KRAS c.181C>A ;(p.Q61K)

Variant ID: 12-25380277-G-T

NM_004985.3(KRAS):c.181C>A;(p.Q61K)

This variant was identified in 315 publications

View GRCh38 version.




Publications:


The Swedish childhood tumor biobank: systematic collection and molecular characterization of all pediatric CNS and other solid tumors in Sweden.

Journal Of Translational Medicine
Díaz de Ståhl, Teresita T; Shamikh, Alia A; Mayrhofer, Markus M; Juhos, Szilvester S; Basmaci, Elisa E; Prochazka, Gabriela G; Garcia, Maxime M; Somarajan, Praveen Raj PR; Zielinska-Chomej, Katarzyna K; Illies, Christopher C; Øra, Ingrid I; Siesjö, Peter P; Sandström, Per-Erik PE; Stenman, Jakob J; Sabel, Magnus M; Gustavsson, Bengt B; Kogner, Per P; Pfeifer, Susan S; Ljungman, Gustaf G; Sandgren, Johanna J; Nistér, Monica M
Publication Date: 2023-05-23

Variant appearance in text: KRAS: Gln61Lys
PubMed Link: 37221626
Variant Present in the following documents:
  • 12967_2023_4178_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

Biorxiv : The Preprint Server For Biology
Ratnasinghe, Brian D BD; Haque, Neshatul N; Wagenknecht, Jessica B JB; Jensen, Davin R DR; Esparza, Guadalupe V GV; Leverence, Elise N EN; De Assuncao, Thiago Milech TM; Mathison, Angela J AJ; Lomberk, Gwen G; Smith, Brian C BC; Volkman, Brian F BF; Urrutia, Raul R; Zimmermann, Michael T MT
Publication Date: 2023-04-28

Variant appearance in text: KRAS: Q61K
PubMed Link: 37207265
Variant Present in the following documents:
  • Main text
  • nihpp-2023.04.28.536249v1.pdf
View BVdb publication page



KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression.

Frontiers In Cell And Developmental Biology
Zhang, Zining Z; Zhang, Heng H; Liao, Xiang X; Tsai, Hsiang-I HI
Publication Date: 2023

Variant appearance in text: KRAS: Q61K
PubMed Link: 37152291
Variant Present in the following documents:
  • Main text
  • fcell-11-1147676.pdf
View BVdb publication page



Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer.

Cell Death And Differentiation
Yang, Kaixin K; Zhang, Wenyang W; Zhong, Linghui L; Xiao, Yinan Y; Sahoo, Sudhakar S; Fassan, Matteo M; Zeng, Kang K; Magee, Peter P; Garofalo, Michela M; Shi, Lei L
Publication Date: 2023-04-11

Variant appearance in text: KRAS: Q61K
PubMed Link: 37041291
Variant Present in the following documents:
  • 41418_2023_1160_MOESM2_ESM.pdf
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: KRAS: Q61K
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
View BVdb publication page



Pathogenic genomic alterations in Chinese pancreatic cancer patients and their therapeutical implications.

Cancer Medicine
Zhao, Zhiming Z; Li, Xiaomo X; Wang, Fei F; Xu, Yong Y; Liu, Si S; Han, Quanli Q; Yang, Zhiying Z; Huang, Weiwei W; Yin, Zhuzeng Z; Liu, Qu Q; Tan, Haidong H; Ma, Tonghui T; Si, Shuang S; Huang, Jia J; Yuan, Hongling H; Li, Wei W; Liu, Rong R
Publication Date: 2023-03-31

Variant appearance in text: KRAS: Q61K
PubMed Link: 36999792
Variant Present in the following documents:
  • CAM4-12-11672.pdf
View BVdb publication page



Alternative mRNA Splicing and Promising Therapies in Cancer.

Biomolecules
Fackenthal, James D JD
Publication Date: 2023-03-20

Variant appearance in text: KRAS: Q61K
PubMed Link: 36979496
Variant Present in the following documents:
  • Main text
  • biomolecules-13-00561.pdf
View BVdb publication page



Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology.

Nature Medicine
Sturm, Dominik D; Capper, David D; Andreiuolo, Felipe F; Gessi, Marco M; Kölsche, Christian C; Reinhardt, Annekathrin A; Sievers, Philipp P; Wefers, Annika K AK; Ebrahimi, Azadeh A; Suwala, Abigail K AK; Gielen, Gerrit H GH; Sill, Martin M; Schrimpf, Daniel D; Stichel, Damian D; Hovestadt, Volker V; Daenekas, Bjarne B; Rode, Agata A; Hamelmann, Stefan S; Previti, Christopher C; Jäger, Natalie N; Buchhalter, Ivo I; Blattner-Johnson, Mirjam M; Jones, Barbara C BC; Warmuth-Metz, Monika M; Bison, Brigitte B; Grund, Kerstin K; Sutter, Christian C; Hirsch, Steffen S; Dikow, Nicola N; Hasselblatt, Martin M; Schüller, Ulrich U; Gerber, Nicolas U NU; White, Christine L CL; Buntine, Molly K MK; Kinross, Kathryn K; Algar, Elizabeth M EM; Hansford, Jordan R JR; Gottardo, Nicholas G NG; Hernáiz Driever, Pablo P; Gnekow, Astrid A; Witt, Olaf O; Müller, Hermann L HL; Calaminus, Gabriele G; Fleischhack, Gudrun G; Kordes, Uwe U; Mynarek, Martin M; Rutkowski, Stefan S; Frühwald, Michael C MC; Kramm, Christof M CM; von Deimling, Andreas A; Pietsch, Torsten T; Sahm, Felix F; Pfister, Stefan M SM; Jones, David T W DTW
Publication Date: 2023-03-16

