KRAS c.173C>T ;(p.T58I)

Variant ID: 12-25380285-G-A

NM_004985.3(KRAS):c.173C>T;(p.T58I)

This variant was identified in 108 publications

View GRCh38 version.




Publications:


Direct GDP-KRASG12C inhibitors and mechanisms of resistance: the tip of the iceberg.

Therapeutic Advances In Medical Oncology
Rosen, Joshua C JC; Sacher, Adrian A; Tsao, Ming-Sound MS
Publication Date: 2023

Variant appearance in text: KRAS: T58I
PubMed Link: 36950276
Variant Present in the following documents:
  • Main text
  • 10.1177_17588359231160141.pdf
View BVdb publication page



KRAS, NRAS, BRAF, HER2 and MSI Status in a Large Consecutive Series of Colorectal Carcinomas.

International Journal Of Molecular Sciences
Martianov, Aleksandr S AS; Mitiushkina, Natalia V NV; Ershova, Anastasia N AN; Martynenko, Darya E DE; Bubnov, Mikhail G MG; Amankwah, Priscilla P; Yanus, Grigory A GA; Aleksakhina, Svetlana N SN; Tiurin, Vladislav I VI; Venina, Aigul R AR; Anuskina, Aleksandra A AA; Gorgul, Yuliy A YA; Shestakova, Anna D AD; Maidin, Mikhail A MA; Belyaev, Alexey M AM; Baboshkina, Liliya S LS; Iyevleva, Aglaya G AG; Imyanitov, Evgeny N EN
Publication Date: 2023-03-02

Variant appearance in text: KRAS: T58I
PubMed Link: 36902296
Variant Present in the following documents:
  • Main text
  • ijms-24-04868.pdf
View BVdb publication page



Characterization of clonal immunoglobulin heavy V-D-J gene rearrangements in Chinese patients with chronic lymphocytic leukemia: Clinical features and molecular profiles.

Frontiers In Oncology
Deng, Xinyue X; Zhang, Meilan M; Wang, Jiachen J; Zhou, Xiaoxi X; Xiao, Min M
Publication Date: 2023

Variant appearance in text: KRAS: T58I
PubMed Link: 36874132
Variant Present in the following documents:
  • Table_1.xlsx, sheet 1
View BVdb publication page



In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders.

Journal Of Chemical Information And Modeling
Leini, Renne R; Pantsar, Tatu T
Publication Date: 2023-02-28

Variant appearance in text: KRAS: T58I
PubMed Link: 36854010
Variant Present in the following documents:
  • Main text
  • ci2c01479.pdf
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: KRAS: 173C>T
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications
Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI
Publication Date: 2023-02-08

Variant appearance in text: KRAS: T58I
PubMed Link: 36755027
Variant Present in the following documents:
  • 41467_2023_36328_MOESM8_ESM.xlsx, sheet 1
View BVdb publication page



Dynamics of age- versus therapy-related clonal hematopoiesis in long-term survivors of pediatric cancer.

Cancer Discovery
Hagiwara, Kohei K; Natarajan, Sivaraman S; Wang, Zhaoming Z; Zubair, Haseeb H; Mulder, Heather L HL; Dong, Li L; Plyler, Emily M EM; Thimmaiah, Padma P; Ma, Xiaotu X; Ness, Kirsten K KK; Li, Zhenghong Z; Mulrooney, Daniel A DA; Wilson, Carmen L CL; Yasui, Yutaka Y; Hudson, Melissa M MM; Easton, John J; Robison, Leslie L LL; Zhang, Jinghui J
Publication Date: 2023-02-08

Variant appearance in text: KRAS: T58I
PubMed Link: 36751942
Variant Present in the following documents:
  • cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 4
  • cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 1
View BVdb publication page



Extremely high infiltration of CD8+PD-L1+ cells detected in a stage III non-small cell lung cancer patient exhibiting hyperprogression during anti-PD-L1 immunotherapy after chemoradiation: A case report.

