KRAS c.353G>C ;(p.C118S)

Variant ID: 12-25378645-C-G

NM_004985.3(KRAS):c.353G>C;(p.C118S)

This variant was identified in 51 publications

View GRCh38 version.




Publications:


Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors.

Elife
Goebel, Lisa L; Kirschner, Tonia T; Koska, Sandra S; Rai, Amrita A; Janning, Petra P; Maffini, Stefano S; Vatheuer, Helge H; Czodrowski, Paul P; Goody, Roger S RS; Müller, Matthias P MP; Rauh, Daniel D
Publication Date: 2023-03-27

Variant appearance in text: KRAS: C118S
PubMed Link: 36972177
Variant Present in the following documents:
  • Main text
  • elife-82184.pdf
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: KRAS: C118S
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor.

Journal Of Medicinal Chemistry
Bröker, Joachim J; Waterson, Alex G AG; Smethurst, Chris C; Kessler, Dirk D; Böttcher, Jark J; Mayer, Moriz M; Gmaschitz, Gerhard G; Phan, Jason J; Little, Andrew A; Abbott, Jason R JR; Sun, Qi Q; Gmachl, Michael M; Rudolph, Dorothea D; Arnhof, Heribert H; Rumpel, Klaus K; Savarese, Fabio F; Gerstberger, Thomas T; Mischerikow, Nikolai N; Treu, Matthias M; Herdeis, Lorenz L; Wunberg, Tobias T; Gollner, Andreas A; Weinstabl, Harald H; Mantoulidis, Andreas A; Krämer, Oliver O; McConnell, Darryl B DB; W Fesik, Stephen S
Publication Date: 2022-11-10

Variant appearance in text: KRAS: C118S
PubMed Link: 36300829
Variant Present in the following documents:
  • jm2c01120.pdf
View BVdb publication page



Modeling receptor flexibility in the structure-based design of KRASG12C inhibitors.

Journal Of Computer-Aided Molecular Design
Zhu, Kai K; Li, Cui C; Wu, Kingsley Y KY; Mohr, Christopher C; Li, Xun X; Lanman, Brian B
Publication Date: 2022-08

Variant appearance in text: KRAS: C118S
PubMed Link: 35930206
Variant Present in the following documents:
  • 10822_2022_Article_467.pdf
View BVdb publication page



Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.

The Journal Of Biological Chemistry
Huynh, Minh V MV; Parsonage, Derek D; Forshaw, Tom E TE; Chirasani, Venkat R VR; Hobbs, G Aaron GA; Wu, Hanzhi H; Lee, Jingyun J; Furdui, Cristina M CM; Poole, Leslie B LB; Campbell, Sharon L SL
Publication Date: 2022-08

Variant appearance in text: KRAS: C118S
PubMed Link: 35753348
Variant Present in the following documents:
  • Main text
  • mmc1.pdf
  • main.pdf
View BVdb publication page



Delineating the RAS Conformational Landscape.

Cancer Research
Parker, Mitchell I MI; Meyer, Joshua E JE; Golemis, Erica A EA; Dunbrack, Roland L RL
Publication Date: 2022-07-05

Variant appearance in text: KRAS: C118S
PubMed Link: 35536216
Variant Present in the following documents:
  • can-22-0804_supplementary_datasets_s1-s4_suppsds1-sds4.xlsx, sheet 1
View BVdb publication page



Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics
Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R
Publication Date: 2022-04-25

Variant appearance in text: KRAS: 353G>C
PubMed Link: 35468810
Variant Present in the following documents:
  • 12920_2022_1235_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Understanding the influence of AMG 510 on the structure of KRASG12C empowered by molecular dynamics simulation.

Computational And Structural Biotechnology Journal
Li, Yu Y; Han, Lei L; Zhang, Ziding Z
Publication Date: 2022

Variant appearance in text: KRAS: C118S
PubMed Link: 35284050
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Recapitulation of cell-like KRAS4b membrane dynamics on complex biomimetic membranes.