Variant appearance in text: KRAS: Q61K
PubMed Link: 36928815
Variant Present in the following documents:
  • 41591_2023_2255_MOESM3_ESM.xlsx, sheet 5
View BVdb publication page



Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

Nature Communications
Veschi, Veronica V; Turdo, Alice A; Modica, Chiara C; Verona, Francesco F; Di Franco, Simone S; Gaggianesi, Miriam M; Tirrò, Elena E; Di Bella, Sebastiano S; Iacono, Melania Lo ML; Pantina, Vincenzo Davide VD; Porcelli, Gaetana G; Mangiapane, Laura Rosa LR; Bianca, Paola P; Rizzo, Aroldo A; Sciacca, Elisabetta E; Pillitteri, Irene I; Vella, Veronica V; Belfiore, Antonino A; Bongiorno, Maria Rita MR; Pistone, Giuseppe G; Memeo, Lorenzo L; Colarossi, Lorenzo L; Giuffrida, Dario D; Colarossi, Cristina C; Vigneri, Paolo P; Todaro, Matilde M; Stassi, Giorgio G
Publication Date: 2023-03-11

Variant appearance in text: KRAS: Q61K; rs121913238
PubMed Link: 36906579
Variant Present in the following documents:
  • 41467_2023_36922_MOESM4_ESM.xls, sheet 2
View BVdb publication page



KRAS, NRAS, BRAF, HER2 and MSI Status in a Large Consecutive Series of Colorectal Carcinomas.

International Journal Of Molecular Sciences
Martianov, Aleksandr S AS; Mitiushkina, Natalia V NV; Ershova, Anastasia N AN; Martynenko, Darya E DE; Bubnov, Mikhail G MG; Amankwah, Priscilla P; Yanus, Grigory A GA; Aleksakhina, Svetlana N SN; Tiurin, Vladislav I VI; Venina, Aigul R AR; Anuskina, Aleksandra A AA; Gorgul, Yuliy A YA; Shestakova, Anna D AD; Maidin, Mikhail A MA; Belyaev, Alexey M AM; Baboshkina, Liliya S LS; Iyevleva, Aglaya G AG; Imyanitov, Evgeny N EN
Publication Date: 2023-03-02

Variant appearance in text: KRAS: Q61K
PubMed Link: 36902296
Variant Present in the following documents:
  • Main text
  • ijms-24-04868.pdf
View BVdb publication page



Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer.

Cancer Discovery
Pradat, Yoann Y; Viot, Julien J; Yurchenko, Andrey A AA; Gunbin, Konstantin K; Cerbone, Luigi L; Deloger, Marc M; Grisay, Guillaume G; Verlingue, Loic L; Scott, Veronique V; Padioleau, Ismael I; Panunzi, Leonardo L; Michiels, Stefan S; Hollebecque, Antoine A; Jules-Clement, Gerome G; Mezquita, Laura L; Laine, Antoine A; Loriot, Yohann Y; Besse, Benjamin B; Friboulet, Luc L; Andre, Fabrice F; Cournede, Paul-Henry PH; Gautheret, Daniel D; Nikolaev, Sergey I SI
Publication Date: 2023-03-02

Variant appearance in text: KRAS: Q61K
PubMed Link: 36862804
Variant Present in the following documents:
  • cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 6
View BVdb publication page



Novel mutant KRAS addiction signature predicts response to the combination of ERBB and MEK inhibitors in lung and pancreatic cancers.

Iscience
Tyc, Katarzyna M KM; Kazi, Aslamuzzaman A; Ranjan, Alok A; Wang, Rui R; Sebti, Said M SM
Publication Date: 2023-03-17

Variant appearance in text: KRAS: Q61K
PubMed Link: 36852277
Variant Present in the following documents:
  • mmc2.xlsx, sheet 2
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: KRAS: 181C>A; Gln61Lys
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment.

Nature Communications
Werba, Gregor G; Weissinger, Daniel D; Kawaler, Emily A EA; Zhao, Ende E; Kalfakakou, Despoina D; Dhara, Surajit S; Wang, Lidong L; Lim, Heather B HB; Oh, Grace G; Jing, Xiaohong X; Beri, Nina N; Khanna, Lauren L; Gonda, Tamas T; Oberstein, Paul P; Hajdu, Cristina C; Loomis, Cynthia C; Heguy, Adriana A; Sherman, Mara H MH; Lund, Amanda W AW; Welling, Theodore H TH; Dolgalev, Igor I; Tsirigos, Aristotelis A; Simeone, Diane M DM
Publication Date: 2023-02-13

Variant appearance in text: KRAS: Q61K
PubMed Link: 36781852
Variant Present in the following documents:
  • 41467_2023_36296_MOESM4_ESM.pdf
View BVdb publication page



Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications
Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI
Publication Date: 2023-02-08

Variant appearance in text: KRAS: Q61K
PubMed Link: 36755027
Variant Present in the following documents:
  • 41467_2023_36328_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Dynamics of age- versus therapy-related clonal hematopoiesis in long-term survivors of pediatric cancer.