Frontiers In Oncology
Wu, Changshun C; Zhou, Kai K; Zheng, Yan Y; Lv, Dongxiao D; Zhao, Miaoqing M; Hu, Yue Y; Qi, Fei F; Wang, Xin X; Feng, Hong H
Publication Date: 2022

Variant appearance in text: KRAS: 173C>T
PubMed Link: 36531043
Variant Present in the following documents:
  • Main text
  • fonc-12-969493.pdf
View BVdb publication page



Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Cheng, Wen-Yan WY; Li, Jian-Feng JF; Zhu, Yong-Mei YM; Lin, Xiang-Jie XJ; Wen, Li-Jun LJ; Zhang, Fan F; Zhang, Yu-Liang YL; Zhao, Ming M; Fang, Hai H; Wang, Sheng-Yue SY; Lin, Xiao-Jing XJ; Qiao, Niu N; Yin, Wei W; Zhang, Jia-Nan JN; Dai, Yu-Ting YT; Jiang, Lu L; Sun, Xiao-Jian XJ; Xu, Yi Y; Zhang, Tong-Tong TT; Chen, Su-Ning SN; Zhu, Hong-Hu HH; Chen, Zhu Z; Jin, Jie J; Wu, De-Pei DP; Shen, Yang Y; Chen, Sai-Juan SJ
Publication Date: 2022-12-06

Variant appearance in text: KRAS: T58I
PubMed Link: 36442087
Variant Present in the following documents:
  • pnas.2211429119.sapp.pdf
  • pnas.2211429119.sd02.xlsx, sheet 1
View BVdb publication page



A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study.

The Lancet. Haematology
,
Publication Date: 2022-11-24

Variant appearance in text: KRAS: 173C>T; T58I
PubMed Link: 36436542
Variant Present in the following documents:
  • mmc2.xlsx, sheet 1
View BVdb publication page



Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.

Cancer Research Communications
Ghezelayagh, Talayeh S TS; Kohrn, Brendan F BF; Fredrickson, Jeanne J; Manhardt, Enna E; Radke, Marc R MR; Katz, Ronit R; Gray, Heidi J HJ; Urban, Renata R RR; Pennington, Kathryn P KP; Liao, John B JB; Doll, Kemi M KM; Simons, Elise J EJ; Burzawa, Jennifer K JK; Goff, Barbara A BA; Speiser, Paul P; Swisher, Elizabeth M EM; Norquist, Barbara M BM; Risques, Rosa Ana RA
Publication Date: 2022-10

Variant appearance in text: KRAS: 173C>T; T58I
PubMed Link: 36311816
Variant Present in the following documents:
  • crc-22-0314-s02.xlsx, sheet 6
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: KRAS: 173C>T; T58I
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Publication Date: 2022-08

Variant appearance in text: KRAS: T58I
PubMed Link: 35835912
Variant Present in the following documents:
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 3
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 4
View BVdb publication page



BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors.

Blood Advances
Buelow, Daelynn R DR; Bhatnagar, Bhavana B; Orwick, Shelley J SJ; Jeon, Jae Yoon JY; Eisenmann, Eric D ED; Stromatt, Jack C JC; Pabla, Navjot Singh NS; Blachly, James S JS; Baker, Sharyn D SD; Blaser, Bradley W BW
Publication Date: 2022-09-13

Variant appearance in text: KRAS: Thr58Ile
PubMed Link: 35797240
Variant Present in the following documents:
  • advancesADV2022007952-suppl2.xlsx, sheet 4
View BVdb publication page



Structural basis for SHOC2 modulation of RAS signalling.

Nature
Liau, Nicholas P D NPD; Johnson, Matthew C MC; Izadi, Saeed S; Gerosa, Luca L; Hammel, Michal M; Bruning, John M JM; Wendorff, Timothy J TJ; Phung, Wilson W; Hymowitz, Sarah G SG; Sudhamsu, Jawahar J
Publication Date: 2022-09

Variant appearance in text: KRAS: T58I
PubMed Link: 35768504
Variant Present in the following documents:
  • Main text
  • 41586_2022_Article_4838.pdf
View BVdb publication page



The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.

