Publications:

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Direct GDP-KRASG12C inhibitors and mechanisms of resistance: the tip of the iceberg.

Therapeutic Advances In Medical Oncology

Rosen, Joshua C JC; Sacher, Adrian A; Tsao, Ming-Sound MS

Publication Date: 2023

Variant appearance in text: KRAS: Y64A

PubMed Link: 36950276

Variant Present in the following documents:

• Main text
• 10.1177_17588359231160141.pdf

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Targeting RAS mutants in malignancies: successes, failures, and reasons for hope.

Cancer Communications (London, England)

Yang, Hang H; Zhou, Xinyi X; Fu, Dongliang D; Le, Chenqin C; Wang, Jiafeng J; Zhou, Quan Q; Liu, Xiangrui X; Yuan, Ying Y; Ding, Kefeng K; Xiao, Qian Q

Publication Date: 2022-10-31

Variant appearance in text: KRAS: Y64A

PubMed Link: 36316602

Variant Present in the following documents:

• Main text
• CAC2-43-42.pdf

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The treatment of advanced non-small cell lung cancer harboring KRAS mutation: a new class of drugs for an old target-a narrative review.

Translational Lung Cancer Research

Spagnuolo, Alessia A; Maione, Paolo P; Gridelli, Cesare C

Publication Date: 2022-06

Variant appearance in text: KRAS: Y64A

PubMed Link: 35832439

Variant Present in the following documents:

• Main text
• tlcr-11-06-1199.pdf

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PepNN: a deep attention model for the identification of peptide binding sites.

Communications Biology

Abdin, Osama O; Nim, Satra S; Wen, Han H; Kim, Philip M PM

Publication Date: 2022-05-26

Variant appearance in text: KRAS: Y64A

PubMed Link: 35618814

Variant Present in the following documents:

• 42003_2022_3445_MOESM3_ESM.xlsx, sheet 1

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Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect.

Frontiers In Molecular Biosciences

He, Xuan X; Du, Kui K; Wang, Yuanhao Y; Fan, Jigang J; Li, Mingyu M; Ni, Duan D; Lu, Shaoyong S; Bian, Xiaolan X; Liu, Yaqin Y

Publication Date: 2022

Variant appearance in text: K-Ras4B: Y64A

PubMed Link: 35463958

Variant Present in the following documents:

• Main text

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Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Calabrese, Fiorella F; Pezzuto, Federica F; Lunardi, Francesca F; Fortarezza, Francesco F; Tzorakoleftheraki, Sofia-Eleni SE; Resi, Maria Vittoria MV; Tiné, Mariaenrica M; Pasello, Giulia G; Hofman, Paul P

Publication Date: 2022-04-09

Variant appearance in text: KRAS: Y64A

PubMed Link: 35456982

Variant Present in the following documents:

• Main text
• ijms-23-04164.pdf

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Daily Practice Assessment of KRAS Status in NSCLC Patients: A New Challenge for the Thoracic Pathologist Is Right around the Corner.

Cancers

Bontoux, Christophe C; Hofman, Véronique V; Brest, Patrick P; Ilié, Marius M; Mograbi, Baharia B; Hofman, Paul P

Publication Date: 2022-03-23

Variant appearance in text: KRAS: Y64A

PubMed Link: 35406400

Variant Present in the following documents:

• cancers-14-01628.pdf

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KRAS: Y64A

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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KRAS G12C Mutations in NSCLC: From Target to Resistance.

Cancers

Addeo, Alfredo A; Banna, Giuseppe Luigi GL; Friedlaender, Alex A

Publication Date: 2021-05-21

Variant appearance in text: KRAS: Y64A

PubMed Link: 34064232

Variant Present in the following documents:

• Main text
• cancers-13-02541.pdf

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Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Moghadamchargari, Zahra Z; Shirzadeh, Mehdi M; Liu, Chang C; Schrecke, Samantha S; Packianathan, Charles C; Russell, David H DH; Zhao, Minglei M; Laganowsky, Arthur A

Publication Date: 2021-03-23

Variant appearance in text: KRAS: Tyr64Ala

PubMed Link: 33723061

Variant Present in the following documents:

• Main text

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Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.

