Variant ID: 12-25398284-C-G

NM_033360.2(KRAS):c.35G>C;(p.Gly12Ala)

This variant was identified in 757 publications




Publications:


Coexistence of Low-Grade Fetal Adenocarcinoma and Adenocarcinoma in situ of the Lung Harboring Different Genetic Mutations: A Case Report and Review of Literature.

Oncotargets And Therapy
S Liu, J Wang, X Luo, X Li, Y Miao, L Wang, Q Li, X Qiu, EH Wang
Publication Date: 2020

Variant appearance in text: KRAS: 35G>C; G12A
PMID: 32753900
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Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy Targets.

Biomed Research International
C Chen, S Liu, R Qu, B Li
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32733937
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Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening.

Oncology Letters
C Yang, W Wu, Y Yang, X Yang, J Sun, W Zhang, K Liu, H Ying, S Jiang, X Yu, Y Shi, Y Zhou, S Zhu, Y Xu, Y Ding, L Xie, B Cai, X Xin, P Chen, R Zhao, Y Wu
Publication Date: 2020-08

Variant appearance in text: KRAS: Gly12Ala
PMID: 32724359
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Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis.

Cancers
A Ottaiano, N Normanno, S Facchini, A Cassata, A Nappi, C Romano, L Silvestro, A De Stefano, AM Rachiglio, C Roma, MR Maiello, S Scala, P Delrio, F Tatangelo, A Di Mauro, G Botti, A Avallone, G Nasti
Publication Date: 2020-07-16

Variant appearance in text: KRAS: G12A
PMID: 32708575
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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports
Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura
Publication Date: 2020-07-23

Variant appearance in text: KRAS: G12A
PMID: 32704002
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miRNAs-Based Molecular Signature for KRAS Mutated and Wild Type Colorectal Cancer: An Explorative Study.

Journal Of Immunology Research
E Milanesi, M Dobre, AI Bucuroiu, V Herlea, TE Manuc, A Salvi, G De Petro, M Manuc, G Becheanu
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32676506
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BRAF and KRAS mutations in metastatic colorectal cancer: future perspectives for personalized therapy.

Gastroenterology Report
ZN Li, L Zhao, LF Yu, MJ Wei
Publication Date: 2020-06

Variant appearance in text: KRAS: G12A
PMID: 32665851
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Genomic characterization of Chinese ovarian clear cell carcinoma identifies driver genes by whole exome sequencing.

Neoplasia (New York, N.Y.)
Q Yang, C Zhang, Y Ren, H Yi, T Luo, F Xing, X Bai, L Cui, L Zhu, J Ouyang, P Jiang, W Fan, J Qiu, F Wang, X Xing, Z Zhang, X Zhang, R Zhang
Publication Date: 2020-07-07

Variant appearance in text: KRAS: G12A
PMID: 32650224
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A paravertebral approach for CT-guided percutaneous biopsy of presumably inaccessible, posterior and centrally located pulmonary nodules.

Radiology Case Reports
K Martini, G Chassagnon, S Bennani, MP Revel
Publication Date: 2020-08

Variant appearance in text: KRAS: Gly12Ala
PMID: 32636977
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Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy.

Frontiers In Pharmacology
E De Mattia, R Roncato, E Palazzari, G Toffoli, E Cecchin
Publication Date: 2020

Variant appearance in text: KRAS: Gly12Ala
PMID: 32625092
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Clinical characteristics and prognostic value of the KRAS G12C mutation in Chinese non-small cell lung cancer patients.

Biomarker Research
SY Liu, H Sun, JY Zhou, GL Jie, Z Xie, Y Shao, X Zhang, JY Ye, CX Chen, XC Zhang, Q Zhou, JJ Yang, YL Wu
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32607238
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FAM83G Is a Novel Inducer of Apoptosis.

Molecules (Basel, Switzerland)
J Okada, N Sunaga, E Yamada, T Saito, A Ozawa, Y Nakajima, K Okada, JE Pessin, S Okada, M Yamada
Publication Date: 2020-06-18

Variant appearance in text: KRAS: G12A
PMID: 32570757
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Histology and its prognostic effect on KRAS-mutated colorectal carcinomas in Korea.

Oncology Letters
HS Lee, DY Hwang, HS Han
Publication Date: 2020-07

Variant appearance in text: KRAS: G12A
PMID: 32565990
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Complex Oncological Decision-Making Utilizing Fast-and-Frugal Trees in a Community Setting-Role of Academic and Hybrid Modeling.

