KRAS c.285T>A ;(p.H95Q)

Variant ID: 12-25380173-A-T

NM_004985.3(KRAS):c.285T>A;(p.H95Q)

This variant was identified in 16 publications

View GRCh38 version.




Publications:


Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS.

Signal Transduction And Targeted Therapy
Yin, Guowei G; Huang, Jing J; Petela, Johnny J; Jiang, Hongmei H; Zhang, Yuetong Y; Gong, Siqi S; Wu, Jiaxin J; Liu, Bei B; Shi, Jianyou J; Gao, Yijun Y
Publication Date: 2023-05-23

Variant appearance in text: KRAS: H95Q
PubMed Link: 37221195
Variant Present in the following documents:
  • Main text
  • 41392_2023_Article_1441.pdf
View BVdb publication page



The Therapeutic Landscape for KRAS-Mutated Colorectal Cancers.

Cancers
Tria, Simon Manuel SM; Burge, Matthew E ME; Whitehall, Vicki L J VLJ
Publication Date: 2023-04-19

Variant appearance in text: KRAS: H95Q
PubMed Link: 37190303
Variant Present in the following documents:
  • Main text
  • cancers-15-02375.pdf
View BVdb publication page



Direct GDP-KRASG12C inhibitors and mechanisms of resistance: the tip of the iceberg.

Therapeutic Advances In Medical Oncology
Rosen, Joshua C JC; Sacher, Adrian A; Tsao, Ming-Sound MS
Publication Date: 2023

Variant appearance in text: KRAS: H95Q
PubMed Link: 36950276
Variant Present in the following documents:
  • Main text
  • 10.1177_17588359231160141.pdf
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Combined KRAS G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS G12C -driven cancers by addressing intrinsic and acquired resistance.

Biorxiv : The Preprint Server For Biology
Thatikonda, Venu V; Lu, Hengyu H; Jurado, Sabine S; Kostyrko, Kaja K; Bristow, Christopher A CA; Bosch, Karin K; Feng, Ningping N; Gao, Sisi S; Gerlach, Daniel D; Gmachl, Michael M; Lieb, Simone S; Jeschko, Astrid A; Machado, Annette A AA; Marszalek, Ethan D ED; Mahendra, Mikhila M; Jaeger, Philipp A PA; Sorokin, Alexey A; Strauss, Sandra S; Trapani, Francesca F; Kopetz, Scott S; Vellano, Christopher P CP; Petronczki, Mark M; Kraut, Norbert N; Heffernan, Timothy P TP; Marszalek, Joseph R JR; Pearson, Mark M; Waizenegger, Irene I; Hofmann, Marco H MH
Publication Date: 2023-01-23

Variant appearance in text: KRAS: H95Q
PubMed Link: 36747713
Variant Present in the following documents:
  • media-1.xlsx, sheet 4
View BVdb publication page



Molecular characterization of acquired resistance to KRAS G12C-EGFR inhibition in colorectal cancer.

Cancer Discovery
Yaeger, Rona R; Mezzadra, Riccardo R; Sinopoli, Jenna J; Bian, Yu Y; Marasco, Michelangelo M; Kaplun, Esther E; Gao, Yijun Y; Zhao, HuiYong H; Da Cruz Paula, Arnaud A; Zhu, Yingjie Y; Chaves Perez, Almudena A; Chadalavada, Kalyani K; Tse, Edison E; Chowdhry, Sudhir S; Bowker, Sydney S; Chang, Qing Q; Qeriqi, Besnik B; Weigelt, Britta B; Nanjangud, Gouri J GJ; Berger, Michael F MF; Der-Torossian, Hirak H; Anderes, Kenna K; Socci, Nicholas D ND; Shia, Jinru J; Riely, Gregory J GJ; Murciano-Goroff, Yonina R YR; Li, Bob T BT; Christensen, James G JG; Reis-Filho, Jorge S JS; Solit, David B DB; de Stanchina, Elisa E; Lowe, Scott W SW; Rosen, Neal N; Misale, Sandra S
Publication Date: 2022-11-10

Variant appearance in text: KRAS: H95Q
PubMed Link: 36355783
Variant Present in the following documents:
  • cd-22-0405_supplementary_table_3_suppst3.xlsx, sheet 1
  • 41.pdf
View BVdb publication page



Targeting RAS mutants in malignancies: successes, failures, and reasons for hope.

