KMT5A c.*1580C>T

Variant ID: 12-123893830-C-T

NM_020382.3(KMT5A):c.*1580C>T

This variant was identified in 40 publications

View GRCh38 version.




Publications:


Genetic variant in miR-17-92 cluster binding sites is associated with esophageal squamous cell carcinoma risk in Chinese population.

Bmc Cancer
Shen, Yi Y; Shao, Yi Y; Ruan, Xiaoli X; Zhu, Lingyan L; Zang, Zhaoping Z; Wei, Tong T; Nakyeyune, Rena R; Wei, Wenqiang W; Liu, Fen F
Publication Date: 2022-12-02

Variant appearance in text: rs16917496
PubMed Link: 36461008
Variant Present in the following documents:
  • Main text
  • 12885_2022_Article_10360.pdf
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Epi-miRNAs: Regulators of the Histone Modification Machinery in Human Cancer.

Journal Of Oncology
Mortazavi, Deniz D; Sohrabi, Behnoush B; Mosallaei, Meysam M; Nariman-Saleh-Fam, Ziba Z; Bastami, Milad M; Mansoori, Yaser Y; Daraei, Abdolreza A; Zununi Vahed, Sepideh S; Navid, Shadan S; Saadatian, Zahra Z; Jamialahmadi, Tannaz T; Teng, Yong Y; Sahebkar, Amirhossein A
Publication Date: 2022

Variant appearance in text: rs16917496
PubMed Link: 35087589
Variant Present in the following documents:
  • JO2022-4889807.pdf
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Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness.

Molecular Oncology
Bernabé-García, Manuel M; Martínez-Balsalobre, Elena E; García-Moreno, Diana D; García-Castillo, Jesús J; Revilla-Nuin, Beatriz B; Blanco-Alcaina, Elena E; Mulero, Victoriano V; Alcaraz-Pérez, Francisca F; Cayuela, María L ML
Publication Date: 2021-07

Variant appearance in text: rs16917496
PubMed Link: 33713376
Variant Present in the following documents:
  • MOL2-15-1818.pdf
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MicroRNA polymorphism: A target for diagnosis and prognosis of hepatocellular carcinoma?

Oncology Letters
Ma, Ruixia R; Zhao, Maomao M; Zou, Xin X; Zhou, Jianye J; Bai, Zhongtian Z
Publication Date: 2021-04

Variant appearance in text: rs16917496
PubMed Link: 33692856
Variant Present in the following documents:
  • Main text
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SNPs within microRNA binding sites and the prognosis of breast cancer.

Aging
Zhang, Liwen L; Han, Lu L; Huang, Yubei Y; Feng, Ziwei Z; Wang, Xin X; Li, Haixin H; Song, Fangfang F; Liu, Luyang L; Li, Junxian J; Zheng, Hong H; Wang, Peishan P; Song, Fengju F; Chen, Kexin K
Publication Date: 2021-02-26

Variant appearance in text: rs16917496
PubMed Link: 33658398
Variant Present in the following documents:
  • Main text
  • aging-13-202612.pdf
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Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells.

Npj Systems Biology And Applications
Immanuel, Selva Rupa Christinal SRC; Ghanate, Avinash D AD; Parmar, Dharmeshkumar S DS; Yadav, Ritu R; Uthup, Riya R; Panchagnula, Venkateswarlu V; Raghunathan, Anu A
Publication Date: 2021-01-08

Variant appearance in text: rs16917496
PubMed Link: 33420045
Variant Present in the following documents:
  • 41540_2020_161_MOESM3_ESM.xlsx, sheet 2
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Genetic Variability in the microRNA Binding Sites of BMPR1B, TGFBR1, IQGAP1, KRAS, SETD8 and RYR3 and Risk of Breast Cancer in Colombian Women.

Oncotargets And Therapy
Garcia Mesa, Karen K; Bermejo, Justo Lorenzo JL; Torres, Diana D; Gilbert, Michael M; Plass, Christoph C; Hamann, Ute U
Publication Date: 2020

Variant appearance in text: rs16917496
PubMed Link: 33311986
Variant Present in the following documents:
  • Main text
  • ott-13-12281.pdf
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The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells.

Scientific Reports
Choi, Dong Kyu DK; Kim, Young Kyu YK; Park, Sang Wook SW; Lee, Heejin H; Lee, Seul S; Kim, Sang A SA; Kim, Soo Jin SJ; Lee, Junyeop J; Kim, Wanil W; Min, Sang-Hyun SH; Yu, Ji Hoon JH
Publication Date: 2020-07-21

Variant appearance in text: rs16917496
PubMed Link: 32694555
Variant Present in the following documents:
  • Main text
  • 41598_2020_Article_69103.pdf
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MicroRNA-binding site polymorphisms and risk of colorectal cancer: A systematic review and meta-analysis.