Nature Communications
Vo, Josh N JN; Wu, Yi-Mi YM; Mishler, Jeanmarie J; Hall, Sarah S; Mannan, Rahul R; Wang, Lisha L; Ning, Yu Y; Zhou, Jin J; Hopkins, Alexander C AC; Estill, James C JC; Chan, Wallace K B WKB; Yesil, Jennifer J; Cao, Xuhong X; Rao, Arvind A; Tsodikov, Alexander A; Talpaz, Moshe M; Cole, Craig E CE; Ye, Jing C JC; , ; Bergsagel, P Leif PL; Auclair, Daniel D; Cho, Hearn Jay HJ; Robinson, Dan R DR; Chinnaiyan, Arul M AM
Publication Date: 2022-06-29

Variant appearance in text: KRAS: 173C>T; Thr58Ile; rs104894364
PubMed Link: 35768438
Variant Present in the following documents:
  • 41467_2022_31430_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Publication Date: 2022-06-15

Variant appearance in text: KRAS: T58I
PubMed Link: 35705558
Variant Present in the following documents:
  • 41467_2022_30496_MOESM2_ESM.xls, sheet 1
View BVdb publication page



The longitudinal dynamics and natural history of clonal haematopoiesis.

Nature
Fabre, Margarete A MA; de Almeida, José Guilherme JG; Fiorillo, Edoardo E; Mitchell, Emily E; Damaskou, Aristi A; Rak, Justyna J; Orrù, Valeria V; Marongiu, Michele M; Chapman, Michael Spencer MS; Vijayabaskar, M S MS; Baxter, Joanna J; Hardy, Claire C; Abascal, Federico F; Williams, Nicholas N; Nangalia, Jyoti J; Martincorena, Iñigo I; Campbell, Peter J PJ; McKinney, Eoin F EF; Cucca, Francesco F; Gerstung, Moritz M; Vassiliou, George S GS
Publication Date: 2022-06

Variant appearance in text: KRAS: T58I
PubMed Link: 35650444
Variant Present in the following documents:
  • 41586_2022_4785_MOESM13_ESM.xlsx, sheet 3
  • 41586_2022_4785_MOESM12_ESM.xlsx, sheet 1
  • 41586_2022_4785_MOESM11_ESM.xlsx, sheet 1
  • 41586_2022_4785_MOESM5_ESM.xlsx, sheet 1
  • 41586_2022_4785_MOESM9_ESM.xlsx, sheet 1
View BVdb publication page



Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q.

Ebiomedicine
Adema, Vera V; Palomo, Laura L; Walter, Wencke W; Mallo, Mar M; Hutter, Stephan S; La Framboise, Thomas T; Arenillas, Leonor L; Meggendorfer, Manja M; Radivoyevitch, Tomas T; Xicoy, Blanca B; Pellagatti, Andrea A; Haferlach, Claudia C; Boultwood, Jacqueline J; Kern, Wolfgang W; Visconte, Valeria V; Sekeres, Mikkael M; Barnard, John J; Haferlach, Torsten T; Solé, Francesc F; Maciejewski, Jaroslaw P JP
Publication Date: 2022-06

Variant appearance in text: KRAS: 173C>T; Thr58Ile
PubMed Link: 35617825
Variant Present in the following documents:
  • mmc3.xlsx, sheet 1
View BVdb publication page



Molecular landscape and therapeutic alterations in Asian soft-tissue sarcoma patients.

Cancer Medicine
Gan, Meifu M; Zhang, Chen C; Qiu, Liqing L; Wang, Yue Y; Bao, Hua H; Yu, Ruoying R; Liu, Rui R; Wu, Xue X; Shao, Yang Y; Hou, Peifeng P; Fei, Zhenglei Z
Publication Date: 2022-11

Variant appearance in text: KRAS: 173C>T; T58I
PubMed Link: 35586877
Variant Present in the following documents:
  • CAM4-11-4070-s004.xlsx, sheet 1
View BVdb publication page



Pharmacogenetics of hepatocellular carcinoma and cholangiocarcinoma.

