Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
The Embo Journal
Petit, Dieter D; Hitzenberger, Manuel M; Koch, Matthias M; Lismont, Sam S; Zoltowska, Katarzyna Marta KM; Enzlein, Thomas T; Hopf, Carsten C; Zacharias, Martin M; Chávez-Gutiérrez, Lucía L
Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering.
Nature Chemical Biology
Ware, Timothy B TB; Franks, Caroline E CE; Granade, Mitchell E ME; Zhang, Mingxing M; Kim, Kee-Beom KB; Park, Kwon-Sik KS; Gahlmann, Andreas A; Harris, Thurl E TE; Hsu, Ku-Lung KL
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate.
The Journal Of Cell Biology
van Zeijl, Leonie L; Ponsioen, Bas B; Giepmans, Ben N G BN; Ariaens, Aafke A; Postma, Friso R FR; Várnai, Péter P; Balla, Tamas T; Divecha, Nullin N; Jalink, Kees K; Moolenaar, Wouter H WH