Publications:

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Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

Biorxiv : The Preprint Server For Biology

Ratnasinghe, Brian D BD; Haque, Neshatul N; Wagenknecht, Jessica B JB; Jensen, Davin R DR; Esparza, Guadalupe V GV; Leverence, Elise N EN; De Assuncao, Thiago Milech TM; Mathison, Angela J AJ; Lomberk, Gwen G; Smith, Brian C BC; Volkman, Brian F BF; Urrutia, Raul R; Zimmermann, Michael T MT

Publication Date: 2023-04-28

Variant appearance in text: KRAS: K117E

PubMed Link: 37207265

Variant Present in the following documents:

• Main text
• nihpp-2023.04.28.536249v1.pdf

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Characteristics and prognosis of rrDLBCL with TP53 mutations and a high-risk subgroup represented by the co-mutations of DDX3X-TP53.

Cancer Medicine

Gao, Fan F; Hu, Kai K; Zheng, Peihao P; Shi, Hui H; Ke, Xiaoyan X

Publication Date: 2023-03-27

Variant appearance in text: KRAS: 349A>G; K117E

PubMed Link: 36971051

Variant Present in the following documents:

• CAM4-12-10267-s001.xlsx, sheet 1

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Genetic landscapes and curative effect of CAR T-cell immunotherapy in relapse and refractory DLBCL patients.

Blood Advances

Shi, Hui H; Zheng, Peihao P; Liu, Rui R; Xu, Teng T; Yang, Fan F; Feng, Shaomei S; Guo, Yuelu Y; Ma, Lixia L; Liu, Haidi H; Lei, Yang Y; Li, Ruiting R; Deng, Biping B; Hou, Shuling S; Li, Yang Y; Zheng, Qinlong Q; Hu, Kai K; Ke, Xiaoyan X

Publication Date: 2022-07-28

Variant appearance in text: KRAS: 349A>G; K117E

PubMed Link: 35901280

Variant Present in the following documents:

• BLOODA_ADV-2021-006845-mmc1.xlsx, sheet 2

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Comparative Panel Sequencing of DNA Variants in cf-, ev- and tumorDNA for Pancreatic Ductal Adenocarcinoma Patients.

Cancers

Waldenmaier, Mareike M; Schulte, Lucas L; Schönfelder, Jonathan J; Fürstberger, Axel A; Kraus, Johann M JM; Daiss, Nora N; Seibold, Tanja T; Morawe, Mareen M; Ettrich, Thomas J TJ; Kestler, Hans A HA; Kahlert, Christoph C; Seufferlein, Thomas T; Eiseler, Tim T

Publication Date: 2022-02-21

Variant appearance in text: KRAS: K117E

PubMed Link: 35205822

Variant Present in the following documents:

• cancers-14-01074.pdf

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Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing.

Frontiers In Genetics

Gao, Fan F; Tian, Lei L; Shi, Hui H; Zheng, Peihao P; Wang, Jing J; Dong, Fei F; Hu, Kai K; Ke, Xiaoyan X

Publication Date: 2021

Variant appearance in text: KRAS: 349A>G; K117E

PubMed Link: 34925435

Variant Present in the following documents:

• DataSheet2.xlsx, sheet 1

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Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition.

Molecular & Cellular Proteomics : Mcp

Schmitt, Marisa M; Sinnberg, Tobias T; Bratl, Katrin K; Zittlau, Katharina K; Garbe, Claus C; Macek, Boris B; Nalpas, Nicolas C NC

Publication Date: 2021-10-19

Variant appearance in text: KRAS: K117E

PubMed Link: 34673281

Variant Present in the following documents:

• mmc2.xlsx, sheet 9

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Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition.

Molecular & Cellular Proteomics : Mcp

Schmitt, Marisa M; Sinnberg, Tobias T; Bratl, Katrin K; Zittlau, Katharina K; Garbe, Claus C; Macek, Boris B; Nalpas, Nicolas C NC

Publication Date: 2021

Variant appearance in text: KRAS: K117E

PubMed Link: 34673281

Variant Present in the following documents:

• mmc2.xlsx, sheet 9

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Whole-exome sequencing of non-BRCA1/BRCA2 mutation carrier cases at high-risk for hereditary breast/ovarian cancer.

