Publications:

---

Deciphering Selectivity Mechanism of BRD9 and TAF1(2) toward Inhibitors Based on Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations.

Molecules (Basel, Switzerland)

Wang, Lifei L; Wang, Yan Y; Yu, Yingxia Y; Liu, Dong D; Zhao, Juan J; Zhang, Lulu L

Publication Date: 2023-03-12

Variant appearance in text: PC: I50V

PubMed Link: 36985555

Variant Present in the following documents:

• molecules-28-02583.pdf

View BVdb publication page

---

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes.

Journal Of Enzyme Inhibition And Medicinal Chemistry

Wang, Lifei L; Lu, Dan D; Wang, Yan Y; Xu, Xiaoyan X; Zhong, Peihua P; Yang, Zhiyong Z

Publication Date: 2023-12

Variant appearance in text: PC: I50V

PubMed Link: 36342274

Variant Present in the following documents:

• IENZ_38_2135511.pdf

View BVdb publication page

---

The structural, dynamic, and thermodynamic basis of darunavir resistance of a heavily mutated HIV-1 protease using molecular dynamics simulation.

Frontiers In Molecular Biosciences

Shabanpour, Yaser Y; Sajjadi, Sharareh S; Behmard, Esmaeil E; Abdolmaleki, Parviz P; Keihan, Amir Homayoun AH

Publication Date: 2022

Variant appearance in text: PC: I50V

PubMed Link: 36046605

Variant Present in the following documents:

• Main text
• fmolb-09-927373.pdf

View BVdb publication page

---

Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.

Acs Infectious Diseases

Lockbaum, Gordon J GJ; Leidner, Florian F; Rusere, Linah N LN; Henes, Mina M; Kosovrasti, Klajdi K; Nachum, Gily S GS; Nalivaika, Ellen A EA; Ali, Akbar A; Yilmaz, Nese Kurt NK; Schiffer, Celia A CA

Publication Date: 2019-02-08

Variant appearance in text: PC: I50V

PubMed Link: 30543749

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease.

Molecular Biology And Evolution

Flynn, William F WF; Haldane, Allan A; Torbett, Bruce E BE; Levy, Ronald M RM

Publication Date: 2017-06-01

Variant appearance in text: PC: I50V

PubMed Link: 28369521

Variant Present in the following documents:

• Main text
• msx095.pdf

View BVdb publication page

---

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Nature Communications

Schütte, Moritz M; Risch, Thomas T; Abdavi-Azar, Nilofar N; Boehnke, Karsten K; Schumacher, Dirk D; Keil, Marlen M; Yildiriman, Reha R; Jandrasits, Christine C; Borodina, Tatiana T; Amstislavskiy, Vyacheslav V; Worth, Catherine L CL; Schweiger, Caroline C; Liebs, Sandra S; Lange, Martin M; Warnatz, Hans-Jörg HJ; Butcher, Lee M LM; Barrett, James E JE; Sultan, Marc M; Wierling, Christoph C; Golob-Schwarzl, Nicole N; Lax, Sigurd S; Uranitsch, Stefan S; Becker, Michael M; Welte, Yvonne Y; Regan, Joseph Lewis JL; Silvestrov, Maxine M; Kehler, Inge I; Fusi, Alberto A; Kessler, Thomas T; Herwig, Ralf R; Landegren, Ulf U; Wienke, Dirk D; Nilsson, Mats M; Velasco, Juan A JA; Garin-Chesa, Pilar P; Reinhard, Christoph C; Beck, Stephan S; Schäfer, Reinhold R; Regenbrecht, Christian R A CR; Henderson, David D; Lange, Bodo B; Haybaeck, Johannes J; Keilholz, Ulrich U; Hoffmann, Jens J; Lehrach, Hans H; Yaspo, Marie-Laure ML

Publication Date: 2017-02-10

Variant appearance in text: PC: I50V

PubMed Link: 28186126

Variant Present in the following documents:

• ncomms14262-s5.xlsx, sheet 2

View BVdb publication page

---

Pleiotropic Effects of Immune Responses Explain Variation in the Prevalence of Fibroproliferative Diseases.

Plos Genetics

Russell, Shirley B SB; Smith, Joan C JC; Huang, Minjun M; Trupin, Joel S JS; Williams, Scott M SM

Publication Date: 2015-11

Variant appearance in text: PC: Ile50Val

PubMed Link: 26540410

Variant Present in the following documents:

• pgen.1005568.pdf

View BVdb publication page

---

Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: lessons learned from HIV-1 protease inhibition.

