Publications:

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Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead.

Genes & Diseases

Li, Hui-Yu HY; Qi, Wei-Liang WL; Wang, Yu-Xiang YX; Meng, Ling-Hua LH

Publication Date: 2023-03

Variant appearance in text: KRAS: N116H

PubMed Link: 37223497

Variant Present in the following documents:

• Main text
• main.pdf

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Direct GDP-KRASG12C inhibitors and mechanisms of resistance: the tip of the iceberg.

Therapeutic Advances In Medical Oncology

Rosen, Joshua C JC; Sacher, Adrian A; Tsao, Ming-Sound MS

Publication Date: 2023

Variant appearance in text: KRAS: N116H

PubMed Link: 36950276

Variant Present in the following documents:

• Main text
• 10.1177_17588359231160141.pdf

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Eliminating oncogenic RAS: back to the future at the drawing board.

Biochemical Society Transactions

Steffen, Candy Laura CL; Kaya, Pelin P; Schaffner-Reckinger, Elisabeth E; Abankwa, Daniel D

Publication Date: 2023-01-23

Variant appearance in text: KRAS: N116H

PubMed Link: 36688434

Variant Present in the following documents:

• Main text
• BST-51-447.pdf

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The treatment of advanced non-small cell lung cancer harboring KRAS mutation: a new class of drugs for an old target-a narrative review.

Translational Lung Cancer Research

Spagnuolo, Alessia A; Maione, Paolo P; Gridelli, Cesare C

Publication Date: 2022-06

Variant appearance in text: KRAS: N116H

PubMed Link: 35832439

Variant Present in the following documents:

• Main text
• tlcr-11-06-1199.pdf

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Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Calabrese, Fiorella F; Pezzuto, Federica F; Lunardi, Francesca F; Fortarezza, Francesco F; Tzorakoleftheraki, Sofia-Eleni SE; Resi, Maria Vittoria MV; Tiné, Mariaenrica M; Pasello, Giulia G; Hofman, Paul P

Publication Date: 2022-04-09

Variant appearance in text: KRAS: N116H

PubMed Link: 35456982

Variant Present in the following documents:

• Main text
• ijms-23-04164.pdf

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Daily Practice Assessment of KRAS Status in NSCLC Patients: A New Challenge for the Thoracic Pathologist Is Right around the Corner.

Cancers

Bontoux, Christophe C; Hofman, Véronique V; Brest, Patrick P; Ilié, Marius M; Mograbi, Baharia B; Hofman, Paul P

Publication Date: 2022-03-23

Variant appearance in text: KRAS: N116H

PubMed Link: 35406400

Variant Present in the following documents:

• cancers-14-01628.pdf

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Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies.

Frontiers In Oncology

Désage, Anne-Laure AL; Léonce, Camille C; Swalduz, Aurélie A; Ortiz-Cuaran, Sandra S

Publication Date: 2022

Variant appearance in text: KRAS: N116H

PubMed Link: 35251972

Variant Present in the following documents:

• Main text
• fonc-12-796832.pdf

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KRAS G12C Mutations in NSCLC: From Target to Resistance.

Cancers

Addeo, Alfredo A; Banna, Giuseppe Luigi GL; Friedlaender, Alex A

Publication Date: 2021-05-21

Variant appearance in text: KRAS: N116H

PubMed Link: 34064232

Variant Present in the following documents:

• Main text
• cancers-13-02541.pdf

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Overcoming Resistance to Drugs Targeting KRAS Mutation.

Innovation (Cambridge (Mass.))

Jiao, Delong D; Yang, Shengyu S

Publication Date: 2020-08-28

Variant appearance in text: KRAS: N116H

PubMed Link: 32939510

Variant Present in the following documents:

• Main text
• main.pdf

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Overcoming Resistance to Drugs Targeting KRAS Mutation.

Innovation (New York, N.Y.)

Jiao, Delong D; Yang, Shengyu S

Publication Date: 2020-08-28

Variant appearance in text: KRAS: N116H

PubMed Link: 32939510

Variant Present in the following documents:

• Main text
• main.pdf

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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Nature Communications

Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U

Publication Date: 2020-07-20

Variant appearance in text: KRAS: N116H

PubMed Link: 32686686

Variant Present in the following documents:

• 41467_2020_17386_MOESM4_ESM.xlsx, sheet 1

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A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks.

