Publications:

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Is adagrasib just another sotorasib?-or, should we differentiate their usage according to patients' clinical presentation?

Translational Lung Cancer Research

Oya, Yuko Y; Mitsudomi, Tetsuya T

Publication Date: 2023-05-31

Variant appearance in text: KRAS: A59S

PubMed Link: 37323182

Variant Present in the following documents:

• Main text
• tlcr-12-05-940.pdf

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Recent Advances in Covalent Drug Discovery.

Pharmaceuticals (Basel, Switzerland)

Schaefer, Daniel D; Cheng, Xinlai X

Publication Date: 2023-04-28

Variant appearance in text: KRAS: A59S

PubMed Link: 37242447

Variant Present in the following documents:

• Main text
• pharmaceuticals-16-00663.pdf

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Direct GDP-KRASG12C inhibitors and mechanisms of resistance: the tip of the iceberg.

Therapeutic Advances In Medical Oncology

Rosen, Joshua C JC; Sacher, Adrian A; Tsao, Ming-Sound MS

Publication Date: 2023

Variant appearance in text: KRAS: A59S

PubMed Link: 36950276

Variant Present in the following documents:

• Main text
• 10.1177_17588359231160141.pdf

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Targeted therapies for KRAS-mutant non-small cell lung cancer: from preclinical studies to clinical development-a narrative review.

Translational Lung Cancer Research

Santarpia, Mariacarmela M; Ciappina, Giuliana G; Spagnolo, Calogera Claudia CC; Squeri, Andrea A; Passalacqua, Maria Ilenia MI; Aguilar, Andrés A; Gonzalez-Cao, Maria M; Giovannetti, Elisa E; Silvestris, Nicola N; Rosell, Rafael R

Publication Date: 2023-02-28

Variant appearance in text: KRAS: A59S

PubMed Link: 36895930

Variant Present in the following documents:

• Main text
• tlcr-12-02-346.pdf

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KRAS Mutations in Solid Tumors: Characteristics, Current Therapeutic Strategy, and Potential Treatment Exploration.

Journal Of Clinical Medicine

Yang, Yunkai Y; Zhang, Huan H; Huang, Shanshan S; Chu, Qian Q

Publication Date: 2023-01-16

Variant appearance in text: KRAS: A59S

PubMed Link: 36675641

Variant Present in the following documents:

• Main text
• jcm-12-00709.pdf

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Targeting KRAS G12C mutations in colorectal cancer.

Gastroenterology Report

Zhao, Ming-He MH; Wu, Ai-Wen AW

Publication Date: 2023

Variant appearance in text: KRAS: A59S

PubMed Link: 36632627

Variant Present in the following documents:

• Main text
• goac083.pdf

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How to manage KRAS G12C-mutated advanced non-small-cell lung cancer.

Drugs In Context

Ricciuti, Biagio B; Mira, Alessia A; Andrini, Elisa E; Scaparone, Pietro P; Michelina, Sandra Vietti SV; Pecci, Federica F; Cantini, Luca L; De Giglio, Andrea A; Lamberti, Giuseppe G; Ambrogio, Chiara C; Metro, Giulio G

Publication Date: 2022

Variant appearance in text: KRAS: A59S

PubMed Link: 36452878

Variant Present in the following documents:

• Main text
• dic-2022-7-4.pdf

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Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria.

American Journal Of Human Genetics

Pejaver, Vikas V; Byrne, Alicia B AB; Feng, Bing-Jian BJ; Pagel, Kymberleigh A KA; Mooney, Sean D SD; Karchin, Rachel R; O'Donnell-Luria, Anne A; Harrison, Steven M SM; Tavtigian, Sean V SV; Greenblatt, Marc S MS; Biesecker, Leslie G LG; Radivojac, Predrag P; Brenner, Steven E SE; ,

Publication Date: 2022-12-01

Variant appearance in text: KRAS: A59S; rs121913528

PubMed Link: 36413997

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

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Enhancing an Oxidative "Trojan Horse" Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside.

Cells

Burska, Agata N AN; Ilyassova, Bayansulu B; Dildabek, Aruzhan A; Khamijan, Medina M; Begimbetova, Dinara D; Molnár, Ferdinand F; Sarbassov, Dos D DD

Publication Date: 2022-11-01

Variant appearance in text: KRAS: A59S

PubMed Link: 36359850

Variant Present in the following documents:

• Main text
• cells-11-03454.pdf

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KRAS in NSCLC: State of the Art and Future Perspectives.