Proteins

Shen, Yang Y; Radhakrishnan, Mala L ML; Tidor, Bruce B

Publication Date: 2015-02

Variant appearance in text: PC: I50V

PubMed Link: 25410041

Variant Present in the following documents:

• PROT-83-351.pdf

View BVdb publication page

---

Revealing origin of decrease in potency of darunavir and amprenavir against HIV-2 relative to HIV-1 protease by molecular dynamics simulations.

Scientific Reports

Chen, Jianzhong J; Liang, Zhiqiang Z; Wang, Wei W; Yi, Changhong C; Zhang, Shaolong S; Zhang, Qinggang Q

Publication Date: 2014-11-03

Variant appearance in text: PC: I50V

PubMed Link: 25362963

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Antiviral resistance and correlates of virologic failure in the first cohort of HIV-infected children gaining access to structured antiretroviral therapy in Lima, Peru: a cross-sectional analysis.

Bmc Infectious Diseases

Rath, Barbara A BA; von Kleist, Max M; Castillo, Maria E ME; Kolevic, Lenka L; Caballero, Patricia P; Soto-Castellares, Giselle G; Amedee, Angela M AM; Robinson, James E JE; Katzenstein, David K DK; Van Dyke, Russell B RB; Oberhelman, Richard A RA

Publication Date: 2013-01-02

Variant appearance in text: PC: I50V

PubMed Link: 23280237

Variant Present in the following documents:

• 1471-2334-13-1.pdf

View BVdb publication page

---

Gene-gene and gene-environmental interactions of childhood asthma: a multifactor dimension reduction approach.

Plos One

Su, Ming-Wei MW; Tung, Kuan-Yen KY; Liang, Pi-Hui PH; Tsai, Ching-Hui CH; Kuo, Nai-Wei NW; Lee, Yungling Leo YL

Publication Date: 2012

Variant appearance in text: PC: Ile50Val

PubMed Link: 22355322

Variant Present in the following documents:

• pone.0030694.pdf

View BVdb publication page

---

Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

Bmc Medical Genetics

Emonts, Marieke M; Hazes, Mieke J M W MJ; Houwing-Duistermaat, Jeanine J JJ; van der Gaast-de Jongh, Christa E CE; de Vogel, Lisette L; Han, Huub K H HK; Wouters, Jacques M G W JM; Laman, Jon D JD; Dolhain, Radboud J E M RJ

Publication Date: 2011-03-07

Variant appearance in text: PC: I50V

PubMed Link: 21385363

Variant Present in the following documents:

• 1471-2350-12-36.pdf

View BVdb publication page

---

Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo.

Antimicrobial Agents And Chemotherapy

Delelis, Olivier O; Thierry, Sylvain S; Subra, Frédéric F; Simon, Françoise F; Malet, Isabelle I; Alloui, Chakib C; Sayon, Sophie S; Calvez, Vincent V; Deprez, Eric E; Marcelin, Anne-Geneviève AG; Tchertanov, Luba L; Mouscadet, Jean-François JF

Publication Date: 2010-01

Variant appearance in text: PC: I50V

PubMed Link: 19901095

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Human immunodeficiency virus type 1 genotypic and pharmacokinetic determinants of the virological response to lopinavir-ritonavir-containing therapy in protease inhibitor-experienced patients.

Antimicrobial Agents And Chemotherapy

Masquelier, Bernard B; Breilh, Dominique D; Neau, Didier D; Lawson-Ayayi, Sylvie S; Lavignolle, Valérie V; Ragnaud, Jean-Marie JM; Dupon, Michel M; Morlat, Philippe P; Dabis, F F; Fleury, H H; ,

Publication Date: 2002-09

Variant appearance in text: PC: I50V

PubMed Link: 12183249

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma.

American Journal Of Human Genetics

Howard, Timothy D TD; Koppelman, Gerard H GH; Xu, Jianfeng J; Zheng, Siqun L SL; Postma, Dirkje S DS; Meyers, Deborah A DA; Bleecker, Eugene R ER

Publication Date: 2002-01

Variant appearance in text: PC: I50V

PubMed Link: 11709756

Variant Present in the following documents:

• Main text

View BVdb publication page

---