Single Nucleotide Polymorphisms' Causal Structure Robustness within Coronary Artery Disease Patients.
Biology
Ganopoulou, Maria M; Moysiadis, Theodoros T; Gounaris, Anastasios A; Mittas, Nikolaos N; Chatzopoulou, Fani F; Chatzidimitriou, Dimitrios D; Sianos, Georgios G; Vizirianakis, Ioannis S IS; Angelis, Lefteris L
Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.
Nature Communications
Han, Younghun Y; Byun, Jinyoung J; Zhu, Catherine C; Sun, Ryan R; Roh, Julia Y JY; Cordell, Heather J HJ; Lee, Hyun-Sung HS; Shaw, Vikram R VR; Kang, Sung Wook SW; Razjouyan, Javad J; Cooley, Matthew A MA; Hassan, Manal M MM; Siminovitch, Katherine A KA; Folseraas, Trine T; Ellinghaus, David D; Bergquist, Annika A; Rushbrook, Simon M SM; Franke, Andre A; Karlsen, Tom H TH; Lazaridis, Konstantinos N KN; , ; McGlynn, Katherine A KA; Roberts, Lewis R LR; Amos, Christopher I CI
CTLA4, SH2B3 and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of type 1 diabetes patients.
Clinical And Experimental Immunology
Vandewalle, Julie J; Desouter, Aster K AK; Van der Auwera, Bart J BJ; Tenoutasse, Sylvie S; Gillard, Pieter P; De Block, Christophe C; Keymeulen, Bart B; Gorus, Frans K FK; Van de Casteele, Mark M; ,
Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia.
Life (Basel, Switzerland)
Abramova, Maria M; Churnosova, Maria M; Efremova, Olesya O; Aristova, Inna I; Reshetnikov, Evgeny E; Polonikov, Alexey A; Churnosov, Mikhail M; Ponomarenko, Irina I
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.
Nature Communications
Levin, Michael G MG; Tsao, Noah L NL; Singhal, Pankhuri P; Liu, Chang C; Vy, Ha My T HMT; Paranjpe, Ishan I; Backman, Joshua D JD; Bellomo, Tiffany R TR; Bone, William P WP; Biddinger, Kiran J KJ; Hui, Qin Q; Dikilitas, Ozan O; Satterfield, Benjamin A BA; Yang, Yifan Y; Morley, Michael P MP; Bradford, Yuki Y; Burke, Megan M; Reza, Nosheen N; Charest, Brian B; , ; Judy, Renae L RL; Puckelwartz, Megan J MJ; Hakonarson, Hakon H; Khan, Atlas A; Kottyan, Leah C LC; Kullo, Iftikhar I; Luo, Yuan Y; McNally, Elizabeth M EM; Rasmussen-Torvik, Laura J LJ; Day, Sharlene M SM; Do, Ron R; Phillips, Lawrence S LS; Ellinor, Patrick T PT; Nadkarni, Girish N GN; Ritchie, Marylyn D MD; Arany, Zoltan Z; Cappola, Thomas P TP; Margulies, Kenneth B KB; Aragam, Krishna G KG; Haggerty, Christopher M CM; Joseph, Jacob J; Sun, Yan V YV; Voight, Benjamin F BF; Damrauer, Scott M SM
Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits.
