Publications:

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Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS.

Signal Transduction And Targeted Therapy

Yin, Guowei G; Huang, Jing J; Petela, Johnny J; Jiang, Hongmei H; Zhang, Yuetong Y; Gong, Siqi S; Wu, Jiaxin J; Liu, Bei B; Shi, Jianyou J; Gao, Yijun Y

Publication Date: 2023-05-23

Variant appearance in text: KRAS: H95R

PubMed Link: 37221195

Variant Present in the following documents:

• Main text
• 41392_2023_Article_1441.pdf

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The Therapeutic Landscape for KRAS-Mutated Colorectal Cancers.

Cancers

Tria, Simon Manuel SM; Burge, Matthew E ME; Whitehall, Vicki L J VLJ

Publication Date: 2023-04-19

Variant appearance in text: KRAS: H95R

PubMed Link: 37190303

Variant Present in the following documents:

• Main text
• cancers-15-02375.pdf

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Combined KRAS G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS G12C -driven cancers by addressing intrinsic and acquired resistance.

Biorxiv : The Preprint Server For Biology

Thatikonda, Venu V; Lu, Hengyu H; Jurado, Sabine S; Kostyrko, Kaja K; Bristow, Christopher A CA; Bosch, Karin K; Feng, Ningping N; Gao, Sisi S; Gerlach, Daniel D; Gmachl, Michael M; Lieb, Simone S; Jeschko, Astrid A; Machado, Annette A AA; Marszalek, Ethan D ED; Mahendra, Mikhila M; Jaeger, Philipp A PA; Sorokin, Alexey A; Strauss, Sandra S; Trapani, Francesca F; Kopetz, Scott S; Vellano, Christopher P CP; Petronczki, Mark M; Kraut, Norbert N; Heffernan, Timothy P TP; Marszalek, Joseph R JR; Pearson, Mark M; Waizenegger, Irene I; Hofmann, Marco H MH

Publication Date: 2023-01-23

Variant appearance in text: KRAS: H95R

PubMed Link: 36747713

Variant Present in the following documents:

• media-1.xlsx, sheet 4

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Targeting KRAS G12C mutations in colorectal cancer.

Gastroenterology Report

Zhao, Ming-He MH; Wu, Ai-Wen AW

Publication Date: 2023

Variant appearance in text: KRAS: H95R

PubMed Link: 36632627

Variant Present in the following documents:

• Main text
• goac083.pdf

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Molecular characterization of acquired resistance to KRAS G12C-EGFR inhibition in colorectal cancer.

Cancer Discovery

Yaeger, Rona R; Mezzadra, Riccardo R; Sinopoli, Jenna J; Bian, Yu Y; Marasco, Michelangelo M; Kaplun, Esther E; Gao, Yijun Y; Zhao, HuiYong H; Da Cruz Paula, Arnaud A; Zhu, Yingjie Y; Chaves Perez, Almudena A; Chadalavada, Kalyani K; Tse, Edison E; Chowdhry, Sudhir S; Bowker, Sydney S; Chang, Qing Q; Qeriqi, Besnik B; Weigelt, Britta B; Nanjangud, Gouri J GJ; Berger, Michael F MF; Der-Torossian, Hirak H; Anderes, Kenna K; Socci, Nicholas D ND; Shia, Jinru J; Riely, Gregory J GJ; Murciano-Goroff, Yonina R YR; Li, Bob T BT; Christensen, James G JG; Reis-Filho, Jorge S JS; Solit, David B DB; de Stanchina, Elisa E; Lowe, Scott W SW; Rosen, Neal N; Misale, Sandra S

Publication Date: 2022-11-10

Variant appearance in text: KRAS: H95R

PubMed Link: 36355783

Variant Present in the following documents:

• 41.pdf

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Targeting RAS mutants in malignancies: successes, failures, and reasons for hope.

Cancer Communications (London, England)

Yang, Hang H; Zhou, Xinyi X; Fu, Dongliang D; Le, Chenqin C; Wang, Jiafeng J; Zhou, Quan Q; Liu, Xiangrui X; Yuan, Ying Y; Ding, Kefeng K; Xiao, Qian Q

Publication Date: 2022-10-31

Variant appearance in text: KRAS: H95R

PubMed Link: 36316602

Variant Present in the following documents:

• Main text
• CAC2-43-42.pdf

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Drugging KRAS: current perspectives and state-of-art review.

