Variant ID: 12-121424861-A-T

NM_000545.5(HNF1A):c.327-1775A>T

This variant was identified in 61 publications




Publications:


The effect of liver enzymes on body composition: A Mendelian randomization study.

Plos One
J Liu, SL Au Yeung, MK Kwok, JYY Leung, LL Hui, GM Leung, CM Schooling
Publication Date: 2020

Variant appearance in text: rs7310409
PubMed Link: 32045441
Variant Present in the following documents:
  • Main text
View BVdb publication page



The effect of liver enzymes on adiposity: a Mendelian randomization study.

Scientific Reports
J Liu, SL Au Yeung, MK Kwok, JYY Leung, SL Lin, LL Hui, GM Leung, CM Schooling
Publication Date: 2019-11-14

Variant appearance in text: rs7310409
PubMed Link: 31727910
Variant Present in the following documents:
  • 41598_2019_52489_MOESM1_ESM.docx
View BVdb publication page



Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study.

Plos One
LG Best, P Balakrishnan, SA Cole, K Haack, JM Kocarnik, N Pankratz, MZ Anderson, N Franceschini, BV Howard, ET Lee, KE North, JG Umans, JM Yracheta, A Navas-Acien, VS Voruganti
Publication Date: 2019

Variant appearance in text: rs7310409
PubMed Link: 31622379
Variant Present in the following documents:
  • pone.0223574.s003.docx
  • pone.0223574.s002.docx
  • Main text
View BVdb publication page



Genetic architecture of human plasma lipidome and its link to cardiovascular disease.

Nature Communications
R Tabassum, JT Rämö, P Ripatti, JT Koskela, M Kurki, J Karjalainen, P Palta, S Hassan, J Nunez-Fontarnau, TTJ Kiiskinen, S Söderlund, N Matikainen, MJ Gerl, MA Surma, C Klose, NO Stitziel, H Laivuori, AS Havulinna, SK Service, V Salomaa, M Pirinen, , M Jauhiainen, MJ Daly, NB Freimer, A Palotie, MR Taskinen, K Simons, S Ripatti
Publication Date: 2019-09-24

Variant appearance in text: rs7310409
PubMed Link: 31551469
Variant Present in the following documents:
  • 41467_2019_11954_MOESM14_ESM.xlsx
  • 41467_2019_11954_MOESM13_ESM.xlsx
View BVdb publication page



Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium.

Obesity (Silver Spring, Md.)
KA Young, ND Palmer, TE Fingerlin, CD Langefeld, JM Norris, N Wang, AH Xiang, X Guo, AH Williams, YI Chen, KD Taylor, JI Rotter, LJ Raffel, MO Goodarzi, RM Watanabe, LE Wagenknecht
Publication Date: 2019-08

Variant appearance in text: rs7310409
PubMed Link: 31219225
Variant Present in the following documents:
  • Main text
  • nihms-1528348.pdf
View BVdb publication page



Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study.

Diabetes
NMG De Silva, MC Borges, AD Hingorani, J Engmann, T Shah, X Zhang, J Luan, C Langenberg, A Wong, D Kuh, JC Chambers, W Zhang, MR Jarvelin, S Sebert, J Auvinen, , TR Gaunt, DA Lawlor
Publication Date: 2019-08

Variant appearance in text: rs7310409
PubMed Link: 31088856
Variant Present in the following documents:
  • Supplemental file
  • Main text
View BVdb publication page



Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease.

Arteriosclerosis, Thrombosis, And Vascular Biology
AO Akinkuolie, PR Lawler, AY Chu, M Caulfield, J Mu, B Ding, F Nyberg, RJ Glynn, PM Ridker, E Hurt-Camejo, DI Chasman, S Mora
Publication Date: 2019-06

Variant appearance in text: rs7310409
PubMed Link: 31070471
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease.

Biomed Research International
Z Xu, H Liu, C Sun, K Si, Y Zhao, Z Zheng
Publication Date: 2018

Variant appearance in text: rs7310409
PubMed Link: 30671475
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Nature Communications
TO Kilpeläinen, AR Bentley, R Noordam, YJ Sung, K Schwander, TW Winkler, H Jakupović, DI Chasman, A Manning, I Ntalla, H Aschard, MR Brown, L de Las Fuentes, N Franceschini, X Guo, D Vojinovic, S Aslibekyan, MF Feitosa, M Kho, SK Musani, M Richard, H Wang, Z Wang, TM Bartz, LF Bielak, A Campbell, R Dorajoo, V Fisher, FP Hartwig, ARVR Horimoto, C Li, KK Lohman, J Marten, X Sim, AV Smith, SM Tajuddin, M Alver, M Amini, M Boissel, JF Chai, X Chen, J Divers, E Evangelou, C Gao, M Graff, SE Harris, M He, FC Hsu, AU Jackson, JH Zhao, AT Kraja, B Kühnel, F Laguzzi, LP Lyytikäinen, IM Nolte, R Rauramaa, M Riaz, A Robino, R Rueedi, HM Stringham, F Takeuchi, PJ van der Most, TV Varga, N Verweij, EB Ware, W Wen, X Li, LR Yanek, N Amin, DK Arnett, E Boerwinkle, M Brumat, B Cade, M Canouil, YI Chen, MP Concas, J Connell, R de Mutsert, HJ de Silva, PS de Vries, A Demirkan, J Ding, CB Eaton, JD Faul, Y Friedlander, KP Gabriel, M Ghanbari, F Giulianini, CC Gu, D Gu, TB Harris, J He, S Heikkinen, CK Heng, SC Hunt, MA Ikram, JB Jonas, WP Koh, P Komulainen, JE Krieger, SB Kritchevsky, Z Kutalik, J Kuusisto, CD Langefeld, C Langenberg, LJ Launer, K Leander, RN Lemaitre, CE Lewis, J Liang, , J Liu, R Mägi, A Manichaikul, T Meitinger, A Metspalu, Y Milaneschi, KL Mohlke, TH Mosley, AD Murray, MA Nalls, EK Nang, CP Nelson, S Nona, JM Norris, CV Nwuba, J O'Connell, ND Palmer, GJ Papanicolau, R Pazoki, NL Pedersen, A Peters, PA Peyser, O Polasek, DJ Porteous, A Poveda, OT Raitakari, SS Rich, N Risch, JG Robinson, LM Rose, I Rudan, PJ Schreiner, RA Scott, SS Sidney, M Sims, JA Smith, H Snieder, T Sofer, JM Starr, B Sternfeld, K Strauch, H Tang, KD Taylor, MY Tsai, J Tuomilehto, AG Uitterlinden, MY van der Ende, D van Heemst, T Voortman, M Waldenberger, P Wennberg, G Wilson, YB Xiang, J Yao, C Yu, JM Yuan, W Zhao, AB Zonderman, DM Becker, M Boehnke, DW Bowden, U de Faire, IJ Deary, P Elliott, T Esko, BI Freedman, P Froguel, P Gasparini, C Gieger, N Kato, M Laakso, TA Lakka, T Lehtimäki, PKE Magnusson, AJ Oldehinkel, BWJH Penninx, NJ Samani, XO Shu, P van der Harst, JV Van Vliet-Ostaptchouk, P Vollenweider, LE Wagenknecht, YX Wang, NJ Wareham, DR Weir, T Wu, W Zheng, X Zhu, MK Evans, PW Franks, V Gudnason, C Hayward, BL Horta, TN Kelly, Y Liu, KE North, AC Pereira, PM Ridker, ES Tai, RM van Dam, ER Fox, SLR Kardia, CT Liu, DO Mook-Kanamori, MA Province, S Redline, CM van Duijn, JI Rotter, CB Kooperberg, WJ Gauderman, BM Psaty, K Rice, PB Munroe, M Fornage, LA Cupples, CN Rotimi, AC Morrison, DC Rao, RJF Loos
Publication Date: 2019-01-22

