Publications:

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An integrated model for predicting KRAS dependency.

Plos Computational Biology

Tsai, Yihsuan S YS; Chareddy, Yogitha S YS; Price, Brandon A BA; Parker, Joel S JS; Pecot, Chad V CV

Publication Date: 2023-05-04

Variant appearance in text: KRAS: T74P

PubMed Link: 37141389

Variant Present in the following documents:

• Main text
• pcbi.1011095.pdf

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Novel mutant KRAS addiction signature predicts response to the combination of ERBB and MEK inhibitors in lung and pancreatic cancers.

Iscience

Tyc, Katarzyna M KM; Kazi, Aslamuzzaman A; Ranjan, Alok A; Wang, Rui R; Sebti, Said M SM

Publication Date: 2023-03-17

Variant appearance in text: KRAS: T74P

PubMed Link: 36852277

Variant Present in the following documents:

• mmc2.xlsx, sheet 2

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Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.

Cancer Research Communications

Ghezelayagh, Talayeh S TS; Kohrn, Brendan F BF; Fredrickson, Jeanne J; Manhardt, Enna E; Radke, Marc R MR; Katz, Ronit R; Gray, Heidi J HJ; Urban, Renata R RR; Pennington, Kathryn P KP; Liao, John B JB; Doll, Kemi M KM; Simons, Elise J EJ; Burzawa, Jennifer K JK; Goff, Barbara A BA; Speiser, Paul P; Swisher, Elizabeth M EM; Norquist, Barbara M BM; Risques, Rosa Ana RA

Publication Date: 2022-10

Variant appearance in text: KRAS: 220A>C; T74P

PubMed Link: 36311816

Variant Present in the following documents:

• crc-22-0314-s02.xlsx, sheet 6

View BVdb publication page

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KRAS Mutation in Rare Tumors: A Landscape Analysis of 3453 Chinese Patients.

Frontiers In Molecular Biosciences

Wang, Shuhang S; Li, Qin Q; Ma, Peiwen P; Fang, Yuan Y; Yu, Yue Y; Jiang, Ning N; Miao, Huilei H; Tang, Qiyu Q; Yang, Yuqi Y; Xing, Shujun S; Chen, Rongrong R; Yi, Xin X; Li, Ning N

Publication Date: 2022

Variant appearance in text: KRAS: T74P

PubMed Link: 35359599

Variant Present in the following documents:

• Main text

View BVdb publication page

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Prognostic Impact of An Integrative Landscape of Clinical, Immune, and Molecular Features in Non-Metastatic Rectal Cancer.

Frontiers In Oncology

Iseas, Soledad S; Sendoya, Juan M JM; Robbio, Juan J; Coraglio, Mariana M; Kujaruk, Mirta M; Mikolaitis, Vanesa V; Rizzolo, Mariana M; Cabanne, Ana A; Ruiz, Gonzalo G; Salanova, Rubén R; Gualdrini, Ubaldo U; Méndez, Guillermo G; Antelo, Marina M; Carballido, Marcela M; Rotondaro, Cecilia C; Viglino, Julieta J; Eleta, Martín M; Di Sibio, Alejandro A; Podhajcer, Osvaldo L OL; Roca, Enrique E; Llera, Andrea S AS; Golubicki, Mariano M; Abba, Martín Carlos MC

Publication Date: 2021

Variant appearance in text: KRAS: T74P

PubMed Link: 35071006

Variant Present in the following documents:

• Main text
• Table_4.xlsx, sheet 1
• fonc-11-801880.pdf

View BVdb publication page

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Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics.

Computational And Structural Biotechnology Journal

Tripathi, Swarnendu S; Dsouza, Nikita R NR; Mathison, Angela J AJ; Leverence, Elise E; Urrutia, Raul R; Zimmermann, Michael T MT

Publication Date: 2022

Variant appearance in text: KRAS: T74P

PubMed Link: 34976316

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KRAS: T74P

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine

Chang, Darwin D; Shain, A Hunter AH

Publication Date: 2021-07-16

Variant appearance in text: KRAS: T74P

PubMed Link: 34272401

Variant Present in the following documents:

• 41525_2021_226_MOESM5_ESM.xlsx, sheet 1

View BVdb publication page

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Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis.

The New England Journal Of Medicine

Sparks, Teresa N TN; Lianoglou, Billie R BR; Adami, Rebecca R RR; Pluym, Ilina D ID; Holliman, Kerry K; Duffy, Jennifer J; Downum, Sarah L SL; Patel, Sachi S; Faubel, Amanda A; Boe, Nina M NM; Field, Nancy T NT; Murphy, Aisling A; Laurent, Louise C LC; Jolley, Jennifer J; Uy, Cherry C; Slavotinek, Anne M AM; Devine, Patrick P; Hodoglugil, Ugur U; Van Ziffle, Jessica J; Sanders, Stephan J SJ; MacKenzie, Tippi C TC; Norton, Mary E ME; , ; ,

Publication Date: 2020-10-29

Variant appearance in text: KRAS: Thr74Pro

PubMed Link: 33027564

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinical significance of chromatin-spliceosome acute myeloid leukemia: a report from the Northern Italy Leukemia Group (NILG) randomized trial 02/06.

