippe RP; Rabinovich, Brian A BA; Hann, Byron B; Dankort, David D; Spellman, Paul T PT; Phillips, Wayne A WA; Gray, Joe W JW; McMahon, Martin M
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Morton, Jennifer P JP; Timpson, Paul P; Karim, Saadia A SA; Ridgway, Rachel A RA; Athineos, Dimitris D; Doyle, Brendan B; Jamieson, Nigel B NB; Oien, Karin A KA; Lowy, Andrew M AM; Brunton, Valerie G VG; Frame, Margaret C MC; Evans, T R Jeffry TR; Sansom, Owen J OJ
Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences.
Nucleic Acids Research
Brázdová, Marie M; Quante, Timo T; Tögel, Lars L; Walter, Korden K; Loscher, Christine C; Tichý, Vlastimil V; Cincárová, Lenka L; Deppert, Wolfgang W; Tolstonog, Genrich V GV