Cancer Drug Resistance (Alhambra, Calif.)
Alonso-Peña, Marta M; Sanchez-Martin, Anabel A; Sanchon-Sanchez, Paula P; Soto-Muñiz, Meraris M; Espinosa-Escudero, Ricardo R; Marin, Jose J G JJG
Publication Date: 2019

Variant appearance in text: KRAS: 173C>T
PubMed Link: 35582588
Variant Present in the following documents:
  • Main text
  • cdr-2-680.pdf
View BVdb publication page



Molecular Portrait of GISTs Associated With Clinicopathological Features: A Retrospective Study With Molecular Analysis by a Custom 9-Gene Targeted Next-Generation Sequencing Panel.

Frontiers In Genetics
Qian, Haoran H; Yan, Na N; Hu, Xiaotong X; Jiang, Junchang J; Cao, Zhengzheng Z; Shen, Dan D
Publication Date: 2022

Variant appearance in text: KRAS: T58I
PubMed Link: 35547262
Variant Present in the following documents:
  • Main text
  • fgene-13-864499.pdf
  • DataSheet1.xlsx, sheet 2
View BVdb publication page



Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms.

Blood
Sperling, Adam S AS; Guerra, Veronica A VA; Kennedy, James A JA; Yan, Yuanqing Y; Hsu, Joanne I JI; Wang, Feng F; Nguyen, Andrew T AT; Miller, Peter G PG; McConkey, Marie E ME; Quevedo Barrios, Vanessa A VA; Furudate, Ken K; Zhang, Linda L; Kanagal-Shamanna, Rashmi R; Zhang, Jianhua J; Little, Latasha L; Gumbs, Curtis C; Daver, Naval N; DiNardo, Courtney D CD; Kadia, Tapan T; Ravandi, Farhad F; Kantarjian, Hagop H; Garcia-Manero, Guillermo G; Futreal, P Andrew PA; Ebert, Benjamin L BL; Takahashi, Koichi K
Publication Date: 2022-10-20

Variant appearance in text: KRAS: T58I
PubMed Link: 35512188
Variant Present in the following documents:
  • BLOOD_BLD-2021-014956-mmc1.pdf
View BVdb publication page



A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Feng, Siyu S; Callow, Marinella G MG; Fortin, Jean-Philippe JP; Khan, Zia Z; Bray, David D; Costa, Mike M; Shi, Zhen Z; Wang, Weiru W; Evangelista, Marie M
Publication Date: 2022-05-03

Variant appearance in text: KRAS: T58I
PubMed Link: 35471904
Variant Present in the following documents:
  • pnas.2120512119.sapp.pdf
  • pnas.202120512.pdf
View BVdb publication page



[Sequential infusion of anti-CD22 and anti-CD19 CAR-T cells in the treatment of relapsed / refractory childhood acute B lymphoblastic leukemia: two cases report].

Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
Zhang, J J; Wu, X X XX; Li, M Y MY; Song, B Q BQ; Zhou, L L LL; Kong, X X; Qiu, H Y HY; Wu, D P DP
Publication Date: 2022-03-14

Variant appearance in text: KRAS: T58I
PubMed Link: 35405786
Variant Present in the following documents:
  • cjh-43-03-258.pdf
View BVdb publication page



Genomic and Epigenomic Landscape of Juvenile Myelomonocytic Leukemia.

Cancers
Fiñana, Claudia C; Gómez-Molina, Noel N; Alonso-Moreno, Sandra S; Belver, Laura L
Publication Date: 2022-03-04

Variant appearance in text: KRAS: T58I
PubMed Link: 35267643
Variant Present in the following documents:
  • Main text
  • cancers-14-01335.pdf
View BVdb publication page



The RASopathies: from pathogenetics to therapeutics.

Disease Models & Mechanisms
Hebron, Katie E KE; Hernandez, Edjay Ralph ER; Yohe, Marielle E ME
Publication Date: 2022-02-01

Variant appearance in text: KRAS: T58I
PubMed Link: 35178568
Variant Present in the following documents:
  • Main text
View BVdb publication page



A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: KRAS: T58I
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
View BVdb publication page



Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.

