KRAS c.187G>A ;(p.E63K)

Variant ID: 12-25380271-C-T

NM_004985.3(KRAS):c.187G>A;(p.E63K)

This variant was identified in 57 publications

View GRCh38 version.




Publications:


Genomic profiling of a metastatic anaplastic melanocytic neuroectodermal tumor arising from a mature thymic teratoma as part of a mediastinal germ cell tumor.

Cold Spring Harbor Molecular Case Studies
Mayeur, Sylvain S; Lhermitte, Benoit B; Gantzer, Justine J; Molitor, Anne A; Stemmelen, Tristan T; Meyer, Sébastien S; Kolmer, Aline A; Kurtz, Jean-Emmanuel JE; Bahram, Seiamak S; Carapito, Raphael R
Publication Date: 2023-04

Variant appearance in text: KRAS: E63K
PubMed Link: 37160315
Variant Present in the following documents:
  • Main text
  • MCS006257May.pdf
View BVdb publication page



Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemia.

Bmc Pediatrics
Shen, Diying D; Liu, Lixia L; Xu, Xiaojun X; Song, Hua H; Zhang, Jingying J; Xu, Weiqun W; Zhao, Fenying F; Liang, Juan J; Liao, Chan C; Wang, Yan Y; Xia, Tian T; Wang, Chengcheng C; Lou, Feng F; Cao, Shanbo S; Qin, Jiayue J; Tang, Yongmin Y
Publication Date: 2023-02-04

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 36739388
Variant Present in the following documents:
  • 12887_2023_3856_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: KRAS: E63K
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.

Blood
Ansari-Pour, Naser N; Samur, Mehmet K MK; Flynt, Erin E; Gooding, Sarah S; Towfic, Fadi F; Stong, Nicholas N; Ortiz Estevez, Maria M; Mavrommatis, Konstantinos K; Walker, Brian A BA; Morgan, Gareth J GJ; Munshi, Nikhil C NC; Avet Loiseau, Herve H; Thakurta, Anjan A
Publication Date: 2022-10-12

Variant appearance in text: KRAS: E63K
PubMed Link: 36223594
Variant Present in the following documents:
  • BLOOD_BLD-2022-017010-mmc2.xlsx, sheet 1
View BVdb publication page



Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.

The Journal Of Pathology
Birkeälv, Sofia S; Harland, Mark M; Matsuyama, Larissa Satiko Alcantara Sekimoto LSAS; Rashid, Mamun M; Mehta, Ishan I; Laye, Jonathan P JP; Haase, Kerstin K; Mell, Tracey T; Iyer, Vivek V; Robles-Espinoza, Carla Daniela CD; McDermott, Ultan U; van Loo, Peter P; Kuijjer, Marieke L ML; Possik, Patricia A PA; Maria Engler, Silvya Stuchi SS; Bishop, D Timothy DT; Newton-Bishop, Julia J; Adams, David J DJ
Publication Date: 2022-10-11

Variant appearance in text: KRAS: E63K
PubMed Link: 36219477
Variant Present in the following documents:
  • PATH-259-56-s006.xlsx, sheet 2
  • PATH-259-56-s004.xlsx, sheet 2
View BVdb publication page



Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood KMT2A-rearranged Acute Leukemia.

Hemasphere
Pilheden, Mattias M; Ahlgren, Louise L; Hyrenius-Wittsten, Axel A; Gonzalez-Pena, Veronica V; Sturesson, Helena H; Hansen Marquart, Hanne Vibeke HV; Lausen, Birgitte B; Castor, Anders A; Pronk, Cornelis Jan CJ; Barbany, Gisela G; Pokrovskaja Tamm, Katja K; Fogelstrand, Linda L; Lohi, Olli O; Norén-Nyström, Ulrika U; Asklin, Johanna J; Chen, Yilun Y; Song, Guangchun G; Walsh, Michael M; Ma, Jing J; Zhang, Jinghui J; Saal, Lao H LH; Gawad, Charles C; Hagström-Andersson, Anna K AK
Publication Date: 2022-10

Variant appearance in text: KRAS: E63K
PubMed Link: 36204688
Variant Present in the following documents:
  • hs9-6-e785-s001.xlsx, sheet 6
View BVdb publication page



KRAS Mutation in Pediatric Intracranial Germ Cell Tumors.

