Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.
Nature Genetics
Schlosser, Pascal P; Scherer, Nora N; Grundner-Culemann, Franziska F; Monteiro-Martins, Sara S; Haug, Stefan S; Steinbrenner, Inga I; Uluvar, Burulça B; Wuttke, Matthias M; Cheng, Yurong Y; Ekici, Arif B AB; Gyimesi, Gergely G; Karoly, Edward D ED; Kotsis, Fruzsina F; Mielke, Johanna J; Gomez, Maria F MF; Yu, Bing B; Grams, Morgan E ME; Coresh, Josef J; Boerwinkle, Eric E; Köttgen, Michael M; Kronenberg, Florian F; Meiselbach, Heike H; Mohney, Robert P RP; Akilesh, Shreeram S; , ; Schmidts, Miriam M; Hediger, Matthias A MA; Schultheiss, Ulla T UT; Eckardt, Kai-Uwe KU; Oefner, Peter J PJ; Sekula, Peggy P; Li, Yong Y; Köttgen, Anna A
FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.
Scientific Reports
Reynolds, Lindsay M LM; Dutta, Rahul R; Seeds, Michael C MC; Lake, Kirsten N KN; Hallmark, Brian B; Mathias, Rasika A RA; Howard, Timothy D TD; Chilton, Floyd H FH
The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.
Npj Genomic Medicine
Oni-Orisan, Akinyemi A; Haldar, Tanushree T; Ranatunga, Dilrini K DK; Medina, Marisa W MW; Schaefer, Catherine C; Krauss, Ronald M RM; Iribarren, Carlos C; Risch, Neil N; Hoffmann, Thomas J TJ
Hirvensalo, Päivi P; Tornio, Aleksi A; Neuvonen, Mikko M; Kiander, Wilma W; Kidron, Heidi H; Paile-Hyvärinen, Maria M; Tapaninen, Tuija T; Backman, Janne T JT; Niemi, Mikko M
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.
Breast Cancer Research And Treatment
Dudenkov, Tanda M TM; Ingle, James N JN; Buzdar, Aman U AU; Robson, Mark E ME; Kubo, Michiaki M; Ibrahim-Zada, Irada I; Batzler, Anthony A; Jenkins, Gregory D GD; Pietrzak, Tracy L TL; Carlson, Erin E EE; Barman, Poulami P; Goetz, Matthew P MP; Northfelt, Donald W DW; Moreno-Aspita, Alvaro A; Williard, Clark V CV; Kalari, Krishna R KR; Nakamura, Yusuke Y; Wang, Liewei L; Weinshilboum, Richard M RM