Cancer Discovery
Hagiwara, Kohei K; Natarajan, Sivaraman S; Wang, Zhaoming Z; Zubair, Haseeb H; Mulder, Heather L HL; Dong, Li L; Plyler, Emily M EM; Thimmaiah, Padma P; Ma, Xiaotu X; Ness, Kirsten K KK; Li, Zhenghong Z; Mulrooney, Daniel A DA; Wilson, Carmen L CL; Yasui, Yutaka Y; Hudson, Melissa M MM; Easton, John J; Robison, Leslie L LL; Zhang, Jinghui J
Publication Date: 2023-02-08

Variant appearance in text: KRAS: Q61K
PubMed Link: 36751942
Variant Present in the following documents:
  • cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 4
View BVdb publication page



Significance of logistic regression scoring model based on natural killer cell-mediated cytotoxic pathway in the diagnosis of colon cancer.

Frontiers In Immunology
Ye, Zhen Z; Zhang, Huanhuan H; Liang, Jianwei J; Yi, Shuying S; Zhan, Xianquan X
Publication Date: 2023

Variant appearance in text: KRAS: Q61K; rs121913238
PubMed Link: 36742322
Variant Present in the following documents:
  • Table_7.xlsx, sheet 1
  • Table_8.xlsx, sheet 1
View BVdb publication page



Genomic Characterization of Rare Primary Cardiac Sarcoma Entities.

Diagnostics (Basel, Switzerland)
Gozzellino, Livia L; Nannini, Margherita M; Pizzi, Carmine C; Leone, Ornella O; Corti, Barbara B; Indio, Valentina V; Baldovini, Chiara C; Paolisso, Pasquale P; Foà, Alberto A; Pacini, Davide D; Folesani, Gianluca G; Schipani, Angela A; Costa, Alice A; Pasquinelli, Gianandrea G; Pantaleo, Maria Abbondanza MA; Astolfi, Annalisa A
Publication Date: 2023-01-06

Variant appearance in text: KRAS: Q61K
PubMed Link: 36673024
Variant Present in the following documents:
  • Main text
  • diagnostics-13-00214.pdf
View BVdb publication page



Prognostic value of KRAS subtype in patients with PDAC undergoing radical resection.

Frontiers In Oncology
Dai, Manxiong M; Jahanzaib, Raja R; Liao, Yan Y; Yao, Fengxuan F; Li, Jia J; Teng, Xiong X; Chen, Kang K; Cheng, Wei W
Publication Date: 2022

Variant appearance in text: KRAS: Q61K
PubMed Link: 36582783
Variant Present in the following documents:
  • Main text
  • fonc-12-1074538.pdf
View BVdb publication page



Tumor genomic profiling and personalized tracking of circulating tumor DNA in Vietnamese colorectal cancer patients.

Frontiers In Oncology
Nguyen, Huu Thinh HT; Nguyen, Trieu Vu TV; Nguyen Hoang, Van-Anh VA; Tran, Duc Huy DH; Le Trinh, Ngoc An NA; Le, Minh Triet MT; Nguyen Tran, Tuan-Anh TA; Pham, Thanh Huyen TH; Dinh, Thi Cuc TC; Nguyen, Tien Sy TS; Nguyen The, Ky Cuong KC; Mai, Hoa H; Chu, Minh Tuan MT; Pham, Dinh Hoang DH; Nguyen, Xuan Chi XC; Ngo Ha, Thien My TM; Nguyen, Duy Sinh DS; Nguyen, Du Quyen DQ; Lu, Y-Thanh YT; Do Thi, Thanh Thuy TT; Truong, Dinh Kiet DK; Nguyen, Quynh Tho QT; Nguyen, Hoai-Nghia HN; Giang, Hoa H; Tu, Lan N LN
Publication Date: 2022

Variant appearance in text: KRAS: Q61K
PubMed Link: 36578946
Variant Present in the following documents:
  • DataSheet_2.xlsx, sheet 2
  • DataSheet_2.xlsx, sheet 1
View BVdb publication page



Mutations matter: An observational study of the prognostic and predictive value of KRAS mutations in metastatic colorectal cancer.

Frontiers In Oncology
Lavacchi, Daniele D; Fancelli, Sara S; Roviello, Giandomenico G; Castiglione, Francesca F; Caliman, Enrico E; Rossi, Gemma G; Venturini, Jacopo J; Pellegrini, Elisa E; Brugia, Marco M; Vannini, Agnese A; Bartoli, Caterina C; Cianchi, Fabio F; Pillozzi, Serena S; Antonuzzo, Lorenzo L
Publication Date: 2022

Variant appearance in text: KRAS: Q61K
PubMed Link: 36523988
Variant Present in the following documents:
  • Main text
  • fonc-12-1055019.pdf
View BVdb publication page



Preclinical Models of Neuroendocrine Neoplasia.