Scientific Reports

Zimmerman, Lior L; Zelichov, Ori O; Aizenmann, Arie A; Barbash, Zohar Z; Vidne, Michael M; Tarcic, Gabi G

Publication Date: 2020-03-06

Variant appearance in text: KRAS: N116H

PubMed Link: 32144301

Variant Present in the following documents:

• Main text
• 41598_2020_Article_61173.pdf

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Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy.

Journal Of Gastrointestinal Oncology

Wang, Chongkai C; Gong, Jun J; Tu, Travis Y TY; Lee, Peter P PP; Fakih, Marwan M

Publication Date: 2018-06

Variant appearance in text: KRAS: N116H

PubMed Link: 29998005

Variant Present in the following documents:

• Main text

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Quantitative Systems Pharmacology Analysis of KRAS G12C Covalent Inhibitors.

Cpt: Pharmacometrics & Systems Pharmacology

Stites, Edward C EC; Shaw, Andrey S AS

Publication Date: 2018-05

Variant appearance in text: KRAS: N116H

PubMed Link: 29484842

Variant Present in the following documents:

• Main text
• PSP4-7-342.pdf

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: KRAS: 346A>C

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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Development and clinical application of an integrative genomic approach to personalized cancer therapy.

Genome Medicine

Uzilov, Andrew V AV; Ding, Wei W; Fink, Marc Y MY; Antipin, Yevgeniy Y; Brohl, Andrew S AS; Davis, Claire C; Lau, Chun Yee CY; Pandya, Chetanya C; Shah, Hardik H; Kasai, Yumi Y; Powell, James J; Micchelli, Mark M; Castellanos, Rafael R; Zhang, Zhongyang Z; Linderman, Michael M; Kinoshita, Yayoi Y; Zweig, Micol M; Raustad, Katie K; Cheung, Kakit K; Castillo, Diane D; Wooten, Melissa M; Bourzgui, Imane I; Newman, Leah C LC; Deikus, Gintaras G; Mathew, Bino B; Zhu, Jun J; Glicksberg, Benjamin S BS; Moe, Aye S AS; Liao, Jun J; Edelmann, Lisa L; Dudley, Joel T JT; Maki, Robert G RG; Kasarskis, Andrew A; Holcombe, Randall F RF; Mahajan, Milind M; Hao, Ke K; Reva, Boris B; Longtine, Janina J; Starcevic, Daniela D; Sebra, Robert R; Donovan, Michael J MJ; Li, Shuyu S; Schadt, Eric E EE; Chen, Rong R

Publication Date: 2016-06-01

Variant appearance in text: KRAS: N116H

PubMed Link: 27245685

Variant Present in the following documents:

• 13073_2016_313_MOESM1_ESM.xlsx, sheet 5

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Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism.

Science (New York, N.Y.)

Lito, Piro P; Solomon, Martha M; Li, Lian-Sheng LS; Hansen, Rasmus R; Rosen, Neal N

Publication Date: 2016-02-05

Variant appearance in text: KRAS: N116H

PubMed Link: 26841430

Variant Present in the following documents:

• Main text

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High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer.

Genome Biology

Tan, Iain Beehuat IB; Malik, Simeen S; Ramnarayanan, Kalpana K; McPherson, John R JR; Ho, Dan Liang DL; Suzuki, Yuka Y; Ng, Sarah Boonhsui SB; Yan, Su S; Lim, Kiat Hon KH; Koh, Dennis D; Hoe, Chew Min CM; Chan, Chung Yip CY; Ten, Rachel R; Goh, Brian Kp BK; Chung, Alexander Yf AY; Tan, Joanna J; Chan, Cheryl Xueli CX; Tay, Su Ting ST; Alexander, Lezhava L; Nagarajan, Niranjan N; Hillmer, Axel M AM; Tang, Choon Leong CL; Chua, Clarinda C; Teh, Bin Tean BT; Rozen, Steve S; Tan, Patrick P

Publication Date: 2015-02-12

Variant appearance in text: KRAS: N116H

PubMed Link: 25808843

Variant Present in the following documents:

• 13059_2015_589_MOESM4_ESM.pdf

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