Publications:

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: LRP6: 1831C>T; Arg611Cys

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: LRP6: 1831C>T; R611C; rs121918313

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

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Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?

Life (Basel, Switzerland)

Butnariu, Lăcrămioara Ionela LI; Florea, Laura L; Badescu, Minerva Codruta MC; Țarcă, Elena E; Costache, Irina-Iuliana II; Gorduza, Eusebiu Vlad EV

Publication Date: 2022-06-09

Variant appearance in text: ADCAD2: R611C

PubMed Link: 35743896

Variant Present in the following documents:

• Main text
• life-12-00865.pdf

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Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications.

Nature Reviews. Cardiology

Akoumianakis, Ioannis I; Polkinghorne, Murray M; Antoniades, Charalambos C

Publication Date: 2022-12

Variant appearance in text: LRP6: R611C

PubMed Link: 35697779

Variant Present in the following documents:

• Main text
• 41569_2022_Article_718.pdf

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Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia.

Metabolites

Ghaleb, Youmna Y; Elbitar, Sandy S; Philippi, Anne A; El Khoury, Petra P; Azar, Yara Y; Andrianirina, Miangaly M; Loste, Alexia A; Abou-Khalil, Yara Y; Nicolas, Gaël G; Le Borgne, Marie M; Moulin, Philippe P; Di-Filippo, Mathilde M; Charrière, Sybil S; Farnier, Michel M; Yelnick, Cécile C; Carreau, Valérie V; Ferrières, Jean J; Lecerf, Jean-Michel JM; Derksen, Alexa A; Bernard, Geneviève G; Gauthier, Marie-Soleil MS; Coulombe, Benoit B; Lütjohann, Dieter D; Fin, Bertrand B; Boland, Anne A; Olaso, Robert R; Deleuze, Jean-François JF; Rabès, Jean-Pierre JP; Boileau, Catherine C; Abifadel, Marianne M; Varret, Mathilde M

Publication Date: 2022-03-18

Variant appearance in text: LRP6: Arg611Cys

PubMed Link: 35323704

Variant Present in the following documents:

• Main text
• metabolites-12-00262.pdf

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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.

Nature Communications

Belenguer, Germán G; Mastrogiovanni, Gianmarco G; Pacini, Clare C; Hall, Zoe Z; Dowbaj, Anna M AM; Arnes-Benito, Robert R; Sljukic, Aleksandra A; Prior, Nicole N; Kakava, Sofia S; Bradshaw, Charles R CR; Davies, Susan S; Vacca, Michele M; Saeb-Parsy, Kourosh K; Koo, Bon-Kyoung BK; Huch, Meritxell M

Publication Date: 2022-01-17

Variant appearance in text: LRP6: R611C

PubMed Link: 35039505

Variant Present in the following documents:

• Main text

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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.

Nature Communications

Belenguer, Germán G; Mastrogiovanni, Gianmarco G; Pacini, Clare C; Hall, Zoe Z; Dowbaj, Anna M AM; Arnes-Benito, Robert R; Sljukic, Aleksandra A; Prior, Nicole N; Kakava, Sofia S; Bradshaw, Charles R CR; Davies, Susan S; Vacca, Michele M; Saeb-Parsy, Kourosh K; Koo, Bon-Kyoung BK; Huch, Meritxell M

Publication Date: 2022-01-17

Variant appearance in text: LRP6: R611C

PubMed Link: 35039505

Variant Present in the following documents:

• Main text

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Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling.

International Journal Of Biological Sciences

Chen, Li-Jie LJ; Lin, Xiu-Xian XX; Guo, Jing J; Xu, Ying Y; Zhang, Song-Xia SX; Chen, Dan D; Zhao, Qing Q; Xiao, Jian J; Lian, Guang-Hui GH; Peng, Shi-Fang SF; Guo, Dong D; Yang, Hong H; Shu, Yan Y; Zhou, Hong-Hao HH; Zhang, Wei W; Chen, Yao Y

Publication Date: 2021

Variant appearance in text: LRP6: R611C

PubMed Link: 34671210

Variant Present in the following documents:

• Main text
• ijbsv17p3936.pdf

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Regulation of the Low-Density Lipoprotein Receptor-Related Protein LRP6 and Its Association With Disease: Wnt/β-Catenin Signaling and Beyond.

