LRP6 c.4468T>G ;(p.S1490A)

Variant ID: 12-12277578-A-C

NM_002336.2(LRP6):c.4468T>G;(p.S1490A)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization.

Journal Of Cell Science
Metcalfe, Ciara C; Mendoza-Topaz, Carolina C; Mieszczanek, Juliusz J; Bienz, Mariann M
Publication Date: 2010-05-01

Variant appearance in text: LRP6: S1490A
PubMed Link: 20388731
Variant Present in the following documents:
  • Main text
View BVdb publication page



Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.

Plos One
Piao, Shunfu S; Lee, Sun-Hye SH; Kim, Hyunjoon H; Yum, Soohwan S; Stamos, Jennifer L JL; Xu, Yongbin Y; Lee, Su-Jin SJ; Lee, Jaewon J; Oh, Sangtaek S; Han, Jin-Kwan JK; Park, Bum-Joon BJ; Weis, William I WI; Ha, Nam-Chul NC
Publication Date: 2008

Variant appearance in text: LRP6: S1490A
PubMed Link: 19107203
Variant Present in the following documents:
  • Main text
  • pone.0004046.pdf
View BVdb publication page



Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.

The Journal Of Biological Chemistry
MacDonald, Bryan T BT; Yokota, Chika C; Tamai, Keiko K; Zeng, Xin X; He, Xi X
Publication Date: 2008-06-06

Variant appearance in text: LRP6: S1490A
PubMed Link: 18362152
Variant Present in the following documents:
  • Main text
View BVdb publication page