Cancer Medicine
Gholami, Morteza M; Larijani, Bagher B; Sharifi, Farshad F; Hasani-Ranjbar, Shirin S; Taslimi, Reza R; Bastami, Milad M; Atlasi, Rasha R; Amoli, Mahsa M MM
Publication Date: 2019-12

Variant appearance in text: rs16917496
PubMed Link: 31637880
Variant Present in the following documents:
  • Main text
  • CAM4-8-7477.pdf
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Genetic and molecular biology of breast cancer among Iranian patients.

Journal Of Translational Medicine
Moghbeli, Meysam M
Publication Date: 2019-07-08

Variant appearance in text: rs16917496
PubMed Link: 31286981
Variant Present in the following documents:
  • Main text
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Molecular Mechanisms in Clear Cell Renal Cell Carcinoma: Role of miRNAs and Hypermethylated miRNA Genes in Crucial Oncogenic Pathways and Processes.

Frontiers In Genetics
Braga, Eleonora A EA; Fridman, Marina V MV; Loginov, Vitaly I VI; Dmitriev, Alexey A AA; Morozov, Sergey G SG
Publication Date: 2019

Variant appearance in text: rs16917496
PubMed Link: 31110513
Variant Present in the following documents:
  • Main text
  • fgene-10-00320.pdf
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Association of an miR-502-binding site polymorphism in the 3'-untranslated region of SET8 with colorectal cancer.

Oncology Letters
Liu, Shuang S; Dong, Hailing H; Wu, Jianhua J; Wang, Cuiju C
Publication Date: 2019-04

Variant appearance in text: rs16917496
PubMed Link: 30881512
Variant Present in the following documents:
  • Main text
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The association between rs16917496 T/C polymorphism of SET8 gene and cancer risk in Asian populations: a meta-analysis.

Bioscience Reports
Wei, Hui-Xia HX; Tian, Guo-Xiang GX; Song, Ju-Kun JK; Yang, Lian-Jie LJ; Wang, Yu-Pei YP
Publication Date: 2018-12-21

Variant appearance in text: rs16917496
PubMed Link: 30341251
Variant Present in the following documents:
  • Main text
  • bsr-38-bsr20180702.pdf
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Involving the microRNA Targetome in Esophageal-Cancer Development and Behavior.

Cancers
Dias, Francisca F; Morais, Mariana M; Teixeira, Ana Luísa AL; Medeiros, Rui R
Publication Date: 2018-10-12

Variant appearance in text: rs16917496
PubMed Link: 30322005
Variant Present in the following documents:
  • Main text
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Gene Expression Analysis of Two Epithelial-mesenchymal Transition-related Genes: Long Noncoding RNA-ATB and SETD8 in Gastric Cancer Tissues.

Advanced Biomedical Research
Nourbakhsh, Nooshin N; Emadi-Baygi, Modjtaba M; Salehi, Rasoul R; Nikpour, Parvaneh P
Publication Date: 2018

Variant appearance in text: rs16917496
PubMed Link: 29657927
Variant Present in the following documents:
  • Main text
  • ABR-7-42.pdf
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miR-502-mediated histone methyltransferase SET8 expression is associated with clear cell renal cell carcinoma risk.

Oncology Letters
Zhang, Shenglei S; Guo, Zhanjun Z; Xu, Jinsheng J; Wang, Jing J; Zhang, Junxia J; Cui, Liwen L; Zhang, Huiran H; Liu, Yueping Y; Bai, Yaling Y
Publication Date: 2017-12

Variant appearance in text: rs16917496
PubMed Link: 29250163
Variant Present in the following documents:
  • Main text
  • ol-14-06-7131.pdf
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Polymorphism (rs16917496) at the miR-502 Binding Site of the Lysine Methyltransferase 5A (SET8) and Its Correlation with Colorectal Cancer in Iranians.

Advanced Biomedical Research
Mosallayi, Meysam M; Simonian, Miganoosh M; Khosravi, Sharifeh S; Salehi, Ahmad Reza AR; Khodadoostan, Mahsa M; Sebghatollahi, Vahid V; Baradaran, Azar A; Salehi, Rasoul R
Publication Date: 2017

Variant appearance in text: rs16917496
PubMed Link: 28808643
Variant Present in the following documents:
  • Main text
  • ABR-6-77.pdf
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Identification of EML4-ALK as an alternative fusion gene in epithelioid inflammatory myofibroblastic sarcoma.