Asian Pacific Journal Of Cancer Prevention : Apjcp
Khaiman, Chusana C; Techavichit, Piti P; Poparn, Hansamon H; Chiangthong, Kanhatai K; Lauhasurayotin, Supanun S; Sosothikul, Darintr D; Shotelersuk, Kanjana K; Nantavithya, Chonnipa C; Jakchairoongruang, Ketsuda K; Amornfa, Jiraporn J; Khongkhaduead, Ekkachai E; Santisukwongchote, Sakun S; Teerapakpinyo, Chinachote C; Shuangshot, Shanop S
Publication Date: 2022-09-01

Variant appearance in text: KRAS: E63K
PubMed Link: 36172682
Variant Present in the following documents:
  • Main text
  • APJCP-23-3179.pdf
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Characteristics and Treatment Outcomes in Advanced-Stage Non-Small Cell Lung Cancer Patients with a KRAS G12C Mutation: A Real-World Study.

Journal Of Clinical Medicine
Illini, Oliver O; Fabikan, Hannah H; Hochmair, Maximilian Johannes MJ; Weinlinger, Christoph C; Krenbek, Dagmar D; Brcic, Luka L; Setinek, Ulrike U; Terbuch, Angelika A; Absenger, Gudrun G; Konjić, Selma S; Valipour, Arschang A
Publication Date: 2022-07-15

Variant appearance in text: KRAS: E63K
PubMed Link: 35887862
Variant Present in the following documents:
  • jcm-11-04098.pdf
View BVdb publication page



Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q.

Ebiomedicine
Adema, Vera V; Palomo, Laura L; Walter, Wencke W; Mallo, Mar M; Hutter, Stephan S; La Framboise, Thomas T; Arenillas, Leonor L; Meggendorfer, Manja M; Radivoyevitch, Tomas T; Xicoy, Blanca B; Pellagatti, Andrea A; Haferlach, Claudia C; Boultwood, Jacqueline J; Kern, Wolfgang W; Visconte, Valeria V; Sekeres, Mikkael M; Barnard, John J; Haferlach, Torsten T; Solé, Francesc F; Maciejewski, Jaroslaw P JP
Publication Date: 2022-06

Variant appearance in text: KRAS: 187G>A; Glu63Lys
PubMed Link: 35617825
Variant Present in the following documents:
  • mmc3.xlsx, sheet 1
View BVdb publication page



Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics
Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R
Publication Date: 2022-04-25

Variant appearance in text: KRAS: 187G>A
PubMed Link: 35468810
Variant Present in the following documents:
  • 12920_2022_1235_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



KRAS Mutation in Rare Tumors: A Landscape Analysis of 3453 Chinese Patients.

Frontiers In Molecular Biosciences
Wang, Shuhang S; Li, Qin Q; Ma, Peiwen P; Fang, Yuan Y; Yu, Yue Y; Jiang, Ning N; Miao, Huilei H; Tang, Qiyu Q; Yang, Yuqi Y; Xing, Shujun S; Chen, Rongrong R; Yi, Xin X; Li, Ning N
Publication Date: 2022

Variant appearance in text: KRAS: E63K
PubMed Link: 35359599
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrating real-time in vivo tumour genomes for longitudinal analysis and management of glioma recurrence.

Clinical And Translational Medicine
Sheng, Zhiyuan Z; Yu, Jinliang J; Deng, Kaiyuan K; Bu, Yage Y; Wu, Shuang S; Xu, Sensen S; Gao, Yushuai Y; Zhang, Qianqian Q; Yan, Zhaoyue Z; Bu, Chaojie C; Chen, Zhongcan Z; Gu, Jianjun J; Jia, Yan Y; Gao, Xinya X; Zemmar, Ajmal A; Sumardi, Fitri F; Hernesniemi, Juha J; Kong, Lingfei L; Liu, Gang G; Li, Ming M; Wang, Meiyun M; Li, Tianxiao T; Bu, Xingyao X
Publication Date: 2021-11

Variant appearance in text: KRAS: 187G>A; Glu63Lys
PubMed Link: 34841677
Variant Present in the following documents:
  • CTM2-11-e567-s004.xlsx, sheet 5
View BVdb publication page



Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence.