Journal Of Hematology & Oncology

Parikh, Kaushal K; Banna, Giuseppe G; Liu, Stephen V SV; Friedlaender, Alex A; Desai, Aakash A; Subbiah, Vivek V; Addeo, Alfredo A

Publication Date: 2022-10-25

Variant appearance in text: KRAS: H95R

PubMed Link: 36284306

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1375.pdf

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The current state of the art and future trends in RAS-targeted cancer therapies.

Nature Reviews. Clinical Oncology

Punekar, Salman R SR; Velcheti, Vamsidhar V; Neel, Benjamin G BG; Wong, Kwok-Kin KK

Publication Date: 2022-10

Variant appearance in text: KRAS: H95R

PubMed Link: 36028717

Variant Present in the following documents:

• 41571_2022_Article_671.pdf

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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Feng, Siyu S; Callow, Marinella G MG; Fortin, Jean-Philippe JP; Khan, Zia Z; Bray, David D; Costa, Mike M; Shi, Zhen Z; Wang, Weiru W; Evangelista, Marie M

Publication Date: 2022-05-03

Variant appearance in text: KRAS: H95R

PubMed Link: 35471904

Variant Present in the following documents:

• pnas.202120512.pdf

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KRAS: A Druggable Target in Colon Cancer Patients.

International Journal Of Molecular Sciences

Negri, Francesca F; Bottarelli, Lorena L; de'Angelis, Gian Luigi GL; Gnetti, Letizia L

Publication Date: 2022-04-08

Variant appearance in text: KRAS: H95R

PubMed Link: 35456940

Variant Present in the following documents:

• Main text
• ijms-23-04120.pdf

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

Cancer Discovery

Weiss, Andreas A; Lorthiois, Edwige E; Barys, Louise L; Beyer, Kim S KS; Bomio-Confaglia, Claudio C; Burks, Heather H; Chen, Xueying X; Cui, Xiaoming X; de Kanter, Ruben R; Dharmarajan, Lekshmi L; Fedele, Carmine C; Gerspacher, Marc M; Guthy, Daniel Alexander DA; Head, Victoria V; Jaeger, Ashley A; Núñez, Eloísa Jiménez EJ; Kearns, Jeffrey D JD; Leblanc, Catherine C; Maira, Sauveur-Michel SM; Murphy, Jason J; Oakman, Helen H; Ostermann, Nils N; Ottl, Johannes J; Rigollier, Pascal P; Roman, Danielle D; Schnell, Christian C; Sedrani, Richard R; Shimizu, Toshio T; Stringer, Rowan R; Vaupel, Andrea A; Voshol, Hans H; Wessels, Peter P; Widmer, Toni T; Wilcken, Rainer R; Xu, Kun K; Zecri, Frederic F; Farago, Anna F AF; Cotesta, Simona S; Brachmann, Saskia M SM

Publication Date: 2022-06-02

Variant appearance in text: KRAS: H95R

PubMed Link: 35404998

Variant Present in the following documents:

• Main text
• 1500.pdf
• cd-22-0158_supp1.pdf

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Understanding the influence of AMG 510 on the structure of KRASG12C empowered by molecular dynamics simulation.

Computational And Structural Biotechnology Journal

Li, Yu Y; Han, Lei L; Zhang, Ziding Z

Publication Date: 2022

Variant appearance in text: KRAS: H95R

PubMed Link: 35284050

Variant Present in the following documents:

• Main text
• main.pdf

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Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition.

Scientific Reports

Vaclova, Tereza T; Chakraborty, Atanu A; Sherwood, James J; Ross, Sarah S; Carroll, Danielle D; Barrett, J Carl JC; Downward, Julian J; de Bruin, Elza C EC

Publication Date: 2022-02-17

Variant appearance in text: KRAS: H95R

PubMed Link: 35177674

Variant Present in the following documents:

• Main text
• 41598_2022_Article_6369.pdf

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Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes.

Npj Precision Oncology

Palma, Gabriela G; Khurshid, Faisal F; Lu, Kevin K; Woodward, Brian B; Husain, Hatim H

Publication Date: 2021-11-29

Variant appearance in text: KRAS: H95R

PubMed Link: 34845311

Variant Present in the following documents:

• Main text
• 41698_2021_Article_237.pdf

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Spotlight on Sotorasib (AMG 510) for KRAS G12C Positive Non-Small Cell Lung Cancer.

