Multidimensional screening yields channelrhodopsin variants having improved photocurrent and order-of-magnitude reductions in calcium and proton currents.
The Journal Of Biological Chemistry
Cho, Yong Ku YK; Park, Demian D; Yang, Aimei A; Chen, Fei F; Chuong, Amy S AS; Klapoetke, Nathan C NC; Boyden, Edward S ES
Independent optical excitation of distinct neural populations.
Nature Methods
Klapoetke, Nathan C NC; Murata, Yasunobu Y; Kim, Sung Soo SS; Pulver, Stefan R SR; Birdsey-Benson, Amanda A; Cho, Yong Ku YK; Morimoto, Tania K TK; Chuong, Amy S AS; Carpenter, Eric J EJ; Tian, Zhijian Z; Wang, Jun J; Xie, Yinlong Y; Yan, Zhixiang Z; Zhang, Yong Y; Chow, Brian Y BY; Surek, Barbara B; Melkonian, Michael M; Jayaraman, Vivek V; Constantine-Paton, Martha M; Wong, Gane Ka-Shu GK; Boyden, Edward S ES