Cancers

Cascetta, Priscilla P; Marinello, Arianna A; Lazzari, Chiara C; Gregorc, Vanesa V; Planchard, David D; Bianco, Roberto R; Normanno, Nicola N; Morabito, Alessandro A

Publication Date: 2022-11-04

Variant appearance in text: KRAS: A59S

PubMed Link: 36358848

Variant Present in the following documents:

• Main text
• cancers-14-05430.pdf

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Molecular Biology and Therapeutic Perspectives for K-Ras Mutant Non-Small Cell Lung Cancers.

Cancers

Cekani, Elona E; Epistolio, Samantha S; Dazio, Giulia G; Cefalì, Marco M; Wannesson, Luciano L; Frattini, Milo M; Froesch, Patrizia P

Publication Date: 2022-08-24

Variant appearance in text: KRAS: 175G>T; A59S

PubMed Link: 36077640

Variant Present in the following documents:

• Main text
• cancers-14-04103.pdf

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The current state of the art and future trends in RAS-targeted cancer therapies.

Nature Reviews. Clinical Oncology

Punekar, Salman R SR; Velcheti, Vamsidhar V; Neel, Benjamin G BG; Wong, Kwok-Kin KK

Publication Date: 2022-10

Variant appearance in text: KRAS: A59S

PubMed Link: 36028717

Variant Present in the following documents:

• Main text
• 41571_2022_Article_671.pdf

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Conquering oncogenic KRAS and its bypass mechanisms.

Theranostics

Hou, Pingping P; Wang, Y Alan YA

Publication Date: 2022

Variant appearance in text: KRAS: A59S

PubMed Link: 35966590

Variant Present in the following documents:

• Main text
• thnov12p5691.pdf

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Targeting KRAS mutant cancers: from druggable therapy to drug resistance.

Molecular Cancer

Zhu, Chunxiao C; Guan, Xiaoqing X; Zhang, Xinuo X; Luan, Xin X; Song, Zhengbo Z; Cheng, Xiangdong X; Zhang, Weidong W; Qin, Jiang-Jiang JJ

Publication Date: 2022-08-04

Variant appearance in text: KRAS: A59S

PubMed Link: 35922812

Variant Present in the following documents:

• Main text
• 12943_2022_Article_1629.pdf

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Targeting KRAS G12C-Mutated Advanced Colorectal Cancer: Research and Clinical Developments.

Oncotargets And Therapy

Ji, Jingran J; Wang, Chongkai C; Fakih, Marwan M

Publication Date: 2022

Variant appearance in text: KRAS: A59S

PubMed Link: 35837349

Variant Present in the following documents:

• Main text
• ott-15-747.pdf

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IGH Translocations in Chinese Patients With Chronic Lymphocytic Leukemia: Clinicopathologic Characteristics and Genetic Profile.

Frontiers In Oncology

Li, Qinlu Q; Xing, Shugang S; Zhang, Heng H; Mao, Xiao X; Xiao, Min M; Wang, Ying Y

Publication Date: 2022

Variant appearance in text: rs121913528

PubMed Link: 35720006

Variant Present in the following documents:

• Table_2.xlsx, sheet 1

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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Feng, Siyu S; Callow, Marinella G MG; Fortin, Jean-Philippe JP; Khan, Zia Z; Bray, David D; Costa, Mike M; Shi, Zhen Z; Wang, Weiru W; Evangelista, Marie M

Publication Date: 2022-05-03

Variant appearance in text: KRAS: A59S

PubMed Link: 35471904

Variant Present in the following documents:

• pnas.202120512.pdf

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Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies.

Frontiers In Oncology

Désage, Anne-Laure AL; Léonce, Camille C; Swalduz, Aurélie A; Ortiz-Cuaran, Sandra S

Publication Date: 2022

Variant appearance in text: KRAS: A59S

PubMed Link: 35251972

Variant Present in the following documents:

• Main text
• fonc-12-796832.pdf

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Targeting KRAS in Non-Small Cell Lung Cancer.

Frontiers In Oncology

Corral de la Fuente, Elena E; Olmedo Garcia, Maria Eugenia ME; Gomez Rueda, Ana A; Lage, Yolanda Y; Garrido, Pilar P

Publication Date: 2021

Variant appearance in text: KRAS: A59S

PubMed Link: 35083149

Variant Present in the following documents:

• Main text
• fonc-11-792635.pdf

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A Breakthrough Brought about by Targeting KRASG12C: Nonconformity Is Punished.