Iscience
Shrestha, Rebika R; Chen, De ; Frank, Peter P; Nissley, Dwight V DV; Turbyville, Thomas J TJ
Publication Date: 2022-01-21

Variant appearance in text: KRAS: C118S
PubMed Link: 35106460
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Ingólfsson, Helgi I HI; Neale, Chris C; Carpenter, Timothy S TS; Shrestha, Rebika R; López, Cesar A CA; Tran, Timothy H TH; Oppelstrup, Tomas T; Bhatia, Harsh H; Stanton, Liam G LG; Zhang, Xiaohua X; Sundram, Shiv S; Di Natale, Francesco F; Agarwal, Animesh A; Dharuman, Gautham G; Kokkila Schumacher, Sara I L SIL; Turbyville, Thomas T; Gulten, Gulcin G; Van, Que N QN; Goswami, Debanjan D; Jean-Francois, Frantz F; Agamasu, Constance C; Chen, De ; Hettige, Jeevapani J JJ; Travers, Timothy T; Sarkar, Sumantra S; Surh, Michael P MP; Yang, Yue Y; Moody, Adam A; Liu, Shusen S; Van Essen, Brian C BC; Voter, Arthur F AF; Ramanathan, Arvind A; Hengartner, Nicolas W NW; Simanshu, Dhirendra K DK; Stephen, Andrew G AG; Bremer, Peer-Timo PT; Gnanakaran, S S; Glosli, James N JN; Lightstone, Felice C FC; McCormick, Frank F; Nissley, Dwight V DV; Streitz, Frederick H FH
Publication Date: 2022-01-04

Variant appearance in text: KRAS: C118S
PubMed Link: 34983849
Variant Present in the following documents:
  • pnas.2113297119.sapp.pdf
View BVdb publication page



Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Ingólfsson, Helgi I HI; Neale, Chris C; Carpenter, Timothy S TS; Shrestha, Rebika R; López, Cesar A CA; Tran, Timothy H TH; Oppelstrup, Tomas T; Bhatia, Harsh H; Stanton, Liam G LG; Zhang, Xiaohua X; Sundram, Shiv S; Di Natale, Francesco F; Agarwal, Animesh A; Dharuman, Gautham G; Kokkila Schumacher, Sara I L SIL; Turbyville, Thomas T; Gulten, Gulcin G; Van, Que N QN; Goswami, Debanjan D; Jean-Francois, Frantz F; Agamasu, Constance C; Chen, De ; Hettige, Jeevapani J JJ; Travers, Timothy T; Sarkar, Sumantra S; Surh, Michael P MP; Yang, Yue Y; Moody, Adam A; Liu, Shusen S; Van Essen, Brian C BC; Voter, Arthur F AF; Ramanathan, Arvind A; Hengartner, Nicolas W NW; Simanshu, Dhirendra K DK; Stephen, Andrew G AG; Bremer, Peer-Timo PT; Gnanakaran, S S; Glosli, James N JN; Lightstone, Felice C FC; McCormick, Frank F; Nissley, Dwight V DV; Streitz, Frederick H FH
Publication Date: 2022-01-04

Variant appearance in text: KRAS: C118S
PubMed Link: 34983849
Variant Present in the following documents:
  • pnas.2113297119.sapp.pdf
View BVdb publication page



A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: KRAS: C118S
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
View BVdb publication page



Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.

Frontiers In Immunology
Li, Na N; Wang, Jiahong J; Zhan, Xianquan X
Publication Date: 2021

Variant appearance in text: KRAS: 353G>C; C118S
PubMed Link: 34887858
Variant Present in the following documents:
  • Table_4.xlsx, sheet 1
View BVdb publication page



The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.