Variant appearance in text: rs7310409
PubMed Link: 30670697
Variant Present in the following documents:
  • 41467_2018_8008_MOESM10_ESM.xlsx
  • 41467_2018_8008_MOESM7_ESM.xlsx
View BVdb publication page



Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.

Nature Communications
E Ferkingstad, A Oddsson, S Gretarsdottir, S Benonisdottir, G Thorleifsson, AM Deaton, S Jonsson, OA Stefansson, GL Norddahl, F Zink, GA Arnadottir, B Gunnarsson, GH Halldorsson, A Helgadottir, BO Jensson, RP Kristjansson, G Sveinbjornsson, DA Sverrisson, G Masson, I Olafsson, GI Eyjolfsson, O Sigurdardottir, H Holm, I Jonsdottir, S Olafsson, T Steingrimsdottir, T Rafnar, ES Bjornsson, U Thorsteinsdottir, DF Gudbjartsson, P Sulem, K Stefansson
Publication Date: 2018-11-30

Variant appearance in text: rs7310409
PubMed Link: 30504769
Variant Present in the following documents:
  • 41467_2018_7460_MOESM9_ESM.xlsx
View BVdb publication page



Mendelian randomization analysis of C-reactive protein on colorectal cancer risk.

International Journal Of Epidemiology
X Wang, JY Dai, D Albanes, V Arndt, SI Berndt, S Bézieau, H Brenner, DD Buchanan, K Butterbach, B Caan, G Casey, PT Campbell, AT Chan, Z Chen, J Chang-Claude, M Cotterchio, DF Easton, GG Giles, E Giovannucci, WM Grady, M Hoffmeister, JL Hopper, L Hsu, MA Jenkins, AD Joshi, JW Lampe, SC Larsson, F Lejbkowicz, L Li, A Lindblom, L Le Marchand, V Martin, RL Milne, V Moreno, PA Newcomb, K Offitt, S Ogino, PDP Pharoah, M Pinchev, JD Potter, HS Rennert, G Rennert, W Saliba, C Schafmayer, RE Schoen, P Schrotz-King, ML Slattery, M Song, C Stegmaier, SJ Weinstein, A Wolk, MO Woods, AH Wu, SB Gruber, U Peters, E White
Publication Date: 2019-06-01

Variant appearance in text: rs7310409
PubMed Link: 30476131
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic polymorphisms of diabetes-related genes, their interaction with diabetes status, and breast cancer incidence and mortality: The Long Island Breast Cancer Study Project.

Molecular Carcinogenesis
H Parada, RJ Cleveland, KE North, J Stevens, SL Teitelbaum, AI Neugut, RM Santella, ME Martinez, MD Gammon
Publication Date: 2019-03

Variant appearance in text: rs7310409
PubMed Link: 30457165
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

American Journal Of Human Genetics
S Ligthart, A Vaez, U Võsa, MG Stathopoulou, PS de Vries, BP Prins, PJ Van der Most, T Tanaka, E Naderi, LM Rose, Y Wu, R Karlsson, M Barbalic, H Lin, R Pool, G Zhu, A Macé, C Sidore, S Trompet, M Mangino, M Sabater-Lleal, JP Kemp, A Abbasi, T Kacprowski, N Verweij, AV Smith, T Huang, C Marzi, MF Feitosa, KK Lohman, ME Kleber, Y Milaneschi, C Mueller, M Huq, E Vlachopoulou, LP Lyytikäinen, C Oldmeadow, J Deelen, M Perola, JH Zhao, B Feenstra, , M Amini, , J Lahti, KE Schraut, M Fornage, B Suktitipat, WM Chen, X Li, T Nutile, G Malerba, J Luan, T Bak, N Schork, F Del Greco M, E Thiering, A Mahajan, RE Marioni, E Mihailov, J Eriksson, AB Ozel, W Zhang, M Nethander, YC Cheng, S Aslibekyan, W Ang, I Gandin, L Yengo, L Portas, C Kooperberg, E Hofer, KB Rajan, C Schurmann, W den Hollander, TS Ahluwalia, J Zhao, HHM Draisma, I Ford, N Timpson, A Teumer, H Huang, S Wahl, Y Liu, J Huang, HW Uh, F Geller, PK Joshi, LR Yanek, E Trabetti, B Lehne, D Vozzi, M Verbanck, G Biino, Y Saba, I Meulenbelt, JR O'Connell, M Laakso, F Giulianini, PKE Magnusson, CM Ballantyne, JJ Hottenga, GW Montgomery, F Rivadineira, R Rueedi, M Steri, KH Herzig, DJ Stott, C Menni, M Frånberg, B St Pourcain, SB Felix, TH Pers, SJL Bakker, P Kraft, A Peters, D Vaidya, G Delgado, JH Smit, V Großmann, J Sinisalo, I Seppälä, SR Williams, EG Holliday, M Moed, C Langenberg, K Räikkönen, J Ding, H Campbell, MM Sale, YI Chen, AL James, D Ruggiero, N Soranzo, CA Hartman, EN Smith, GS Berenson, C Fuchsberger, D Hernandez, CMT Tiesler, V Giedraitis, D Liewald, K Fischer, D Mellström, A Larsson, Y Wang, WR Scott, M Lorentzon, J Beilby, KA Ryan, CE Pennell, D Vuckovic, B Balkau, MP Concas, R Schmidt, CF Mendes de Leon, EP Bottinger, M Kloppenburg, L Paternoster, M Boehnke, AW Musk, G Willemsen, DM Evans, PAF Madden, M Kähönen, Z Kutalik, M Zoledziewska, V Karhunen, SB Kritchevsky, N Sattar, G Lachance, R Clarke, TB Harris, OT Raitakari, JR Attia, D van Heemst, E Kajantie, R Sorice, G Gambaro, RA Scott, AA Hicks, L Ferrucci, M Standl, CM Lindgren, JM Starr, M Karlsson, L Lind, JZ Li, JC Chambers, TA Mori, EJCN de Geus, AC Heath, NG Martin, J Auvinen, BM Buckley, AJM de Craen, M Waldenberger, K Strauch, T Meitinger, RJ Scott, M McEvoy, M Beekman, C Bombieri, PM Ridker, KL Mohlke, NL Pedersen, AC Morrison, DI Boomsma, JB Whitfield, DP Strachan, A Hofman, P Vollenweider, F Cucca, MR Jarvelin, JW Jukema, TD Spector, A Hamsten, T Zeller, AG Uitterlinden, M Nauck, V Gudnason, L Qi, H Grallert, IB Borecki, JI Rotter, W März, PS Wild, ML Lokki, M Boyle, V Salomaa, M Melbye, JG Eriksson, JF Wilson, BWJH Penninx, DM Becker, BB Worrall, G Gibson, RM Krauss, M Ciullo, G Zaza, NJ Wareham, AJ Oldehinkel, LJ Palmer, SS Murray, PP Pramstaller, S Bandinelli, J Heinrich, E Ingelsson, IJ Deary, R Mägi, L Vandenput, P van der Harst, KC Desch, JS Kooner, C Ohlsson, C Hayward, T Lehtimäki, AR Shuldiner, DK Arnett, LJ Beilin, A Robino, P Froguel, M Pirastu, T Jess, W Koenig, RJF Loos, DA Evans, H Schmidt, GD Smith, PE Slagboom, G Eiriksdottir, AP Morris, BM Psaty, RP Tracy, IM Nolte, E Boerwinkle, S Visvikis-Siest, AP Reiner, M Gross, JC Bis, L Franke, OH Franco, EJ Benjamin, DI Chasman, J Dupuis, H Snieder, A Dehghan, BZ Alizadeh
Publication Date: 2018-11-01