Blood Cancer Discovery
Fornerod, Maarten M; Ma, Jing J; Noort, Sanne S; Liu, Yu Y; Walsh, Michael P MP; Shi, Lei L; Nance, Stephanie S; Liu, Yanling Y; Wang, Yuanyuan Y; Song, Guangchun G; Lamprecht, Tamara T; Easton, John J; Mulder, Heather L HL; Yergeau, Donald D; Myers, Jacquelyn J; Kamens, Jennifer L JL; Obeng, Esther A EA; Pigazzi, Martina M; Jarosova, Marie M; Kelaidi, Charikleia C; Polychronopoulou, Sophia S; Lamba, Jatinder K JK; Baker, Sharyn D SD; Rubnitz, Jeffrey E JE; Reinhardt, Dirk D; van den Heuvel-Eibrink, Marry M MM; Locatelli, Franco F; Hasle, Henrik H; Klco, Jeffery M JM; Downing, James R JR; Zhang, Jinghui J; Pounds, Stanley S; Zwaan, C Michel CM; Gruber, Tanja A TA; , ; , ; , ; , ; , ; ,
Publication Date: 2021-11

Variant appearance in text: KRAS: T58I
PubMed Link: 34778799
Variant Present in the following documents:
  • bloodcandisc-2-586-s001.xlsx, sheet 11
View BVdb publication page



Myeloid Clonal Infiltrate Identified With Next-Generation Sequencing in Skin Lesions Associated With Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: A Case Series.

Frontiers In Immunology
Martin de Frémont, Grégoire G; Hirsch, Pierre P; Gimenez de Mestral, Santiago S; Moguelet, Philippe P; Ditchi, Yoan Y; Emile, Jean-François JF; Senet, Patricia P; Georgin-Lavialle, Sophie S; Hanslik, Thomas T; Maurier, François F; Adedjouma, Amir A; Abisror, Noémie N; Mahevas, Thibault T; Malard, Florent F; Adès, Lionel L; Fenaux, Pierre P; Fain, Olivier O; Chasset, François F; Mekinian, Arsène A
Publication Date: 2021

Variant appearance in text: KRAS: 173C>T
PubMed Link: 34671345
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: KRAS: T58I
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Clinical Application of Whole Exome Sequencing for Monogenic Disorders in PICU of China.

Frontiers In Genetics
Liu, Yingchao Y; Hao, Chanjuan C; Li, Kechun K; Hu, Xuyun X; Gao, Hengmiao H; Zeng, Jiansheng J; Guo, Ruolan R; Liu, Jun J; Guo, Jun J; Li, Zheng Z; Qi, Zhan Z; Jia, Xinlei X; Li, Wei W; Qian, Suyun S
Publication Date: 2021

Variant appearance in text: KRAS: 173C>T; Thr58Ile
PubMed Link: 34539730
Variant Present in the following documents:
  • Main text
  • Table_1.xlsx, sheet 1
  • fgene-12-677699.pdf
View BVdb publication page



Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2-/- acute myeloid leukemia.

Cancer Communications (London, England)
Song, Jiachun J; Du, Longting L; Liu, Ping P; Wang, Fuhui F; Zhang, Bo B; Xie, Yinyin Y; Lu, Jing J; Jin, Yi Y; Zhou, Yan Y; Lv, Gang G; Zhang, Jianmin J; Chen, Saijuan S; Chen, Zhu Z; Sun, Xiaojian X; Zhang, Yuanliang Y; Huang, Qiuhua Q
Publication Date: 2021-09

Variant appearance in text: KRAS: T58I
PubMed Link: 34196511
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Loree, Jonathan M JM; Wang, Yucai Y; Syed, Muddassir A MA; Sorokin, Alexey V AV; Coker, Oluwadara O; Xiu, Joanne J; Weinberg, Benjamin A BA; Vanderwalde, Ari M AM; Tesfaye, Anteneh A; Raymond, Victoria M VM; Miron, Benjamin B; Tarcic, Gabi G; Zelichov, Ori O; Broaddus, Russell R RR; Ng, Patrick Kwok Shing PKS; Jeong, Kang Jin KJ; Tsang, Yiu Huen YH; Mills, Gordon B GB; Overman, Michael J MJ; Grothey, Axel A; Marshall, John L JL; Kopetz, Scott S
Publication Date: 2021-08-15

Variant appearance in text: KRAS: T58I
PubMed Link: 34117033
Variant Present in the following documents:
  • Main text
View BVdb publication page



Juvenile myelomonocytic leukemia-A comprehensive review and recent advances in management.

