GAB2 c.377-4588C>T

Variant ID: 11-77966034-G-A

NM_080491.2(GAB2):c.377-4588C>T

This variant was identified in 7 publications

View GRCh38 version.




Publications:


Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology.

Plos One
Zou, Fanggeng F; Belbin, Olivia O; Carrasquillo, Minerva M MM; Culley, Oliver J OJ; Hunter, Talisha A TA; Ma, Li L; Bisceglio, Gina D GD; Allen, Mariet M; Dickson, Dennis W DW; Graff-Radford, Neill R NR; Petersen, Ronald C RC; , ; Morgan, Kevin K; Younkin, Steven G SG
Publication Date: 2013

Variant appearance in text: rs2510038
PubMed Link: 23724096
Variant Present in the following documents:
  • Main text
  • pone.0064802.pdf
View BVdb publication page



Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins.

Twin Research And Human Genetics : The Official Journal Of The International Society For Twin Studies
Hibar, Derrek P DP; Jahanshad, Neda N; Stein, Jason L JL; Kohannim, Omid O; Toga, Arthur W AW; Medland, Sarah E SE; Hansell, Narelle K NK; McMahon, Katie L KL; de Zubicaray, Greig I GI; Montgomery, Grant W GW; Martin, Nicholas G NG; Wright, Margaret J MJ; Thompson, Paul M PM
Publication Date: 2012-06

Variant appearance in text: rs2510038
PubMed Link: 22856364
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEε4 carriers.

Neuroimage
Liang, Winnie S WS; Chen, Kewei K; Lee, Wendy W; Sidhar, Kunal K; Corneveaux, Jason J JJ; Allen, April N AN; Myers, Amanda A; Villa, Stephen S; Meechoovet, Bessie B; Pruzin, Jeremy J; Bandy, Daniel D; Fleisher, Adam S AS; Langbaum, Jessica B S JB; Huentelman, Matthew J MJ; Jensen, Kendall K; Dunckley, Travis T; Caselli, Richard J RJ; Kaib, Susan S; Reiman, Eric M EM
Publication Date: 2011-02-01

Variant appearance in text: rs2510038
PubMed Link: 20888920
Variant Present in the following documents:
  • Main text
View BVdb publication page



The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.

Neurobiology Of Aging
Guerreiro, Rita J RJ; Gustafson, Deborah R DR; Hardy, John J
Publication Date: 2012-03

Variant appearance in text: rs2510038
PubMed Link: 20594621
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identifying genetic interactions in genome-wide data using Bayesian networks.

Genetic Epidemiology
Jiang, Xia X; Barmada, M Michael MM; Visweswaran, Shyam S
Publication Date: 2010-09

Variant appearance in text: rs2510038
PubMed Link: 20568290
Variant Present in the following documents:
  • Main text
View BVdb publication page



GAB2 is not associated with late-onset Alzheimer's disease in Japanese.

European Journal Of Human Genetics : Ejhg
Miyashita, Akinori A; Arai, Hiroyuki H; Asada, Takashi T; Imagawa, Masaki M; Shoji, Mikio M; Higuchi, Susumu S; Urakami, Katsuya K; Toyabe, Shinichi S; Akazawa, Kohei K; Kanazawa, Ichiro I; Ihara, Yasuo Y; Kuwano, Ryozo R
Publication Date: 2009-05

Variant appearance in text: rs2510038
PubMed Link: 18854865
Variant Present in the following documents:
  • Main text
View BVdb publication page



GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

Neuron
Reiman, Eric M EM; Webster, Jennifer A JA; Myers, Amanda J AJ; Hardy, John J; Dunckley, Travis T; Zismann, Victoria L VL; Joshipura, Keta D KD; Pearson, John V JV; Hu-Lince, Diane D; Huentelman, Matthew J MJ; Craig, David W DW; Coon, Keith D KD; Liang, Winnie S WS; Herbert, RiLee H RH; Beach, Thomas T; Rohrer, Kristen C KC; Zhao, Alice S AS; Leung, Doris D; Bryden, Leslie L; Marlowe, Lauren L; Kaleem, Mona M; Mastroeni, Diego D; Grover, Andrew A; Heward, Christopher B CB; Ravid, Rivka R; Rogers, Joseph J; Hutton, Michael L ML; Melquist, Stacey S; Petersen, Ron C RC; Alexander, Gene E GE; Caselli, Richard J RJ; Kukull, Walter W; Papassotiropoulos, Andreas A; Stephan, Dietrich A DA
Publication Date: 2007-06-07

Variant appearance in text: rs2510038
PubMed Link: 17553421
Variant Present in the following documents:
  • Main text
View BVdb publication page