Journal Of Clinical Medicine
R Salgia, I Mambetsariev, T Tan, A Schwer, DP Pearlstein, H Chehabi, A Baroz, J Fricke, R Pharaon, H Romo, T Waddington, R Babikian, L Buck, P Kulkarni, M Cianfrocca, B Djulbegovic, SK Pal
Publication Date: 2020-06-16

Variant appearance in text: KRAS: G12A
PMID: 32560187
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A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Molecular Medicine (Cambridge, Mass.)
G Saha, R Singh, A Mandal, S Das, E Chattopadhyay, P Panja, P Roy, N DeSarkar, S Gulati, S Ghatak, S Ghosh, S Banerjee, B Roy, S Ghosh, D Chaudhuri, N Arora, NK Biswas, N Sikdar
Publication Date: 2020-06-17

Variant appearance in text: KRAS: G12A
PMID: 32552660
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Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach.

Cancer Informatics
V D'Afonseca, AD Arencibia, A Echeverría-Vega, L Cerpa, JP Cayún, NM Varela, M Salazar, LA Quiñones
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32546937
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A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer.

Plos One
K Shinjo, K Hara, G Nagae, T Umeda, K Katsushima, M Suzuki, Y Murofushi, Y Umezu, I Takeuchi, S Takahashi, Y Okuno, K Matsuo, H Ito, S Tajima, H Aburatani, K Yamao, Y Kondo
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32520974
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Detection of Colorectal Cancer and Advanced Adenoma by Liquid Biopsy (Decalib Study): The ddPCR Challenge.

Cancers
A Junca, G Tachon, C Evrard, C Villalva, E Frouin, L Karayan-Tapon, D Tougeron
Publication Date: 2020-06-06

Variant appearance in text: KRAS: G12A
PMID: 32517177
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New insights into classification and risk stratification of encapsulated thyroid tumors with a predominantly papillary architecture.

Journal Of Pathology And Translational Medicine
CK Jung, SY Park, JH Kim, K Kakudo
Publication Date: 2020-05

Variant appearance in text: KRAS: G12A
PMID: 32460473
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Small Molecule KRAS Inhibitors: The Future for Targeted Pancreatic Cancer Therapy?

Cancers
J Gillson, Y Ramaswamy, G Singh, AA Gorfe, N Pavlakis, J Samra, A Mittal, S Sahni
Publication Date: 2020-05-24

Variant appearance in text: KRAS: G12A
PMID: 32456277
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Experimental Treatment of Mucinous Peritoneal Metastases Using Patient-Derived Xenograft Models.

Translational Oncology
KG Fleten, C Lund-Andersen, S Waagene, TW Abrahamsen, Y Mørch, K Boye, A Torgunrud, K Flatmark
Publication Date: 2020-05-21

Variant appearance in text: KRAS: G12A
PMID: 32447231
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Tissue gene mutation profiles in patients with colorectal cancer and their clinical implications.

Biomedical Reports
J Ye, M Lin, C Zhang, X Zhu, S Li, H Liu, J Yin, H Yu, K Zhu
Publication Date: 2020-07

Variant appearance in text: KRAS: G12A
PMID: 32440349
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NADPH oxidase 1 is highly expressed in human large and small bowel cancers.

Plos One
J Lu, G Jiang, Y Wu, S Antony, JL Meitzler, A Juhasz, H Liu, K Roy, H Makhlouf, R Chuaqui, D Butcher, MM Konaté, JH Doroshow
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32428030
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Detection of Fusion Genes Using a Targeted RNA Sequencing Panel in Gastrointestinal and Rare Cancers.

Journal Of Oncology
SJ Lee, JY Hong, K Kim, KM Kim, SY Kang, T Lee, ST Kim, SH Park, YS Park, HY Lim, WK Kang, J Lee, JO Park
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32411236
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Targeted RNA sequencing with touch imprint cytology samples for non-small cell lung cancer patients.

Thoracic Cancer
K Seto, K Masago, S Fujita, M Haneda, Y Horio, T Hida, H Kuroda, W Hosoda, KI Okubo
Publication Date: 2020-05-05

Variant appearance in text: KRAS: Gly12Ala
PMID: 32372482
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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer
PC Mack, KC Banks, CR Espenschied, RA Burich, OA Zill, CE Lee, JW Riess, SA Mortimer, A Talasaz, RB Lanman, DR Gandara
Publication Date: 2020-05-04

Variant appearance in text: KRAS: G12A
PMID: 32365229
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RAS Mutational Status Detection in Tissue, Plasma, and Stool Samples for Colorectal Cancer.