Frontiers In Cell And Developmental Biology

Jeong, Wonyoung W; Jho, Eek-Hoon EH

Publication Date: 2021

Variant appearance in text: LRP6: R611C

PubMed Link: 34589484

Variant Present in the following documents:

• Main text
• fcell-09-714330.pdf

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WNT3A rs752107(C > T) Polymorphism Is Associated With an Increased Risk of Essential Hypertension and Related Cardiovascular Diseases.

Frontiers In Cardiovascular Medicine

Ren, Huan H; Luo, Jian-Quan JQ; Ouyang, Fan F; Cheng, Li L; Chen, Xiao-Ping XP; Zhou, Hong-Hao HH; Huang, Wei-Hua WH; Zhang, Wei W

Publication Date: 2021

Variant appearance in text: LRP6: R611C

PubMed Link: 34322525

Variant Present in the following documents:

• Main text
• fcvm-08-675222.pdf

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The complex role of Wnt ligands in type 2 diabetes mellitus and related complications.

Journal Of Cellular And Molecular Medicine

Nie, Xiaobo X; Wei, Xiaoyun X; Ma, Han H; Fan, Lili L; Chen, Wei-Dong WD

Publication Date: 2021-07

Variant appearance in text: LRP6: R611C

PubMed Link: 34042263

Variant Present in the following documents:

• Main text
• JCMM-25-6479.pdf

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Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease.

Journal Of Cellular Signaling

Weerackoon, Nadisha N; Gunawardhana, Kushan L KL; Mani, Arya A

Publication Date: 2021

Variant appearance in text: LRP6: R611C

PubMed Link: 33969358

Variant Present in the following documents:

• Main text

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Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells.

International Journal Of Molecular Sciences

Janitschke, Daniel D; Lauer, Anna A AA; Bachmann, Cornel M CM; Seyfried, Martin M; Grimm, Heike S HS; Hartmann, Tobias T; Grimm, Marcus O W MOW

Publication Date: 2020-11-27

Variant appearance in text: LRP6: R611C

PubMed Link: 33260941

Variant Present in the following documents:

• ijms-21-09015-s001.pdf

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The role of Wnt signalling in development of coronary artery disease and its risk factors.

Open Biology

Liu, Ya Y; Neogi, Arpita A; Mani, Arya A

Publication Date: 2020-10

Variant appearance in text: LRP6: R611C

PubMed Link: 33081636

Variant Present in the following documents:

• Main text
• rsob-10-200128.pdf

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Sclerostin and Vascular Pathophysiology.

International Journal Of Molecular Sciences

Catalano, Antonino A; Bellone, Federica F; Morabito, Nunziata N; Corica, Francesco F

Publication Date: 2020-07-06

Variant appearance in text: LRP6: R611C

PubMed Link: 32640551

Variant Present in the following documents:

• Main text
• ijms-21-04779.pdf

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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports

Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM

Publication Date: 2020-06-23

Variant appearance in text: LRP6: R611C

PubMed Link: 32579932

Variant Present in the following documents:

• mmc5.xlsx, sheet 3

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Rare genetic susceptibility variants assessment in autism spectrum disorder: detection rate and practical use.

Translational Psychiatry

Husson, Thomas T; Lecoquierre, François F; Cassinari, Kevin K; Charbonnier, Camille C; Quenez, Olivier O; Goldenberg, Alice A; Guerrot, Anne-Marie AM; Richard, Anne-Claire AC; Drouin-Garraud, Valérie V; Brehin, Anne-Claire AC; Soleimani, Maryam M; Taton, Romain R; Rotharmel, Maud M; Rosier, Antoine A; Chambon, Pascal P; Le Meur, Nathalie N; Joly-Helas, Géraldine G; Saugier-Veber, Pascale P; Boland, Anne A; Deleuze, Jean-François JF; Olaso, Robert R; Frebourg, Thierry T; Nicolas, Gael G; Guillin, Olivier O; Campion, Dominique D

Publication Date: 2020-02-24

Variant appearance in text: LRP6: 1831C>T; Arg611*

PubMed Link: 32094338

Variant Present in the following documents:

• 41398_2020_760_MOESM2_ESM.xlsx, sheet 1

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Lipoprotein receptor signalling in atherosclerosis.