Frontiers In Oncology
Yu, Jinliang J; Sheng, Zhiyuan Z; Wu, Shuang S; Gao, Yushuai Y; Yan, Zhaoyue Z; Bu, Chaojie C; Gu, Jianjun J; Bu, Yage Y; Deng, Kaiyuan K; Xu, Sensen S; Chen, Zhongcan Z; Zhang, Qianqian Q; Zemmar, Ajmal A; Hernesniemi, Juha J; Wang, Meiyun M; Liu, Gang G; Li, Tianxiao T; Bu, Xingyao X
Publication Date: 2021

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 34712610
Variant Present in the following documents:
  • DataSheet_1.xls, sheet 6
View BVdb publication page



Molecular profiling of advanced malignancies guides first-line N-of-1 treatments in the I-PREDICT treatment-naïve study.

Genome Medicine
Sicklick, Jason K JK; Kato, Shumei S; Okamura, Ryosuke R; Patel, Hitendra H; Nikanjam, Mina M; Fanta, Paul T PT; Hahn, Michael E ME; De, Pradip P; Williams, Casey C; Guido, Jessica J; Solomon, Benjamin M BM; McKay, Rana R RR; Krie, Amy A; Boles, Sarah G SG; Ross, Jeffrey S JS; Lee, J Jack JJ; Leyland-Jones, Brian B; Lippman, Scott M SM; Kurzrock, Razelle R
Publication Date: 2021-10-04

Variant appearance in text: KRAS: E63K
PubMed Link: 34607609
Variant Present in the following documents:
  • 13073_2021_969_MOESM1_ESM.xlsx, sheet 2
  • 13073_2021_969_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (Cambridge (Mass.))
Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J
Publication Date: 2021-05-28

Variant appearance in text: KRAS: E63K
PubMed Link: 34557754
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.

Innovation (New York, N.Y.)
Du, Xiaojing X; Yang, Biwei B; An, Quanlin Q; Assaraf, Yehuda G YG; Cao, Xin X; Xia, Jinglin J
Publication Date: 2021-05-28

Variant appearance in text: KRAS: E63K
PubMed Link: 34557754
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Infrequent RAS mutation is not associated with specific histological phenotype in gliomas.

Bmc Cancer
Makino, Yasuhide Y; Arakawa, Yoshiki Y; Yoshioka, Ema E; Shofuda, Tomoko T; Minamiguchi, Sachiko S; Kawauchi, Takeshi T; Tanji, Masahiro M; Kanematsu, Daisuke D; Nonaka, Masahiro M; Okita, Yoshiko Y; Kodama, Yoshinori Y; Mano, Masayuki M; Hirose, Takanori T; Mineharu, Yohei Y; Miyamoto, Susumu S; Kanemura, Yonehiro Y
Publication Date: 2021-09-15

Variant appearance in text: KRAS: E63K
PubMed Link: 34525976
Variant Present in the following documents:
  • Main text
  • 12885_2021_Article_8733.pdf
View BVdb publication page



Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma.

Nature Communications
Frontzek, Fabian F; Staiger, Annette M AM; Zapukhlyak, Myroslav M; Xu, Wendan W; Bonzheim, Irina I; Borgmann, Vanessa V; Sander, Philip P; Baptista, Maria Joao MJ; Heming, Jan-Niklas JN; Berning, Philipp P; Wullenkord, Ramona R; Erdmann, Tabea T; Lutz, Mathias M; Veratti, Pia P; Ehrenfeld, Sophia S; Wienand, Kirsty K; Horn, Heike H; Goodlad, John R JR; Wilson, Matthew R MR; Anagnostopoulos, Ioannis I; Lamping, Mario M; Gonzalez-Barca, Eva E; Climent, Fina F; Salar, Antonio A; Castellvi, Josep J; Abrisqueta, Pau P; Menarguez, Javier J; Aldamiz, Teresa T; Richter, Julia J; Klapper, Wolfram W; Tzankov, Alexandar A; Dirnhofer, Stefan S; Rosenwald, Andreas A; Mate, José Luis JL; Tapia, Gustavo G; Lenz, Peter P; Miething, Cornelius C; Hartmann, Wolfgang W; Chapuy, Björn B; Fend, Falko F; Ott, German G; Navarro, José-Tomas JT; Grau, Michael M; Lenz, Georg G
Publication Date: 2021-08-31

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 34465776
Variant Present in the following documents:
  • 41467_2021_25405_MOESM9_ESM.xlsx, sheet 1
  • 41467_2021_25405_MOESM7_ESM.xlsx, sheet 2
View BVdb publication page



Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma.