American Journal Of Blood Research
Gupta, Aditya Kumar AK; Meena, Jagdish Prasad JP; Chopra, Anita A; Tanwar, Pranay P; Seth, Rachna R
Publication Date: 2021

Variant appearance in text: KRAS: T58I
PubMed Link: 33796386
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integration of whole genome sequencing into a healthcare setting: high diagnostic rates across multiple clinical entities in 3219 rare disease patients.

Genome Medicine
Stranneheim, Henrik H; Lagerstedt-Robinson, Kristina K; Magnusson, Måns M; Kvarnung, Malin M; Nilsson, Daniel D; Lesko, Nicole N; Engvall, Martin M; Anderlid, Britt-Marie BM; Arnell, Henrik H; Johansson, Carolina Backman CB; Barbaro, Michela M; Björck, Erik E; Bruhn, Helene H; Eisfeldt, Jesper J; Freyer, Christoph C; Grigelioniene, Giedre G; Gustavsson, Peter P; Hammarsjö, Anna A; Hellström-Pigg, Maritta M; Iwarsson, Erik E; Jemt, Anders A; Laaksonen, Mikael M; Enoksson, Sara Lind SL; Malmgren, Helena H; Naess, Karin K; Nordenskjöld, Magnus M; Oscarson, Mikael M; Pettersson, Maria M; Rasi, Chiara C; Rosenbaum, Adam A; Sahlin, Ellika E; Sardh, Eliane E; Stödberg, Tommy T; Tesi, Bianca B; Tham, Emma E; Thonberg, Håkan H; Töhönen, Virpi V; von Döbeln, Ulrika U; Vassiliou, Daphne D; Vonlanthen, Sofie S; Wikström, Ann-Charlotte AC; Wincent, Josephine J; Winqvist, Ola O; Wredenberg, Anna A; Ygberg, Sofia S; Zetterström, Rolf H RH; Marits, Per P; Soller, Maria Johansson MJ; Nordgren, Ann A; Wirta, Valtteri V; Lindstrand, Anna A; Wedell, Anna A
Publication Date: 2021-03-17

Variant appearance in text: KRAS: 173C>T; Thr58Ile
PubMed Link: 33726816
Variant Present in the following documents:
  • 13073_2021_855_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: KRAS: 173C>T; T58I
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
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Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects.

Frontiers In Cell And Developmental Biology
You, Xiaona X; Ryu, Myung-Jeom MJ; Cho, Eunjin E; Sang, Yanzhi Y; Damnernsawad, Alisa A; Zhou, Yun Y; Liu, Yangang Y; Zhang, Jing J; Lee, Youngsook Y
Publication Date: 2021

Variant appearance in text: KRAS: T58I
PubMed Link: 33681212
Variant Present in the following documents:
  • Main text
  • fcell-09-633661.pdf
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EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.

Leukemia
Berg, Johannes Lorenz JL; Perfler, Bianca B; Hatzl, Stefan S; Uhl, Barbara B; Reinisch, Andreas A; Pregartner, Gudrun G; Berghold, Andrea A; Penz, Thomas T; Schuster, Michael M; Geissler, Klaus K; Prokesch, Andreas A; Müller-Tidow, Carsten C; Hoefler, Gerald G; Kashofer, Karl K; Wölfler, Albert A; Sill, Heinz H; Caraffini, Veronica V; Zebisch, Armin A
Publication Date: 2021-05

Variant appearance in text: KRAS: T58I
PubMed Link: 33589750
Variant Present in the following documents:
  • 41375_2021_1161_MOESM1_ESM.pdf
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Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia.

