In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis.
Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States.
Acs Central Science
Lim, Shuhui S; Khoo, Regina R; Juang, Yu-Chi YC; Gopal, Pooja P; Zhang, Huibin H; Yeo, Constance C; Peh, Khong Ming KM; Teo, Jinkai J; Ng, Simon S; Henry, Brian B; Partridge, Anthony W AW
Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior.
Elife
Goswami, Debanjan D; Chen, De ; Yang, Yue Y; Gudla, Prabhakar R PR; Columbus, John J; Worthy, Karen K; Rigby, Megan M; Wheeler, Madeline M; Mukhopadhyay, Suman S; Powell, Katie K; Burgan, William W; Wall, Vanessa V; Esposito, Dominic D; Simanshu, Dhirendra K DK; Lightstone, Felice C FC; Nissley, Dwight V DV; McCormick, Frank F; Turbyville, Thomas T
Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.
Nature Communications
Mitchell, Khadijah A KA; Nichols, Noah N; Tang, Wei W; Walling, Jennifer J; Stevenson, Holly H; Pineda, Marbin M; Stefanescu, Roxana R; Edelman, Daniel C DC; Girvin, Andrew T AT; Zingone, Adriana A; Sinha, Sanju S; Bowman, Elise E; Rossi, Emily L EL; Arauz, Rony F RF; Jack Zhu, Yuelin Y; Lack, Justin J; Weingartner, Elizabeth E; Waterfall, Joshua J JJ; Pine, Sharon R SR; Simmons, John J; Meltzer, Paul P; Ryan, BrĂd M BM
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.
Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M