Journal Of Personalized Medicine
Ilcus, Cristina C; Silaghi, Horatiu H; Georgescu, Carmen Emanuela CE; Georgiu, Carmen C; Ciurea, Anca Ileana AI; Nicoara, Simona Delia SD; Silaghi, Cristina Alina CA
Publication Date: 2021-07-14

Variant appearance in text: KRAS: 187G>A
PubMed Link: 34357128
Variant Present in the following documents:
  • Main text
  • jpm-11-00661.pdf
View BVdb publication page



Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology
Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN
Publication Date: 2021

Variant appearance in text: KRAS: E63K
PubMed Link: 34113354
Variant Present in the following documents:
  • Table_1.xlsx, sheet 28
  • Table_1.xlsx, sheet 26
View BVdb publication page



The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma.

Molecular Oncology
Montico, Barbara B; Giurato, Giorgio G; Pecoraro, Giovanni G; Salvati, Annamaria A; Covre, Alessia A; Colizzi, Francesca F; Steffan, Agostino A; Weisz, Alessandro A; Maio, Michele M; Sigalotti, Luca L; Fratta, Elisabetta E
Publication Date: 2022-02

Variant appearance in text: KRAS: E63K
PubMed Link: 34080276
Variant Present in the following documents:
  • Main text
View BVdb publication page



The pleiotropic role of circular and long noncoding RNAs in cutaneous melanoma.

Molecular Oncology
Montico, Barbara B; Giurato, Giorgio G; Pecoraro, Giovanni G; Salvati, Annamaria A; Covre, Alessia A; Colizzi, Francesca F; Steffan, Agostino A; Weisz, Alessandro A; Maio, Michele M; Sigalotti, Luca L; Fratta, Elisabetta E
Publication Date: 2021-06-03

Variant appearance in text: KRAS: E63K
PubMed Link: 34080276
Variant Present in the following documents:
  • Main text
View BVdb publication page



Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
Publication Date: 2021-04-19

Variant appearance in text: KRAS: E63K
PubMed Link: 33875650
Variant Present in the following documents:
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Managing Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors Through Co-Targeting MEK/ERK Signaling.

Lung Cancer (Auckland, N.Z.)
Yu, Danlei D; Zhao, Wen W; Vallega, Karin A KA; Sun, Shi-Yong SY
Publication Date: 2021

Variant appearance in text: KRAS: E63K
PubMed Link: 33574724
Variant Present in the following documents:
  • Main text
  • lctt-12-1.pdf
View BVdb publication page



Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics
Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM
Publication Date: 2020-12

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 33230298
Variant Present in the following documents:
  • NIHMS1637640-supplement-SuppData1.xlsx, sheet 1
View BVdb publication page



Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica
Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP
Publication Date: 2021-12-01

Variant appearance in text: KRAS: E63K
PubMed Link: 33147938
Variant Present in the following documents:
  • 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 3
View BVdb publication page



Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica
Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP
Publication Date: 2021-12-01

Variant appearance in text: KRAS: E63K
PubMed Link: 33147938
Variant Present in the following documents:
  • 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 3
View BVdb publication page



Clinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix.

Cancer Genomics & Proteomics
Jung, Hera H; Bae, Go Eun GE; Kim, Hye Min HM; Kim, Hyun-Soo HS
Publication Date: 2020

Variant appearance in text: KRAS: 187G>A; Glu63Lys
PubMed Link: 32859641
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of relevant genetic alterations in cancer using topological data analysis.

Nature Communications
Rabadán, Raúl R; Mohamedi, Yamina Y; Rubin, Udi U; Chu, Tim T; Alghalith, Adam N AN; Elliott, Oliver O; Arnés, Luis L; Cal, Santiago S; Obaya, Álvaro J ÁJ; Levine, Arnold J AJ; Cámara, Pablo G PG
Publication Date: 2020-07-30

Variant appearance in text: KRAS: E63K
PubMed Link: 32732999
Variant Present in the following documents:
  • 41467_2020_17659_MOESM3_ESM.xls, sheet 1
View BVdb publication page



Cross-species oncogenic signatures of breast cancer in canine mammary tumors.

Nature Communications
Kim, Tae-Min TM; Yang, In Seok IS; Seung, Byung-Joon BJ; Lee, Sejoon S; Kim, Dohyun D; Ha, Yoo-Jin YJ; Seo, Mi-Kyoung MK; Kim, Ka-Kyung KK; Kim, Hyun Seok HS; Cheong, Jae-Ho JH; Sur, Jung-Hyang JH; Nam, Hojung H; Kim, Sangwoo S
Publication Date: 2020-07-17

Variant appearance in text: KRAS: E63K
PubMed Link: 32680987
Variant Present in the following documents:
  • Main text
View BVdb publication page



NRAS mutant E132K identified in young-onset sporadic colorectal cancer and the canonical mutants G12D and Q61K affect distinct oncogenic phenotypes.