Haematologica
Hecht, Anna A; Meyer, Julia A JA; Behnert, Astrid A; Wong, Eric E; Chehab, Farid F; Olshen, Adam A; Hechmer, Aaron A; Aftandilian, Catherine C; Bhat, Rukhmi R; Choi, Sung Won SW; Chonat, Satheesh S; Farrar, Jason E JE; Fluchel, Mark M; Frangoul, Haydar H; Han, Jennifer H JH; Kolb, Edward A EA; Kuo, Dennis J DJ; MacMillan, Margaret L ML; Maese, Luke L; Maloney, Kelly W KW; Narendran, Aru A; Oshrine, Benjamin B; Schultz, Kirk R KR; Sulis, Maria L ML; Van Mater, David D; Tasian, Sarah K SK; Hofmann, Wolf-Karsten WK; Loh, Mignon L ML; Stieglitz, Elliot E
Publication Date: 2020-12-30

Variant appearance in text: KRAS: T58I
PubMed Link: 33375775
Variant Present in the following documents:
  • Main text
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Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia.

Haematologica
Hecht, Anna A; Meyer, Julia A JA; Behnert, Astrid A; Wong, Eric E; Chehab, Farid F; Olshen, Adam A; Hechmer, Aaron A; Aftandilian, Catherine C; Bhat, Rukhmi R; Choi, Sung Won SW; Chonat, Satheesh S; Farrar, Jason E JE; Fluchel, Mark M; Frangoul, Haydar H; Han, Jennifer H JH; Kolb, Edward A EA; Kuo, Dennis J DJ; MacMillan, Margaret L ML; Maese, Luke L; Maloney, Kelly W KW; Narendran, Aru A; Oshrine, Benjamin B; Schultz, Kirk R KR; Sulis, Maria L ML; Van Mater, David D; Tasian, Sarah K SK; Hofmann, Wolf-Karsten WK; Loh, Mignon L ML; Stieglitz, Elliot E
Publication Date: 2022-01-01

Variant appearance in text: KRAS: T58I
PubMed Link: 33375775
Variant Present in the following documents:
  • Main text
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A flexible computational pipeline for research analyses of unsolved clinical exome cases.

Npj Genomic Medicine
Lassmann, Timo T; Francis, Richard W RW; Weeks, Alexia A; Tang, Dave D; Jamieson, Sarra E SE; Broley, Stephanie S; Dawkins, Hugh J S HJS; Dreyer, Lauren L; Goldblatt, Jack J; Groza, Tudor T; Kamien, Benjamin B; Kiraly-Borri, Cathy C; McKenzie, Fiona F; Murphy, Lesley L; Pachter, Nicholas N; Pathak, Gargi G; Poulton, Cathryn C; Samanek, Amanda A; Skoss, Rachel R; Slee, Jennie J; Townshend, Sharron S; Ward, Michelle M; Baynam, Gareth S GS; Blackwell, Jenefer M JM
Publication Date: 2020-12-10

Variant appearance in text: KRAS: Thr58Ile
PubMed Link: 33303739
Variant Present in the following documents:
  • 41525_2020_Article_161.pdf
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Somatic mutations and T-cell clonality in patients with immunodeficiency.

Haematologica
Savola, Paula P; Martelius, Timi T; Kankainen, Matti M; Huuhtanen, Jani J; Lundgren, Sofie S; Koski, Yrjö Y; Eldfors, Samuli S; Kelkka, Tiina T; Keränen, Mikko A I MAI; Ellonen, Pekka P; Kovanen, Panu E PE; Kytölä, Soili S; Saarela, Janna J; Lähdesmäki, Harri H; Seppänen, Mikko R J MRJ; Mustjoki, Satu S
Publication Date: 2020-12-01

Variant appearance in text: KRAS: T58I
PubMed Link: 33256375
Variant Present in the following documents:
  • Main text
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Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica
Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP
Publication Date: 2021-12-01

Variant appearance in text: KRAS: T58I
PubMed Link: 33147938
Variant Present in the following documents:
  • 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 14
  • 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 3
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Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica
Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP
Publication Date: 2021-12-01

Variant appearance in text: KRAS: T58I
PubMed Link: 33147938
Variant Present in the following documents:
  • 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 14
  • 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 3
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KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.