Cardiovascular Research

Mineo, Chieko C

Publication Date: 2020-06-01

Variant appearance in text: LRP6: R611C

PubMed Link: 31834409

Variant Present in the following documents:

• Main text

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Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.

International Journal Of Molecular Medicine

Wang, Xiu-Mei XM; Wang, Xiao-Yi XY; Huang, Yu-Mei YM; Chen, Xia X; Lü, Mu-Han MH; Shi, Lei L; Li, Chang-Ping CP

Publication Date: 2019-12

Variant appearance in text: LRP6: R611C; rs121918313

PubMed Link: 31638173

Variant Present in the following documents:

• Main text
• ijmm-44-06-2201.pdf

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Optimizing clinical exome design and parallel gene-testing for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes.

Plos Genetics

Capalbo, Antonio A; Valero, Roberto Alonso RA; Jimenez-Almazan, Jorge J; Pardo, Pere Mir PM; Fabiani, Marco M; Jiménez, David D; Simon, Carlos C; Rodriguez, Julio Martin JM

Publication Date: 2019-10

Variant appearance in text: LRP6: 1831C>T; Arg611Cys; rs121918313

PubMed Link: 31589614

Variant Present in the following documents:

• pgen.1008409.s001.xlsx, sheet 1

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TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia.

Arteriosclerosis, Thrombosis, And Vascular Biology

Srivastava, Roshni R; Rolyan, Harshvardhan H; Xie, Yi Y; Li, Na N; Bhat, Neha N; Hong, Lingjuan L; Esteghamat, Fatemehsadat F; Adeniran, Adebowale A; Geirsson, Arnar A; Zhang, Jiasheng J; Ge, Guanghao G; Nobrega, Marcelo M; Martin, Kathleen A KA; Mani, Arya A

Publication Date: 2019-02

Variant appearance in text: LRP6: R611C

PubMed Link: 30567484

Variant Present in the following documents:

• Main text
• atv-39-250.pdf

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The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome.

Nutrition Research (New York, N.Y.)

Abou Ziki, Maen D MD; Mani, Arya A

Publication Date: 2019-10

Variant appearance in text: LRP6: R611C

PubMed Link: 30049588

Variant Present in the following documents:

• Main text

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WNT Signaling in Cardiac and Vascular Disease.

Pharmacological Reviews

Foulquier, Sébastien S; Daskalopoulos, Evangelos P EP; Lluri, Gentian G; Hermans, Kevin C M KCM; Deb, Arjun A; Blankesteijn, W Matthijs WM

Publication Date: 2018-01

Variant appearance in text: LRP6: R611C

PubMed Link: 29247129

Variant Present in the following documents:

• Main text

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Molecular genetics and targeted therapy of WNT-related human diseases (Review).

International Journal Of Molecular Medicine

Katoh, Masuko M; Katoh, Masaru M

Publication Date: 2017-09

Variant appearance in text: LRP6: R611C

PubMed Link: 28731148

Variant Present in the following documents:

• Main text
• ijmm-40-03-0587.pdf

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Wnt signaling in cardiovascular disease: opportunities and challenges.

Current Opinion In Lipidology

Gay, Austin A; Towler, Dwight A DA

Publication Date: 2017-10

Variant appearance in text: LRP6: R611C

PubMed Link: 28723729

Variant Present in the following documents:

• Main text

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Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.

Atherosclerosis

Masoudkabir, Farzad F; Sarrafzadegan, Nizal N; Gotay, Carolyn C; Ignaszewski, Andrew A; Krahn, Andrew D AD; Davis, Margot K MK; Franco, Christopher C; Mani, Arya A

Publication Date: 2017-08

Variant appearance in text: LRP6: R611C

PubMed Link: 28624099

Variant Present in the following documents:

• Main text

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Wnt signaling, a novel pathway regulating blood pressure? State of the art review.