Cancer Communications (London, England)
Yang, Hang H; Zhou, Xinyi X; Fu, Dongliang D; Le, Chenqin C; Wang, Jiafeng J; Zhou, Quan Q; Liu, Xiangrui X; Yuan, Ying Y; Ding, Kefeng K; Xiao, Qian Q
Publication Date: 2022-10-31

Variant appearance in text: KRAS: H95Q
PubMed Link: 36316602
Variant Present in the following documents:
  • Main text
  • CAC2-43-42.pdf
View BVdb publication page



Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

Cancer Discovery
Weiss, Andreas A; Lorthiois, Edwige E; Barys, Louise L; Beyer, Kim S KS; Bomio-Confaglia, Claudio C; Burks, Heather H; Chen, Xueying X; Cui, Xiaoming X; de Kanter, Ruben R; Dharmarajan, Lekshmi L; Fedele, Carmine C; Gerspacher, Marc M; Guthy, Daniel Alexander DA; Head, Victoria V; Jaeger, Ashley A; Núñez, Eloísa Jiménez EJ; Kearns, Jeffrey D JD; Leblanc, Catherine C; Maira, Sauveur-Michel SM; Murphy, Jason J; Oakman, Helen H; Ostermann, Nils N; Ottl, Johannes J; Rigollier, Pascal P; Roman, Danielle D; Schnell, Christian C; Sedrani, Richard R; Shimizu, Toshio T; Stringer, Rowan R; Vaupel, Andrea A; Voshol, Hans H; Wessels, Peter P; Widmer, Toni T; Wilcken, Rainer R; Xu, Kun K; Zecri, Frederic F; Farago, Anna F AF; Cotesta, Simona S; Brachmann, Saskia M SM
Publication Date: 2022-06-02

Variant appearance in text: KRAS: H95Q
PubMed Link: 35404998
Variant Present in the following documents:
  • cd-22-0158_supp1.pdf
View BVdb publication page



Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance.

Cancers
Reita, Damien D; Pabst, Lucile L; Pencreach, Erwan E; Guérin, Eric E; Dano, Laurent L; Rimelen, Valérie V; Voegeli, Anne-Claire AC; Vallat, Laurent L; Mascaux, Céline C; Beau-Faller, Michèle M
Publication Date: 2022-03-04

Variant appearance in text: KRAS: H95Q
PubMed Link: 35267628
Variant Present in the following documents:
  • Main text
  • cancers-14-01321.pdf
View BVdb publication page



Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition.

Scientific Reports
Vaclova, Tereza T; Chakraborty, Atanu A; Sherwood, James J; Ross, Sarah S; Carroll, Danielle D; Barrett, J Carl JC; Downward, Julian J; de Bruin, Elza C EC
Publication Date: 2022-02-17

Variant appearance in text: KRAS: H95Q
PubMed Link: 35177674
Variant Present in the following documents:
  • Main text
  • 41598_2022_Article_6369.pdf
View BVdb publication page



Spotlight on Sotorasib (AMG 510) for KRAS G12C Positive Non-Small Cell Lung Cancer.

Lung Cancer (Auckland, N.Z.)
Zhang, Shannon S SS; Nagasaka, Misako M
Publication Date: 2021

Variant appearance in text: KRAS: H95Q
PubMed Link: 34675734
Variant Present in the following documents:
  • Main text
  • lctt-12-115.pdf
View BVdb publication page



Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges.

Molecular Cancer
Tang, Daolin D; Kroemer, Guido G; Kang, Rui R
Publication Date: 2021-10-04

Variant appearance in text: KRAS: H95Q
PubMed Link: 34607583
Variant Present in the following documents:
  • Main text
  • 12943_2021_Article_1422.pdf
View BVdb publication page



RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site.

Nature Communications
Haza, Katarzyna Z KZ; Martin, Heather L HL; Rao, Ajinkya A; Turner, Amy L AL; Saunders, Sophie E SE; Petersen, Britta B; Tiede, Christian C; Tipping, Kevin K; Tang, Anna A AA; Ajayi, Modupe M; Taylor, Thomas T; Harvey, Maia M; Fishwick, Keri M KM; Adams, Thomas L TL; Gaule, Thembaninkosi G TG; Trinh, Chi H CH; Johnson, Matthew M; Breeze, Alexander L AL; Edwards, Thomas A TA; McPherson, Michael J MJ; Tomlinson, Darren C DC
Publication Date: 2021-06-30

Variant appearance in text: KRAS: H95Q
PubMed Link: 34193876
Variant Present in the following documents:
  • Main text
  • 41467_2021_Article_24316.pdf
View BVdb publication page



Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States.

Acs Central Science
Lim, Shuhui S; Khoo, Regina R; Juang, Yu-Chi YC; Gopal, Pooja P; Zhang, Huibin H; Yeo, Constance C; Peh, Khong Ming KM; Teo, Jinkai J; Ng, Simon S; Henry, Brian B; Partridge, Anthony W AW
Publication Date: 2021-02-24

Variant appearance in text: KRAS: H95Q
PubMed Link: 33655066
Variant Present in the following documents:
  • Main text
  • oc0c01337_si_001.pdf
View BVdb publication page



KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.

Nature Communications
Bery, Nicolas N; Legg, Sandrine S; Debreczeni, Judit J; Breed, Jason J; Embrey, Kevin K; Stubbs, Christopher C; Kolasinska-Zwierz, Paulina P; Barrett, Nathalie N; Marwood, Rose R; Watson, Jo J; Tart, Jon J; Overman, Ross R; Miller, Ami A; Phillips, Christopher C; Minter, Ralph R; Rabbitts, Terence H TH
Publication Date: 2019-06-13

Variant appearance in text: KRAS: H95Q
PubMed Link: 31197133
Variant Present in the following documents:
  • Main text
  • 41467_2019_Article_10419.pdf
View BVdb publication page