Scientific Reports
Yu, Ryan Timothy D RTD; Garcia, Reynaldo L RL
Publication Date: 2020-07-03

Variant appearance in text: KRAS: E63K
PubMed Link: 32620824
Variant Present in the following documents:
  • Main text
  • 41598_2020_Article_67796.pdf
View BVdb publication page



Genomic landscape of platinum resistant and sensitive testicular cancers.

Nature Communications
Loveday, Chey C; Litchfield, Kevin K; Proszek, Paula Z PZ; Cornish, Alex J AJ; Santo, Flavia F; Levy, Max M; Macintyre, Geoff G; Holryod, Amy A; Broderick, Peter P; Dudakia, Darshna D; Benton, Barbara B; Bakir, Maise Al MA; Hiley, Crispin C; Grist, Emily E; Swanton, Charles C; Huddart, Robert R; Powles, Tom T; Chowdhury, Simon S; Shipley, Janet J; O'Connor, Simon S; Brenton, James D JD; Reid, Alison A; de Castro, David Gonzalez DG; Houlston, Richard S RS; Turnbull, Clare C
Publication Date: 2020-05-04

Variant appearance in text: KRAS: E63K
PubMed Link: 32366847
Variant Present in the following documents:
  • 41467_2020_15768_MOESM5_ESM.xlsx, sheet 2
  • 41467_2020_15768_MOESM7_ESM.xlsx, sheet 2
View BVdb publication page



[Acquired Drug Resistance Mechanism of Osimertinib in the Targeted Therapy of Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Zhao, Zitong Z; Ni, Yu Y; Li, Li L; Xin, Tao T
Publication Date: 2020-04-20

Variant appearance in text: KRAS: E63K
PubMed Link: 32316715
Variant Present in the following documents:
  • Main text
  • zgfazz-23-4-274.pdf
View BVdb publication page



Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology
Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M
Publication Date: 2020-01-07

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 31925297
Variant Present in the following documents:
  • 42003_2019_736_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Tectal glioma harbors high rates of KRAS G12R and concomitant KRAS and BRAF alterations.

Acta Neuropathologica
Chiang, Jason J; Li, Xiaoyu X; Liu, Anthony P Y APY; Qaddoumi, Ibrahim I; Acharya, Sahaja S; Ellison, David W DW
Publication Date: 2020-03

Variant appearance in text: KRAS: E63K
PubMed Link: 31822998
Variant Present in the following documents:
  • Main text
View BVdb publication page



Blood-Based Next-Generation Sequencing Analysis of Appendiceal Cancers.

The Oncologist
Shaib, Walid L WL; Zakka, Katerina K; Staley, Charles C; Roberts, Ali A; Akce, Mehmet M; Wu, Christina C; Alese, Olatunji B OB; El-Rayes, Bassel F BF
Publication Date: 2020-05

Variant appearance in text: KRAS: E63K
PubMed Link: 31784493
Variant Present in the following documents:
  • Main text
View BVdb publication page



MYC dysregulation in the progression of multiple myeloma.

Leukemia
Misund, Kristine K; Keane, Niamh N; Stein, Caleb K CK; Asmann, Yan W YW; Day, Grady G; Welsh, Seth S; Van Wier, Scott A SA; Riggs, Daniel L DL; Ahmann, Greg G; Chesi, Marta M; Viswanatha, David S DS; Kumar, Shaji K SK; Dispenzieri, Angela A; Gonzalez-Calle, Veronica V; Kyle, Robert A RA; O'Dwyer, Michael M; Rajkumar, S Vincent SV; Kortüm, K Martin KM; Keats, J Jonathan JJ; , ; Fonseca, Rafael R; Stewart, A Keith AK; Kuehl, W Michael WM; Braggio, Esteban E; Bergsagel, P Leif PL
Publication Date: 2020-01

Variant appearance in text: KRAS: 187G>A; Glu63Lys
PubMed Link: 31439946
Variant Present in the following documents:
  • NIHMS1531599-supplement-Table.xlsx, sheet 13
View BVdb publication page



Phenotypic characterization of the novel, non-hotspot oncogenic KRAS mutants E31D and E63K.