Variant appearance in text: rs7310409
PubMed Link: 30388399
Variant Present in the following documents:
  • Main text
  • mmc2.xlsx
View BVdb publication page



Prediction model for pancreatic cancer risk in the general Japanese population.

Plos One
M Nakatochi, Y Lin, H Ito, K Hara, F Kinoshita, Y Kobayashi, H Ishii, M Ozaka, T Sasaki, N Sasahira, M Morimoto, S Kobayashi, M Ueno, S Ohkawa, N Egawa, S Kuruma, M Mori, H Nakao, C Wang, T Nishiyama, T Kawaguchi, M Takahashi, F Matsuda, S Kikuchi, K Matsuo
Publication Date: 2018

Variant appearance in text: rs7310409
PubMed Link: 30192808
Variant Present in the following documents:
  • pone.0203386.s002.xlsx
  • pone.0203386.s001.docx
View BVdb publication page



Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

Nature Communications
C Yao, G Chen, C Song, J Keefe, M Mendelson, T Huan, BB Sun, A Laser, JC Maranville, H Wu, JE Ho, P Courchesne, A Lyass, MG Larson, C Gieger, J Graumann, AD Johnson, J Danesh, H Runz, SJ Hwang, C Liu, AS Butterworth, K Suhre, D Levy
Publication Date: 2018-08-15

Variant appearance in text: rs7310409
PubMed Link: 30111768
Variant Present in the following documents:
  • 41467_2018_5512_MOESM11_ESM.xlsx
  • 41467_2018_5512_MOESM7_ESM.xlsx
View BVdb publication page



HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties.

Elife
EV Abel, M Goto, B Magnuson, S Abraham, N Ramanathan, E Hotaling, AA Alaniz, C Kumar-Sinha, ML Dziubinski, S Urs, L Wang, J Shi, M Waghray, M Ljungman, HC Crawford, DM Simeone
Publication Date: 2018-08-03

Variant appearance in text: rs7310409
PubMed Link: 30074477
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Nature Communications
AP Klein, BM Wolpin, HA Risch, RZ Stolzenberg-Solomon, E Mocci, M Zhang, F Canzian, EJ Childs, JW Hoskins, A Jermusyk, J Zhong, F Chen, D Albanes, G Andreotti, AA Arslan, A Babic, WR Bamlet, L Beane-Freeman, SI Berndt, A Blackford, M Borges, A Borgida, PM Bracci, L Brais, P Brennan, H Brenner, B Bueno-de-Mesquita, J Buring, D Campa, G Capurso, GM Cavestro, KG Chaffee, CC Chung, S Cleary, M Cotterchio, F Dijk, EJ Duell, L Foretova, C Fuchs, N Funel, S Gallinger, JM M Gaziano, M Gazouli, GG Giles, E Giovannucci, M Goggins, GE Goodman, PJ Goodman, T Hackert, C Haiman, P Hartge, M Hasan, P Hegyi, KJ Helzlsouer, J Herman, I Holcatova, EA Holly, R Hoover, RJ Hung, EJ Jacobs, K Jamroziak, V Janout, R Kaaks, KT Khaw, EA Klein, M Kogevinas, C Kooperberg, MH Kulke, J Kupcinskas, RJ Kurtz, D Laheru, S Landi, RT Lawlor, IM Lee, L LeMarchand, L Lu, N Malats, A Mambrini, S Mannisto, RL Milne, B Mohelníková-Duchoňová, RE Neale, JP Neoptolemos, AL Oberg, SH Olson, I Orlow, C Pasquali, AV Patel, U Peters, R Pezzilli, M Porta, FX Real, N Rothman, G Scelo, HD Sesso, G Severi, XO Shu, D Silverman, JP Smith, P Soucek, M Sund, R Talar-Wojnarowska, F Tavano, MD Thornquist, GS Tobias, SK Van Den Eeden, Y Vashist, K Visvanathan, P Vodicka, J Wactawski-Wende, Z Wang, N Wentzensen, E White, H Yu, K Yu, A Zeleniuch-Jacquotte, W Zheng, P Kraft, D Li, S Chanock, O Obazee, GM Petersen, LT Amundadottir
Publication Date: 2018-02-08

Variant appearance in text: rs7310409
PubMed Link: 29422604
Variant Present in the following documents:
  • Main text
View BVdb publication page



Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms.

Carcinogenesis
O Obazee, G Capurso, F Tavano, L Archibugi, A De Bonis, W Greenhalf, T Key, C Pasquali, AC Milanetto, T Hackert, P Fogar, V Liço, C Dervenis, RT Lawlor, L Landoni, M Gazouli, CF Zambon, N Funel, O Strobel, K Jamroziak, C Cantù, E Malecka-Panas, S Landi, JP Neoptolemos, D Basso, R Talar-Wojnarowska, M Rinzivillo, A Andriulli, F Canzian, D Campa
Publication Date: 2018-03-08

Variant appearance in text: rs7310409
PubMed Link: 29309705
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.