Human Mutation

Felicio, Paula S PS; Grasel, Rebeca S RS; Campacci, Natalia N; de Paula, Andre E AE; Galvão, Henrique C R HCR; Torrezan, Giovana T GT; Sabato, Cristina S CS; Fernandes, Gabriela C GC; Souza, Cristiano P CP; Michelli, Rodrigo D RD; Andrade, Carlos E CE; Barros, Bruna Durães De Figueiredo BDF; Matsushita, Marcus M MM; Revil, Timothée T; Ragoussis, Jiannis J; Couch, Fergus J FJ; Hart, Steven N SN; Reis, Rui M RM; Melendez, Matias E ME; Tonin, Patricia N PN; Carraro, Dirce M DM; Palmero, Edenir I EI

Publication Date: 2021-03

Variant appearance in text: KRAS: 349A>G

PubMed Link: 33326660

Variant Present in the following documents:

• HUMU-42-290.pdf

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Whole-exome sequencing of non-BRCA1/BRCA2 mutation carrier cases at high-risk for hereditary breast/ovarian cancer.

Human Mutation

Felicio, Paula S PS; Grasel, Rebeca S RS; Campacci, Natalia N; de Paula, Andre E AE; Galvão, Henrique C R HCR; Torrezan, Giovana T GT; Sabato, Cristina S CS; Fernandes, Gabriela C GC; Souza, Cristiano P CP; Michelli, Rodrigo D RD; Andrade, Carlos E CE; Barros, Bruna Durães De Figueiredo BDF; Matsushita, Marcus M MM; Revil, Timothée T; Ragoussis, Jiannis J; Couch, Fergus J FJ; Hart, Steven N SN; Reis, Rui M RM; Melendez, Matias E ME; Tonin, Patricia N PN; Carraro, Dirce M DM; Palmero, Edenir I EI

Publication Date: 2021-03

Variant appearance in text: KRAS: 349A>G

PubMed Link: 33326660

Variant Present in the following documents:

• HUMU-42-290.pdf

View BVdb publication page

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Identification of relevant genetic alterations in cancer using topological data analysis.

Nature Communications

Rabadán, Raúl R; Mohamedi, Yamina Y; Rubin, Udi U; Chu, Tim T; Alghalith, Adam N AN; Elliott, Oliver O; Arnés, Luis L; Cal, Santiago S; Obaya, Álvaro J ÁJ; Levine, Arnold J AJ; Cámara, Pablo G PG

Publication Date: 2020-07-30

Variant appearance in text: KRAS: K117E

PubMed Link: 32732999

Variant Present in the following documents:

• 41467_2020_17659_MOESM3_ESM.xls, sheet 1

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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Nature Communications

Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U

Publication Date: 2020-07-20

Variant appearance in text: KRAS: K117E

PubMed Link: 32686686

Variant Present in the following documents:

• 41467_2020_17386_MOESM4_ESM.xlsx, sheet 1

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Mutational spectrum and classification of novel mutations in patients with metastatic gastrointestinal stromal tumours.

International Journal Of Oncology

Bombac, Alenka A; Zakotnik, Branko B; Bucic, Marina M; Setrajcic Dragos, Vita V; Gazic, Barbara B; Stegel, Vida V; Klancar, Gasper G; Novakovic, Srdjan S

Publication Date: 2020-06

Variant appearance in text: KRAS: 349A>G; Lys117Glu

PubMed Link: 32236636

Variant Present in the following documents:

• Supplementary_Data.pdf

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Somatic genetic alterations in a large cohort of pediatric thyroid nodules.

Endocrine Connections

Pekova, Barbora B; Dvorakova, Sarka S; Sykorova, Vlasta V; Vacinova, Gabriela G; Vaclavikova, Eliska E; Moravcova, Jitka J; Katra, Rami R; Vlcek, Petr P; Sykorova, Pavla P; Kodetova, Daniela D; Vcelak, Josef J; Bendlova, Bela B

Publication Date: 2019-06

Variant appearance in text: KRAS: 349A>G

PubMed Link: 31085772

Variant Present in the following documents:

• EC-19-0069.pdf

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Molecular characterization of circulating colorectal tumor cells defines genetic signatures for individualized cancer care.

