Genetic variations in relation to bleeding and pharmacodynamics of dabigatran in Chinese patients with nonvalvular atrial fibrillation: A nationwide multicentre prospective cohort study.
Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis.
The European Respiratory Journal
Gafar, Fajri F; Wasmann, Roeland E RE; McIlleron, Helen M HM; Aarnoutse, Rob E RE; Schaaf, H Simon HS; Marais, Ben J BJ; Agarwal, Dipti D; Antwi, Sampson S; Bang, Nguyen D ND; Bekker, Adrie A; Bell, David J DJ; Chabala, Chishala C; Choo, Louise L; Davies, Geraint R GR; Day, Jeremy N JN; Dayal, Rajeshwar R; Denti, Paolo P; Donald, Peter R PR; Engidawork, Ephrem E; Garcia-Prats, Anthony J AJ; Gibb, Diana D; Graham, Stephen M SM; Hesseling, Anneke C AC; Heysell, Scott K SK; Idris, Misgana I MI; Kabra, Sushil K SK; Kinikar, Aarti A; Hemanth Kumar, Agibothu K AK; Kwara, Awewura A; Lodha, Rakesh R; Magis-Escurra, Cecile C; Martinez, Nilza N; Mathew, Binu S BS; Mave, Vidya V; Mduma, Estomih E; Mlotha-Mitole, Rachel R; Mpagama, Stellah G SG; Mukherjee, Aparna A; Nataprawira, Heda M HM; Peloquin, Charles A CA; Pouplin, Thomas T; Ramachandran, Geetha G; Ranjalkar, Jaya J; Roy, Vandana V; Ruslami, Rovina R; Shah, Ira I; Singh, Yatish Y; Sturkenboom, Marieke G G MGG; Svensson, Elin M EM; Swaminathan, Soumya S; Thatte, Urmila U; Thee, Stephanie S; Thomas, Tania A TA; Tikiso, Tjokosela T; Touw, Daan J DJ; Turkova, Anna A; Velpandian, Thirumurthy T; Verhagen, Lilly M LM; Winckler, Jana L JL; Yang, Hongmei H; Yunivita, Vycke V; Taxis, Katja K; Stevens, Jasper J; Alffenaar, Jan-Willem C JC; ,
Next-generation whole exome sequencing to delineate the genetic basis of primary congenital glaucoma.
Scientific Reports
Rauf, Bushra B; Khan, Shahid Y SY; Jiao, Xiaodong X; Irum, Bushra B; Ashfaq, Ramla R; Zehra, Mubashra M; Khan, Asma A AA; Naeem, Muhammad Asif MA; Shahzad, Mohsin M; Riazuddin, Sheikh S; Hejtmancik, J Fielding JF; Riazuddin, S Amer SA
Frequency of functional exonic single-nucleotide polymorphisms and haplotype distribution in the SLCO1B1 gene across genetic ancestry groups in the Qatari population.
Scientific Reports
Dashti, Mohammed M; Al-Matrouk, Abdullah A; Channanath, Arshad A; Al-Mulla, Fahd F; Thanaraj, Thangavel Alphonse TA
Predictors of Efavirenz Plasma Exposure, Auto-Induction Profile, and Effect of Pharmacogenetic Variations among HIV-Infected Children in Ethiopia: A Prospective Cohort Study.
Journal Of Personalized Medicine
Chala, Adugna A; Tadesse, Birkneh Tilahun BT; Chaka, Tolossa Eticha TE; Mukonzo, Jackson J; Kitabi, Eliford Ngaimisi EN; Tadesse, Sintayehu S; Pohanka, Anton A; Makonnen, Eyasu E; Aklillu, Eleni E
Predictors of Efavirenz Plasma Exposure, Auto-Induction Profile, and Effect of Pharmacogenetic Variations among HIV-Infected Children in Ethiopia: A Prospective Cohort Study.
Journal Of Personalized Medicine
Chala, Adugna A; Tadesse, Birkneh Tilahun BT; Chaka, Tolossa Eticha TE; Mukonzo, Jackson J; Kitabi, Eliford Ngaimisi EN; Tadesse, Sintayehu S; Pohanka, Anton A; Makonnen, Eyasu E; Aklillu, Eleni E
Inflammatory profile of patients with tuberculosis with or without HIV-1 co-infection: a prospective cohort study and immunological network analysis.
The Lancet. Microbe
Bruyn, Elsa Du ED; Fukutani, Kiyoshi F KF; Rockwood, Neesha N; Schutz, Charlotte C; Meintjes, Graeme G; Arriaga, María B MB; Cubillos-Angulo, Juan M JM; Tibúrcio, Rafael R; Sher, Alan A; Riou, Catherine C; Wilkinson, Katalin A KA; Andrade, Bruno B BB; Wilkinson, Robert J RJ
Association of genetic polymorphisms of CYP2E1, NAT2, GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.
Bmj Open
Yang, Seungwon S; Hwang, Se Jung SJ; Park, Jung Yun JY; Chung, Eun Kyoung EK; Lee, Jangik I JI
Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes.
Pharmacogenetics And Genomics
Tshabalala, Sibongile S; Choudhury, Ananyo A; Beeton-Kempen, Natasha N; Martinson, Neil N; Ramsay, Michèle M; Mancama, Dalu D
Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines?
Antimicrobial Agents And Chemotherapy
Sekaggya-Wiltshire, Christine C; Chirehwa, Maxwell M; Musaazi, Joseph J; von Braun, Amrei A; Buzibye, Allan A; Muller, Daniel D; Gutteck, Ursula U; Motta, Ilaria I; Calcagno, Andrea A; Fehr, Jan S JS; Kambugu, Andrew A; Castelnuovo, Barbara B; Lamorde, Mohammed M; Denti, Paolo P
A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine.