Atherosclerosis

Abou Ziki, Maen D MD; Mani, Arya A

Publication Date: 2017-07

Variant appearance in text: LRP6: Arg611Cys

PubMed Link: 28522145

Variant Present in the following documents:

• Main text

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Mutation of miR-21 targets endogenous lipoprotein receptor-related protein 6 and nonalcoholic fatty liver disease.

American Journal Of Translational Research

Li, Chang-Ping CP; Li, Hong-Jue HJ; Nie, Jiao J; Chen, Xia X; Zhou, Xian X

Publication Date: 2017

Variant appearance in text: LRP6: R611C

PubMed Link: 28337300

Variant Present in the following documents:

• Main text

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Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease.

International Journal Of Molecular Sciences

Guo, Jian J; Li, Yang Y; Ren, Yi-Hong YH; Sun, Zhijun Z; Dong, Jie J; Yan, Han H; Xu, Yujun Y; Wang, Dao Wen DW; Zheng, Gu-Yan GY; Du, Jie J; Tian, Xiao-Li XL

Publication Date: 2016-07-22

Variant appearance in text: LRP6: R611C; rs121918313

PubMed Link: 27455246

Variant Present in the following documents:

• Main text
• ijms-17-01173-s001.pdf
• ijms-17-01173.pdf

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Genetics of coronary artery disease and myocardial infarction.

World Journal Of Cardiology

Dai, Xuming X; Wiernek, Szymon S; Evans, James P JP; Runge, Marschall S MS

Publication Date: 2016-01-26

Variant appearance in text: LRP6: R611C

PubMed Link: 26839654

Variant Present in the following documents:

• Main text

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Metabolic syndrome: genetic insights into disease pathogenesis.

Current Opinion In Lipidology

Abou Ziki, Maen D MD; Mani, Arya A

Publication Date: 2016-04

Variant appearance in text: LRP6: R611C

PubMed Link: 26825138

Variant Present in the following documents:

• Main text

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: ADCAD2: R611C

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

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Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.

Cell Reports

Srivastava, Roshni R; Zhang, Jiasheng J; Go, Gwang-Woong GW; Narayanan, Anand A; Nottoli, Timothy P TP; Mani, Arya A

Publication Date: 2015-10-27

Variant appearance in text: LRP6: R611C

PubMed Link: 26489464

Variant Present in the following documents:

• Main text

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LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodeling.

Bone Research

Li, Changjun C; Williams, Bart O BO; Cao, Xu X; Wan, Mei M

Publication Date: 2014

Variant appearance in text: LRP6: R611C

PubMed Link: 26273519

Variant Present in the following documents:

• Main text

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A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.

Bone Research

Maupin, Kevin A KA; Droscha, Casey J CJ; Williams, Bart O BO

Publication Date: 2013-03

Variant appearance in text: LRP6: Arg611Cys

PubMed Link: 26273492

Variant Present in the following documents:

• Main text

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: LRP6: R611C

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 3

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Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis.

Nutrients

Go, Gwang-woong GW

Publication Date: 2015-06-03

Variant appearance in text: LRP6: R611C

PubMed Link: 26046396

Variant Present in the following documents:

• Main text

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Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.

Circulation Research

Cheng, Su-Li SL; Ramachandran, Bindu B; Behrmann, Abraham A; Shao, Jian-Su JS; Mead, Megan M; Smith, Carolyn C; Krchma, Karen K; Bello Arredondo, Yoanna Y; Kovacs, Attila A; Kapoor, Kapil K; Brill, Laurence M LM; Perera, Ranjan R; Williams, Bart O BO; Towler, Dwight A DA

Publication Date: 2015-07-03

Variant appearance in text: LRP6: R611C

PubMed Link: 26034040

Variant Present in the following documents:

• Main text

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Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk.