Nature Genetics
X Lu, GM Peloso, DJ Liu, Y Wu, H Zhang, W Zhou, J Li, CS Tang, R Dorajoo, H Li, J Long, X Guo, M Xu, CN Spracklen, Y Chen, X Liu, Y Zhang, CC Khor, J Liu, L Sun, L Wang, YT Gao, Y Hu, K Yu, Y Wang, CYY Cheung, F Wang, J Huang, Q Fan, Q Cai, S Chen, J Shi, X Yang, W Zhao, WH Sheu, SS Cherny, M He, AB Feranil, LS Adair, P Gordon-Larsen, S Du, R Varma, YI Chen, XO Shu, KSL Lam, TY Wong, SK Ganesh, Z Mo, K Hveem, LG Fritsche, JB Nielsen, HF Tse, Y Huo, CY Cheng, YE Chen, W Zheng, ES Tai, W Gao, X Lin, W Huang, G Abecasis, , S Kathiresan, KL Mohlke, T Wu, PC Sham, D Gu, CJ Willer
Publication Date: 2017-12

Variant appearance in text: rs7310409
PubMed Link: 29083407
Variant Present in the following documents:
  • NIHMS909133-supplement-2.xlsx
View BVdb publication page



Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L.

Frontiers In Pharmacology
A Labriet, E De Mattia, E Cecchin, É Lévesque, D Jonker, F Couture, A Buonadonna, M D'Andrea, L Villeneuve, G Toffoli, C Guillemette
Publication Date: 2017

Variant appearance in text: rs7310409
PubMed Link: 29066969
Variant Present in the following documents:
  • Table_1.pdf
View BVdb publication page



Variation in Maturity-Onset Diabetes of the Young Genes Influence Response to Interventions for Diabetes Prevention.

The Journal Of Clinical Endocrinology And Metabolism
LK Billings, KA Jablonski, AS Warner, YC Cheng, JB McAteer, L Tipton, AR Shuldiner, DA Ehrmann, AK Manning, D Dabelea, PW Franks, SE Kahn, TI Pollin, WC Knowler, D Altshuler, JC Florez,
Publication Date: 2017-08-01

Variant appearance in text: rs7310409
PubMed Link: 28453780
Variant Present in the following documents:
  • jc.2016-3429.st1.xlsx
View BVdb publication page



Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.

Plos Genetics
L Folkersen, E Fauman, M Sabater-Lleal, RJ Strawbridge, M Frånberg, B Sennblad, D Baldassarre, F Veglia, SE Humphries, R Rauramaa, U de Faire, AJ Smit, P Giral, S Kurl, E Mannarino, S Enroth, Å Johansson, SB Enroth, S Gustafsson, L Lind, C Lindgren, AP Morris, V Giedraitis, A Silveira, A Franco-Cereceda, E Tremoli, , U Gyllensten, E Ingelsson, S Brunak, P Eriksson, D Ziemek, A Hamsten, A Mälarstig
Publication Date: 2017-04

Variant appearance in text: rs7310409
PubMed Link: 28369058
Variant Present in the following documents:
  • pgen.1006706.s004.pdf
View BVdb publication page



Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

Nature Genetics
CM Phelan, KB Kuchenbaecker, JP Tyrer, SP Kar, K Lawrenson, SJ Winham, J Dennis, A Pirie, MJ Riggan, G Chornokur, MA Earp, PC Lyra, JM Lee, S Coetzee, J Beesley, L McGuffog, P Soucy, E Dicks, A Lee, D Barrowdale, J Lecarpentier, G Leslie, CM Aalfs, KKH Aben, M Adams, J Adlard, IL Andrulis, H Anton-Culver, N Antonenkova, , G Aravantinos, N Arnold, BK Arun, B Arver, J Azzollini, J Balmaña, SN Banerjee, L Barjhoux, RB Barkardottir, Y Bean, MW Beckmann, A Beeghly-Fadiel, J Benitez, M Bermisheva, MQ Bernardini, MJ Birrer, L Bjorge, A Black, K Blankstein, MJ Blok, C Bodelon, N Bogdanova, A Bojesen, B Bonanni, Å Borg, AR Bradbury, JD Brenton, C Brewer, L Brinton, P Broberg, A Brooks-Wilson, F Bruinsma, J Brunet, B Buecher, R Butzow, SS Buys, T Caldes, MA Caligo, I Campbell, R Cannioto, ME Carney, T Cescon, SB Chan, J Chang-Claude, S Chanock, XQ Chen, YE Chiew, J Chiquette, WK Chung, KBM Claes, T Conner, LS Cook, J Cook, DW Cramer, JM Cunningham, AA D'Aloisio, MB Daly, F Damiola, SD Damirovna, A Dansonka-Mieszkowska, F Dao, R Davidson, A DeFazio, C Delnatte, KF Doheny, O Diez, YC Ding, JA Doherty, SM Domchek, CM Dorfling, T Dörk, L Dossus, M Duran, M Dürst, B Dworniczak, D Eccles, T Edwards, R Eeles, U Eilber, B Ejlertsen, AB Ekici, S Ellis, M Elvira, , KH Eng, C Engel, DG Evans, PA Fasching, S Ferguson, SF Ferrer, JM Flanagan, ZC Fogarty, RT Fortner, F Fostira, WD Foulkes, G Fountzilas, BL Fridley, TM Friebel, E Friedman, D Frost, PA Ganz, J Garber, MJ García, V Garcia-Barberan, A Gehrig, , A Gentry-Maharaj, AM Gerdes, GG Giles, R Glasspool, G Glendon, AK Godwin, DE Goldgar, T Goranova, M Gore, MH Greene, J Gronwald, S Gruber, E Hahnen, CA Haiman, N Håkansson, U Hamann, TVO Hansen, PA Harrington, HR Harris, J Hauke, , A Hein, A Henderson, MAT Hildebrandt, P Hillemanns, S Hodgson, CK Høgdall, E Høgdall, FBL Hogervorst, H Holland, MJ Hooning, K Hosking, RY Huang, PJ Hulick, J Hung, DJ Hunter, DG Huntsman, T Huzarski, EN Imyanitov, C Isaacs, ES Iversen, L Izatt, A Izquierdo, A Jakubowska, P James, R Janavicius, M Jernetz, A Jensen, UB Jensen, EM John, S Johnatty, ME Jones, P Kannisto, BY Karlan, A Karnezis, K Kast, , CJ Kennedy, E Khusnutdinova, LA Kiemeney, JI Kiiski, SW Kim, SK Kjaer, M Köbel, RK Kopperud, TA Kruse, J Kupryjanczyk, A Kwong, Y Laitman, D Lambrechts, N Larrañaga, MC Larson, C Lazaro, ND Le, L Le Marchand, JW Lee, SB Lele, A Leminen, D Leroux, J Lester, F Lesueur, DA Levine, D Liang, C Liebrich, J Lilyquist, L Lipworth, J Lissowska, KH Lu, J Lubinński, C Luccarini, L Lundvall, PL Mai, G Mendoza-Fandiño, S Manoukian, LFAG Massuger, T May, S Mazoyer, JN McAlpine, V McGuire, JR McLaughlin, I McNeish, H Meijers-Heijboer, A Meindl, U Menon, AR Mensenkamp, MA Merritt, RL Milne, G Mitchell, F Modugno, J Moes-Sosnowska, M Moffitt, M Montagna, KB Moysich, AM Mulligan, J Musinsky, KL Nathanson, L Nedergaard, RB Ness, SL Neuhausen, H Nevanlinna, D Niederacher, RL Nussbaum, K Odunsi, E Olah, OI Olopade, H Olsson, C Olswold, DM O'Malley, KR Ong, NC Onland-Moret, , N Orr, S Orsulic, A Osorio, D Palli, L Papi, TW Park-Simon, J Paul, CL Pearce, IS Pedersen, PHM Peeters, B Peissel, A Peixoto, T Pejovic, LM Pelttari, JB Permuth, P Peterlongo, L Pezzani, G Pfeiler, KA Phillips, M Piedmonte, MC Pike, AM Piskorz, SR Poblete, T Pocza, EM Poole, B Poppe, ME Porteous, F Prieur, D Prokofyeva, E Pugh, MA Pujana, P Pujol, P Radice, J Rantala, C Rappaport-Fuerhauser, G Rennert, K Rhiem, P Rice, A Richardson, M Robson, GC Rodriguez, C Rodríguez-Antona, J Romm, MA Rookus, MA Rossing, JH Rothstein, A Rudolph, IB Runnebaum, HB Salvesen, DP Sandler, MJ Schoemaker, L Senter, VW Setiawan, G Severi, P Sharma, T Shelford, N Siddiqui, LE Side, W Sieh, CF Singer, H Sobol, H Song, MC Southey, AB Spurdle, Z Stadler, D Steinemann, D Stoppa-Lyonnet, LE Sucheston-Campbell, G Sukiennicki, R Sutphen, C Sutter, AJ Swerdlow, CI Szabo, L Szafron, YY Tan, JA Taylor, MK Tea, MR Teixeira, SH Teo, KL Terry, PJ Thompson, LCV Thomsen, DL Thull, L Tihomirova, AV Tinker, M Tischkowitz, S Tognazzo, AE Toland, A Tone, B Trabert, RC Travis, A Trichopoulou, N Tung, SS Tworoger, AM van Altena, D Van Den Berg, AH van der Hout, RB van der Luijt, M Van Heetvelde, E Van Nieuwenhuysen, EJ van Rensburg, A Vanderstichele, R Varon-Mateeva, A Vega, DV Edwards, I Vergote, RA Vierkant, J Vijai, A Vratimos, L Walker, C Walsh, D Wand, S Wang-Gohrke, B Wappenschmidt, PM Webb, CR Weinberg, JN Weitzel, N Wentzensen, AS Whittemore, JT Wijnen, LR Wilkens, A Wolk, M Woo, X Wu, AH Wu, H Yang, D Yannoukakos, A Ziogas, KK Zorn, SA Narod, DF Easton, CI Amos, JM Schildkraut, SJ Ramus, L Ottini, MT Goodman, SK Park, LE Kelemen, HA Risch, M Thomassen, K Offit, J Simard, RK Schmutzler, D Hazelett, AN Monteiro, FJ Couch, A Berchuck, G Chenevix-Trench, EL Goode, TA Sellers, SA Gayther, AC Antoniou, PDP Pharoah
Publication Date: 2017-05