Biomed Research International
L Zhu, Y Wang, Y Zhou, Q Dong, Y Liu, J Zhang
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32351996
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Impact of the Italian Society of Anatomic Pathology and Diagnostic Cytology Classification of Thyroid Nodules in the Treatment of Indeterminate Follicular Lesions: Five-Year Results at a Single Center.

International Journal Of Endocrinology
M Pastoricchio, A Cubisino, A Lanzaro, M Troian, F Zanconati, S Bernardi, B Fabris, N de Manzini, C Dobrinja
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32351561
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[Acquired Drug Resistance Mechanism of Osimertinib in the Targeted Therapy of Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Z Zhao, Y Ni, L Li, T Xin
Publication Date: 2020-04-20

Variant appearance in text: KRAS: G12A
PMID: 32316715
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BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.

Plos One
S Al-Salam, C Sharma, B Afandi, K Al Dahmani, AS Al-Zahrani, A Al Shamsi, J Al Kaabi
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32315324
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New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma.

Drugs
RR Singh, EM O'Reilly
Publication Date: 2020-04-18

Variant appearance in text: KRAS: G12A
PMID: 32306207
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Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines.

Metabolomics : Official Journal Of The Metabolomic Society
D Varshavi, D Varshavi, N McCarthy, K Veselkov, HC Keun, JR Everett
Publication Date: 2020-04-16

Variant appearance in text: KRAS: G12A
PMID: 32300895
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Ovarian mucinous tumors with mural nodules: immunohistochemical and molecular analysis of 3 cases.

Diagnostic Pathology
Y Shao, Q Liu, H Shi, B Lu
Publication Date: 2020-04-14

Variant appearance in text: KRAS: G12A
PMID: 32290854
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RAS/RAF mutations in tumor samples and cell-free DNA from plasma and bone marrow aspirates in multiple myeloma patients.

Journal Of Cancer
Q Li, HJ Huang, J Ma, Y Wang, Z Cao, G Karlin-Neumann, F Janku, Z Liu
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32284750
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Rapid Molecular Response to Dasatinib in a Pediatric Relapsed Acute Lymphoblastic Leukemia With NCOR1-LYN Fusion.

Frontiers In Oncology
HP Dai, J Yin, Z Li, CX Yang, T Cao, P Chen, YH Zong, MQ Zhu, XM Zhu, S Xiao, DP Wu, XW Tang
Publication Date: 2020

Variant appearance in text: KRAS: Gly12Ala
PMID: 32266142
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Immunogenicity and Immune Silence in Human Cancer.

Frontiers In Immunology
M Yarmarkovich, A Farrel, A Sison, M di Marco, P Raman, JL Parris, D Monos, H Lee, S Stevanovic, JM Maris
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32256484
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Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation.

Nature Communications
S Hamarsheh, L Osswald, BS Saller, S Unger, D De Feo, JM Vinnakota, M Konantz, FM Uhl, H Becker, M Lübbert, K Shoumariyeh, C Schürch, G Andrieux, N Venhoff, A Schmitt-Graeff, S Duquesne, D Pfeifer, MA Cooper, C Lengerke, M Boerries, J Duyster, CM Niemeyer, M Erlacher, BR Blazar, B Becher, O Groß, T Brummer, R Zeiser
Publication Date: 2020-04-03

Variant appearance in text: KRAS: G12A
PMID: 32246016
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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

Nature
K Han, SE Pierce, A Li, K Spees, GR Anderson, JA Seoane, YH Lo, M Dubreuil, M Olivas, RA Kamber, M Wainberg, K Kostyrko, MR Kelly, M Yousefi, SW Simpkins, D Yao, K Lee, CJ Kuo, PK Jackson, A Sweet-Cordero, A Kundaje, AJ Gentles, C Curtis, MM Winslow, MC Bassik
Publication Date: 2020-04

Variant appearance in text: KRAS: G12A
PMID: 32238925
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Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma.

Bmc Cancer
P Sriskandarajah, A De Haven Brandon, K MacLeod, NO Carragher, V Kirkin, M Kaiser, SR Whittaker
Publication Date: 2020-03-30

Variant appearance in text: KRAS: G12A
PMID: 32228485
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Harmonization of Next-Generation Sequencing Procedure in Italian Laboratories: A Multi-Institutional Evaluation of the SiRe® Panel.