Oncology Letters
Angeles, Arlou Kristina J AKJ; Yu, Ryan Timothy D RTD; Cutiongco-De La Paz, Eva Maria EM; Garcia, Reynaldo L RL
Publication Date: 2019-07

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 31289513
Variant Present in the following documents:
  • Main text
  • ol-18-01-0420.pdf
View BVdb publication page



DNA-Repair Gene Mutations Are Highly Prevalent in Circulating Tumour DNA from Multiple Myeloma Patients.

Cancers
Mithraprabhu, Sridurga S; Hocking, Jay J; Ramachandran, Malarmathy M; Choi, Kawa K; Klarica, Daniela D; Khong, Tiffany T; Reynolds, John J; Spencer, Andrew A
Publication Date: 2019-06-29

Variant appearance in text: KRAS: E63K
PubMed Link: 31261969
Variant Present in the following documents:
  • cancers-11-00917-s001.xlsx, sheet 2
View BVdb publication page



Unusual KRAS missense mutation (p.E63K) in patient with juvenile pilocytic astrocytoma of the tectum.

Bmj Case Reports
Chau, Lianne Q LQ; Levy, Michael L ML; Crawford, John Ross JR
Publication Date: 2019-02-22

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 30798277
Variant Present in the following documents:
  • Main text
View BVdb publication page



Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.

Nature Communications
Russo, Mariangela M; Lamba, Simona S; Lorenzato, Annalisa A; Sogari, Alberto A; Corti, Giorgio G; Rospo, Giuseppe G; Mussolin, Benedetta B; Montone, Monica M; Lazzari, Luca L; Arena, Sabrina S; Oddo, Daniele D; Linnebacher, Michael M; Sartore-Bianchi, Andrea A; Pietrantonio, Filippo F; Siena, Salvatore S; Di Nicolantonio, Federica F; Bardelli, Alberto A
Publication Date: 2018-06-12

Variant appearance in text: KRAS: E63K
PubMed Link: 29895949
Variant Present in the following documents:
  • Main text
  • 41467_2018_4506_MOESM2_ESM.pdf
  • 41467_2018_4506_MOESM1_ESM.pdf
  • 41467_2018_Article_4506.pdf
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Importance of Comprehensive Molecular Profiling for Clinical Outcome in Children With Recurrent Cancer.

Frontiers In Pediatrics
Østrup, Olga O; Nysom, Karsten K; Scheie, David D; Schmidt, Ane Y AY; Mathiasen, Rene R; Hjalgrim, Lisa L LL; Olsen, Tina E TE; Skjøth-Rasmussen, Jane J; Henriksen, Birthe M BM; Nielsen, Finn C FC; Wehner, Peder S PS; Schrøder, Henrik H; Sehested, Astrid M AM; Rechnitzer, Catherine C; Rossing, Maria M
Publication Date: 2018

Variant appearance in text: KRAS: E63K
PubMed Link: 29732366
Variant Present in the following documents:
  • Main text
  • fped-06-00114.pdf
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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: KRAS: E63K
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 1
  • pone.0196434.s001.xlsx, sheet 2
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Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports
Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS
Publication Date: 2018-04-03

Variant appearance in text: KRAS: Glu63Lys
PubMed Link: 29617658
Variant Present in the following documents:
  • NIHMS958974-supplement-6.xlsx, sheet 1
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The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia.

Haematologica
Fedders, Henning H; Alsadeq, Ameera A; Schmäh, Juliane J; Vogiatzi, Fotini F; Zimmermann, Martin M; Möricke, Anja A; Lenk, Lennart L; Stadt, Udo Zur UZ; Horstmann, Martin A MA; Pieters, Rob R; Schrappe, Martin M; Stanulla, Martin M; Cario, Gunnar G; Schewe, Denis M DM
Publication Date: 2017-11

Variant appearance in text: KRAS: E63K
PubMed Link: 28838992
Variant Present in the following documents:
  • Main text
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Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04

Variant appearance in text: KRAS: 187G>A; Glu63Lys
PubMed Link: 28775315
Variant Present in the following documents:
  • 41467_2017_289_MOESM7_ESM.xlsx, sheet 1
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Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations.