Lung Cancer (Auckland, N.Z.)

Zhang, Shannon S SS; Nagasaka, Misako M

Publication Date: 2021

Variant appearance in text: KRAS: H95R

PubMed Link: 34675734

Variant Present in the following documents:

• Main text
• lctt-12-115.pdf

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Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges.

Molecular Cancer

Tang, Daolin D; Kroemer, Guido G; Kang, Rui R

Publication Date: 2021-10-04

Variant appearance in text: KRAS: H95R

PubMed Link: 34607583

Variant Present in the following documents:

• Main text
• 12943_2021_Article_1422.pdf

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Profiling of 520 Candidate Genes in 50 Surgically Treated Chinese Small Cell Lung Cancer Patients.

Frontiers In Oncology

Yuan, Ting T; Wang, Xin X; Sun, Sijin S; Cao, Zheng Z; Feng, Xiaoli X; Gao, Yibo Y

Publication Date: 2021

Variant appearance in text: KRAS: 284A>G; His95Arg

PubMed Link: 34168983

Variant Present in the following documents:

• DataSheet_2.xlsx, sheet 3

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Impact of extracellular matrix stiffness on genomic heterogeneity in MYCN-amplified neuroblastoma cell line.

Journal Of Experimental & Clinical Cancer Research : Cr

López-Carrasco, Amparo A; Martín-Vañó, Susana S; Burgos-Panadero, Rebeca R; Monferrer, Ezequiel E; Berbegall, Ana P AP; Fernández-Blanco, Beatriz B; Navarro, Samuel S; Noguera, Rosa R

Publication Date: 2020-10-28

Variant appearance in text: KRAS: 284A>G; H95R

PubMed Link: 33109237

Variant Present in the following documents:

• 13046_2020_1729_MOESM3_ESM.xlsx, sheet 2
• 13046_2020_1729_MOESM3_ESM.xlsx, sheet 1

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An updated review on phenocopies of primary immunodeficiency diseases.

Genes & Diseases

Singh, Ankita A; Jindal, Ankur K AK; Joshi, Vibhu V; Anjani, Gummadi G; Rawat, Amit A

Publication Date: 2020-03

Variant appearance in text: KRAS: H95R

PubMed Link: 32181272

Variant Present in the following documents:

• Main text
• main.pdf

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Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Nature Communications

Cammareri, Patrizia P; Rose, Aidan M AM; Vincent, David F DF; Wang, Jun J; Nagano, Ai A; Libertini, Silvana S; Ridgway, Rachel A RA; Athineos, Dimitris D; Coates, Philip J PJ; McHugh, Angela A; Pourreyron, Celine C; Dayal, Jasbani H S JH; Larsson, Jonas J; Weidlich, Simone S; Spender, Lindsay C LC; Sapkota, Gopal P GP; Purdie, Karin J KJ; Proby, Charlotte M CM; Harwood, Catherine A CA; Leigh, Irene M IM; Clevers, Hans H; Barker, Nick N; Karlsson, Stefan S; Pritchard, Catrin C; Marais, Richard R; Chelala, Claude C; South, Andrew P AP; Sansom, Owen J OJ; Inman, Gareth J GJ

Publication Date: 2016-08-25

Variant appearance in text: KRAS: H95R

PubMed Link: 27558455

Variant Present in the following documents:

• ncomms12493-s14.xlsx, sheet 1

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Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.

Nature

Wong, Terrence N TN; Ramsingh, Giridharan G; Young, Andrew L AL; Miller, Christopher A CA; Touma, Waseem W; Welch, John S JS; Lamprecht, Tamara L TL; Shen, Dong D; Hundal, Jasreet J; Fulton, Robert S RS; Heath, Sharon S; Baty, Jack D JD; Klco, Jeffery M JM; Ding, Li L; Mardis, Elaine R ER; Westervelt, Peter P; DiPersio, John F JF; Walter, Matthew J MJ; Graubert, Timothy A TA; Ley, Timothy J TJ; Druley, Todd T; Link, Daniel C DC; Wilson, Richard K RK

Publication Date: 2015-02-26

Variant appearance in text: KRAS: H95R

PubMed Link: 25487151

Variant Present in the following documents:

• NIHMS635306-supplement-5.xlsx, sheet 1

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