Frontiers In Oncology
U Malapelle, F Pepe, P Pisapia, R Sgariglia, M Nacchio, C De Luca, R Lacalamita, S Tommasi, R Pinto, G Palomba, G Palmieri, D Vacirca, M Barberis, I Bottillo, P Grammatico, LR Grillo, V Costa, R Smeraglio, D Bruzzese, G Troncone
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32219061
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Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity in preclinical models of RAS-mediated midostaurin-resistant acute myeloid leukemia cells.

Oncotarget
T Aikawa, N Togashi, K Iwanaga, H Okada, Y Nishiya, S Inoue, MJ Levis, T Isoyama
Publication Date: 2020-03-17

Variant appearance in text: KRAS: G12A
PMID: 32215183
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An enzymatic on/off switch-mediated assay for KRAS hotspot point mutation detection of circulating tumor DNA.

Journal Of Clinical Laboratory Analysis
QL Wang, CL Zhou, YF Yin, L Xiao, Y Wang, K Li
Publication Date: 2020-03-24

Variant appearance in text: KRAS: G12A
PMID: 32207862
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Targeted sequencing analysis of cell-free DNA from metastatic non-small-cell lung cancer patients: clinical and biological implications.

Translational Lung Cancer Research
R Pasquale, L Forgione, C Roma, F Fenizia, F Bergantino, AM Rachiglio, A De Luca, M Gallo, MR Maiello, G Palumbo, A Morabito, R Azzaro, N Normanno
Publication Date: 2020-02

Variant appearance in text: KRAS: Gly12Ala
PMID: 32206554
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Clinicopathological parameters for circulating tumor DNA shedding in surgically resected non-small cell lung cancer with EGFR or KRAS mutation.

Plos One
MS Cho, CH Park, S Lee, HS Park
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 32196518
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Coexisting EGFR and TP53 Mutations in Lung Adenocarcinoma Patients Are Associated With COMP and ITGB8 Upregulation and Poor Prognosis.

Frontiers In Molecular Biosciences
C Zheng, X Li, Y Ren, Z Yin, B Zhou
Publication Date: 2020

Variant appearance in text: N/A
PMID: 32175330
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Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.

Scientific Reports
S Del Carmen, LA Corchete, R Gervas, A Rodriguez, M Garcia, JA Álcazar, J García, O Bengoechea, L Muñoz-Bellvis, JM Sayagués, M Abad
Publication Date: 2020-03-13

Variant appearance in text: KRAS: G12A
PMID: 32170146
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Analysis of tumor microenvironmental features to refine prognosis by T, N risk group in patients with stage III colon cancer (NCCTG N0147) (Alliance).

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
H Lee, D Sha, NR Foster, Q Shi, SR Alberts, TC Smyrk, FA Sinicrope
Publication Date: 2020-01-25

Variant appearance in text: KRAS: 35G>C; G12A
PMID: 32165096
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The Prognostic Value of 18F-FDG PET/CT and KRAS Mutation in Colorectal Cancers

Molecular Imaging And Radionuclide Therapy
E Arslan, T Aksoy, RU Gürsu, N Dursun, E Çakar, TF Çermik
Publication Date: 2020-02-17

Variant appearance in text: KRAS: Gly12Ala
PMID: 32079384
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Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines.

Cancers
S Weißbach, SC Heredia-Guerrero, S Barnsteiner, L Großhans, J Bodem, H Starz, C Langer, S Appenzeller, S Knop, T Steinbrunn, S Rost, H Einsele, RC Bargou, A Rosenwald, T Stühmer, E Leich
Publication Date: 2020-02-16

Variant appearance in text: KRAS: G12A
PMID: 32079091
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The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine
JJ Adashek, S Kato, SM Lippman, R Kurzrock
Publication Date: 2020-02-17

Variant appearance in text: KRAS: G12A
PMID: 32066498
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Comparative Study of NGS Platform Ion Torrent Personal Genome Machine and Therascreen Rotor-Gene Q for the Detection of Somatic Variants in Cancer.