Orphanet Journal Of Rare Diseases
Jiang, Quan Q; Tong, Han-Xing HX; Hou, Ying-Yong YY; Zhang, Yong Y; Li, Jing-Lei JL; Zhou, Yu-Hong YH; Xu, Jing J; Wang, Jiong-Yuan JY; Lu, Wei-Qi WQ
Publication Date: 2017-05-23

Variant appearance in text: rs16917496
PubMed Link: 28535796
Variant Present in the following documents:
  • 13023_2017_647_MOESM1_ESM.xlsx, sheet 4
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Dysregulated MicroRNA Expression Profiles and Potential Cellular, Circulating and Polymorphic Biomarkers in Non-Hodgkin Lymphoma.

Genes
Bradshaw, Gabrielle G; Sutherland, Heidi G HG; Haupt, Larisa M LM; Griffiths, Lyn R LR
Publication Date: 2016-12-17

Variant appearance in text: rs16917496
PubMed Link: 27999330
Variant Present in the following documents:
  • Main text
  • genes-07-00130.pdf
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MiRNAs and miRNA Polymorphisms Modify Drug Response.

International Journal Of Environmental Research And Public Health
Li, Mu-Peng MP; Hu, Yao-Dong YD; Hu, Xiao-Lei XL; Zhang, Yan-Jiao YJ; Yang, Yong-Long YL; Jiang, Chun C; Tang, Jie J; Chen, Xiao-Ping XP
Publication Date: 2016-11-08

Variant appearance in text: rs16917496
PubMed Link: 27834829
Variant Present in the following documents:
  • Main text
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The emerging role of lysine methyltransferase SETD8 in human diseases.

Clinical Epigenetics
Milite, Ciro C; Feoli, Alessandra A; Viviano, Monica M; Rescigno, Donatella D; Cianciulli, Agostino A; Balzano, Amodio Luca AL; Mai, Antonello A; Castellano, Sabrina S; Sbardella, Gianluca G
Publication Date: 2016

Variant appearance in text: rs16917496
PubMed Link: 27688818
Variant Present in the following documents:
  • Main text
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miR-502 medaited histone methyltransferase SET8 expression is associated with outcome of esophageal squamous cell carcinoma.

Scientific Reports
Wang, Cuiju C; Wu, Jianhua J; Zhao, Yue Y; Guo, Zhanjun Z
Publication Date: 2016-09-08

Variant appearance in text: rs16917496
PubMed Link: 27605386
Variant Present in the following documents:
  • Main text
  • srep32921.pdf
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A polymorphism at the microRNA binding site in the 3'-untranslated region of C14orf101 is associated with the risk of gastric cancer development.

Experimental And Therapeutic Medicine
Wang, Cuiju C; Zhao, Yufei Y; Ming, Yanming Y; Zhao, Shengnan S; Guo, Zhanjun Z
Publication Date: 2016-09

Variant appearance in text: rs16917496
PubMed Link: 27602096
Variant Present in the following documents:
  • Main text
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A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer.

Oncotarget
Liu, Ben B; Zhang, Xining X; Song, Fengju F; Liu, Qun Q; Dai, Hongji H; Zheng, Hong H; Cui, Ping P; Zhang, Lina L; Zhang, Wei W; Chen, Kexin K
Publication Date: 2016-06-07

Variant appearance in text: rs16917496
PubMed Link: 27144429
Variant Present in the following documents:
  • Main text
  • oncotarget-07-34277.pdf
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Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach.

Human Genomics
Karageorgos, Ioannis I; Mizzi, Clint C; Giannopoulou, Efstathia E; Pavlidis, Cristiana C; Peters, Brock A BA; Zagoriti, Zoi Z; Stenson, Peter D PD; Mitropoulos, Konstantinos K; Borg, Joseph J; Kalofonos, Haralabos P HP; Drmanac, Radoje R; Stubbs, Andrew A; van der Spek, Peter P; Cooper, David N DN; Katsila, Theodora T; Patrinos, George P GP
Publication Date: 2015-06-20

Variant appearance in text: rs16917496
PubMed Link: 26092435
Variant Present in the following documents:
  • 40246_2015_34_MOESM1_ESM.xlsx, sheet 2
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Critical analysis of the potential for microRNA biomarkers in breast cancer management.

Breast Cancer (Dove Medical Press)
Graveel, Carrie R CR; Calderone, Heather M HM; Westerhuis, Jennifer J JJ; Winn, Mary E ME; Sempere, Lorenzo F LF
Publication Date: 2015

Variant appearance in text: rs16917496
PubMed Link: 25759599
Variant Present in the following documents:
  • Main text
  • bctt-7-059.pdf
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RNA-based drugs and vaccines.

Expert Review Of Vaccines
Lundstrom, Kenneth K
Publication Date: 2015-02

Variant appearance in text: rs16917496
PubMed Link: 25220891
Variant Present in the following documents:
  • Main text
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MicroRNA binding site polymorphisms as biomarkers in cancer management and research.