European Journal Of Neurology

Harriott, A M AM; Heckman, M G MG; Rayaprolu, S S; Soto-Ortolaza, A I AI; Diehl, N N NN; Kanekiyo, T T; Liu, C-C CC; Bu, G G; Malik, R R; , ; Cole, J W JW; Meschia, J F JF; Ross, O A OA

Publication Date: 2015-08

Variant appearance in text: rs121918313

PubMed Link: 26031789

Variant Present in the following documents:

• Main text

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Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology

Wang, Shuxia S; Song, Kangxing K; Srivastava, Roshni R; Dong, Chao C; Go, Gwang-Woong GW; Li, Na N; Iwakiri, Yasuko Y; Mani, Arya A

Publication Date: 2015-08

Variant appearance in text: LRP6: R611C

PubMed Link: 25917329

Variant Present in the following documents:

• Main text

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Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat.

Oncotarget

Song, Kangxing K; Wang, Shuxia S; Mani, Mitra M; Mani, Arya A

Publication Date: 2014-11-30

Variant appearance in text: LRP6: R611C

PubMed Link: 25526027

Variant Present in the following documents:

• Main text

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The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction.

Lipids In Health And Disease

Xu, Shun S; Cheng, Jie J; Chen, Yu-Ning YN; Li, Keshen K; Ma, Ze-Wei ZW; Cen, Jin-Ming JM; Liu, Xinguang X; Yang, Xi-Li XL; Chen, Can C; Xiong, Xing-Dong XD

Publication Date: 2014-06-07

Variant appearance in text: LRP6: R611C

PubMed Link: 24906453

Variant Present in the following documents:

• Main text
• 1476-511X-13-94.pdf

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The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.

Cell Metabolism

Go, Gwang-Woong GW; Srivastava, Roshni R; Hernandez-Ono, Antonio A; Gang, Gyoungok G; Smith, Stephen B SB; Booth, Carmen J CJ; Ginsberg, Henry N HN; Mani, Arya A

Publication Date: 2014-02-04

Variant appearance in text: LRP6: R611C

PubMed Link: 24506864

Variant Present in the following documents:

• Main text

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Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics

Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z

Publication Date: 2013

Variant appearance in text: LRP6: R611C

PubMed Link: 23819521

Variant Present in the following documents:

• 1471-2164-14-S3-S7-S1.xlsx, sheet 2

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Rare nonconservative LRP6 mutations are associated with metabolic syndrome.

Human Mutation

Singh, Rajvir R; Smith, Emily E; Fathzadeh, Mohsen M; Liu, Wenzhong W; Go, Gwang-Woong GW; Subrahmanyan, Lakshman L; Faramarzi, Saeed S; McKenna, William W; Mani, Arya A

Publication Date: 2013-09

Variant appearance in text: LRP6: R611C

PubMed Link: 23703864

Variant Present in the following documents:

• Main text

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LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.

Cell Metabolism

Singh, Rajvir R; De Aguiar, Renata Belfort RB; Naik, Sarita S; Mani, Sheida S; Ostadsharif, Kamal K; Wencker, Detlef D; Sotoudeh, Masoud M; Malekzadeh, Reza R; Sherwin, Robert S RS; Mani, Arya A

Publication Date: 2013-02-05

Variant appearance in text: LRP6: R611C

PubMed Link: 23395167

Variant Present in the following documents:

• Main text

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LRP5 and LRP6 in development and disease.

Trends In Endocrinology And Metabolism: Tem

Joiner, Danese M DM; Ke, Jiyuan J; Zhong, Zhendong Z; Xu, H Eric HE; Williams, Bart O BO

Publication Date: 2013-01

Variant appearance in text: LRP6: R611C

PubMed Link: 23245947

Variant Present in the following documents:

• Main text

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Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Li, Xiaofeng X; Shan, Jufang J; Chang, Woochul W; Kim, Ingyu I; Bao, Ju J; Lee, Ho-Jin HJ; Zhang, Xinxin X; Samuel, Varman T VT; Shulman, Gerald I GI; Liu, Dakai D; Zheng, Jie J JJ; Wu, Dianqing D

Publication Date: 2012-07-10

Variant appearance in text: LRP6: R611C

PubMed Link: 22733757

Variant Present in the following documents:

• Main text

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Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis.