Variant appearance in text: rs7310409
PubMed Link: 28346442
Variant Present in the following documents:
  • Main text
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Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development.

Plos One
K Rosta, Z Al-Aissa, O Hadarits, J Harreiter, Á Nádasdi, F Kelemen, D Bancher-Todesca, Z Komlósi, L Németh, J Rigó, I Sziller, A Somogyi, A Kautzky-Willer, G Firneisz
Publication Date: 2017

Variant appearance in text: rs7310409
PubMed Link: 28072873
Variant Present in the following documents:
  • pone.0169781.s003.pdf
  • pone.0169781.s002.pdf
  • pone.0169781.s001.pdf
  • pone.0169781.s004.pdf
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Liver Enzymes and Risk of Ischemic Heart Disease and Type 2 Diabetes Mellitus: A Mendelian Randomization Study.

Scientific Reports
J Liu, SL Au Yeung, SL Lin, GM Leung, CM Schooling
Publication Date: 2016-12-20

Variant appearance in text: rs7310409
PubMed Link: 27996050
Variant Present in the following documents:
  • Main text
  • srep38813-s1.pdf
View BVdb publication page



New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss.

Journal Of Cachexia, Sarcopenia And Muscle
N Johns, C Stretch, BH Tan, TS Solheim, S Sørhaug, NA Stephens, I Gioulbasanis, RJ Skipworth, DA Deans, A Vigano, JA Ross, OF Bathe, ML Tremblay, S Kaasa, F Strasser, B Gagnon, VE Baracos, S Damaraju, KC Fearon
Publication Date: 2017-02

Variant appearance in text: rs7310409
PubMed Link: 27897403
Variant Present in the following documents:
  • JCSM-8-122-s001.docx
View BVdb publication page



Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.

Nature Genetics
V Iotchkova, J Huang, JA Morris, D Jain, C Barbieri, K Walter, JL Min, L Chen, W Astle, M Cocca, P Deelen, H Elding, AE Farmaki, CS Franklin, M Franberg, TR Gaunt, A Hofman, T Jiang, ME Kleber, G Lachance, J Luan, G Malerba, A Matchan, D Mead, Y Memari, I Ntalla, K Panoutsopoulou, R Pazoki, JRB Perry, F Rivadeneira, M Sabater-Lleal, B Sennblad, SY Shin, L Southam, M Traglia, F van Dijk, EM van Leeuwen, G Zaza, W Zhang, , N Amin, A Butterworth, JC Chambers, G Dedoussis, A Dehghan, OH Franco, L Franke, M Frontini, G Gambaro, P Gasparini, A Hamsten, A Issacs, JS Kooner, C Kooperberg, C Langenberg, W Marz, RA Scott, MA Swertz, D Toniolo, AG Uitterlinden, CM van Duijn, H Watkins, E Zeggini, MT Maurano, NJ Timpson, AP Reiner, PL Auer, N Soranzo
Publication Date: 2016-11

Variant appearance in text: rs7310409
PubMed Link: 27668658
Variant Present in the following documents:
  • NIHMS71079-supplement-Supplementary_Data.pdf
View BVdb publication page



Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions.

Npj Genomic Medicine
H Li, I Achour, L Bastarache, J Berghout, V Gardeux, J Li, Y Lee, L Pesce, X Yang, KS Ramos, I Foster, JC Denny, JH Moore, YA Lussier
Publication Date: 2016

Variant appearance in text: rs7310409
PubMed Link: 27482468
Variant Present in the following documents:
  • npjgenmed20166-s4.xls
View BVdb publication page



Association study of C-reactive protein associated gene HNF1A with ischemic stroke in Chinese population.

Bmc Medical Genetics
H Shi, S Leng, H Liang, Y Zheng, L Chen
Publication Date: 2016-07-26

Variant appearance in text: rs7310409
PubMed Link: 27460564
Variant Present in the following documents:
  • Main text
  • 12881_2016_313_MOESM1_ESM.docx
View BVdb publication page



Pancreatic Cancer Genetics.

International Journal Of Biological Sciences
LT Amundadottir
Publication Date: 2016

Variant appearance in text: rs7310409
PubMed Link: 26929738
Variant Present in the following documents:
  • Main text
View BVdb publication page



New insights from monogenic diabetes for "common" type 2 diabetes.