Cancers
Sedlack, Andrew J H AJH; Saleh-Anaraki, Kimia K; Kumar, Suresh S; Ear, Po Hien PH; Lines, Kate E KE; Roper, Nitin N; Pacak, Karel K; Bergsland, Emily E; Quelle, Dawn E DE; Howe, James R JR; Pommier, Yves Y; Del Rivero, Jaydira J
Publication Date: 2022-11-17

Variant appearance in text: KRAS: Gln61Lys
PubMed Link: 36428741
Variant Present in the following documents:
  • Main text
View BVdb publication page



Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria.

American Journal Of Human Genetics
Pejaver, Vikas V; Byrne, Alicia B AB; Feng, Bing-Jian BJ; Pagel, Kymberleigh A KA; Mooney, Sean D SD; Karchin, Rachel R; O'Donnell-Luria, Anne A; Harrison, Steven M SM; Tavtigian, Sean V SV; Greenblatt, Marc S MS; Biesecker, Leslie G LG; Radivojac, Predrag P; Brenner, Steven E SE; ,
Publication Date: 2022-12-01

Variant appearance in text: KRAS: Q61K; rs121913238
PubMed Link: 36413997
Variant Present in the following documents:
  • mmc2.xlsx, sheet 1
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: KRAS: Q61K
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Molecular characterization of acquired resistance to KRAS G12C-EGFR inhibition in colorectal cancer.

Cancer Discovery
Yaeger, Rona R; Mezzadra, Riccardo R; Sinopoli, Jenna J; Bian, Yu Y; Marasco, Michelangelo M; Kaplun, Esther E; Gao, Yijun Y; Zhao, HuiYong H; Da Cruz Paula, Arnaud A; Zhu, Yingjie Y; Chaves Perez, Almudena A; Chadalavada, Kalyani K; Tse, Edison E; Chowdhry, Sudhir S; Bowker, Sydney S; Chang, Qing Q; Qeriqi, Besnik B; Weigelt, Britta B; Nanjangud, Gouri J GJ; Berger, Michael F MF; Der-Torossian, Hirak H; Anderes, Kenna K; Socci, Nicholas D ND; Shia, Jinru J; Riely, Gregory J GJ; Murciano-Goroff, Yonina R YR; Li, Bob T BT; Christensen, James G JG; Reis-Filho, Jorge S JS; Solit, David B DB; de Stanchina, Elisa E; Lowe, Scott W SW; Rosen, Neal N; Misale, Sandra S
Publication Date: 2022-11-10

Variant appearance in text: KRAS: Q61K
PubMed Link: 36355783
Variant Present in the following documents:
  • cd-22-0405_supplementary_table_3_suppst3.xlsx, sheet 1
View BVdb publication page



NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma.

Cell Reports
Ramakrishnan, Gopalakrishnan G; Parajuli, Parash P; Singh, Pura P; Friend, Creighton C; Hurwitz, Eric E; Prunier, Celine C; Razzaque, Mohammed S MS; Xu, Keli K; Atfi, Azeddine A
Publication Date: 2022-11-08

Variant appearance in text: KRAS: Q61K
PubMed Link: 36351408
Variant Present in the following documents:
  • NIHMS1848910-supplement-2.xlsx, sheet 1
  • NIHMS1848910-supplement-2.xlsx, sheet 3
View BVdb publication page



Heterogeneity of the cancer cell line metabolic landscape.

Molecular Systems Biology
Shorthouse, David D; Bradley, Jenna J; Critchlow, Susan E SE; Bendtsen, Claus C; Hall, Benjamin A BA
Publication Date: 2022-11

Variant appearance in text: KRAS: Gln61Lys
PubMed Link: 36321551
Variant Present in the following documents:
  • MSB-18-e11006-s010.xlsx, sheet 1
View BVdb publication page



Classification of Pediatric Gangliogliomas Based on the Histological Infiltration.

Current Oncology (Toronto, Ont.)
Alturkustani, Murad M
Publication Date: 2022-09-21

Variant appearance in text: KRAS: Q61K
PubMed Link: 36290809
Variant Present in the following documents:
  • Main text
  • curroncol-29-00532.pdf
View BVdb publication page



Predictive mutation signature of immunotherapy benefits in NSCLC based on machine learning algorithms.

Frontiers In Immunology
Liu, Zhichao Z; Lin, Guo G; Yan, Zeping Z; Li, Linduo L; Wu, Xingchen X; Shi, Jingrong J; He, Jianxing J; Zhao, Lei L; Liang, Hengrui H; Wang, Wei W
Publication Date: 2022

Variant appearance in text: KRAS: 181C>A; Q61K
PubMed Link: 36238300
Variant Present in the following documents:
  • Table_1.xlsx, sheet 4
View BVdb publication page



TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review.

Annals Of Hematology
Zhang, Heyang H; Zhan, Qianru Q; Wang, Xiaoxue X; Gao, Feng F; Yu, Jinxiang J; Wang, Jing J; Fu, Wei W; Wang, Pingping P; Wei, Xin X; Zhang, Lijun L
Publication Date: 2022-12

Variant appearance in text: KRAS: Q61K
PubMed Link: 36181538
Variant Present in the following documents:
  • Main text
  • 277_2022_Article_4979.pdf
View BVdb publication page



EPHA5 mutation was associated with adverse outcome of atezolizumab treatment in late-stage non-small cell lung cancers.