High-Throughput
A Lombardi, M Russo, A Luce, F Morgillo, V Tirino, G Misso, E Martinelli, T Troiani, V Desiderio, G Papaccio, F Iovino, G Argenziano, E Moscarella, P Sperlongano, G Galizia, R Addeo, A Necas, A Necasova, F Ciardiello, A Ronchi, M Caraglia, A Grimaldi
Publication Date: 2020-02-11

Variant appearance in text: KRAS: G12A
PMID: 32054005
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Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

Bmc Cancer
V Manoharan, EH Karunanayake, KH Tennekoon, S De Silva, AIA Imthikab, K De Silva, P Angunawela, S Vishwakula, J Lunec
Publication Date: 2020-01-30

Variant appearance in text: N/A
PMID: 32000721
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Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities.

Frontiers In Oncology
J Gojo, Z Pavelka, D Zapletalova, MT Schmook, L Mayr, S Madlener, M Kyr, K Vejmelkova, M Smrcka, T Czech, C Dorfer, J Skotakova, AA Azizi, M Chocholous, D Reisinger, D Lastovicka, D Valik, C Haberler, A Peyrl, H Noskova, K Pál, M Jezova, R Veselska, S Kozakova, O Slaby, I Slavc, J Sterba
Publication Date: 2019

Variant appearance in text: KRAS: G12A
PMID: 31998633
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The current understanding of KRAS protein structure and dynamics.

Computational And Structural Biotechnology Journal
T Pantsar
Publication Date: 2020

Variant appearance in text: KRAS: G12A
PMID: 31988705
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Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients.

British Journal Of Cancer
S Guo, X Shi, J Shen, S Gao, H Wang, S Shen, Y Pan, B Li, X Xu, Z Shao, G Jin
Publication Date: 2020-01-23

Variant appearance in text: KRAS: G12A
PMID: 31969677
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Comparison of clinicopathological features and KRAS gene mutation of left-sided and right-sided colon cancers.

International Journal Of Clinical And Experimental Pathology
X Xue, X Li, Z Pan, L Zhao, Y Ding
Publication Date: 2017

Variant appearance in text: KRAS: Gly12ALA
PMID: 31966490
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Frequent KRAS and HRAS mutations in squamous cell papillomas of the head and neck.

The Journal Of Pathology. Clinical Research
E Sasaki, K Masago, S Fujita, N Hanai, Y Yatabe
Publication Date: 2020-01-20

Variant appearance in text: KRAS: G12A
PMID: 31960612
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Latency and interval therapy affect the evolution in metastatic colorectal cancer.

Scientific Reports
H Nikbakht, S Jessa, MA Sukhai, M Arseneault, T Zhang, L Letourneau, M Thomas, M Bourgey, MHA Roehrl, R Eveleigh, EX Chen, M Krzyzanowska, MJ Moore, A Giesler, C Yu, PL Bedard, S Kamel-Reid, J Majewski, LL Siu, Y Riazalhosseini, DM Graham
Publication Date: 2020-01-17

Variant appearance in text: KRAS: G12A
PMID: 31953485
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Correlation between clinicopathological features and KRAS, NRAS, and BRAF mutation status in Chinese colorectal cancer patients.

International Journal Of Clinical And Experimental Pathology
X Zhu, X Meng, W Xiang, W Dai, Q Bai, W Sheng, Y Lu, P Qi, L Wu, G Cai, X Zhou
Publication Date: 2018

Variant appearance in text: KRAS: G12A
PMID: 31938404
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Not all mutations of KRAS predict poor prognosis in patients with colorectal cancer.

International Journal Of Clinical And Experimental Pathology
W Li, Y Liu, S Cai, C Yang, Z Lin, L Zhou, L Liu, X Cheng, W Zeng
Publication Date: 2019

Variant appearance in text: KRAS: G12A
PMID: 31933906
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Somatic genetic aberrations in gallbladder cancer: comparison between Chinese and US patients.

Hepatobiliary Surgery And Nutrition
P Yang, M Javle, F Pang, W Zhao, R Abdel-Wahab, X Chen, F Meric-Bernstam, H Chen, MJ Borad, Y Liu, C Zou, S Mu, Y Xing, K Wang, C Peng, X Che
Publication Date: 2019-12

Variant appearance in text: KRAS: G12A
PMID: 31929987
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Inter-laboratory proficiency testing scheme for tumour next-generation sequencing in Ontario: a pilot study.

Current Oncology (Toronto, Ont.)
T Spence, N Stickle, C Yu, H Chow, H Feilotter, B Lo, E McCready, B Sadikovic, LL Siu, PL Bedard, TL Stockley
Publication Date: 2019-12

Variant appearance in text: KRAS: 35G>C; Gly12Ala
PMID: 31896942
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Standardization of Somatic Variant Classifications in Solid and Haematological Tumours by a Two-Level Approach of Biological and Clinical Classes: An Initiative of the Belgian ComPerMed Expert Panel.