Nature Communications
Gebregiworgis, Teklab T; Kano, Yoshihito Y; St-Germain, Jonathan J; Radulovich, Nikolina N; Udaskin, Molly L ML; Mentes, Ahmet A; Huang, Richard R; Poon, Betty P K BPK; He, Wenguang W; Valencia-Sama, Ivette I; Robinson, Claire M CM; Huestis, Melissa M; Miao, Jinmin J; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Irwin, Meredith S MS; Lee, Jeffrey E JE; Tsao, Ming-Sound MS; Raught, Brian B; Marshall, Christopher B CB; Ohh, Michael M; Ikura, Mitsuhiko M
Publication Date: 2021-11-01

Variant appearance in text: KRAS: C118S
PubMed Link: 34725361
Variant Present in the following documents:
  • Main text
  • 41467_2021_26526_MOESM1_ESM.pdf
  • 41467_2021_Article_26526.pdf
View BVdb publication page



Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.

Chemical Science
Lee, Ki-Young KY; Enomoto, Masahiro M; Gebregiworgis, Teklab T; Gasmi-Seabrook, Geneviève M C GMC; Ikura, Mitsuhiko M; Marshall, Christopher B CB
Publication Date: 2021-10-06

Variant appearance in text: KRAS: C118S
PubMed Link: 34703570
Variant Present in the following documents:
  • SC-012-D1SC03484G-s001.pdf
View BVdb publication page



NMR 1H, 13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation.

Biomolecular Nmr Assignments
Sharma, Alok K AK; Dyba, Marcin M; Tonelli, Marco M; Smith, Brian B; Gillette, William K WK; Esposito, Dominic D; Nissley, Dwight V DV; McCormick, Frank F; Maciag, Anna E AE
Publication Date: 2022-04

Variant appearance in text: KRAS: C118S
PubMed Link: 34686998
Variant Present in the following documents:
  • Main text
  • 12104_2021_Article_10050.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: KRAS: C118S
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



The Ras dimer structure.

Chemical Science
Rudack, Till T; Teuber, Christian C; Scherlo, Marvin M; Güldenhaupt, Jörn J; Schartner, Jonas J; Lübben, Mathias M; Klare, Johann J; Gerwert, Klaus K; Kötting, Carsten C
Publication Date: 2021-05-04

Variant appearance in text: K-Ras4B: C118S
PubMed Link: 34194708
Variant Present in the following documents:
  • SC-012-D1SC00957E-s003.pdf
View BVdb publication page



Monoubiquitination of KRAS at Lysine104 and Lysine147 Modulates Its Dynamics and Interaction with Partner Proteins.

The Journal Of Physical Chemistry. B
Nair, Vinay V VV; Yin, Guowei G; Zhang, Jerry J; Hancock, John F JF; Campbell, Sharon L SL; Gorfe, Alemayehu A AA
Publication Date: 2021-05-13

Variant appearance in text: KRAS: C118S
PubMed Link: 33929846
Variant Present in the following documents:
  • Main text
View BVdb publication page



Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
Publication Date: 2021-04-19

Variant appearance in text: KRAS: C118S
PubMed Link: 33875650
Variant Present in the following documents:
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 5
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.

Nature Communications
Tran, Timothy H TH; Chan, Albert H AH; Young, Lucy C LC; Bindu, Lakshman L; Neale, Chris C; Messing, Simon S; Dharmaiah, Srisathiyanarayanan S; Taylor, Troy T; Denson, John-Paul JP; Esposito, Dominic D; Nissley, Dwight V DV; Stephen, Andrew G AG; McCormick, Frank F; Simanshu, Dhirendra K DK
Publication Date: 2021-02-19

Variant appearance in text: KRAS: C118S
PubMed Link: 33608534
Variant Present in the following documents:
  • Main text
  • 41467_2021_Article_21422.pdf
View BVdb publication page



KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface.

