Publications:

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The Importance of Mg2+ -Free State in Nucleotide Exchange of Oncogenic K-Ras Mutants.

Chemistry (Weinheim An Der Bergstrasse, Germany)

Pálfy, Gyula G; Menyhárd, Dóra K DK; Ákontz-Kiss, Hanna H; Vida, István I; Batta, Gyula G; Tőke, Orsolya O; Perczel, András A

Publication Date: 2022-10-21

Variant appearance in text: K-Ras4B: T35S

PubMed Link: 35781716

Variant Present in the following documents:

• CHEM-28-0.pdf

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The path to the clinic: a comprehensive review on direct KRASG12C inhibitors.

Journal Of Experimental & Clinical Cancer Research : Cr

Kwan, Albert K AK; Piazza, Gary A GA; Keeton, Adam B AB; Leite, Caio A CA

Publication Date: 2022-01-19

Variant appearance in text: KRAS: T35S

PubMed Link: 35045886

Variant Present in the following documents:

• Main text
• 13046_2021_Article_2225.pdf

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The path to the clinic: a comprehensive review on direct KRASG12C inhibitors.

Journal Of Experimental & Clinical Cancer Research : Cr

Kwan, Albert K AK; Piazza, Gary A GA; Keeton, Adam B AB; Leite, Caio A CA

Publication Date: 2022-01-19

Variant appearance in text: KRAS: T35S

PubMed Link: 35045886

Variant Present in the following documents:

• Main text
• 13046_2021_Article_2225.pdf

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Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach.

Cell Reports

McFall, Thomas T; Stites, Edward C EC

Publication Date: 2021-12-14

Variant appearance in text: KRAS: T35S

PubMed Link: 34910921

Variant Present in the following documents:

• Main text
• NIHMS1764636-supplement-2.pdf
• nihms-1764636.pdf

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NMR 1H, 13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation.

Biomolecular Nmr Assignments

Sharma, Alok K AK; Dyba, Marcin M; Tonelli, Marco M; Smith, Brian B; Gillette, William K WK; Esposito, Dominic D; Nissley, Dwight V DV; McCormick, Frank F; Maciag, Anna E AE

Publication Date: 2022-04

Variant appearance in text: KRAS: Thr35Ser

PubMed Link: 34686998

Variant Present in the following documents:

• Main text
• 12104_2021_Article_10050.pdf

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A structural model of a Ras-Raf signalosome.

Nature Structural & Molecular Biology

Mysore, Venkatesh P VP; Zhou, Zhi-Wei ZW; Ambrogio, Chiara C; Li, Lianbo L; Kapp, Jonas N JN; Lu, Chunya C; Wang, Qi Q; Tucker, Maxwell R MR; Okoro, Jeffrey J JJ; Nagy-Davidescu, Gabriela G; Bai, Xiaochen X; Plückthun, Andreas A; Jänne, Pasi A PA; Westover, Kenneth D KD; Shan, Yibing Y; Shaw, David E DE

Publication Date: 2021-10

Variant appearance in text: KRAS: T35S

PubMed Link: 34625747

Variant Present in the following documents:

• Main text

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Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives.

Biomolecules

Tisi, Renata R; Gaponenko, Vadim V; Vanoni, Marco M; Sacco, Elena E

Publication Date: 2020-11-10

Variant appearance in text: KRAS: T35S

PubMed Link: 33182807

Variant Present in the following documents:

• Main text

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Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy.

Nature Communications

Ong, Taren T; Trivedi, Niraj N; Wakefield, Randall R; Frase, Sharon S; Solecki, David J DJ

Publication Date: 2020-10-20

Variant appearance in text: KRAS: T35S

PubMed Link: 33082319

Variant Present in the following documents:

• 41467_2020_Article_19063.pdf

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Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas.

Plos One

Sharma, Neeru N; Sonavane, Uddhavesh U; Joshi, Rajendra R

Publication Date: 2020

Variant appearance in text: KRAS: T35S

PubMed Link: 33064725

Variant Present in the following documents:

• Main text
• pone.0234836.pdf

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KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface.

