Efficacy and safety of first-line checkpoint inhibitors-based treatments for non-oncogene-addicted non-small-cell lung cancer: a systematic review and meta-analysis.
Esmo Open
Siciliano, M A MA; Caridà, G G; Ciliberto, D D; d'Apolito, M M; Pelaia, C C; Caracciolo, D D; Riillo, C C; Correale, P P; Galvano, A A; Russo, A A; Barbieri, V V; Tassone, P P; Tagliaferri, P P
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Nature Communications
Gebregiworgis, Teklab T; Kano, Yoshihito Y; St-Germain, Jonathan J; Radulovich, Nikolina N; Udaskin, Molly L ML; Mentes, Ahmet A; Huang, Richard R; Poon, Betty P K BPK; He, Wenguang W; Valencia-Sama, Ivette I; Robinson, Claire M CM; Huestis, Melissa M; Miao, Jinmin J; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Irwin, Meredith S MS; Lee, Jeffrey E JE; Tsao, Ming-Sound MS; Raught, Brian B; Marshall, Christopher B CB; Ohh, Michael M; Ikura, Mitsuhiko M
Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy.
Acs Nano
Xie, Ying Y; Hang, Yu Y; Wang, Yazhe Y; Sleightholm, Richard R; Prajapati, Dipakkumar R DR; Bader, Johannes J; Yu, Ao A; Tang, Weimin W; Jaramillo, Lee L; Li, Jing J; Singh, Rakesh K RK; Oupický, David D
NMR solution structure of an asymmetric intermolecular leaped V-shape G-quadruplex: selective recognition of the d(G2NG3NG4) sequence motif by a short linear G-rich DNA probe.
Nucleic Acids Research
Wan, Chanjuan C; Fu, Wenqiang W; Jing, Haitao H; Zhang, Na N
Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
Cancer Research
Hata, Aaron N AN; Yeo, Alan A; Faber, Anthony C AC; Lifshits, Eugene E; Chen, Zhao Z; Cheng, Katherine A KA; Walton, Zandra Z; Sarosiek, Kristopher A KA; Letai, Anthony A; Heist, Rebecca S RS; Mino-Kenudson, Mari M; Wong, Kwok-Kin KK; Engelman, Jeffrey A JA