KRAS c.404G>A ;(p.R135K)

Variant ID: 12-25378594-C-T

NM_004985.3(KRAS):c.404G>A;(p.R135K)

This variant was identified in 11 publications

View GRCh38 version.




Publications:


Prognosis and Characterization of Microenvironment in Cervical Cancer Influenced by Fatty Acid Metabolism-Related Genes.

Journal Of Oncology
Zhou, Yanjun Y; Zhu, Jiahao J; Gu, Mengxuan M; Gu, Ke K
Publication Date: 2023

Variant appearance in text: KRAS: R135K
PubMed Link: 36936374
Variant Present in the following documents:
  • JO2023-6851036.pdf
View BVdb publication page



In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis.

International Journal Of Molecular Sciences
Tu, Gao G; Liu, Qing Q; Qiu, Yue Y; Leung, Elaine Lai-Han EL; Yao, Xiaojun X
Publication Date: 2022-11-10

Variant appearance in text: K-Ras4B: R135K
PubMed Link: 36430323
Variant Present in the following documents:
  • ijms-23-13845.pdf
View BVdb publication page



Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect.

Frontiers In Molecular Biosciences
He, Xuan X; Du, Kui K; Wang, Yuanhao Y; Fan, Jigang J; Li, Mingyu M; Ni, Duan D; Lu, Shaoyong S; Bian, Xiaolan X; Liu, Yaqin Y
Publication Date: 2022

Variant appearance in text: K-Ras4B: R135K
PubMed Link: 35463958
Variant Present in the following documents:
  • Main text
  • fmolb-09-860962.pdf
View BVdb publication page



Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States.

Acs Central Science
Lim, Shuhui S; Khoo, Regina R; Juang, Yu-Chi YC; Gopal, Pooja P; Zhang, Huibin H; Yeo, Constance C; Peh, Khong Ming KM; Teo, Jinkai J; Ng, Simon S; Henry, Brian B; Partridge, Anthony W AW
Publication Date: 2021-02-24

Variant appearance in text: KRAS: R135K
PubMed Link: 33655066
Variant Present in the following documents:
  • Main text
  • oc0c01337_si_001.pdf
View BVdb publication page



Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior.

Elife
Goswami, Debanjan D; Chen, De ; Yang, Yue Y; Gudla, Prabhakar R PR; Columbus, John J; Worthy, Karen K; Rigby, Megan M; Wheeler, Madeline M; Mukhopadhyay, Suman S; Powell, Katie K; Burgan, William W; Wall, Vanessa V; Esposito, Dominic D; Simanshu, Dhirendra K DK; Lightstone, Felice C FC; Nissley, Dwight V DV; McCormick, Frank F; Turbyville, Thomas T
Publication Date: 2020-01-20

Variant appearance in text: KRAS: R135K
PubMed Link: 31958057
Variant Present in the following documents:
  • Main text
  • elife-47654.pdf
View BVdb publication page



Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.

Nature Communications
Mitchell, Khadijah A KA; Nichols, Noah N; Tang, Wei W; Walling, Jennifer J; Stevenson, Holly H; Pineda, Marbin M; Stefanescu, Roxana R; Edelman, Daniel C DC; Girvin, Andrew T AT; Zingone, Adriana A; Sinha, Sanju S; Bowman, Elise E; Rossi, Emily L EL; Arauz, Rony F RF; Jack Zhu, Yuelin Y; Lack, Justin J; Weingartner, Elizabeth E; Waterfall, Joshua J JJ; Pine, Sharon R SR; Simmons, John J; Meltzer, Paul P; Ryan, BrĂ­d M BM
Publication Date: 2019-12-16

Variant appearance in text: KRAS: 404G>A; R135K
PubMed Link: 31844068
Variant Present in the following documents:
  • 41467_2019_13732_MOESM12_ESM.xlsx, sheet 1
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: KRAS: R135K
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
  • pone.0196434.s001.xlsx, sheet 1
View BVdb publication page



Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation.

International Journal Of Molecular Sciences
Ni, Duan D; Song, Kun K; Zhang, Jian J; Lu, Shaoyong S
Publication Date: 2017-10-26

Variant appearance in text: KRAS: R135K
PubMed Link: 29072601
Variant Present in the following documents:
  • ijms-18-02249.pdf
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: KRAS: 404G>A
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Publication Date: 2015

Variant appearance in text: KRAS: R135K
PubMed Link: 26010451
Variant Present in the following documents:
  • pone.0127146.s014.xlsx, sheet 3
View BVdb publication page



Novel KRAS gene mutations in sporadic colorectal cancer.

Plos One
Naser, Walid M WM; Shawarby, Mohamed A MA; Al-Tamimi, Dalal M DM; Seth, Arun A; Al-Quorain, Abdulaziz A; Nemer, Areej M Al AM; Albagha, Omar M E OM
Publication Date: 2014

Variant appearance in text: KRAS: 404G>A; R135K
PubMed Link: 25412182
Variant Present in the following documents:
  • Main text
  • pone.0113350.pdf
  • pone.0113350.s003.xls, sheet 1
View BVdb publication page