Bmc Pulmonary Medicine
Li, Zhenxiang Z; Zhou, Qing Q; Wang, Qi Q; Wang, Haiyong H; Yue, Weiming W
Publication Date: 2022-09-19

Variant appearance in text: KRAS: 181C>A; Q61K
PubMed Link: 36123678
Variant Present in the following documents:
  • 12890_2022_2161_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.

Journal Of The American Chemical Society
Zhang, Ziyang Z; Morstein, Johannes J; Ecker, Andrew K AK; Guiley, Keelan Z KZ; Shokat, Kevan M KM
Publication Date: 2022-09-07

Variant appearance in text: KRAS: Q61K
PubMed Link: 36001446
Variant Present in the following documents:
  • Main text
  • ja2c05377.pdf
View BVdb publication page



Evolution of intra-tumoral heterogeneity across different pathological stages in papillary thyroid carcinoma.

Cancer Cell International
Affinito, Ornella O; Orlandella, Francesca Maria FM; Luciano, Neila N; Salvatore, Marco M; Salvatore, Giuliana G; Franzese, Monica M
Publication Date: 2022-08-22

Variant appearance in text: KRAS: 181C>A; Q61K; rs121913238
PubMed Link: 35996174
Variant Present in the following documents:
  • 12935_2022_2680_MOESM5_ESM.xlsx, sheet 2
View BVdb publication page



Prognostic value of baseline genetic features and newly identified TP53 mutations in advanced breast cancer.

Molecular Oncology
Zhang, Lanxin L; Sun, Siwen S; Zhao, Xiaotian X; Liu, Jingwen J; Xu, Yang Y; Xu, Lingzhi L; Song, Chen C; Li, Na N; Yu, Jing J; Zhao, Shanshan S; Yu, Peiyao P; Fang, Fengqi F; Xie, Jiping J; Ji, Xuening X; Yu, Ruoying R; Ou, Qiuxiang Q; Zhao, Zuowei Z; Li, Man M
Publication Date: 2022-10

Variant appearance in text: KRAS: 181C>A
PubMed Link: 35971249
Variant Present in the following documents:
  • MOL2-16-3689-s005.xlsx, sheet 1
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: KRAS: 181C>A; Q61K
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Durinikova, Erika E; Reilly, Nicole M NM; Buzo, Kristi K; Mariella, Elisa E; Chilà, Rosaria R; Lorenzato, Annalisa A; Dias, João M L JML; Grasso, Gaia G; Pisati, Federica F; Lamba, Simona S; Corti, Giorgio G; Degasperi, Andrea A; Cancelliere, Carlotta C; Mauri, Gianluca G; Andrei, Pietro P; Linnebacher, Michael M; Marsoni, Silvia S; Siena, Salvatore S; Sartore-Bianchi, Andrea A; Nik-Zainal, Serena S; Di Nicolantonio, Federica F; Bardelli, Alberto A; Arena, Sabrina S
Publication Date: 2022-09-01

Variant appearance in text: KRAS: Q61K
PubMed Link: 35881546
Variant Present in the following documents:
  • EMS151756-supplement-Table_S1.xlsx, sheet 1
View BVdb publication page



Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Publication Date: 2022-08

Variant appearance in text: KRAS: Q61K
PubMed Link: 35835912
Variant Present in the following documents:
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 2
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 4
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Acquired Resistance to Osimertinib in EGFR-Mutated Non-Small Cell Lung Cancer: How Do We Overcome It?

International Journal Of Molecular Sciences
Bertoli, Elisa E; De Carlo, Elisa E; Del Conte, Alessandro A; Stanzione, Brigida B; Revelant, Alberto A; Fassetta, Kelly K; Spina, Michele M; Bearz, Alessandra A
Publication Date: 2022-06-22

Variant appearance in text: KRAS: Q61K
PubMed Link: 35805940
Variant Present in the following documents:
  • Main text
  • ijms-23-06936.pdf
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Identification of cell type-specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors.

The Journal Of Biological Chemistry
Lebedev, Timofey D TD; Khabusheva, Elmira R ER; Mareeva, Sofia R SR; Ivanenko, Karina A KA; Morozov, Alexey V AV; Spirin, Pavel V PV; Rubtsov, Petr M PM; Snezhkina, Anastasiya V AV; Kudryavtseva, Anna V AV; Sorokin, Maxim I MI; Buzdin, Anton A AA; Prassolov, Vladimir S VS
Publication Date: 2022-08

Variant appearance in text: KRAS: Q61K
PubMed Link: 35787369
Variant Present in the following documents:
  • mmc6.xlsx, sheet 1
View BVdb publication page



Non-canonical genomic driver mutations of urethane carcinogenesis.

Plos One
Li, Siqi S; Counter, Christopher M CM
Publication Date: 2022

Variant appearance in text: KRAS: Q61K
PubMed Link: 35482806
Variant Present in the following documents:
  • pone.0267147.pdf
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Performance of Idylla™ RAS-BRAF mutation test for formalin-fixed paraffin-embedded tissues of colorectal cancer.