Frontiers In Genetics
DS Tallapragada, S Bhaskar, GR Chandak
Publication Date: 2015

Variant appearance in text: rs7310409
PubMed Link: 26300908
Variant Present in the following documents:
  • Main text
View BVdb publication page



Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels.

Nature Communications
K Setoh, C Terao, S Muro, T Kawaguchi, Y Tabara, M Takahashi, T Nakayama, S Kosugi, A Sekine, R Yamada, M Mishima, F Matsuda
Publication Date: 2015-07-15

Variant appearance in text: rs7310409
PubMed Link: 26174136
Variant Present in the following documents:
  • ncomms8754-s1.pdf
View BVdb publication page



Pancreatic cancer-associated gene polymorphisms in a nation-wide cohort of p16-Leiden germline mutation carriers; a case-control study.

Bmc Research Notes
TP Potjer, N van der Stoep, JJ Houwing-Duistermaat, IC Konings, CM Aalfs, PC van den Akker, MG Ausems, CJ Dommering, LE van der Kolk, MC Maiburg, L Spruijt, A Wagner, HF Vasen, FJ Hes
Publication Date: 2015-06-26

Variant appearance in text: rs7310409
PubMed Link: 26111702
Variant Present in the following documents:
  • Main text
View BVdb publication page



Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

Nature Genetics
EJ Childs, E Mocci, D Campa, PM Bracci, S Gallinger, M Goggins, D Li, RE Neale, SH Olson, G Scelo, LT Amundadottir, WR Bamlet, MF Bijlsma, A Blackford, M Borges, P Brennan, H Brenner, HB Bueno-de-Mesquita, F Canzian, G Capurso, GM Cavestro, KG Chaffee, SJ Chanock, SP Cleary, M Cotterchio, L Foretova, C Fuchs, N Funel, M Gazouli, M Hassan, JM Herman, I Holcatova, EA Holly, RN Hoover, RJ Hung, V Janout, TJ Key, J Kupcinskas, RC Kurtz, S Landi, L Lu, E Malecka-Panas, A Mambrini, B Mohelnikova-Duchonova, JP Neoptolemos, AL Oberg, I Orlow, C Pasquali, R Pezzilli, C Rizzato, A Saldia, A Scarpa, RZ Stolzenberg-Solomon, O Strobel, F Tavano, YK Vashist, P Vodicka, BM Wolpin, H Yu, GM Petersen, HA Risch, AP Klein
Publication Date: 2015-08

Variant appearance in text: rs7310409
PubMed Link: 26098869
Variant Present in the following documents:
  • Main text
  • NIHMS695333-supplement-1.pdf
View BVdb publication page



A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease.

Biochemistry Research International
R Liu, H Liu, H Gu, X Teng, Y Nie, Z Zhou, Y Zhao, S Hu, Z Zheng
Publication Date: 2014

Variant appearance in text: rs7310409
PubMed Link: 25202455
Variant Present in the following documents:
  • Main text
View BVdb publication page



Abstracts of the China Heart Congress, August 7-10, 2014, Beijing, China.

Cardiology
.
Publication Date: 2014

Variant appearance in text: rs7310409
PubMed Link: 25195731
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



A new susceptibility locus for myocardial infarction, hypertension, type 2 diabetes mellitus, and dyslipidemia on chromosome 12q24.

Disease Markers
SM Wakil, NP Muiya, AI Tahir, M Al-Najai, B Baz, E Andres, N Mazhar, N Al Tassan, M Alshahid, BF Meyer, N Dzimiri
Publication Date: 2014

Variant appearance in text: rs7310409
PubMed Link: 25057215
Variant Present in the following documents:
  • Main text
  • 291419.f1.pdf
View BVdb publication page



Cis and trans effects of human genomic variants on gene expression.

Plos Genetics
J Bryois, A Buil, DM Evans, JP Kemp, SB Montgomery, DF Conrad, KM Ho, S Ring, M Hurles, P Deloukas, G Davey Smith, ET Dermitzakis
Publication Date: 2014-07

Variant appearance in text: rs7310409
PubMed Link: 25010687
Variant Present in the following documents:
  • pgen.1004461.s012.xlsx
View BVdb publication page



New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.

Plos One
N Vinayagamoorthy, HJ Hu, SH Yim, SH Jung, J Jo, SH Jee, YJ Chung
Publication Date: 2014

Variant appearance in text: rs7310409
PubMed Link: 24763700
Variant Present in the following documents:
  • pone.0095866.s001.pdf
View BVdb publication page



Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.

Circulation. Cardiovascular Genetics
JM Kocarnik, SA Pendergrass, CL Carty, JS Pankow, FR Schumacher, I Cheng, P Durda, JL Ambite, E Deelman, NR Cook, S Liu, J Wactawski-Wende, C Hutter, K Brown-Gentry, S Wilson, LG Best, N Pankratz, CP Hong, SA Cole, VS Voruganti, P Bůžkova, NW Jorgensen, NS Jenny, LR Wilkens, CA Haiman, LN Kolonel, A Lacroix, K North, R Jackson, L Le Marchand, LA Hindorff, DC Crawford, M Gross, U Peters
Publication Date: 2014-04

Variant appearance in text: rs7310409
PubMed Link: 24622110
Variant Present in the following documents:
  • Main text
  • NIHMS575195-supplement-000173_-_Supplemental_Material.pdf
View BVdb publication page



Biobanking across the phenome - at the center of chronic disease research.

Bmc Public Health
M Imboden, NM Probst-Hensch
Publication Date: 2013-11-25

Variant appearance in text: rs7310409
PubMed Link: 24274136
Variant Present in the following documents:
  • 1471-2458-13-1094-S2.xlsx
View BVdb publication page



Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene.

The Journal Of Pharmacology And Experimental Therapeutics
VP O'Brien, K Bokelmann, J Ramírez, K Jobst, MJ Ratain, J Brockmöller, MV Tzvetkov
Publication Date: 2013-10

Variant appearance in text: rs7310409
PubMed Link: 23922447
Variant Present in the following documents:
  • Main text
View BVdb publication page



Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?

Plos One
R Dorajoo, R Li, MK Ikram, J Liu, P Froguel, J Lee, X Sim, RT Ong, WT Tay, C Peng, TL Young, AI Blakemore, CY Cheng, T Aung, P Mitchell, JJ Wang, CC Klaver, E Boerwinkle, R Klein, DS Siscovick, RA Jensen, V Gudnason, AV Smith, YY Teo, TY Wong, ES Tai, CK Heng, Y Friedlander
Publication Date: 2013

Variant appearance in text: rs7310409
PubMed Link: 23844046
Variant Present in the following documents:
  • Main text
  • pone.0067650.s001.doc
View BVdb publication page



SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.

European Journal Of Human Genetics : Ejhg
OD Meirelles, J Ding, T Tanaka, S Sanna, HT Yang, DB Dudekula, F Cucca, L Ferrucci, G Abecasis, D Schlessinger
Publication Date: 2013-06

Variant appearance in text: rs7310409
PubMed Link: 23092954
Variant Present in the following documents:
  • Main text
  • ejhg2012215x1.doc
View BVdb publication page



Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.