Cancers
G Froyen, M Le Mercier, E Lierman, K Vandepoele, F Nollet, E Boone, J Van der Meulen, K Jacobs, S Lambin, S Vander Borght, E Van Valckenborgh, A Antoniou, A Hébrant
Publication Date: 2019-12-16

Variant appearance in text: KRAS: G12A
PMID: 31888289
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PROTACs: great opportunities for academia and industry.

Signal Transduction And Targeted Therapy
X Sun, H Gao, Y Yang, M He, Y Wu, Y Song, Y Tong, Y Rao
Publication Date: 2019

Variant appearance in text: KRAS: G12A
PMID: 31885879
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KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan.

Plos One
M Awidi, N Ababneh, M Shomaf, F Al Fararjeh, L Owaidi, M AlKhatib, B Al Tarawneh, A Awidi
Publication Date: 2019

Variant appearance in text: KRAS: G12A
PMID: 31881025
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Elemental and mutational analysis of lung tissue in lung adenocarcinoma patients.

Translational Lung Cancer Research
R Chiba, N Morikawa, K Sera, K Ishida, H Nagashima, W Shigeeda, H Deguchi, M Tomoyasu, T Hosokawa, H Saito, T Sugai, K Yamauchi, M Maemondo
Publication Date: 2019-11

Variant appearance in text: KRAS: G12A
PMID: 31857947
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BRAF -mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma.

Oncotarget
MH Chui, SK Kjaer, K Frederiksen, CG Hannibal, TL Wang, R Vang, IM Shih
Publication Date: 2019-12-03

Variant appearance in text: KRAS: G12A
PMID: 31839880
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Identification of Circulating Genomic and Metabolic Biomarkers in Intrahepatic Cholangiocarcinoma.

Cancers
H Winter, PJ Kaisaki, J Harvey, E Giacopuzzi, MP Ferla, MM Pentony, SJL Knight, RA Sharma, JC Taylor, JSO McCullagh
Publication Date: 2019-11-28

Variant appearance in text: KRAS: G12A
PMID: 31795195
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Blood-Based Next-Generation Sequencing Analysis of Appendiceal Cancers.

The Oncologist
WL Shaib, K Zakka, C Staley, A Roberts, M Akce, C Wu, OB Alese, BF El-Rayes
Publication Date: 2019-11-29

Variant appearance in text: KRAS: G12A
PMID: 31784493
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Quantitative monitoring of circulating tumor DNA in patients with advanced pancreatic cancer undergoing chemotherapy.

Cancer Science
M Sugimori, K Sugimori, H Tsuchiya, Y Suzuki, S Tsuyuki, Y Kaneta, A Hirotani, K Sanga, Y Tozuka, S Komiyama, T Sato, S Tezuka, Y Goda, K Irie, H Miwa, Y Miura, T Ishii, T Kaneko, M Nagahama, W Shibata, A Nozaki, S Maeda
Publication Date: 2019-11-19

Variant appearance in text: KRAS: G12A
PMID: 31746520
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Circulating tumor DNA as a prognostic indicator in resectable pancreatic ductal adenocarcinoma: A systematic review and meta-analysis.

Scientific Reports
JS Lee, TM Rhee, D Pietrasz, JB Bachet, P Laurent-Puig, SY Kong, E Takai, S Yachida, T Shibata, JW Lee, HC Park, DY Zang, K Jeon, J Lee, M Kim, HS Kim, HJ Kang, YK Lee
Publication Date: 2019-11-18

Variant appearance in text: KRAS: G12A
PMID: 31740696
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Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR.

Bmc Medical Genomics
Y Nagakubo, Y Hirotsu, K Amemiya, T Oyama, H Mochizuki, M Omata
Publication Date: 2019-11-11

Variant appearance in text: KRAS: G12A
PMID: 31711486
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EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma.

Bmc Pulmonary Medicine
M Colombino, P Paliogiannis, A Cossu, DA Santeufemia, , MC Sini, M Casula, G Palomba, A Manca, M Pisano, V Doneddu, G Palmieri
Publication Date: 2019-11-11

Variant appearance in text: KRAS: G12A
PMID: 31711449
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The prevalence and prognostic value of KRAS co-mutation subtypes in Chinese advanced non-small cell lung cancer patients.

