Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.
Blood
Ansari-Pour, Naser N; Samur, Mehmet K MK; Flynt, Erin E; Gooding, Sarah S; Towfic, Fadi F; Stong, Nicholas N; Ortiz Estevez, Maria M; Mavrommatis, Konstantinos K; Walker, Brian A BA; Morgan, Gareth J GJ; Munshi, Nikhil C NC; Avet Loiseau, Herve H; Thakurta, Anjan A
The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.
Nature Communications
Vo, Josh N JN; Wu, Yi-Mi YM; Mishler, Jeanmarie J; Hall, Sarah S; Mannan, Rahul R; Wang, Lisha L; Ning, Yu Y; Zhou, Jin J; Hopkins, Alexander C AC; Estill, James C JC; Chan, Wallace K B WKB; Yesil, Jennifer J; Cao, Xuhong X; Rao, Arvind A; Tsodikov, Alexander A; Talpaz, Moshe M; Cole, Craig E CE; Ye, Jing C JC; , ; Bergsagel, P Leif PL; Auclair, Daniel D; Cho, Hearn Jay HJ; Robinson, Dan R DR; Chinnaiyan, Arul M AM
Publication Date: 2022-06-29
Variant appearance in text: KRAS: 190T>G; Tyr64Asp
EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Leukemia
Berg, Johannes Lorenz JL; Perfler, Bianca B; Hatzl, Stefan S; Uhl, Barbara B; Reinisch, Andreas A; Pregartner, Gudrun G; Berghold, Andrea A; Penz, Thomas T; Schuster, Michael M; Geissler, Klaus K; Prokesch, Andreas A; Müller-Tidow, Carsten C; Hoefler, Gerald G; Kashofer, Karl K; Wölfler, Albert A; Sill, Heinz H; Caraffini, Veronica V; Zebisch, Armin A
Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients.
International Journal Of Molecular Sciences
Geissler, Klaus K; Jäger, Eva E; Barna, Agnes A; Gurbisz, Michael M; Graf, Temeida T; Graf, Elmir E; Nösslinger, Thomas T; Pfeilstöcker, Michael M; Tüchler, Heinz H; Sliwa, Thamer T; Keil, Felix F; Geissler, Christoph C; Heibl, Sonja S; Thaler, Josef J; Machherndl-Spandl, Sigrid S; Zach, Otto O; Weltermann, Ansgar A; Bettelheim, Peter P; Stauder, Reinhard R; Zebisch, Armin A; Sill, Heinz H; Schwarzinger, Ilse I; Schneeweiss, Bruno B; Öhler, Leopold L; Ulsperger, Ernst E; Kusec, Rajko R; Germing, Ulrich U; Sperr, Wolfgang R WR; Knöbl, Paul P; Jäger, Ulrich U; Hörmann, Gregor G; Valent, Peter P
Publication Date: 2020-04-24
Variant appearance in text: KRAS: 190T>G; Tyr64Asp
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Nature Communications
Kano, Yoshihito Y; Gebregiworgis, Teklab T; Marshall, Christopher B CB; Radulovich, Nikolina N; Poon, Betty P K BPK; St-Germain, Jonathan J; Cook, Jonathan D JD; Valencia-Sama, Ivette I; Grant, Benjamin M M BMM; Herrera, Silvia Gabriela SG; Miao, Jinmin J; Raught, Brian B; Irwin, Meredith S MS; Lee, Jeffrey E JE; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Tsao, Ming-Sound MS; Ikura, Mitsuhiko M; Ohh, Michael M
Molecular signaling in multiple myeloma: association of RAS/RAF mutations and MEK/ERK pathway activation.
Oncogenesis
Xu, J J; Pfarr, N N; Endris, V V; Mai, E K EK; Md Hanafiah, N H NH; Lehners, N N; Penzel, R R; Weichert, W W; Ho, A D AD; Schirmacher, P P; Goldschmidt, H H; Andrulis, M M; Raab, M S MS
Mutational landscape reflects the biological continuum of plasma cell dyscrasias.
Blood Cancer Journal
Rossi, A A; Voigtlaender, M M; Janjetovic, S S; Thiele, B B; Alawi, M M; März, M M; Brandt, A A; Hansen, T T; Radloff, J J; Schön, G G; Hegenbart, U U; Schönland, S S; Langer, C C; Bokemeyer, C C; Binder, M M
KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control.
Oncotarget
Le Calvez-Kelm, Florence F; Foll, Matthieu M; Wozniak, Magdalena B MB; Delhomme, Tiffany M TM; Durand, Geoffroy G; Chopard, Priscilia P; Pertesi, Maroulio M; Fabianova, Eleonora E; Adamcakova, Zora Z; Holcatova, Ivana I; Foretova, Lenka L; Janout, Vladimir V; Vallee, Maxime P MP; Rinaldi, Sabina S; Brennan, Paul P; McKay, James D JD; Byrnes, Graham B GB; Scelo, Ghislaine G
LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.
Bmc Bioinformatics
Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L
Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules.
Blood Cancer Journal
Leich, E E; Weißbach, S S; Klein, H-U HU; Grieb, T T; Pischimarov, J J; Stühmer, T T; Chatterjee, M M; Steinbrunn, T T; Langer, C C; Eilers, M M; Knop, S S; Einsele, H H; Bargou, R R; Rosenwald, A A
Initial genome sequencing and analysis of multiple myeloma.
Nature
Chapman, Michael A MA; Lawrence, Michael S MS; Keats, Jonathan J JJ; Cibulskis, Kristian K; Sougnez, Carrie C; Schinzel, Anna C AC; Harview, Christina L CL; Brunet, Jean-Philippe JP; Ahmann, Gregory J GJ; Adli, Mazhar M; Anderson, Kenneth C KC; Ardlie, Kristin G KG; Auclair, Daniel D; Baker, Angela A; Bergsagel, P Leif PL; Bernstein, Bradley E BE; Drier, Yotam Y; Fonseca, Rafael R; Gabriel, Stacey B SB; Hofmeister, Craig C CC; Jagannath, Sundar S; Jakubowiak, Andrzej J AJ; Krishnan, Amrita A; Levy, Joan J; Liefeld, Ted T; Lonial, Sagar S; Mahan, Scott S; Mfuko, Bunmi B; Monti, Stefano S; Perkins, Louise M LM; Onofrio, Robb R; Pugh, Trevor J TJ; Rajkumar, S Vincent SV; Ramos, Alex H AH; Siegel, David S DS; Sivachenko, Andrey A; Stewart, A Keith AK; Trudel, Suzanne S; Vij, Ravi R; Voet, Douglas D; Winckler, Wendy W; Zimmerman, Todd T; Carpten, John J; Trent, Jeff J; Hahn, William C WC; Garraway, Levi A LA; Meyerson, Matthew M; Lander, Eric S ES; Getz, Gad G; Golub, Todd R TR