Carcinogenesis
D Li, EJ Duell, K Yu, HA Risch, SH Olson, C Kooperberg, BM Wolpin, L Jiao, X Dong, B Wheeler, AA Arslan, HB Bueno-de-Mesquita, CS Fuchs, S Gallinger, M Gross, P Hartge, RN Hoover, EA Holly, EJ Jacobs, AP Klein, A LaCroix, MT Mandelson, G Petersen, W Zheng, I Agalliu, D Albanes, MC Boutron-Ruault, PM Bracci, JE Buring, F Canzian, K Chang, SJ Chanock, M Cotterchio, JM Gaziano, EL Giovannucci, M Goggins, G Hallmans, SE Hankinson, JA Hoffman Bolton, DJ Hunter, A Hutchinson, KB Jacobs, M Jenab, KT Khaw, P Kraft, V Krogh, RC Kurtz, RR McWilliams, JB Mendelsohn, AV Patel, KG Rabe, E Riboli, XO Shu, A Tjønneland, GS Tobias, D Trichopoulos, J Virtamo, K Visvanathan, J Watters, H Yu, A Zeleniuch-Jacquotte, L Amundadottir, RZ Stolzenberg-Solomon
Publication Date: 2012-07

Variant appearance in text: rs7310409
PubMed Link: 22523087
Variant Present in the following documents:
  • Main text
View BVdb publication page



C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.

Human Molecular Genetics
AP Doumatey, G Chen, F Tekola Ayele, J Zhou, M Erdos, D Shriner, H Huang, J Adeleye, W Balogun, O Fasanmade, T Johnson, J Oli, G Okafor, A Amoah, BA Eghan, K Agyenim-Boateng, J Acheampong, C Adebamowo, NP Gerry, MF Christman, A Adeyemo, CN Rotimi
Publication Date: 2012-07-01

Variant appearance in text: rs7310409
PubMed Link: 22492993
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

Nature Genetics
JC Chambers, W Zhang, J Sehmi, X Li, MN Wass, P Van der Harst, H Holm, S Sanna, M Kavousi, SE Baumeister, LJ Coin, G Deng, C Gieger, NL Heard-Costa, JJ Hottenga, B Kühnel, V Kumar, V Lagou, L Liang, J Luan, PM Vidal, I Mateo Leach, PF O'Reilly, JF Peden, N Rahmioglu, P Soininen, EK Speliotes, X Yuan, G Thorleifsson, BZ Alizadeh, LD Atwood, IB Borecki, MJ Brown, P Charoen, F Cucca, D Das, EJ de Geus, AL Dixon, A Döring, G Ehret, GI Eyjolfsson, M Farrall, NG Forouhi, N Friedrich, W Goessling, DF Gudbjartsson, TB Harris, AL Hartikainen, S Heath, GM Hirschfield, A Hofman, G Homuth, E Hyppönen, HL Janssen, T Johnson, AJ Kangas, IP Kema, JP Kühn, S Lai, M Lathrop, MM Lerch, Y Li, TJ Liang, JP Lin, RJ Loos, NG Martin, MF Moffatt, GW Montgomery, PB Munroe, K Musunuru, Y Nakamura, CJ O'Donnell, I Olafsson, BW Penninx, A Pouta, BP Prins, I Prokopenko, R Puls, A Ruokonen, MJ Savolainen, D Schlessinger, JN Schouten, U Seedorf, S Sen-Chowdhry, KA Siminovitch, JH Smit, TD Spector, W Tan, TM Teslovich, T Tukiainen, AG Uitterlinden, MM Van der Klauw, RS Vasan, C Wallace, H Wallaschofski, HE Wichmann, G Willemsen, P Würtz, C Xu, LM Yerges-Armstrong, , , , , , , , GR Abecasis, KR Ahmadi, DI Boomsma, M Caulfield, WO Cookson, CM van Duijn, P Froguel, K Matsuda, MI McCarthy, C Meisinger, V Mooser, KH Pietiläinen, G Schumann, H Snieder, MJ Sternberg, RP Stolk, HC Thomas, U Thorsteinsdottir, M Uda, G Waeber, NJ Wareham, DM Waterworth, H Watkins, JB Whitfield, JC Witteman, BH Wolffenbuttel, CS Fox, M Ala-Korpela, K Stefansson, P Vollenweider, H Völzke, EE Schadt, J Scott, MR Järvelin, P Elliott, JS Kooner
Publication Date: 2011-10-16

Variant appearance in text: rs7310409
PubMed Link: 22001757
Variant Present in the following documents:
  • NIHMS411128-supplement-Supplemental.pdf
  • Main text
View BVdb publication page



Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults.

Journal Of Human Genetics
G Curocichin, Y Wu, TW McDade, CW Kuzawa, JB Borja, L Qin, EM Lange, LS Adair, LA Lange, KL Mohlke
Publication Date: 2011-12

Variant appearance in text: rs7310409
PubMed Link: 21937998
Variant Present in the following documents:
  • Main text
  • NIHMS334518-supplement-Supplementary.doc
View BVdb publication page



Common variants in CRP and LEPR influence high sensitivity C-reactive protein levels in North Indians.

Plos One
A Mahajan, R Tabassum, S Chavali, OP Dwivedi, G Chauhan, S Ghosh, N Tandon, D Bharadwaj
Publication Date: 2011

Variant appearance in text: rs7310409
PubMed Link: 21931794
Variant Present in the following documents:
  • pone.0024645.s003.doc
View BVdb publication page



Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

Plos Genetics
RS Fehrmann, RC Jansen, JH Veldink, HJ Westra, D Arends, MJ Bonder, J Fu, P Deelen, HJ Groen, A Smolonska, RK Weersma, RM Hofstra, WA Buurman, S Rensen, MG Wolfs, M Platteel, A Zhernakova, CC Elbers, EM Festen, G Trynka, MH Hofker, CG Saris, RA Ophoff, LH van den Berg, DA van Heel, C Wijmenga, GJ Te Meerman, L Franke
Publication Date: 2011-08

Variant appearance in text: rs7310409
PubMed Link: 21829388
Variant Present in the following documents:
  • pgen.1002197.s012.xls
View BVdb publication page



Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

Inflammation
Y Wu, TW McDade, CW Kuzawa, J Borja, Y Li, LS Adair, KL Mohlke, LA Lange
Publication Date: 2012-04

Variant appearance in text: rs7310409
PubMed Link: 21647738
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus.

Cancer Research
BL Pierce, H Ahsan
Publication Date: 2011-07-01

Variant appearance in text: rs7310409
PubMed Link: 21498636
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.