Haematologica

Caprioli, Chiara C; Lussana, Federico F; Salmoiraghi, Silvia S; Cavagna, Roberta R; Buklijas, Ksenija K; Elidi, Lara L; Zanghi', Pamela P; Michelato, Anna A; Delaini, Federica F; Oldani, Elena E; Intermesoli, Tamara T; Grassi, Anna A; Gianfaldoni, Giacomo G; Mannelli, Francesco F; Ferrero, Dario D; Audisio, Ernesta E; Terruzzi, Elisabetta E; De Paoli, Lorella L; Cattaneo, Chiara C; Borlenghi, Erika E; Cavattoni, Irene I; Tajana, Monica M; Scattolin, Anna Maria AM; Mattei, Daniele D; Corradini, Paolo P; Campiotti, Leonardo L; Ciceri, Fabio F; Bernardi, Massimo M; Todisco, Elisabetta E; Cortelezzi, Agostino A; Falini, Brunangelo B; Pavoni, Chiara C; Bassan, Renato R; Spinelli, Orietta O; Rambaldi, Alessandro A

Publication Date: 2021-10-01

Variant appearance in text: KRAS: 220A>C; Thr74Pro

PubMed Link: 32855275

Variant Present in the following documents:

• 2020_252825_CAPRIOLI_SUPPL.pdf

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Cas9 activates the p53 pathway and selects for p53-inactivating mutations.

Nature Genetics

Enache, Oana M OM; Rendo, Veronica V; Abdusamad, Mai M; Lam, Daniel D; Davison, Desiree D; Pal, Sangita S; Currimjee, Naomi N; Hess, Julian J; Pantel, Sasha S; Nag, Anwesha A; Thorner, Aaron R AR; Doench, John G JG; Vazquez, Francisca F; Beroukhim, Rameen R; Golub, Todd R TR; Ben-David, Uri U

Publication Date: 2020-07

Variant appearance in text: KRAS: 220A>C; T74P

PubMed Link: 32424350

Variant Present in the following documents:

• NIHMS1581982-supplement-1581982_Supp_Dataset1-7.xlsx, sheet 7

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: KRAS: T74P

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology

Muñoz-Maldonado, Carmen C; Zimmer, Yitzhak Y; Medová, Michaela M

Publication Date: 2019

Variant appearance in text: KRAS: T74P

PubMed Link: 31681616

Variant Present in the following documents:

• Main text
• fonc-09-01088.pdf

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Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports

Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS

Publication Date: 2018-04-03

Variant appearance in text: KRAS: 220A>C

PubMed Link: 29617658

Variant Present in the following documents:

• NIHMS958974-supplement-5.xlsx, sheet 1
• NIHMS958974-supplement-6.xlsx, sheet 1

View BVdb publication page

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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Nature Communications

Schütte, Moritz M; Risch, Thomas T; Abdavi-Azar, Nilofar N; Boehnke, Karsten K; Schumacher, Dirk D; Keil, Marlen M; Yildiriman, Reha R; Jandrasits, Christine C; Borodina, Tatiana T; Amstislavskiy, Vyacheslav V; Worth, Catherine L CL; Schweiger, Caroline C; Liebs, Sandra S; Lange, Martin M; Warnatz, Hans-Jörg HJ; Butcher, Lee M LM; Barrett, James E JE; Sultan, Marc M; Wierling, Christoph C; Golob-Schwarzl, Nicole N; Lax, Sigurd S; Uranitsch, Stefan S; Becker, Michael M; Welte, Yvonne Y; Regan, Joseph Lewis JL; Silvestrov, Maxine M; Kehler, Inge I; Fusi, Alberto A; Kessler, Thomas T; Herwig, Ralf R; Landegren, Ulf U; Wienke, Dirk D; Nilsson, Mats M; Velasco, Juan A JA; Garin-Chesa, Pilar P; Reinhard, Christoph C; Beck, Stephan S; Schäfer, Reinhold R; Regenbrecht, Christian R A CR; Henderson, David D; Lange, Bodo B; Haybaeck, Johannes J; Keilholz, Ulrich U; Hoffmann, Jens J; Lehrach, Hans H; Yaspo, Marie-Laure ML

Publication Date: 2017-02-10

Variant appearance in text: KRAS: T74P

PubMed Link: 28186126

Variant Present in the following documents:

• ncomms14262-s5.xlsx, sheet 2

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LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics

Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L

Publication Date: 2016-02-09

Variant appearance in text: KRAS: T74P

PubMed Link: 26860319

Variant Present in the following documents:

• 12859_2016_935_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics

Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z

Publication Date: 2013

Variant appearance in text: KRAS: T74P

PubMed Link: 23819521

Variant Present in the following documents:

• 1471-2164-14-S3-S7-S1.xlsx, sheet 3
• 1471-2164-14-S3-S7-S1.xlsx, sheet 2

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: KRAS: T74P

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

View BVdb publication page

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High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.

Blood

Tyner, Jeffrey W JW; Erickson, Heidi H; Deininger, Michael W N MW; Willis, Stephanie G SG; Eide, Christopher A CA; Levine, Ross L RL; Heinrich, Michael C MC; Gattermann, Norbert N; Gilliland, D Gary DG; Druker, Brian J BJ; Loriaux, Marc M MM

Publication Date: 2009-02-19

Variant appearance in text: KRAS: T74P

PubMed Link: 19075190

Variant Present in the following documents:

• Main text

View BVdb publication page

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