Iscience

Yin, Guowei G; Zhang, Jerry J; Nair, Vinay V; Truong, Vinh V; Chaia, Angelo A; Petela, Johnny J; Harrison, Joseph J; Gorfe, Alemayehu A AA; Campbell, Sharon L SL

Publication Date: 2020-08-10

Variant appearance in text: KRAS: T35S

PubMed Link: 32882514

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

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Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery.

Cancer Metastasis Reviews

Pálfy, Gyula G; Menyhárd, Dóra K DK; Perczel, András A

Publication Date: 2020-12

Variant appearance in text: K-Ras4B: T35S

PubMed Link: 32815102

Variant Present in the following documents:

• Main text
• 10555_2020_Article_9917.pdf

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IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.

Plos One

Gasilina, Anjelika A; Premnauth, Gurdat G; Gurjar, Purujit P; Biesiada, Jacek J; Hegde, Shailaja S; Milewski, David D; Ma, Gang G; Kalin, Tanya V TV; Merino, Edward E; Meller, Jarek J; Seibel, William W; Cancelas, José A JA; Vinnedge, Lisa Privette LP; Nassar, Nicolas N NN

Publication Date: 2020

Variant appearance in text: KRAS: T35S

PubMed Link: 32163428

Variant Present in the following documents:

• Main text

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The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B Signaling.

Biophysical Journal

Neale, Chris C; García, Angel E AE

Publication Date: 2020-03-10

Variant appearance in text: K-Ras4B: T35S

PubMed Link: 32027820

Variant Present in the following documents:

• Main text

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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.

Cancer Discovery

Hobbs, G Aaron GA; Baker, Nicole M NM; Miermont, Anne M AM; Thurman, Ryan D RD; Pierobon, Mariaelena M; Tran, Timothy H TH; Anderson, Andrew O AO; Waters, Andrew M AM; Diehl, J Nathaniel JN; Papke, Bjoern B; Hodge, Richard G RG; Klomp, Jennifer E JE; Goodwin, Craig M CM; DeLiberty, Jonathan M JM; Wang, Junning J; Ng, Raymond W S RWS; Gautam, Prson P; Bryant, Kirsten L KL; Esposito, Dominic D; Campbell, Sharon L SL; Petricoin, Emanuel F EF; Simanshu, Dhirendra K DK; Aguirre, Andrew J AJ; Wolpin, Brian M BM; Wennerberg, Krister K; Rudloff, Udo U; Cox, Adrienne D AD; Der, Channing J CJ

Publication Date: 2020-01

Variant appearance in text: KRAS: T35S

PubMed Link: 31649109

Variant Present in the following documents:

• Main text

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1H, 15N backbone assignment and comparative analysis of the wild type and G12C, G12D, G12V mutants of K-Ras bound to GDP at physiological pH.

Biomolecular Nmr Assignments

Pálfy, Gyula G; Vida, István I; Perczel, András A

Publication Date: 2020-04

Variant appearance in text: K-Ras4B: T35S

PubMed Link: 31468366

Variant Present in the following documents:

• Main text
• 12104_2019_Article_9909.pdf

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1H, 15N backbone assignment and comparative analysis of the wild type and G12C, G12D, G12V mutants of K-Ras bound to GDP at physiological pH.

Biomolecular Nmr Assignments

Pálfy, Gyula G; Vida, István I; Perczel, András A

Publication Date: 2020-04

Variant appearance in text: K-Ras4B: T35S

PubMed Link: 31468366

Variant Present in the following documents:

• Main text
• 12104_2019_Article_9909.pdf

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Drugging an undruggable pocket on KRAS.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Kessler, Dirk D; Gmachl, Michael M; Mantoulidis, Andreas A; Martin, Laetitia J LJ; Zoephel, Andreas A; Mayer, Moriz M; Gollner, Andreas A; Covini, David D; Fischer, Silke S; Gerstberger, Thomas T; Gmaschitz, Teresa T; Goodwin, Craig C; Greb, Peter P; Häring, Daniela D; Hela, Wolfgang W; Hoffmann, Johann J; Karolyi-Oezguer, Jale J; Knesl, Petr P; Kornigg, Stefan S; Koegl, Manfred M; Kousek, Roland R; Lamarre, Lyne L; Moser, Franziska F; Munico-Martinez, Silvia S; Peinsipp, Christoph C; Phan, Jason J; Rinnenthal, Jörg J; Sai, Jiqing J; Salamon, Christian C; Scherbantin, Yvonne Y; Schipany, Katharina K; Schnitzer, Renate R; Schrenk, Andreas A; Sharps, Bernadette B; Siszler, Gabriella G; Sun, Qi Q; Waterson, Alex A; Wolkerstorfer, Bernhard B; Zeeb, Markus M; Pearson, Mark M; Fesik, Stephen W SW; McConnell, Darryl B DB