Iscience
Yin, Guowei G; Zhang, Jerry J; Nair, Vinay V; Truong, Vinh V; Chaia, Angelo A; Petela, Johnny J; Harrison, Joseph J; Gorfe, Alemayehu A AA; Campbell, Sharon L SL
Publication Date: 2020-08-10

Variant appearance in text: KRAS: C118S
PubMed Link: 32882514
Variant Present in the following documents:
  • mmc1.pdf
  • main.pdf
View BVdb publication page



Biology, pathology, and therapeutic targeting of RAS.

Advances In Cancer Research
Rhett, J Matthew JM; Khan, Imran I; O'Bryan, John P JP
Publication Date: 2020

Variant appearance in text: KRAS: C118S
PubMed Link: 32723567
Variant Present in the following documents:
  • Main text
View BVdb publication page



KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations.

Scientific Reports
Pantsar, Tatu T
Publication Date: 2020-07-20

Variant appearance in text: KRAS: C118S
PubMed Link: 32686745
Variant Present in the following documents:
  • Main text
  • 41598_2020_Article_68950.pdf
View BVdb publication page



The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2.

The Journal Of Biological Chemistry
Arrington, Megan E ME; Temple, Brenda B; Schaefer, Antje A; Campbell, Sharon L SL
Publication Date: 2020-08-21

Variant appearance in text: KRAS: C118S
PubMed Link: 32636302
Variant Present in the following documents:
  • Main text
View BVdb publication page



Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.

Chemmedchem
Mortier, Jérémie J; Friberg, Anders A; Badock, Volker V; Moosmayer, Dieter D; Schroeder, Jens J; Steigemann, Patrick P; Siegel, Franziska F; Gradl, Stefan S; Bauser, Marcus M; Hillig, Roman C RC; Briem, Hans H; Eis, Knut K; Bader, Benjamin B; Nguyen, Duy D; Christ, Clara D CD
Publication Date: 2020-05-19

Variant appearance in text: KRAS: C118S
PubMed Link: 32237114
Variant Present in the following documents:
  • CMDC-15-827-s001.pdf
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: KRAS: C118S
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



The current understanding of KRAS protein structure and dynamics.

Computational And Structural Biotechnology Journal
Pantsar, Tatu T
Publication Date: 2020

Variant appearance in text: KRAS: C118S
PubMed Link: 31988705
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins.

Angewandte Chemie (International Ed. In English)
Zhang, Ziyang Z; Shokat, Kevan M KM
Publication Date: 2019-11-04

Variant appearance in text: KRAS: C118S
PubMed Link: 31557383
Variant Present in the following documents:
  • Main text
View BVdb publication page



Drugging an undruggable pocket on KRAS.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Kessler, Dirk D; Gmachl, Michael M; Mantoulidis, Andreas A; Martin, Laetitia J LJ; Zoephel, Andreas A; Mayer, Moriz M; Gollner, Andreas A; Covini, David D; Fischer, Silke S; Gerstberger, Thomas T; Gmaschitz, Teresa T; Goodwin, Craig C; Greb, Peter P; Häring, Daniela D; Hela, Wolfgang W; Hoffmann, Johann J; Karolyi-Oezguer, Jale J; Knesl, Petr P; Kornigg, Stefan S; Koegl, Manfred M; Kousek, Roland R; Lamarre, Lyne L; Moser, Franziska F; Munico-Martinez, Silvia S; Peinsipp, Christoph C; Phan, Jason J; Rinnenthal, Jörg J; Sai, Jiqing J; Salamon, Christian C; Scherbantin, Yvonne Y; Schipany, Katharina K; Schnitzer, Renate R; Schrenk, Andreas A; Sharps, Bernadette B; Siszler, Gabriella G; Sun, Qi Q; Waterson, Alex A; Wolkerstorfer, Bernhard B; Zeeb, Markus M; Pearson, Mark M; Fesik, Stephen W SW; McConnell, Darryl B DB
Publication Date: 2019-08-06