Cancers

Ning, Wenjuan W; Yang, Zhang Z; Kocher, Gregor J GJ; Dorn, Patrick P; Peng, Ren-Wang RW

Publication Date: 2022-01-13

Variant appearance in text: KRAS: A59S

PubMed Link: 35053550

Variant Present in the following documents:

• Main text

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A Breakthrough Brought about by Targeting KRASG12C: Nonconformity Is Punished.

Cancers

Ning, Wenjuan W; Yang, Zhang Z; Kocher, Gregor J GJ; Dorn, Patrick P; Peng, Ren-Wang RW

Publication Date: 2022-01-13

Variant appearance in text: KRAS: A59S

PubMed Link: 35053550

Variant Present in the following documents:

• Main text

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Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer.

Frontiers In Oncology

Blaquier, Juan Bautista JB; Cardona, Andrés Felipe AF; Recondo, Gonzalo G

Publication Date: 2021

Variant appearance in text: KRAS: A59S

PubMed Link: 35004309

Variant Present in the following documents:

• Main text
• fonc-11-787585.pdf

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KRAS mutation: from undruggable to druggable in cancer.

Signal Transduction And Targeted Therapy

Huang, Lamei L; Guo, Zhixing Z; Wang, Fang F; Fu, Liwu L

Publication Date: 2021-11-15

Variant appearance in text: KRAS: A59S

PubMed Link: 34776511

Variant Present in the following documents:

• Main text
• 41392_2021_Article_780.pdf

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Spotlight on Sotorasib (AMG 510) for KRAS G12C Positive Non-Small Cell Lung Cancer.

Lung Cancer (Auckland, N.Z.)

Zhang, Shannon S SS; Nagasaka, Misako M

Publication Date: 2021

Variant appearance in text: KRAS: A59S

PubMed Link: 34675734

Variant Present in the following documents:

• Main text

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KRAS G12C Mutations in NSCLC: From Target to Resistance.

Cancers

Addeo, Alfredo A; Banna, Giuseppe Luigi GL; Friedlaender, Alex A

Publication Date: 2021-05-21

Variant appearance in text: KRAS: A59S

PubMed Link: 34064232

Variant Present in the following documents:

• Main text
• cancers-13-02541.pdf

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A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer.

Bmc Cancer

Xiao, Jian J; Li, Wenyun W; Huang, Yan Y; Huang, Mengli M; Li, Shanshan S; Zhai, Xiaohui X; Zhao, Jing J; Gao, Chan C; Xie, Wenzhuan W; Qin, Hao H; Cai, Shangli S; Bai, Yuezong Y; Lan, Ping P; Zou, Yifeng Y

Publication Date: 2021-03-16

Variant appearance in text: KRAS: A59S

PubMed Link: 33726687

Variant Present in the following documents:

• 12885_2021_7942_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs121913528

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: KRAS: A59S

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Computational Screening and Analysis of Lung Cancer Related Non-Synonymous Single Nucleotide Polymorphisms on the Human Kirsten Rat Sarcoma Gene.

Molecules (Basel, Switzerland)

Wang, Qiankun Q; Mehmood, Aamir A; Wang, Heng H; Xu, Qin Q; Xiong, Yi Y; Wei, Dong-Qing DQ

Publication Date: 2019-05-21

Variant appearance in text: KRAS: A59S; rs121913528

PubMed Link: 31117243

Variant Present in the following documents:

• Main text
• molecules-24-01951.pdf

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Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.

Genome Medicine

Alfaro, Javier A JA; Ignatchenko, Alexandr A; Ignatchenko, Vladimir V; Sinha, Ankit A; Boutros, Paul C PC; Kislinger, Thomas T

Publication Date: 2017-07-18

Variant appearance in text: KRAS: A59S

PubMed Link: 28716134

Variant Present in the following documents:

• 13073_2017_454_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: KRAS: 175G>T; rs121913528

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: KRAS: 175G>T; A59S

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

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BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection.

British Journal Of Cancer

Schirripa, M M; Bergamo, F F; Cremolini, C C; Casagrande, M M; Lonardi, S S; Aprile, G G; Yang, D D; Marmorino, F F; Pasquini, G G; Sensi, E E; Lupi, C C; De Maglio, G G; Borrelli, N N; Pizzolitto, S S; Fasola, G G; Bertorelle, R R; Rugge, M M; Fontanini, G G; Zagonel, V V; Loupakis, F F; Falcone, A A

Publication Date: 2015-06-09

Variant appearance in text: KRAS: A59S

PubMed Link: 25942399

Variant Present in the following documents:

View BVdb publication page

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