International Journal Of Clinical Oncology
Makutani, Yusuke Y; Sakai, Kazuko K; Yamada, Masahiro M; Wada, Toshiaki T; Chikugo, Takaaki T; Satou, Takao T; Iwasa, Yoko Y; Yamamoto, Hidekazu H; de Velasco, Marco A MA; Nishio, Kazuto K; Kawamura, Junichiro J
Publication Date: 2022-07

Variant appearance in text: KRAS: 181C>A; Q61K
PubMed Link: 35474548
Variant Present in the following documents:
  • 10147_2022_2167_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics
Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R
Publication Date: 2022-04-25

Variant appearance in text: KRAS: 181C>A; Q61K
PubMed Link: 35468810
Variant Present in the following documents:
  • 12920_2022_1235_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.

American Journal Of Human Genetics
Palles, Claire C; West, Hannah D HD; Chew, Edward E; Galavotti, Sara S; Flensburg, Christoffer C; Grolleman, Judith E JE; Jansen, Erik A M EAM; Curley, Helen H; Chegwidden, Laura L; Arbe-Barnes, Edward H EH; Lander, Nicola N; Truscott, Rebekah R; Pagan, Judith J; Bajel, Ashish A; Sherwood, Kitty K; Martin, Lynn L; Thomas, Huw H; Georgiou, Demetra D; Fostira, Florentia F; Goldberg, Yael Y; Adams, David J DJ; van der Biezen, Simone A M SAM; Christie, Michael M; Clendenning, Mark M; Thomas, Laura E LE; Deltas, Constantinos C; Dimovski, Aleksandar J AJ; Dymerska, Dagmara D; Lubinski, Jan J; Mahmood, Khalid K; van der Post, Rachel S RS; Sanders, Mathijs M; Weitz, Jürgen J; Taylor, Jenny C JC; Turnbull, Clare C; Vreede, Lilian L; van Wezel, Tom T; Whalley, Celina C; Arnedo-Pac, Claudia C; Caravagna, Giulio G; Cross, William W; Chubb, Daniel D; Frangou, Anna A; Gruber, Andreas J AJ; Kinnersley, Ben B; Noyvert, Boris B; Church, David D; Graham, Trevor T; Houlston, Richard R; Lopez-Bigas, Nuria N; Sottoriva, Andrea A; Wedge, David D; , ; , ; , ; Jenkins, Mark A MA; Kuiper, Roland P RP; Roberts, Andrew W AW; Cheadle, Jeremy P JP; Ligtenberg, Marjolijn J L MJL; Hoogerbrugge, Nicoline N; Koelzer, Viktor H VH; Rivas, Andres Dacal AD; Winship, Ingrid M IM; Ponte, Clara Ruiz CR; Buchanan, Daniel D DD; Power, Derek G DG; Green, Andrew A; Tomlinson, Ian P M IPM; Sampson, Julian R JR; Majewski, Ian J IJ; de Voer, Richarda M RM
Publication Date: 2022-05-05

Variant appearance in text: KRAS: 181C>A; Gln61Lys
PubMed Link: 35460607
Variant Present in the following documents:
  • mmc2.xlsx, sheet 2
View BVdb publication page



[Targeted Therapy and Mechanism of Drug Resistance in Non-small Cell Lung Cancer 
with Epidermal Growth Factor Receptor Gene Mutation].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Huang, Junxia J; Wang, Hong H
Publication Date: 2022-03-20

Variant appearance in text: KRAS: Q61K
PubMed Link: 35340161
Variant Present in the following documents:
  • zgfazz-25-3-183.pdf
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Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

International Journal Of Molecular Medicine
Chevrier, Sandy S; Brasselet, Astrid A; Carnet, Marion M; Chevriaux, Angélique A; Gibeaud, Anne A; Jourdain, Marine M; Mananet, Hugo H; Truntzer, Caroline C; Beltjens, Françoise F; Charon-Barra, Céline C; Arnould, Laurent L; Albuisson, Juliette J; Comte, Anthony A; Derangère, Valentin V; Goussot, Vincent V; Boidot, Romain R
Publication Date: 2022-05

Variant appearance in text: KRAS: 181C>A; Gln61Lys
PubMed Link: 35244186
Variant Present in the following documents:
  • Supplementary_Data2.xlsx, sheet 1
View BVdb publication page



Precision medicine-based therapies in advanced colorectal cancer: The University of California San Diego Molecular Tumor Board experience.

Molecular Oncology
Louie, Bryan H BH; Kato, Shumei S; Kim, Ki Hwan KH; Lim, Hyo Jeong HJ; Lee, Suzanna S; Okamura, Ryosuke R; Fanta, Paul T PT; Kurzrock, Razelle R
Publication Date: 2022-07

Variant appearance in text: KRAS: Q61K
PubMed Link: 35238467
Variant Present in the following documents:
  • MOL2-16-2575-s001.xlsx, sheet 1
View BVdb publication page



Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers.

Virchows Archiv : An International Journal Of Pathology
Ukkola, Iiris I; Nummela, Pirjo P; Kero, Mia M; Tammio, Hanna H; Tuominen, Jenni J; Kairisto, Veli V; Kallajoki, Markku M; Haglund, Caj C; Peltomäki, Päivi P; Kytölä, Soili S; Ristimäki, Ari A
Publication Date: 2022-04

Variant appearance in text: KRAS: Q61K
PubMed Link: 35237889
Variant Present in the following documents:
  • 428_2022_3302_MOESM1_ESM.pdf
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: KRAS: Gln61Lys
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Targeted siRNA nanocarrier: a platform technology for cancer treatment.

