Publications:

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Molecular characterization of acquired resistance to KRAS G12C-EGFR inhibition in colorectal cancer.

Cancer Discovery

Yaeger, Rona R; Mezzadra, Riccardo R; Sinopoli, Jenna J; Bian, Yu Y; Marasco, Michelangelo M; Kaplun, Esther E; Gao, Yijun Y; Zhao, HuiYong H; Da Cruz Paula, Arnaud A; Zhu, Yingjie Y; Chaves Perez, Almudena A; Chadalavada, Kalyani K; Tse, Edison E; Chowdhry, Sudhir S; Bowker, Sydney S; Chang, Qing Q; Qeriqi, Besnik B; Weigelt, Britta B; Nanjangud, Gouri J GJ; Berger, Michael F MF; Der-Torossian, Hirak H; Anderes, Kenna K; Socci, Nicholas D ND; Shia, Jinru J; Riely, Gregory J GJ; Murciano-Goroff, Yonina R YR; Li, Bob T BT; Christensen, James G JG; Reis-Filho, Jorge S JS; Solit, David B DB; de Stanchina, Elisa E; Lowe, Scott W SW; Rosen, Neal N; Misale, Sandra S

Publication Date: 2022-11-10

Variant appearance in text: KRAS: H95L

PubMed Link: 36355783

Variant Present in the following documents:

• Main text
• cd-22-0405_supplementary_table_3_suppst3.xlsx, sheet 1
• 41.pdf

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The longitudinal dynamics and natural history of clonal haematopoiesis.

Nature

Fabre, Margarete A MA; de Almeida, José Guilherme JG; Fiorillo, Edoardo E; Mitchell, Emily E; Damaskou, Aristi A; Rak, Justyna J; Orrù, Valeria V; Marongiu, Michele M; Chapman, Michael Spencer MS; Vijayabaskar, M S MS; Baxter, Joanna J; Hardy, Claire C; Abascal, Federico F; Williams, Nicholas N; Nangalia, Jyoti J; Martincorena, Iñigo I; Campbell, Peter J PJ; McKinney, Eoin F EF; Cucca, Francesco F; Gerstung, Moritz M; Vassiliou, George S GS

Publication Date: 2022-06

Variant appearance in text: KRAS: H95L

PubMed Link: 35650444

Variant Present in the following documents:

• 41586_2022_4785_MOESM12_ESM.xlsx, sheet 2

View BVdb publication page

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RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site.

Nature Communications

Haza, Katarzyna Z KZ; Martin, Heather L HL; Rao, Ajinkya A; Turner, Amy L AL; Saunders, Sophie E SE; Petersen, Britta B; Tiede, Christian C; Tipping, Kevin K; Tang, Anna A AA; Ajayi, Modupe M; Taylor, Thomas T; Harvey, Maia M; Fishwick, Keri M KM; Adams, Thomas L TL; Gaule, Thembaninkosi G TG; Trinh, Chi H CH; Johnson, Matthew M; Breeze, Alexander L AL; Edwards, Thomas A TA; McPherson, Michael J MJ; Tomlinson, Darren C DC

Publication Date: 2021-06-30

Variant appearance in text: KRAS: H95L

PubMed Link: 34193876

Variant Present in the following documents:

• Main text
• 41467_2021_Article_24316.pdf

View BVdb publication page

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Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States.

Acs Central Science

Lim, Shuhui S; Khoo, Regina R; Juang, Yu-Chi YC; Gopal, Pooja P; Zhang, Huibin H; Yeo, Constance C; Peh, Khong Ming KM; Teo, Jinkai J; Ng, Simon S; Henry, Brian B; Partridge, Anthony W AW

Publication Date: 2021-02-24

Variant appearance in text: KRAS: H95L

PubMed Link: 33655066

Variant Present in the following documents:

• Main text
• oc0c01337_si_001.pdf

View BVdb publication page

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KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.

Nature Communications

Bery, Nicolas N; Legg, Sandrine S; Debreczeni, Judit J; Breed, Jason J; Embrey, Kevin K; Stubbs, Christopher C; Kolasinska-Zwierz, Paulina P; Barrett, Nathalie N; Marwood, Rose R; Watson, Jo J; Tart, Jon J; Overman, Ross R; Miller, Ami A; Phillips, Christopher C; Minter, Ralph R; Rabbitts, Terence H TH

Publication Date: 2019-06-13

Variant appearance in text: KRAS: H95L

PubMed Link: 31197133

Variant Present in the following documents:

• Main text
• 41467_2019_Article_10419.pdf

View BVdb publication page

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CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network.

Oncotarget

Fertig, Elana J EJ; Ozawa, Hiroyuki H; Thakar, Manjusha M; Howard, Jason D JD; Kagohara, Luciane T LT; Krigsfeld, Gabriel G; Ranaweera, Ruchira S RS; Hughes, Robert M RM; Perez, Jimena J; Jones, Siân S; Favorov, Alexander V AV; Carey, Jacob J; Stein-O'Brien, Genevieve G; Gaykalova, Daria A DA; Ochs, Michael F MF; Chung, Christine H CH

Publication Date: 2016-11-08

Variant appearance in text: KRAS: H95L

PubMed Link: 27650546

Variant Present in the following documents:

• oncotarget-07-73845-s007.xlsx, sheet 1

View BVdb publication page

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