Variant appearance in text: KRAS: C118S
PubMed Link: 31332011
Variant Present in the following documents:
  • Main text
  • pnas.201904529.pdf
  • pnas.1904529116.sapp.pdf
View BVdb publication page



Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Hillig, Roman C RC; Sautier, Brice B; Schroeder, Jens J; Moosmayer, Dieter D; Hilpmann, André A; Stegmann, Christian M CM; Werbeck, Nicolas D ND; Briem, Hans H; Boemer, Ulf U; Weiske, Joerg J; Badock, Volker V; Mastouri, Julia J; Petersen, Kirstin K; Siemeister, Gerhard G; Kahmann, Jan D JD; Wegener, Dennis D; Böhnke, Niels N; Eis, Knut K; Graham, Keith K; Wortmann, Lars L; von Nussbaum, Franz F; Bader, Benjamin B
Publication Date: 2019-02-12

Variant appearance in text: KRAS: C118S
PubMed Link: 30683722
Variant Present in the following documents:
  • Main text
  • pnas.1812963116.sapp.pdf
  • pnas.201812963.pdf
View BVdb publication page



Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

Nature Communications
Kano, Yoshihito Y; Gebregiworgis, Teklab T; Marshall, Christopher B CB; Radulovich, Nikolina N; Poon, Betty P K BPK; St-Germain, Jonathan J; Cook, Jonathan D JD; Valencia-Sama, Ivette I; Grant, Benjamin M M BMM; Herrera, Silvia Gabriela SG; Miao, Jinmin J; Raught, Brian B; Irwin, Meredith S MS; Lee, Jeffrey E JE; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Tsao, Ming-Sound MS; Ikura, Mitsuhiko M; Ohh, Michael M
Publication Date: 2019-01-15

Variant appearance in text: KRAS: C118S
PubMed Link: 30644389
Variant Present in the following documents:
  • Main text
  • 41467_2018_Article_8115.pdf
View BVdb publication page



gRASping the redox lever to modulate cancer cell fate signaling.

Redox Biology
Foo, Chuan Han Jonathan CHJ; Pervaiz, Shazib S
Publication Date: 2019-07

Variant appearance in text: KRAS: C118S
PubMed Link: 30638892
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native Nanodiscs.

Biophysical Journal
Prakash, Priyanka P; Litwin, Douglas D; Liang, Hong H; Sarkar-Banerjee, Suparna S; Dolino, Drew D; Zhou, Yong Y; Hancock, John F JF; Jayaraman, Vasanthi V; Gorfe, Alemayehu A AA
Publication Date: 2019-01-22

Variant appearance in text: KRAS: C118S
PubMed Link: 30616834
Variant Present in the following documents:
  • Main text
View BVdb publication page



Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles.

Biophysical Journal
Liao, Tsung-Jen TJ; Jang, Hyunbum H; Fushman, David D; Nussinov, Ruth R
Publication Date: 2018-08-21

Variant appearance in text: KRAS: C118S
PubMed Link: 30097175
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

Variant appearance in text: KRAS: C118S
PubMed Link: 30053901
Variant Present in the following documents:
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 19
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 13
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 8
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 10
View BVdb publication page



Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Ntai, Ioanna I; Fornelli, Luca L; DeHart, Caroline J CJ; Hutton, Josiah E JE; Doubleday, Peter F PF; LeDuc, Richard D RD; van Nispen, Alexandra J AJ; Fellers, Ryan T RT; Whiteley, Gordon G; Boja, Emily S ES; Rodriguez, Henry H; Kelleher, Neil L NL
Publication Date: 2018-04-17

Variant appearance in text: KRAS: Cys118Ser
PubMed Link: 29610327
Variant Present in the following documents:
  • Main text
View BVdb publication page



RAS ubiquitylation modulates effector interactions.