Oncogene
Bäumer, Nicole N; Tiemann, Jessica J; Scheller, Annika A; Meyer, Theresa T; Wittmann, Lisa L; Suburu, Matias Ezequiel Gutierrez MEG; Greune, Lilo L; Peipp, Matthias M; Kellmann, Neele N; Gumnior, Annika A; Brand, Caroline C; Hartmann, Wolfgang W; Rossig, Claudia C; Müller-Tidow, Carsten C; Neri, Dario D; Strassert, Cristian A CA; Rüter, Christian C; Dersch, Petra P; Lenz, Georg G; Koeffler, H Phillip HP; Berdel, Wolfgang E WE; Bäumer, Sebastian S
Publication Date: 2022-04

Variant appearance in text: KRAS: Q61K
PubMed Link: 35220407
Variant Present in the following documents:
  • 41388_2022_Article_2241.pdf
View BVdb publication page



Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition.

Scientific Reports
Vaclova, Tereza T; Chakraborty, Atanu A; Sherwood, James J; Ross, Sarah S; Carroll, Danielle D; Barrett, J Carl JC; Downward, Julian J; de Bruin, Elza C EC
Publication Date: 2022-02-17

Variant appearance in text: KRAS: Q61K
PubMed Link: 35177674
Variant Present in the following documents:
  • 41598_2022_6369_MOESM1_ESM.pdf
View BVdb publication page



RAS Mutation Conversion in Bevacizumab-Treated Metastatic Colorectal Cancer Patients: A Liquid Biopsy Based Study.

Cancers
Nicolazzo, Chiara C; Belardinilli, Francesca F; Vestri, Annarita A; Magri, Valentina V; De Renzi, Gianluigi G; De Meo, Michela M; Caponnetto, Salvatore S; Di Nicolantonio, Federica F; Cortesi, Enrico E; Giannini, Giuseppe G; Gazzaniga, Paola P
Publication Date: 2022-02-04

Variant appearance in text: KRAS: Q61K
PubMed Link: 35159069
Variant Present in the following documents:
  • Main text
View BVdb publication page



RAS Mutation Conversion in Bevacizumab-Treated Metastatic Colorectal Cancer Patients: A Liquid Biopsy Based Study.

Cancers
Nicolazzo, Chiara C; Belardinilli, Francesca F; Vestri, Annarita A; Magri, Valentina V; De Renzi, Gianluigi G; De Meo, Michela M; Caponnetto, Salvatore S; Di Nicolantonio, Federica F; Cortesi, Enrico E; Giannini, Giuseppe G; Gazzaniga, Paola P
Publication Date: 2022-02-04

Variant appearance in text: KRAS: Q61K
PubMed Link: 35159069
Variant Present in the following documents:
  • Main text
View BVdb publication page



Evaluating Pancreatic and Biliary Neoplasms with Small Biopsy-Based Next Generation Sequencing (NGS): Doing More with Less.

Cancers
Nikas, Ilias P IP; Mountzios, Giannis G; Sydney, Guy I GI; Ioakim, Kalliopi J KJ; Won, Jae-Kyung JK; Papageorgis, Panagiotis P
Publication Date: 2022-01-13

Variant appearance in text: KRAS: Q61K
PubMed Link: 35053560
Variant Present in the following documents:
  • Main text
View BVdb publication page



Analysis of genetic variants in myeloproliferative neoplasms using a 22-gene next-generation sequencing panel.

Bmc Medical Genomics
Tan, Jaymi J; Chow, Yock Ping YP; Zainul Abidin, Norziha N; Chang, Kian Meng KM; Selvaratnam, Veena V; Tumian, Nor Rafeah NR; Poh, Yang Ming YM; Veerakumarasivam, Abhi A; Laffan, Michael Arthur MA; Wong, Chieh Lee CL
Publication Date: 2022-01-15

Variant appearance in text: KRAS: Q61K
PubMed Link: 35033063
Variant Present in the following documents:
  • 12920_2021_1145_MOESM3_ESM.pdf
View BVdb publication page



Analysis of genetic variants in myeloproliferative neoplasms using a 22-gene next-generation sequencing panel.

Bmc Medical Genomics
Tan, Jaymi J; Chow, Yock Ping YP; Zainul Abidin, Norziha N; Chang, Kian Meng KM; Selvaratnam, Veena V; Tumian, Nor Rafeah NR; Poh, Yang Ming YM; Veerakumarasivam, Abhi A; Laffan, Michael Arthur MA; Wong, Chieh Lee CL
Publication Date: 2022-01-15

Variant appearance in text: KRAS: Q61K
PubMed Link: 35033063
Variant Present in the following documents:
  • 12920_2021_1145_MOESM3_ESM.pdf
View BVdb publication page



Targeting PGM3 as a Novel Therapeutic Strategy in KRAS/LKB1 Co-Mutant Lung Cancer.

Cells
Lee, Hyunmin H; Cai, Feng F; Kelekar, Neil N; Velupally, Nipun K NK; Kim, Jiyeon J
Publication Date: 2022-01-05

Variant appearance in text: KRAS: Q61K
PubMed Link: 35011738
Variant Present in the following documents:
  • Main text
View BVdb publication page



Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.