Antimicrobial Agents And Chemotherapy
Francis, Jose J; Zvada, Simbarashe P SP; Denti, Paolo P; Hatherill, Mark M; Charalambous, Salome S; Mungofa, Stanley S; Dawson, Rodney R; Dorman, Susan S; Gupte, Nikhil N; Wiesner, Lubbe L; Jindani, Amina A; Harrison, Thomas S TS; Olagunju, Adeniyi A; Egan, Deirdre D; Owen, Andrew A; McIlleron, Helen M HM
A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines.
The Pediatric Infectious Disease Journal
Pinto, Jorge A JA; Capparelli, Edmund V EV; Warshaw, Meredith M; Zimmer, Bonnie B; Cressey, Tim R TR; Spector, Stephen A SA; Qin, Min M; Smith, Betsy B; Siberry, George K GK; Mirochnick, Mark M; ,
Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis.
Antimicrobial Agents And Chemotherapy
Sloan, Derek J DJ; McCallum, Andrew D AD; Schipani, Alessandro A; Egan, Deirdre D; Mwandumba, Henry C HC; Ward, Steve A SA; Waterhouse, David D; Banda, Gertrude G; Allain, Theresa J TJ; Owen, Andrew A; Khoo, Saye H SH; Davies, Geraint R GR
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem Cell Reports
Garate, Zita Z; Quintana-Bustamante, Oscar O; Crane, Ana M AM; Olivier, Emmanuel E; Poirot, Laurent L; Galetto, Roman R; Kosinski, Penelope P; Hill, Collin C; Kung, Charles C; Agirre, Xabi X; Orman, Israel I; Cerrato, Laura L; Alberquilla, Omaira O; Rodriguez-Fornes, Fatima F; Fusaki, Noemi N; Garcia-Sanchez, Felix F; Maia, Tabita M TM; Ribeiro, Maria L ML; Sevilla, Julian J; Prosper, Felipe F; Jin, Shengfang S; Mountford, Joanne J; Guenechea, Guillermo G; Gouble, Agnes A; Bueren, Juan A JA; Davis, Brian R BR; Segovia, Jose C JC
Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition.
Pharmaceuticals (Basel, Switzerland)
Thomford, Nicholas E NE; Dzobo, Kevin K; Chopera, Denis D; Wonkam, Ambroise A; Skelton, Michelle M; Blackhurst, Dee D; Chirikure, Shadreck S; Dandara, Collet C
Novel dosing strategies increase exposures of the potent antituberculosis drug rifapentine but are poorly tolerated in healthy volunteers.
Antimicrobial Agents And Chemotherapy
Dooley, Kelly E KE; Savic, Radojka M RM; Park, Jeong-Gun JG; Cramer, Yoninah Y; Hafner, Richard R; Hogg, Evelyn E; Janik, Jennifer J; Marzinke, Mark A MA; Patterson, Kristine K; Benson, Constance A CA; Hovind, Laura L; Dorman, Susan E SE; Haas, David W DW; ,
Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA-824 with concomitant lopinavir-ritonavir, efavirenz, or rifampin.
Antimicrobial Agents And Chemotherapy
Dooley, Kelly E KE; Luetkemeyer, Anne F AF; Park, Jeong-Gun JG; Allen, Reena R; Cramer, Yoninah Y; Murray, Stephen S; Sutherland, Deborah D; Aweeka, Francesca F; Koletar, Susan L SL; Marzan, Florence F; Bao, Jing J; Savic, Rada R; Haas, David W DW; ,
Nutritional supplementation increases rifampin exposure among tuberculosis patients coinfected with HIV.
Antimicrobial Agents And Chemotherapy
Jeremiah, Kidola K; Denti, Paolo P; Chigutsa, Emmanuel E; Faurholt-Jepsen, Daniel D; PrayGod, George G; Range, Nyagosya N; Castel, Sandra S; Wiesner, Lubbe L; Hagen, Christian Munch CM; Christiansen, Michael M; Changalucha, John J; McIlleron, Helen H; Friis, Henrik H; Andersen, Aase Bengaard AB
Factors associated with variability in rifampin plasma pharmacokinetics and the relationship between rifampin concentrations and induction of efavirenz clearance.
Pharmacotherapy
Kwara, Awewura A; Cao, Lei L; Yang, Hongmei H; Poethke, Pamela P; Kurpewski, Jaclynn J; Tashima, Karen T KT; Mahjoub, Behrang D BD; Court, Michael H MH; Peloquin, Charles A CA
Meta-analysis of clinical studies supports the pharmacokinetic variability hypothesis for acquired drug resistance and failure of antituberculosis therapy.
Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Pasipanodya, Jotam G JG; Srivastava, Shashikant S; Gumbo, Tawanda T
The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.
Antimicrobial Agents And Chemotherapy
Chigutsa, Emmanuel E; Visser, Marianne E ME; Swart, Elizabeth C EC; Denti, Paolo P; Pushpakom, Sudeep S; Egan, Deirdre D; Holford, Nicholas H G NH; Smith, Peter J PJ; Maartens, Gary G; Owen, Andrew A; McIlleron, Helen H
HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.
Pharmacogenetics And Genomics
Hartkoorn, Ruben C RC; Kwan, Wai San WS; Shallcross, Victoria V; Chaikan, Ammara A; Liptrott, Neill N; Egan, Deirdre D; Sora, Enrique Salcedo ES; James, Chloë E CE; Gibbons, Sara S; Bray, Pat G PG; Back, David J DJ; Khoo, Saye H SH; Owen, Andrew A