Pharmacogenomics And Personalized Medicine
Cipollini, Monica M; Landi, Stefano S; Gemignani, Federica F
Publication Date: 2014

Variant appearance in text: rs16917496
PubMed Link: 25114582
Variant Present in the following documents:
  • Main text
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Genome-wide association study combined with biological context can reveal more disease-related SNPs altering microRNA target seed sites.

Bmc Genomics
Wu, Di D; Yang, Gang G; Zhang, Lifang L; Xue, Jiwei J; Wen, Zhining Z; Li, Menglong M
Publication Date: 2014-08-08

Variant appearance in text: rs16917496
PubMed Link: 25106527
Variant Present in the following documents:
  • Main text
  • 12864_2014_Article_6678.pdf
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Genetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population.

Plos One
Xu, Jiali J; Yin, Zhiqiang Z; Gao, Wen W; Liu, Lingxiang L; Yin, Yongmei Y; Liu, Ping P; Shu, Yongqian Y
Publication Date: 2013

Variant appearance in text: rs16917496
PubMed Link: 24146953
Variant Present in the following documents:
  • Main text
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SNPs in microRNA binding sites as prognostic and predictive cancer biomarkers.

Critical Reviews In Oncogenesis
Preskill, Carina C; Weidhaas, Joanne B JB
Publication Date: 2013

Variant appearance in text: rs16917496
PubMed Link: 23614619
Variant Present in the following documents:
  • Main text
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Polymorphisms of microRNA sequences or binding sites and lung cancer: a meta-analysis and systematic review.

Plos One
Chen, Zhiwei Z; Xu, Ling L; Ye, Xiangyun X; Shen, Shengping S; Li, Ziming Z; Niu, Xiaomin X; Lu, Shun S
Publication Date: 2013

Variant appearance in text: rs16917496
PubMed Link: 23613771
Variant Present in the following documents:
  • Main text
  • pone.0061008.pdf
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The role of microRNAs in cancer susceptibility.

Biomed Research International
Iuliano, Rodolfo R; Vismara, Marco Flavio Michele MF; Dattilo, Vincenzo V; Trapasso, Francesco F; Baudi, Francesco F; Perrotti, Nicola N
Publication Date: 2013

Variant appearance in text: rs16917496
PubMed Link: 23586049
Variant Present in the following documents:
  • Main text
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A polymorphism at the miR-502 binding site in the 3' untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer.

Experimental And Therapeutic Medicine
Ding, Cuimin C; Li, Ruijuan R; Peng, Jingcui J; Li, Shengmian S; Guo, Zhanjun Z
Publication Date: 2012-04

Variant appearance in text: rs16917496
PubMed Link: 22969952
Variant Present in the following documents:
  • Main text
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A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS.

Bmc Genomics
Richardson, Kris K; Lai, Chao-Qiang CQ; Parnell, Laurence D LD; Lee, Yu-Chi YC; Ordovas, Jose M JM
Publication Date: 2011-10-13

Variant appearance in text: rs16917496
PubMed Link: 21995669
Variant Present in the following documents:
  • Main text
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Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer.

Journal Of Cellular And Molecular Medicine
Slaby, Ondrej O; Bienertova-Vasku, Julie J; Svoboda, Marek M; Vyzula, Rostislav R
Publication Date: 2012-01

Variant appearance in text: rs16917496
PubMed Link: 21692980
Variant Present in the following documents:
  • Main text
  • jcmm0016-0008.pdf
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Single-nucleotide polymorphisms among microRNA: big effects on cancer.

Chinese Journal Of Cancer
Song, Feng-Ju FJ; Chen, Ke-Xin KX
Publication Date: 2011-06

Variant appearance in text: rs16917496
PubMed Link: 21627860
Variant Present in the following documents:
  • Main text
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MicroRNA binding site polymorphisms as biomarkers of cancer risk.

Expert Review Of Molecular Diagnostics
Pelletier, Cory C; Weidhaas, Joanne B JB
Publication Date: 2010-09

Variant appearance in text: rs16917496
PubMed Link: 20843204
Variant Present in the following documents:
  • Main text
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Genetic variation in microRNA networks: the implications for cancer research.

Nature Reviews. Cancer
Ryan, Bríd M BM; Robles, Ana I AI; Harris, Curtis C CC
Publication Date: 2010-06

Variant appearance in text: rs16917496
PubMed Link: 20495573
Variant Present in the following documents:
  • Main text
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Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers.

Nucleic Acids Research
Yu, Zhenbao Z; Li, Zhen Z; Jolicoeur, Normand N; Zhang, Linhua L; Fortin, Yves Y; Wang, Edwin E; Wu, Meiqun M; Shen, Shi-Hsiang SH
Publication Date: 2007

Variant appearance in text: rs16917496
PubMed Link: 17584784
Variant Present in the following documents:
  • Main text
  • gkm480.pdf
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