Cancer Medicine
D Cai, C Hu, L Li, S Deng, J Yang, H Han-Zhang, M Li
Publication Date: 2019-11-10

Variant appearance in text: KRAS: G12A
PMID: 31709742
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Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma.

Blood Advances
YT Lin, GP Way, BG Barwick, MC Mariano, M Marcoulis, ID Ferguson, C Driessen, LH Boise, CS Greene, AP Wiita
Publication Date: 2019-11-12

Variant appearance in text: KRAS: G12A
PMID: 31698452
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A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology
C Muñoz-Maldonado, Y Zimmer, M Medová
Publication Date: 2019

Variant appearance in text: KRAS: G12A
PMID: 31681616
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Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer.

Bmc Cancer
SZ Martin, DC Wagner, N Hörner, D Horst, H Lang, KE Tagscherer, W Roth
Publication Date: 2019-11-01

Variant appearance in text: KRAS: G12A
PMID: 31675944
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MicroRNA-425-5p Expression Affects BRAF/RAS/MAPK Pathways In Colorectal Cancers.

International Journal Of Medical Sciences
A Angius, G Pira, AM Scanu, P Uva, G Sotgiu, L Saderi, A Manca, C Serra, E Uleri, C Piu, M Caocci, G Ibba, A Zinellu, MR Cesaraccio, F Sanges, MR Muroni, A Dolei, P Cossu-Rocca, MR De Miglio
Publication Date: 2019

Variant appearance in text: KRAS: Gly12Ala
PMID: 31673240
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An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

Ebiomedicine
H Wang, Q Lv, Y Xu, Z Cai, J Zheng, X Cheng, Y Dai, PA Jänne, C Ambrogio, J Köhler
Publication Date: 2019-11

Variant appearance in text: KRAS: G12A
PMID: 31668570
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The Activity of Immune Checkpoint Inhibition in KRAS Mutated Non-small Cell Lung Cancer: A Single Centre Experience.

Cancer Genomics & Proteomics
J Torralvo, A Friedlaender, V Achard, A Addeo
Publication Date: 2019

Variant appearance in text: KRAS: G12A
PMID: 31659111
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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.

Cancer Discovery
GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, AO Anderson, AM Waters, JN Diehl, B Papke, RG Hodge, JE Klomp, CM Goodwin, JM DeLiberty, J Wang, RWS Ng, P Gautam, KL Bryant, D Esposito, SL Campbell, EF Petricoin, DK Simanshu, AJ Aguirre, BM Wolpin, K Wennerberg, U Rudloff, AD Cox, CJ Der
Publication Date: 2019-10-24

Variant appearance in text: KRAS: G12A
PMID: 31649109
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Mutations of RAS genes in endometrial polyps.

Oncology Reports
T Takeda, K Banno, Y Kobayashi, M Adachi, M Yanokura, E Tominaga, K Kosaki, D Aoki
Publication Date: 2019-12

Variant appearance in text: KRAS: G12A
PMID: 31638232
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Precision treatment in colorectal cancer: Now and the future.

Jgh Open : An Open Access Journal Of Gastroenterology And Hepatology
TO Yau
Publication Date: 2019-10

Variant appearance in text: KRAS: G12A
PMID: 31633039
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Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses.

Cell Reports
T Botton, E Talevich, VK Mishra, T Zhang, AH Shain, C Berquet, A Gagnon, RL Judson, R Ballotti, A Ribas, M Herlyn, S Rocchi, KM Brown, NK Hayward, I Yeh, BC Bastian
Publication Date: 2019-10-15

Variant appearance in text: KRAS: G12A
PMID: 31618628
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Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
GG Zhu, K Nafa, N Agaram, A Zehir, R Benayed, J Sadowska, L Borsu, C Kelly, WD Tap, N Fabbri, E Athanasian, PJ Boland, JH Healey, MF Berger, M Ladanyi, M Hameed
Publication Date: 2019-10-15

Variant appearance in text: KRAS: G12A
PMID: 31615936
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New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness.

Frontiers In Oncology
H Yang, SQ Liang, RA Schmid, RW Peng
Publication Date: 2019

Variant appearance in text: KRAS: G12A
PMID: 31612108
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KRAS Mutations Predict Response and Outcome in Advanced Lung Adenocarcinoma Patients Receiving First-Line Bevacizumab and Platinum-Based Chemotherapy.