Jci Insight
Wong, Jasmine C JC; Perez-Mancera, Pedro A PA; Huang, Tannie Q TQ; Kim, Jangkyung J; Grego-Bessa, Joaquim J; Del Pilar Alzamora, Maria M; Kogan, Scott C SC; Sharir, Amnon A; Keefe, Susan H SH; Morales, Carolina E CE; Schanze, Denny D; Castel, Pau P; Hirose, Kentaro K; Huang, Guo N GN; Zenker, Martin M; Sheppard, Dean D; Klein, Ophir D OD; Tuveson, David A DA; Braun, Benjamin S BS; Shannon, Kevin K
Publication Date: 2020-11-05

Variant appearance in text: KRAS: T58I
PubMed Link: 32990679
Variant Present in the following documents:
  • Main text
  • jciinsight-5-140495.pdf
  • jciinsight-5-140495-s121.pdf
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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports
Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA
Publication Date: 2020-09-21

Variant appearance in text: KRAS: T58I
PubMed Link: 32958805
Variant Present in the following documents:
  • 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2
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The Clinical Significance of RAS, PIK3CA, and PTEN Mutations in Non-Small Cell Lung Cancer Using Cell-Free DNA.

Journal Of Clinical Medicine
Chang, Won Jin WJ; Sung, Jae Sook JS; Lee, Sung Yong SY; Kang, Eun Joo EJ; Kwon, Nak-Jung NJ; Kim, Hae Mi HM; Shin, Sang Won SW; Choi, Jung Yoon JY; Choi, Yoon Ji YJ; Kim, Ju Won JW; Park, Kyong Hwa KH; Kim, Yeul Hong YH
Publication Date: 2020-08-14

Variant appearance in text: KRAS: T58I
PubMed Link: 32823871
Variant Present in the following documents:
  • jcm-09-02642-s001.pdf
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The duality of human oncoproteins: drivers of cancer and congenital disorders.

Nature Reviews. Cancer
Castel, Pau P; Rauen, Katherine A KA; McCormick, Frank F
Publication Date: 2020-07

Variant appearance in text: KRAS: T58I
PubMed Link: 32341551
Variant Present in the following documents:
  • Main text
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Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
Dunnett-Kane, V V; Burkitt-Wright, E E; Blackhall, F H FH; Malliri, A A; Evans, D G DG; Lindsay, C R CR
Publication Date: 2020-07

Variant appearance in text: KRAS: T58I
PubMed Link: 32240795
Variant Present in the following documents:
  • Main text
  • main.pdf
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GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.

Birth Defects Research
Bera, Asim K AK; Lu, Jia J; Lu, Chunya C; Li, Lianbo L; Gondi, Sudershan S; Yan, Wei W; Nelson, Andrew A; Zhang, Goujun G; Westover, Kenneth D KD
Publication Date: 2020-06

Variant appearance in text: KRAS: T58I
PubMed Link: 32187889
Variant Present in the following documents:
  • Main text
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A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks.

Scientific Reports
Zimmerman, Lior L; Zelichov, Ori O; Aizenmann, Arie A; Barbash, Zohar Z; Vidne, Michael M; Tarcic, Gabi G
Publication Date: 2020-03-06

Variant appearance in text: KRAS: T58I
PubMed Link: 32144301
Variant Present in the following documents:
  • Main text
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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: KRAS: T58I
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
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Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer.

Cancer Research And Treatment
Choi, Jung Yoon JY; Choi, Sunho S; Lee, Minhyeok M; Park, Young Soo YS; Sung, Jae Sook JS; Chang, Won Jin WJ; Kim, Ju Won JW; Choi, Yoon Ji YJ; Kim, Jin J; Kim, Dong-Sik DS; Lee, Sung-Ho SH; Seok, Junhee J; Park, Kyong Hwa KH; Kim, Seon Hahn SH; Kim, Yeul Hong YH
Publication Date: 2020-07

Variant appearance in text: KRAS: T58I
PubMed Link: 32065847
Variant Present in the following documents:
  • crt-2020-044.pdf
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Cardiofaciocutaneous Syndrome Phenotype in a Case with de novo KRAS Pathogenic Variant.

Molecular Syndromology
Sanri, Aslihan A; Gurkan, Hakan H; Demir, Selma S
Publication Date: 2020-01

Variant appearance in text: KRAS: 173C>T; Thr58Ile
PubMed Link: 32021610
Variant Present in the following documents:
  • Main text
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