Small Gtpases
Thurman, Ryan R; Siraliev-Perez, Edhriz E; Campbell, Sharon L SL
Publication Date: 2020-05

Variant appearance in text: KRAS: C118S
PubMed Link: 29185849
Variant Present in the following documents:
  • Main text
View BVdb publication page



Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.

Biochemistry
McGregor, Lynn M LM; Jenkins, Meredith L ML; Kerwin, Caitlin C; Burke, John E JE; Shokat, Kevan M KM
Publication Date: 2017-06-27

Variant appearance in text: KRAS: C118S
PubMed Link: 28621541
Variant Present in the following documents:
  • Main text
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: KRAS: C118S
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation.

The Journal Of Biological Chemistry
Yin, Guowei G; Kistler, Samantha S; George, Samuel D SD; Kuhlmann, Nora N; Garvey, Leslie L; Huynh, Minh M; Bagni, Rachel K RK; Lammers, Michael M; Der, Channing J CJ; Campbell, Sharon L SL
Publication Date: 2017-03-17

Variant appearance in text: KRAS: C118S
PubMed Link: 28154176
Variant Present in the following documents:
  • Main text
View BVdb publication page



The role of wild type RAS isoforms in cancer.

Seminars In Cell & Developmental Biology
Zhou, Bingying B; Der, Channing J CJ; Cox, Adrienne D AD
Publication Date: 2016-10

Variant appearance in text: KRAS: C118S
PubMed Link: 27422332
Variant Present in the following documents:
  • Main text
View BVdb publication page



LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics
Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L
Publication Date: 2016-02-09

Variant appearance in text: KRAS: C118S
PubMed Link: 26860319
Variant Present in the following documents:
  • 12859_2016_935_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences.

The Journal Of Physical Chemistry. B
Chakrabarti, Mayukh M; Jang, Hyunbum H; Nussinov, Ruth R
Publication Date: 2016-02-04

Variant appearance in text: K-Ras4B: C118S
PubMed Link: 26761128
Variant Present in the following documents:
  • Main text
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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Mazhab-Jafari, Mohammad T MT; Marshall, Christopher B CB; Smith, Matthew J MJ; Gasmi-Seabrook, Geneviève M C GM; Stathopulos, Peter B PB; Inagaki, Fuyuhiko F; Kay, Lewis E LE; Neel, Benjamin G BG; Ikura, Mitsuhiko M
Publication Date: 2015-05-26

Variant appearance in text: KRAS: C118S
PubMed Link: 25941399
Variant Present in the following documents:
  • Main text
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Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S.

Plos One
Huang, Lu L; Counter, Christopher M CM
Publication Date: 2015

Variant appearance in text: KRAS: C118S
PubMed Link: 25902334
Variant Present in the following documents:
  • Main text
  • pone.0123918.pdf
  • pone.0123918.s001.pdf
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Decreased tumorigenesis in mice with a Kras point mutation at C118.

Nature Communications
Huang, Lu L; Carney, John J; Cardona, Diana M DM; Counter, Christopher M CM
Publication Date: 2014-11-14

Variant appearance in text: KRAS: C118S
PubMed Link: 25394415
Variant Present in the following documents:
  • Main text
  • nihms-632226.pdf
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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: KRAS: C118S
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
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Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nature Medicine
Xie, Mingchao M; Lu, Charles C; Wang, Jiayin J; McLellan, Michael D MD; Johnson, Kimberly J KJ; Wendl, Michael C MC; McMichael, Joshua F JF; Schmidt, Heather K HK; Yellapantula, Venkata V; Miller, Christopher A CA; Ozenberger, Bradley A BA; Welch, John S JS; Link, Daniel C DC; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Chen, Feng F; Wilson, Richard K RK; Ley, Timothy J TJ; Ding, Li L
Publication Date: 2014-12

Variant appearance in text: KRAS: C118S
PubMed Link: 25326804
Variant Present in the following documents:
  • NIHMS630249-supplement-6.xlsx, sheet 1
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