Cancers
AK Ghimessy, A Gellert, E Schlegl, B Hegedus, E Raso, T Barbai, J Timar, G Ostoros, Z Megyesfalvi, B Gieszer, J Moldvay, F Renyi-Vamos, Z Lohinai, MA Hoda, T Klikovits, W Klepetko, V Laszlo, B Dome
Publication Date: 2019-10-09

Variant appearance in text: KRAS: G12A
PMID: 31600989
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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Cell Reports
R Sulahian, JJ Kwon, KH Walsh, E Pailler, TL Bosse, M Thaker, D Almanza, JM Dempster, J Pan, F Piccioni, N Dumont, A Gonzalez, J Rennhack, B Nabet, JA Bachman, A Goodale, Y Lee, M Bagul, R Liao, A Navarro, TL Yuan, RWS Ng, S Raghavan, NS Gray, A Tsherniak, F Vazquez, DE Root, AJ Firestone, J Settleman, WC Hahn, AJ Aguirre
Publication Date: 2019-10-01

Variant appearance in text: KRAS: G12A
PMID: 31577942
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Development of Patient-Derived Preclinical Platform for Metastatic Pancreatic Cancer: PDOX and a Subsequent Organoid Model System Using Percutaneous Biopsy Samples.

Frontiers In Oncology
SI Choi, AR Jeon, MK Kim, YS Lee, JE Im, JW Koh, SS Han, SY Kong, KA Yoon, YH Koh, JH Lee, WJ Lee, SJ Park, EK Hong, SM Woo, YH Kim
Publication Date: 2019

Variant appearance in text: KRAS: G12A
PMID: 31572675
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Morpho-Molecular Assessment Indicates New Prognostic Aspects and Personalized Therapeutic Options in Sinonasal Melanoma.

Cancers
SN Freiberger, GB Morand, P Turko, U Wager, R Dummer, M Hüllner, D Holzmann, NJ Rupp, MP Levesque
Publication Date: 2019-09-07

Variant appearance in text: KRAS: Gly12Ala
PMID: 31500314
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Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA.

Scientific Reports
V Rowlands, AJ Rutkowski, E Meuser, TH Carr, EA Harrington, JC Barrett
Publication Date: 2019-09-02

Variant appearance in text: KRAS: G12A
PMID: 31477768
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Genetic variants and clinical significance of pediatric acute lymphoblastic leukemia.

Annals Of Translational Medicine
HH Zhang, HS Wang, XW Qian, CQ Fan, J Li, H Miao, XH Zhu, Y Yu, JH Meng, P Cao, J Le, JY Jiang, WJ Jiang, P Wang, XW Zhai
Publication Date: 2019-07

Variant appearance in text: N/A
PMID: 31475166
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High Frequency of KRAS Codon 146 and FBXW7 Mutations in Thai Patients with Stage II-III Colon Cancer.

Asian Pacific Journal Of Cancer Prevention : Apjcp
K Korphaisarn, A Pongpaibul, E Roothumnong, K Pongsuktavorn, L Thamlikitkul, T Anekpuritanang, N Poungvarin, W Thongnoppakhun, M Pithukpakorn
Publication Date: 2019-08-01

Variant appearance in text: KRAS: G12A
PMID: 31450901
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Abstracts : 31 st European Congress of Pathology.

Virchows Archiv : An International Journal Of Pathology
.
Publication Date: 2019-09

Variant appearance in text: KRAS: G12A
PMID: 31440833
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Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles.

Oncotarget
MS Strand, BA Krasnick, H Pan, X Zhang, Y Bi, C Brooks, C Wetzel, N Sankpal, T Fleming, SP Goedegebuure, DG DeNardo, WE Gillanders, WG Hawkins, SA Wickline, RC Fields
Publication Date: 2019-07-30

Variant appearance in text: KRAS: G12A
PMID: 31413817
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000256078.4 c.35G>C p.Gly12Ala missense_variant 2/6 -
ENST00000311936.3 c.35G>C p.Gly12Ala missense_variant 2/5 -
ENST00000556131.1 c.35G>C p.Gly12Ala missense_variant 2/3 -
ENST00000557334.1 c.35G>C p.Gly12Ala missense_variant 2/3 -
NM_001369786.1 c.35G>C p.Gly12Ala missense_variant 2/6 -
NM_001369787.1 c.35G>C p.Gly12Ala missense_variant 2/5 -
NM_004985.5 c.35G>C p.Gly12Ala missense_variant 2/5 -
NM_033360.4 c.35G>C p.Gly12Ala missense_variant 2/6 -