Oncotarget
Cosgarea, Ioana I; Ugurel, Selma S; Sucker, Antje A; Livingstone, Elisabeth E; Zimmer, Lisa L; Ziemer, Mirjana M; Utikal, Jochen J; Mohr, Peter P; Pfeiffer, Christiane C; Pföhler, Claudia C; Hillen, Uwe U; Horn, Susanne S; Schadendorf, Dirk D; Griewank, Klaus G KG; Roesch, Alexander A
Publication Date: 2017-06-20

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 28380455
Variant Present in the following documents:
  • Main text
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NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics.

Molecular Oncology
Cirenajwis, Helena H; Lauss, Martin M; Ekedahl, Henrik H; Törngren, Therese T; Kvist, Anders A; Saal, Lao H LH; Olsson, Håkan H; Staaf, Johan J; Carneiro, Ana A; Ingvar, Christian C; Harbst, Katja K; Hayward, Nicholas K NK; Jönsson, Göran G
Publication Date: 2017-04

Variant appearance in text: KRAS: 187G>A; E63K
PubMed Link: 28267273
Variant Present in the following documents:
  • MOL2-11-438-s003.xls, sheet 1
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ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer.

Oncotarget
Geißler, Anna-Lena AL; Geißler, Miriam M; Kottmann, Daniel D; Lutz, Lisa L; Fichter, Christiane D CD; Fritsch, Ralph R; Weddeling, Britta B; Makowiec, Frank F; Werner, Martin M; Lassmann, Silke S
Publication Date: 2017-03-07

Variant appearance in text: KRAS: Glu63Lys
PubMed Link: 28199979
Variant Present in the following documents:
  • Main text
  • oncotarget-08-17164.pdf
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PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.

Plos Computational Biology
Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J
Publication Date: 2016-05

Variant appearance in text: KRAS: E63K
PubMed Link: 27224906
Variant Present in the following documents:
  • pcbi.1004962.s005.xlsx, sheet 1
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Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.

Oncotarget
Messina, Monica M; Chiaretti, Sabina S; Wang, Jiguang J; Fedullo, Anna Lucia AL; Peragine, Nadia N; Gianfelici, Valentina V; Piciocchi, Alfonso A; Brugnoletti, Fulvia F; Di Giacomo, Filomena F; Pauselli, Simona S; Holmes, Antony B AB; Puzzolo, Maria Cristina MC; Ceglie, Giulia G; Apicella, Valerio V; Mancini, Marco M; Te Kronnie, Geertruy G; Testi, Anna Maria AM; Vitale, Antonella A; Vignetti, Marco M; Guarini, Anna A; Rabadan, Raul R; Foà, Robin R
Publication Date: 2016-03-22

Variant appearance in text: KRAS: E63K
PubMed Link: 26883104
Variant Present in the following documents:
  • Main text
  • oncotarget-07-13886.pdf
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LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics
Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L
Publication Date: 2016-02-09

Variant appearance in text: KRAS: E63K
PubMed Link: 26860319
Variant Present in the following documents:
  • 12859_2016_935_MOESM2_ESM.xlsx, sheet 1
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Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Publication Date: 2015

Variant appearance in text: KRAS: E63K
PubMed Link: 26010451
Variant Present in the following documents:
  • pone.0127146.s014.xlsx, sheet 3
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Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

British Journal Of Cancer
Wong, S Q SQ; Fellowes, A A; Doig, K K; Ellul, J J; Bosma, T J TJ; Irwin, D D; Vedururu, R R; Tan, A Y-C AY; Weiss, J J; Chan, K S KS; Lucas, M M; Thomas, D M DM; Dobrovic, A A; Parisot, J P JP; Fox, S B SB
Publication Date: 2015-04-14

Variant appearance in text: KRAS: 187G>A; Glu63Lys
PubMed Link: 25742471
Variant Present in the following documents:
  • bjc201580x7.xls, sheet 1
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High-throughput profiling identifies clinically actionable mutations in salivary duct carcinoma.

Journal Of Translational Medicine
Ku, Bo Mi BM; Jung, Hyun Ae HA; Sun, Jong-Mu JM; Ko, Young Hyeh YH; Jeong, Han-Sin HS; Son, Young-Ik YI; Baek, Chung-Hwan CH; Park, Keunchil K; Ahn, Myung-Ju MJ
Publication Date: 2014-10-25

Variant appearance in text: KRAS: E63K
PubMed Link: 25343854
Variant Present in the following documents:
  • Main text
  • 12967_2014_Article_299.pdf
View BVdb publication page