Nature Communications
Liu, Lili L; Khan, Atlas A; Sanchez-Rodriguez, Elena E; Zanoni, Francesca F; Li, Yifu Y; Steers, Nicholas N; Balderes, Olivia O; Zhang, Junying J; Krithivasan, Priya P; LeDesma, Robert A RA; Fischman, Clara C; Hebbring, Scott J SJ; Harley, John B JB; Moncrieffe, Halima H; Kottyan, Leah C LC; Namjou-Khales, Bahram B; Walunas, Theresa L TL; Knevel, Rachel R; Raychaudhuri, Soumya S; Karlson, Elizabeth W EW; Denny, Joshua C JC; Stanaway, Ian B IB; Crosslin, David D; Rauen, Thomas T; Floege, Jürgen J; Eitner, Frank F; Moldoveanu, Zina Z; Reily, Colin C; Knoppova, Barbora B; Hall, Stacy S; Sheff, Justin T JT; Julian, Bruce A BA; Wyatt, Robert J RJ; Suzuki, Hitoshi H; Xie, Jingyuan J; Chen, Nan N; Zhou, Xujie X; Zhang, Hong H; Hammarström, Lennart L; Viktorin, Alexander A; Magnusson, Patrik K E PKE; Shang, Ning N; Hripcsak, George G; Weng, Chunhua C; Rundek, Tatjana T; Elkind, Mitchell S V MSV; Oelsner, Elizabeth C EC; Barr, R Graham RG; Ionita-Laza, Iuliana I; Novak, Jan J; Gharavi, Ali G AG; Kiryluk, Krzysztof K
Next-generation whole exome sequencing to delineate the genetic basis of primary congenital glaucoma.
Scientific Reports
Rauf, Bushra B; Khan, Shahid Y SY; Jiao, Xiaodong X; Irum, Bushra B; Ashfaq, Ramla R; Zehra, Mubashra M; Khan, Asma A AA; Naeem, Muhammad Asif MA; Shahzad, Mohsin M; Riazuddin, Sheikh S; Hejtmancik, J Fielding JF; Riazuddin, S Amer SA
Visualizing novel connections and genetic similarities across diseases using a network-medicine based approach.
Scientific Reports
Ferolito, Brian B; do Valle, Italo Faria IF; Gerlovin, Hanna H; Costa, Lauren L; Casas, Juan P JP; Gaziano, J Michael JM; Gagnon, David R DR; Begoli, Edmon E; Barabási, Albert-László AL; Cho, Kelly K
Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions.
Npj Parkinson'S Disease
Cukier, Holly N HN; Kim, Hyunjin H; Griswold, Anthony J AJ; Codreanu, Simona G SG; Prince, Lisa M LM; Sherrod, Stacy D SD; McLean, John A JA; Dykxhoorn, Derek M DM; Ess, Kevin C KC; Hedera, Peter P; Bowman, Aaron B AB; Neely, M Diana MD
Analysis of Tryptophan and Its Main Metabolite Kynurenine and the Risk of Multiple Cancers Based on the Bidirectional Mendelian Randomization Analysis.
Frontiers In Oncology
Li, Ran R; Wang, Xuanyang X; Zhang, Yuntao Y; Xu, Xiaoqing X; Wang, Lulu L; Wei, Chunbo C; Liu, Lin L; Wang, Ziqi Z; Li, Ying Y
Physician-Confirmed and Administrative Definitions of Stroke in UK Biobank Reflect the Same Underlying Genetic Trait.
Frontiers In Neurology
Rannikmäe, Kristiina K; Rawlik, Konrad K; Ferguson, Amy C AC; Avramidis, Nikos N; Jiang, Muchen M; Pirastu, Nicola N; Shen, Xia X; Davidson, Emma E; Woodfield, Rebecca R; Malik, Rainer R; Dichgans, Martin M; Tenesa, Albert A; Sudlow, Cathie C
The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction.
Frontiers In Pharmacology
Trompet, Stella S; Postmus, Iris I; Warren, Helen R HR; Noordam, Raymond R; Smit, Roelof A J RAJ; Theusch, Elizabeth E; Li, Xiaohui X; Arsenault, Benoit B; Chasman, Daniel I DI; Hitman, Graham A GA; Munroe, Patricia B PB; Rotter, Jerome I JI; Psaty, Bruce M BM; Caulfield, Mark J MJ; Krauss, Ron M RM; Cupples, Adrienne L AL; Jukema, Wouter J WJ
Personalized Cell Therapy for Patients with Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-Based Responder and Non-Responder Prediction.