Publication Date: 2019-08-06

Variant appearance in text: KRAS: T35S

PubMed Link: 31332011

Variant Present in the following documents:

• Main text
• pnas.201904529.pdf
• pnas.1904529116.sapp.pdf

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Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro.

Cancer Science

Hirata, Eishu E; Ichikawa, Takehiko T; Horike, Shin-Ichi SI; Kiyokawa, Etsuko E

Publication Date: 2018-12

Variant appearance in text: KRAS: T35S

PubMed Link: 30281889

Variant Present in the following documents:

• CAS-109-4045.pdf

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Deconstruction of the Ras switching cycle through saturation mutagenesis.

Elife

Bandaru, Pradeep P; Shah, Neel H NH; Bhattacharyya, Moitrayee M; Barton, John P JP; Kondo, Yasushi Y; Cofsky, Joshua C JC; Gee, Christine L CL; Chakraborty, Arup K AK; Kortemme, Tanja T; Ranganathan, Rama R; Kuriyan, John J

Publication Date: 2017-07-07

Variant appearance in text: KRAS: T35S

PubMed Link: 28686159

Variant Present in the following documents:

• Main text
• elife-27810.pdf

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Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules.

Cell

Grabocka, Elda E; Bar-Sagi, Dafna D

Publication Date: 2016-12-15

Variant appearance in text: KRAS: T35S

PubMed Link: 27984728

Variant Present in the following documents:

• Main text

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Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Chemical Society Reviews

Lu, Shaoyong S; Jang, Hyunbum H; Gu, Shuo S; Zhang, Jian J; Nussinov, Ruth R

Publication Date: 2016-09-21

Variant appearance in text: K-Ras4B: T35S

PubMed Link: 27396271

Variant Present in the following documents:

• Main text

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Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover.

The Embo Journal

Hong, Xin X; Nguyen, Hung Thanh HT; Chen, Qingfeng Q; Zhang, Rui R; Hagman, Zandra Z; Voorhoeve, P Mathijs PM; Cohen, Stephen M SM

Publication Date: 2014-11-03

Variant appearance in text: KRAS: T35S

PubMed Link: 25180228

Variant Present in the following documents:

• embj0033-2447-sd1.pdf

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Ras and autophagy in cancer development and therapy.

Oncotarget

Schmukler, Eran E; Kloog, Yoel Y; Pinkas-Kramarski, Ronit R

Publication Date: 2014-02-15

Variant appearance in text: KRAS: T35S

PubMed Link: 24583697

Variant Present in the following documents:

• Main text

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Ras effector mutant expression suggest a negative regulator inhibits lung tumor formation.

Plos One

Vandal, Guillaume G; Geiling, Benjamin B; Dankort, David D

Publication Date: 2014

Variant appearance in text: KRAS: T35S

PubMed Link: 24489653

Variant Present in the following documents:

• Main text
• pone.0084745.pdf

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.

Nature

Ostrem, Jonathan M JM; Peters, Ulf U; Sos, Martin L ML; Wells, James A JA; Shokat, Kevan M KM

Publication Date: 2013-11-28

Variant appearance in text: KRAS: T35S

PubMed Link: 24256730

Variant Present in the following documents:

• Main text

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Ras history: The saga continues.

Small Gtpases

Cox, Adrienne D AD; Der, Channing J CJ

Publication Date: 2010-07

Variant appearance in text: K-Ras4B: T35S

PubMed Link: 21686117

Variant Present in the following documents:

• Main text

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Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase.

Molecular And Cellular Biology

McFall, A A; Ulkü, A A; Lambert, Q T QT; Kusa, A A; Rogers-Graham, K K; Der, C J CJ

Publication Date: 2001-08

Variant appearance in text: K-Ras4B: T35S

PubMed Link: 11463831

Variant Present in the following documents:

• Main text

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