Human Molecular Genetics
Y Okada, A Takahashi, H Ohmiya, N Kumasaka, Y Kamatani, N Hosono, T Tsunoda, K Matsuda, T Tanaka, M Kubo, Y Nakamura, K Yamamoto, N Kamatani
Publication Date: 2011-03-15

Variant appearance in text: rs7310409
PubMed Link: 21196492
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Nature Genetics
BF Voight, LJ Scott, V Steinthorsdottir, AP Morris, C Dina, RP Welch, E Zeggini, C Huth, YS Aulchenko, G Thorleifsson, LJ McCulloch, T Ferreira, H Grallert, N Amin, G Wu, CJ Willer, S Raychaudhuri, SA McCarroll, C Langenberg, OM Hofmann, J Dupuis, L Qi, AV Segrè, M van Hoek, P Navarro, K Ardlie, B Balkau, R Benediktsson, AJ Bennett, R Blagieva, E Boerwinkle, LL Bonnycastle, K Bengtsson Boström, B Bravenboer, S Bumpstead, NP Burtt, G Charpentier, PS Chines, M Cornelis, DJ Couper, G Crawford, AS Doney, KS Elliott, AL Elliott, MR Erdos, CS Fox, CS Franklin, M Ganser, C Gieger, N Grarup, T Green, S Griffin, CJ Groves, C Guiducci, S Hadjadj, N Hassanali, C Herder, B Isomaa, AU Jackson, PR Johnson, T Jørgensen, WH Kao, N Klopp, A Kong, P Kraft, J Kuusisto, T Lauritzen, M Li, A Lieverse, CM Lindgren, V Lyssenko, M Marre, T Meitinger, K Midthjell, MA Morken, N Narisu, P Nilsson, KR Owen, F Payne, JR Perry, AK Petersen, C Platou, C Proença, I Prokopenko, W Rathmann, NW Rayner, NR Robertson, G Rocheleau, M Roden, MJ Sampson, R Saxena, BM Shields, P Shrader, G Sigurdsson, T Sparsø, K Strassburger, HM Stringham, Q Sun, AJ Swift, B Thorand, J Tichet, T Tuomi, RM van Dam, TW van Haeften, T van Herpt, JV van Vliet-Ostaptchouk, GB Walters, MN Weedon, C Wijmenga, J Witteman, RN Bergman, S Cauchi, FS Collins, AL Gloyn, U Gyllensten, T Hansen, WA Hide, GA Hitman, A Hofman, DJ Hunter, K Hveem, M Laakso, KL Mohlke, AD Morris, CN Palmer, PP Pramstaller, I Rudan, E Sijbrands, LD Stein, J Tuomilehto, A Uitterlinden, M Walker, NJ Wareham, RM Watanabe, GR Abecasis, BO Boehm, H Campbell, MJ Daly, AT Hattersley, FB Hu, JB Meigs, JS Pankow, O Pedersen, HE Wichmann, I Barroso, JC Florez, TM Frayling, L Groop, R Sladek, U Thorsteinsdottir, JF Wilson, T Illig, P Froguel, CM van Duijn, K Stefansson, D Altshuler, M Boehnke, MI McCarthy, ,
Publication Date: 2010-07

Variant appearance in text: rs7310409
PubMed Link: 20581827
Variant Present in the following documents:
  • NIHMS34421-supplement-02.pdf
View BVdb publication page



Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

Plos Genetics
AC Nica, SB Montgomery, AS Dimas, BE Stranger, C Beazley, I Barroso, ET Dermitzakis
Publication Date: 2010-04-01

Variant appearance in text: rs7310409
PubMed Link: 20369022
Variant Present in the following documents:
  • pgen.1000895.s001.xls
View BVdb publication page



Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

Circulation. Cardiovascular Genetics
JS Danik, G Paré, DI Chasman, RY Zee, DJ Kwiatkowski, A Parker, JP Miletich, PM Ridker
Publication Date: 2009-04

Variant appearance in text: rs7310409
PubMed Link: 20031577
Variant Present in the following documents:
  • Main text
View BVdb publication page



Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Proceedings Of The National Academy Of Sciences Of The United States Of America
LA Hindorff, P Sethupathy, HA Junkins, EM Ramos, JP Mehta, FS Collins, TA Manolio
Publication Date: 2009-06-09

Variant appearance in text: rs7310409
PubMed Link: 19474294
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

Plos Genetics
JK Lowe, JB Maller, I Pe'er, BM Neale, J Salit, EE Kenny, JL Shea, R Burkhardt, JG Smith, W Ji, M Noel, JN Foo, ML Blundell, V Skilling, L Garcia, ML Sullivan, HE Lee, A Labek, H Ferdowsian, SB Auerbach, RP Lifton, C Newton-Cheh, JL Breslow, M Stoffel, MJ Daly, DM Altshuler, JM Friedman
Publication Date: 2009-02

Variant appearance in text: rs7310409
PubMed Link: 19197348
Variant Present in the following documents:
  • Main text
View BVdb publication page



Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

Human Molecular Genetics
KL Mohlke, M Boehnke, GR Abecasis
Publication Date: 2008-10-15

Variant appearance in text: rs7310409
PubMed Link: 18852197
Variant Present in the following documents:
  • Main text
View BVdb publication page



Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.

American Journal Of Human Genetics
AP Reiner, MJ Barber, Y Guan, PM Ridker, LA Lange, DI Chasman, JD Walston, GM Cooper, NS Jenny, MJ Rieder, JP Durda, JD Smith, J Novembre, RP Tracy, JI Rotter, M Stephens, DA Nickerson, RM Krauss
Publication Date: 2008-05

Variant appearance in text: rs7310409
PubMed Link: 18439552
Variant Present in the following documents:
  • Main text
View BVdb publication page



Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.

American Journal Of Human Genetics
PM Ridker, G Pare, A Parker, RY Zee, JS Danik, JE Buring, D Kwiatkowski, NR Cook, JP Miletich, DI Chasman
Publication Date: 2008-05

Variant appearance in text: rs7310409
PubMed Link: 18439548
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000257555.6 c.327-1775A>T - intron_variant - 1/9
ENST00000400024.2 c.327-1775A>T - intron_variant - 1/6
ENST00000402929.1 c.327-1775A>T - intron_variant - 1/5
ENST00000535955.1 c.42+8366A>T - intron_variant - 1/1
ENST00000538626.1 c.72+8218A>T - intron_variant - 1/1
ENST00000538646.1 c.327-1775A>T - intron_variant,NMD_transcript_variant - 1/5
ENST00000540108.1 c.327-6462A>T - intron_variant,NMD_transcript_variant - 1/8
ENST00000541395.1 c.327-1775A>T - intron_variant - 1/8
ENST00000541924.1 c.327-1775A>T - intron_variant,NMD_transcript_variant - 1/5
ENST00000543427.1 c.-25-1775A>T - intron_variant - 2/6
ENST00000544413.1 c.327-1775A>T - intron_variant - 1/9
ENST00000544574.1 c.72+8218A>T - intron_variant,NMD_transcript_variant - 1/2
ENST00000560968.1 c.470-1775A>T - intron_variant,NMD_transcript_variant - 1/9
NM_000545.6 c.327-1775A>T - intron_variant - 1/9
NM_001306179.2 c.327-1775A>T - intron_variant - 1/9