Cells
Salybekov, Amankeldi A AA; Wolfien, Markus M; Kobayashi, Shuzo S; Steinhoff, Gustav G; Asahara, Takayuki T
Personalized Cell Therapy for Patients with Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-Based Responder and Non-Responder Prediction.
Cells
Salybekov, Amankeldi A AA; Wolfien, Markus M; Kobayashi, Shuzo S; Steinhoff, Gustav G; Asahara, Takayuki T
Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
Circulation
Dou, Huijuan H; Kotini, Andriana A; Liu, Wenli W; Fidler, Trevor T; Endo-Umeda, Kaori K; Sun, Xiaoli X; Olszewska, Malgorzata M; Xiao, Tong T; Abramowicz, Sandra S; Yalcinkaya, Mustafa M; Hardaway, Brian B; Tsimikas, Sotirios S; Que, Xuchu X; Bick, Alexander A; Emdin, Conor C; Natarajan, Pradeep P; Papapetrou, Eirini P EP; Witztum, Joseph L JL; Wang, Nan N; Tall, Alan R AR
Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
Circulation
Dou, Huijuan H; Kotini, Andriana A; Liu, Wenli W; Fidler, Trevor T; Endo Umeda, Kaori K; Sun, Xiaoli X; Olszewska, Malgorzata M; Xiao, Tong T; Abramowicz, Sandra S; Yalcinkaya, Mustafa M; Hardaway, Brian B; Tsimikas, Sotirios S; Que, Xuchu X; Bick, Alexander A; Emdin, Connor C; Natarajan, Pradeep P; Papapetrou, Eirini P EP; Witztum, Joseph L JL; Wang, Nan N; Tall, Alan R AR
Epione application: An integrated web‑toolkit of clinical genomics and personalized medicine in systemic lupus erythematosus.
International Journal Of Molecular Medicine
Papageorgiou, Louis L; Alkenaris, Haris H; Zervou, Maria I MI; Vlachakis, Dimitriοs D; Matalliotakis, Ioannis I; Spandidos, Demetrios A DA; Bertsias, George G; Goulielmos, George N GN; Eliopoulos, Elias E
Epidemiology, management and the associated burden of mental health illness, atopic and autoimmune conditions, and common infections in alopecia areata: protocol for an observational study series.
Bmj Open
Harries, Matthew M; Macbeth, Abby E AE; Holmes, Susan S; Thompson, Andrew R AR; Chiu, Wing Sin WS; Gallardo, William Romero WR; Messenger, Andrew G AG; Tziotzios, Christos C; de Lusignan, Simon S
Analysis of the Potential Genetic Links between Psoriasis and Cardiovascular Risk Factors.
International Journal Of Molecular Sciences
Purzycka-Bohdan, Dorota D; Kisielnicka, Anna A; Bohdan, Michał M; Szczerkowska-Dobosz, Aneta A; Sobalska-Kwapis, Marta M; Nedoszytko, Bogusław B; Nowicki, Roman J RJ
Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.
Genome Biology
Ge, Xiangyu X; Frank-Bertoncelj, Mojca M; Klein, Kerstin K; McGovern, Amanda A; Kuret, Tadeja T; Houtman, Miranda M; Burja, Blaž B; Micheroli, Raphael R; Shi, Chenfu C; Marks, Miriam M; Filer, Andrew A; Buckley, Christopher D CD; Orozco, Gisela G; Distler, Oliver O; Morris, Andrew P AP; Martin, Paul P; Eyre, Stephen S; Ospelt, Caroline C
The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene.
Scientific Reports
Bagheri, Minoo M; Wang, Chuan C; Shi, Mingjian M; Manouchehri, Ali A; Murray, Katherine T KT; Murphy, Matthew B MB; Shaffer, Christian M CM; Singh, Kritika K; Davis, Lea K LK; Jarvik, Gail P GP; Stanaway, Ian B IB; Hebbring, Scott S; Reilly, Muredach P MP; Gerszten, Robert E RE; Wang, Thomas J TJ; Mosley, Jonathan D JD; Ferguson, Jane F JF