Oncotarget

Kong, Say Li SL; Liu, Xingliang X; Suhaimi, Nur-Afidah Mohamed NM; Koh, Kenneth Jia Hao KJH; Hu, Min M; Lee, Daniel Yoke San DYS; Cima, Igor I; Phyo, Wai Min WM; Lee, Esther Xing Wei EXW; Tai, Joyce A JA; Foong, Yu Miin YM; Vo, Jess Honganh JH; Koh, Poh Koon PK; Zhang, Tong T; Ying, Jackie Y JY; Lim, Bing B; Tan, Min-Han MH; Hillmer, Axel M AM

Publication Date: 2017-09-15

Variant appearance in text: KRAS: K117E

PubMed Link: 28978093

Variant Present in the following documents:

• oncotarget-08-68026-s002.xlsx, sheet 3
• oncotarget-08-68026-s002.xlsx, sheet 5
• oncotarget-08-68026-s002.xlsx, sheet 7

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Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.

Genome Medicine

Alfaro, Javier A JA; Ignatchenko, Alexandr A; Ignatchenko, Vladimir V; Sinha, Ankit A; Boutros, Paul C PC; Kislinger, Thomas T

Publication Date: 2017-07-18

Variant appearance in text: KRAS: K117E

PubMed Link: 28716134

Variant Present in the following documents:

• 13073_2017_454_MOESM6_ESM.xlsx, sheet 1

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Cetuximab in treatment of metastatic colorectal cancer: final survival analyses and extended RAS data from the NORDIC-VII study.

British Journal Of Cancer

Guren, Tormod Kyrre TK; Thomsen, Maria M; Kure, Elin H EH; Sorbye, Halfdan H; Glimelius, Bengt B; Pfeiffer, Per P; Österlund, Pia P; Sigurdsson, Fridbjörn F; Lothe, Inger Marie Bowitz IMB; Dalsgaard, Astrid Marie AM; Skovlund, Eva E; Christoffersen, Thoralf T; Tveit, Kjell Magne KM

Publication Date: 2017-05-09

Variant appearance in text: KRAS: K117E

PubMed Link: 28399112

Variant Present in the following documents:

• Main text

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Role of specific DNA mutations in the peripheral blood of colorectal cancer patients for the assessment of tumor stage and residual disease following tumor resection.

Oncology Letters

Norcic, Gregor G; Jelenc, Franc F; Cerkovnik, Petra P; Stegel, Vida V; Novakovic, Srdjan S

Publication Date: 2016-11

Variant appearance in text: KRAS: 349A>G

PubMed Link: 27900004

Variant Present in the following documents:

• Main text
• ol-12-05-3356.pdf

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Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer.

Oncotarget

Thomsen, Maria M; Kersten, Christian C; Sorbye, Halfdan H; Skovlund, Eva E; Glimelius, Bengt B; Pfeiffer, Per P; Johansen, Julia S JS; Kure, Elin H EH; Ikdahl, Tone T; Tveit, Kjell Magne KM; Christoffersen, Thoralf T; Guren, Tormod Kyrre TK

Publication Date: 2016-11-15

Variant appearance in text: KRAS: K117E

PubMed Link: 27738330

Variant Present in the following documents:

• Main text
• oncotarget-07-75013.pdf

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Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab.

Journal Of Translational Medicine

Giampieri, Riccardo R; Mandolesi, Alessandra A; Abouelkhair, Khaled M KM; Loretelli, Cristian C; Del Prete, Michela M; Faloppi, Luca L; Maristella, Bianconi B; Ibrahim, Ezzeldin M EM; Scarpelli, Marina M; Cascinu, Stefano S; Scartozzi, Mario M

Publication Date: 2015-05-07

Variant appearance in text: KRAS: K117E

PubMed Link: 25943333

Variant Present in the following documents:

• Main text
• 12967_2015_Article_501.pdf

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