Journal For Immunotherapy Of Cancer

Hong, Tae Hee TH; Cha, Hongui H; Shim, Joon Ho JH; Lee, Boram B; Chung, Jongsuk J; Lee, Chung C; Kim, Nayoung K D NKD; Choi, Yoon-La YL; Hwang, Soohyun S; Lee, Yoomi Y; Park, Sehhoon S; Jung, Hyun Ae HA; Kim, Ji-Yeon JY; Park, Yeon Hee YH; Sun, Jong-Mu JM; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Lee, Se-Hoon SH; Park, Woong-Yang WY

Publication Date: 2020-10

Variant appearance in text: KRAS: Y64A

PubMed Link: 33077514

Variant Present in the following documents:

• jitc-2020-001199supp002.pdf

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Overcoming Resistance to Drugs Targeting KRAS Mutation.

Innovation (Cambridge (Mass.))

Jiao, Delong D; Yang, Shengyu S

Publication Date: 2020-08-28

Variant appearance in text: KRAS: Y64A

PubMed Link: 32939510

Variant Present in the following documents:

• Main text
• main.pdf

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Overcoming Resistance to Drugs Targeting KRAS Mutation.

Innovation (New York, N.Y.)

Jiao, Delong D; Yang, Shengyu S

Publication Date: 2020-08-28

Variant appearance in text: KRAS: Y64A

PubMed Link: 32939510

Variant Present in the following documents:

• Main text
• main.pdf

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Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.

Cell Reports

Yan, Wupeng W; Markegard, Evan E; Dharmaiah, Srisathiyanarayanan S; Urisman, Anatoly A; Drew, Matthew M; Esposito, Dominic D; Scheffzek, Klaus K; Nissley, Dwight V DV; McCormick, Frank F; Simanshu, Dhirendra K DK

Publication Date: 2020-07-21

Variant appearance in text: KRAS: Y64A

PubMed Link: 32697994

Variant Present in the following documents:

• Main text
• nihms-1613940.pdf

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: KRAS: Y64A

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Quantitative Systems Pharmacology Analysis of KRAS G12C Covalent Inhibitors.

Cpt: Pharmacometrics & Systems Pharmacology

Stites, Edward C EC; Shaw, Andrey S AS

Publication Date: 2018-05

Variant appearance in text: KRAS: Y64A

PubMed Link: 29484842

Variant Present in the following documents:

• Main text
• PSP4-7-342.pdf

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Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration.

Nature Communications

Shin, Seung-Min SM; Choi, Dong-Ki DK; Jung, Keunok K; Bae, Jeomil J; Kim, Ji-Sun JS; Park, Seong-Wook SW; Song, Ki-Hoon KH; Kim, Yong-Sung YS

Publication Date: 2017-05-10

Variant appearance in text: KRAS: Y64A

PubMed Link: 28489072

Variant Present in the following documents:

• ncomms15090.pdf

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Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism.

Science (New York, N.Y.)

Lito, Piro P; Solomon, Martha M; Li, Lian-Sheng LS; Hansen, Rasmus R; Rosen, Neal N

Publication Date: 2016-02-05

Variant appearance in text: KRAS: Y64A

PubMed Link: 26841430

Variant Present in the following documents:

• Main text

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H-Ras forms dimers on membrane surfaces via a protein-protein interface.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Lin, Wan-Chen WC; Iversen, Lars L; Tu, Hsiung-Lin HL; Rhodes, Christopher C; Christensen, Sune M SM; Iwig, Jeffrey S JS; Hansen, Scott D SD; Huang, William Y C WY; Groves, Jay T JT

Publication Date: 2014-02-25

Variant appearance in text: K-Ras4B: Y64A

PubMed Link: 24516166

Variant Present in the following documents:

• Main text

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