Blood Advances
Tran, Thai Hoa TH; Langlois, Sylvie S; Meloche, Caroline C; Caron, Maxime M; Saint-Onge, Pascal P; Rouette, Alexandre A; Bataille, Alain R AR; Jimenez-Cortes, Camille C; Sontag, Thomas T; Bittencourt, Henrique H; Laverdière, Caroline C; Lavallée, Vincent-Philippe VP; Leclerc, Jean-Marie JM; Cole, Peter D PD; Gennarini, Lisa M LM; Kahn, Justine M JM; Kelly, Kara M KM; Michon, Bruno B; Santiago, Raoul R; Stevenson, Kristen E KE; Welch, Jennifer J G JJG; Schroeder, Kaitlin M KM; Koch, Victoria V; Cellot, Sonia S; Silverman, Lewis B LB; Sinnett, Daniel D
Publication Date: 2022-02-22

Variant appearance in text: KRAS: Q61K
PubMed Link: 34933343
Variant Present in the following documents:
  • advancesADV2021005634-suppl1.xlsx, sheet 1
View BVdb publication page



Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach.

Cell Reports
McFall, Thomas T; Stites, Edward C EC
Publication Date: 2021-12-14

Variant appearance in text: KRAS: Q61K
PubMed Link: 34910921
Variant Present in the following documents:
  • NIHMS1764636-supplement-2.pdf
  • nihms-1764636.pdf
View BVdb publication page



Global molecular alterations involving recurrence or progression of pediatric brain tumors.

Neoplasia (New York, N.Y.)
Chen, Fengju F; Chandrashekar, Darshan S DS; Scheurer, Michael E ME; Varambally, Sooryanarayana S; Creighton, Chad J CJ
Publication Date: 2022-01

Variant appearance in text: KRAS: Q61K
PubMed Link: 34864569
Variant Present in the following documents:
  • mmc2.xlsx, sheet 1
View BVdb publication page



A scalable high-throughput targeted next-generation sequencing assay for comprehensive genomic profiling of solid tumors.

Plos One
Conroy, Jeffrey M JM; Pabla, Sarabjot S; Glenn, Sean T ST; Seager, R J RJ; Van Roey, Erik E; Gao, Shuang S; Burgher, Blake B; Andreas, Jonathan J; Giamo, Vincent V; Mallon, Melissa M; Lee, Yong Hee YH; DePietro, Paul P; Nesline, Mary M; Wang, Yirong Y; Lenzo, Felicia L FL; Klein, Roger R; Zhang, Shengle S
Publication Date: 2021

Variant appearance in text: KRAS: Q61K
PubMed Link: 34855780
Variant Present in the following documents:
  • Main text
View BVdb publication page



A scalable high-throughput targeted next-generation sequencing assay for comprehensive genomic profiling of solid tumors.

Plos One
Conroy, Jeffrey M JM; Pabla, Sarabjot S; Glenn, Sean T ST; Seager, R J RJ; Van Roey, Erik E; Gao, Shuang S; Burgher, Blake B; Andreas, Jonathan J; Giamo, Vincent V; Mallon, Melissa M; Lee, Yong Hee YH; DePietro, Paul P; Nesline, Mary M; Wang, Yirong Y; Lenzo, Felicia L FL; Klein, Roger R; Zhang, Shengle S
Publication Date: 2021

Variant appearance in text: KRAS: Q61K
PubMed Link: 34855780
Variant Present in the following documents:
  • Main text
View BVdb publication page



Individualized Treatment Strategy for Cutaneous Melanoma: Where Are We Now and Where Are We Going?

Frontiers In Oncology
Zeng, Huihua H; Liu, Fen F; Zhou, Hairong H; Zeng, Changchun C
Publication Date: 2021

Variant appearance in text: KRAS: Q61K
PubMed Link: 34804979
Variant Present in the following documents:
  • fonc-11-775100.pdf
View BVdb publication page



Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.

Nature Cancer
Westcott, Peter M K PMK; Sacks, Nathan J NJ; Schenkel, Jason M JM; Ely, Zackery A ZA; Smith, Olivia O; Hauck, Haley H; Jaeger, Alex M AM; Zhang, Daniel D; Backlund, Coralie M CM; Beytagh, Mary C MC; Patten, J J JJ; Elbashir, Ryan R; Eng, George G; Irvine, Darrell J DJ; Yilmaz, Omer H OH; Jacks, Tyler T
Publication Date: 2021-10

Variant appearance in text: KRAS: 181C>A; Gln61Lys
PubMed Link: 34738089
Variant Present in the following documents:
  • NIHMS1725490-supplement-Source_Data_Figure_1.xlsx, sheet 1
View BVdb publication page



The Genomic Landscape of Serrated Lesion of the Colorectum: Similarities and Differences With Tubular and Tubulovillous Adenomas.

Frontiers In Oncology
Tornillo, Luigi L; Lehmann, Frank Serge FS; Garofoli, Andrea A; Paradiso, Viola V; Ng, Charlotte K Y CKY; Piscuoglio, Salvatore S
Publication Date: 2021

Variant appearance in text: KRAS: Q61K
PubMed Link: 34712603
Variant Present in the following documents:
  • Main text
  • fonc-11-668466.pdf
View BVdb publication page