The Yale Journal Of Biology And Medicine

Go, Gwang-Woong GW; Mani, Arya A

Publication Date: 2012-03

Variant appearance in text: LRP6: R611C

PubMed Link: 22461740

Variant Present in the following documents:

• Main text

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LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake.

The Journal Of Biological Chemistry

Ye, Zhi-jia ZJ; Go, Gwang-Woong GW; Singh, Rajvir R; Liu, Wenzhong W; Keramati, Ali Reza AR; Mani, Arya A

Publication Date: 2012-01-06

Variant appearance in text: LRP6: R611C

PubMed Link: 22128165

Variant Present in the following documents:

• Main text

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Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

Developmental Cell

Ahn, Victoria E VE; Chu, Matthew Ling-Hon ML; Choi, Hee-Jung HJ; Tran, Denise D; Abo, Arie A; Weis, William I WI

Publication Date: 2011-11-15

Variant appearance in text: LRP6: R611C

PubMed Link: 22000856

Variant Present in the following documents:

• Main text

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Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.

Nature Structural & Molecular Biology

Cheng, Zhihong Z; Biechele, Travis T; Wei, Zhiyi Z; Morrone, Seamus S; Moon, Randall T RT; Wang, Liguo L; Xu, Wenqing W

Publication Date: 2011-10-09

Variant appearance in text: LRP6: R611C

PubMed Link: 21984209

Variant Present in the following documents:

• Main text

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Modulation of canonical Wnt signaling by the extracellular matrix component biglycan.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Berendsen, Agnes D AD; Fisher, Larry W LW; Kilts, Tina M TM; Owens, Rick T RT; Robey, Pamela G PG; Gutkind, J Silvio JS; Young, Marian F MF

Publication Date: 2011-10-11

Variant appearance in text: LRP6: R611C

PubMed Link: 21969569

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Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Keramati, Ali R AR; Singh, Rajvir R; Lin, Aiping A; Faramarzi, Saeed S; Ye, Zhi-jia ZJ; Mane, Shrikant S; Tellides, George G; Lifton, Richard P RP; Mani, Arya A

Publication Date: 2011-02-01

Variant appearance in text: LRP6: R611C

PubMed Link: 21245321

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Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.

Circulation Research

Liu, Wenzhong W; Mani, Sheida S; Davis, Nicole R NR; Sarrafzadegan, Nizal N; Kavathas, Paula B PB; Mani, Arya A

Publication Date: 2008-11-21

Variant appearance in text: LRP6: R611C

PubMed Link: 18948618

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Msx2 exerts bone anabolism via canonical Wnt signaling.

The Journal Of Biological Chemistry

Cheng, Su-Li SL; Shao, Jian-Su JS; Cai, Jun J; Sierra, Oscar L OL; Towler, Dwight A DA

Publication Date: 2008-07-18

Variant appearance in text: LRP6: R611C

PubMed Link: 18487199

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Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.

Proceedings Of The National Academy Of Sciences Of The United States Of America

De Ferrari, Giancarlo V GV; Papassotiropoulos, Andreas A; Biechele, Travis T; Wavrant De-Vrieze, Fabienne F; Avila, Miguel E ME; Major, Michael B MB; Myers, Amanda A; Sáez, Katia K; Henríquez, Juan P JP; Zhao, Alice A; Wollmer, M Axel MA; Nitsch, Roger M RM; Hock, Christoph C; Morris, Chris M CM; Hardy, John J; Moon, Randall T RT

Publication Date: 2007-05-29

Variant appearance in text: LRP6: R611C

PubMed Link: 17517621

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LRP6 mutation in a family with early coronary disease and metabolic risk factors.

Science (New York, N.Y.)

Mani, Arya A; Radhakrishnan, Jayaram J; Wang, He H; Mani, Alaleh A; Mani, Mohammad-Ali MA; Nelson-Williams, Carol C; Carew, Khary S KS; Mane, Shrikant S; Najmabadi, Hossein H; Wu, Dan D; Lifton, Richard P RP

Publication Date: 2007-03-02

Variant appearance in text: LRP6: R611C

PubMed Link: 17332414

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