Variant ID: 12-25398284-C-T

NM_033360.2(KRAS):c.35G>A;(p.Gly12Asp)

This variant was identified in 3455 publications




Publications:


Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma.

International Journal Of Molecular Sciences
N Sperb, M Tsesmelis, T Wirth
Publication Date: 2020-07-31

Variant appearance in text: KRAS: G12D
PMID: 32752017
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Cells of origin of lung cancers: lessons from mouse studies.

Genes & Development
G Ferone, MC Lee, J Sage, A Berns
Publication Date: 2020-08-01

Variant appearance in text: KRAS: G12D
PMID: 32747478
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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
J Li, W Jiang, J Wei, J Zhang, L Cai, M Luo, Z Wang, W Sun, S Wang, C Wang, C Dai, J Liu, G Wang, J Wang, Q Xu, Y Deng
Publication Date: 2020-08-01

Variant appearance in text: KRAS: G12D
PMID: 32738923
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Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy Targets.

Biomed Research International
C Chen, S Liu, R Qu, B Li
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32733937
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Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation.

Oncotarget
RC Gaba, L Elkhadragy, FE Boas, S Chaki, HH Chen, M El-Kebir, KD Garcia, EF Giurini, G Guzman, FV LoBianco, MF Neto, JL Newson, A Qazi, M Regan, LA Rund, RM Schwind, MC Stewart, FM Thomas, HE Whiteley, J Wu, LB Schook, KM Schachtschneider
Publication Date: 2020-07-14

Variant appearance in text: KRAS: G12D
PMID: 32733642
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Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening.

Oncology Letters
C Yang, W Wu, Y Yang, X Yang, J Sun, W Zhang, K Liu, H Ying, S Jiang, X Yu, Y Shi, Y Zhou, S Zhu, Y Xu, Y Ding, L Xie, B Cai, X Xin, P Chen, R Zhao, Y Wu
Publication Date: 2020-08

Variant appearance in text: KRAS: Gly12Asp
PMID: 32724359
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Efficient mutation screening for cervical cancers from circulating tumor DNA in blood.

Bmc Cancer
SY Lee, DK Chae, SH Lee, Y Lim, J An, CH Chae, BC Kim, J Bhak, D Bolser, DH Cho
Publication Date: 2020-07-27

Variant appearance in text: KRAS: G12D
PMID: 32718341
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Pancreatic Macrophages: Critical Players in Obesity-Promoted Pancreatic Cancer.

Cancers
Y Teper, G Eibl
Publication Date: 2020-07-17

Variant appearance in text: KRAS: G12D
PMID: 32709161
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Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis.

Cancers
A Ottaiano, N Normanno, S Facchini, A Cassata, A Nappi, C Romano, L Silvestro, A De Stefano, AM Rachiglio, C Roma, MR Maiello, S Scala, P Delrio, F Tatangelo, A Di Mauro, G Botti, A Avallone, G Nasti
Publication Date: 2020-07-16

Variant appearance in text: KRAS: G12D
PMID: 32708575
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Identification of a Clinical Cutoff Value for Multiplex KRASG12/G13 Mutation Detection in Colorectal Adenocarcinoma Patients Using Digital Droplet PCR, and Comparison with Sanger Sequencing and PNA Clamping Assay.

Journal Of Clinical Medicine
KH Lee, TH Lee, MK Choi, IS Kwon, GE Bae, MK Yeo
Publication Date: 2020-07-18

Variant appearance in text: KRAS: G12D
PMID: 32708359
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Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer.

Cancers
L Seeneevassen, J Giraud, S Molina-Castro, E Sifré, C Tiffon, C Beauvoit, C Staedel, F Mégraud, P Lehours, OCB Martin, H Boeuf, P Dubus, C Varon
Publication Date: 2020-07-22

Variant appearance in text: KRAS: 35G>A
PMID: 32707998
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Defining relative mutational difficulty to understand cancer formation.

Cell Discovery
L Shan, J Yu, Z He, S Chen, M Liu, H Ding, L Xu, J Zhao, A Yang, H Jiang
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32704382
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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports
Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura
Publication Date: 2020-07-23

Variant appearance in text: KRAS: G12D
PMID: 32704002
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AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer.

Cell Communication And Signaling : Ccs
H Ye, Y Liu, K Wu, H Luo, L Cui
Publication Date: 2020-07-23

Variant appearance in text: KRAS: G12D
PMID: 32703218
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Applied precision medicine in metastatic pancreatic ductal adenocarcinoma.

Therapeutic Advances In Medical Oncology
H Taghizadeh, L Müllauer, RM Mader, M Schindl, GW Prager
Publication Date: 2020

Variant appearance in text: KRAS: Gly12Asp
PMID: 32699558
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Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis.

Diagnostic Pathology
P Dundr, M Gregová, K Němejcová, M Bártů, N Hájková, J Hojný, I Stružinská, D Fischerová
Publication Date: 2020-07-21

Variant appearance in text: KRAS: G12D
PMID: 32693840
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KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations.

Scientific Reports
T Pantsar
Publication Date: 2020-07-20

Variant appearance in text: KRAS: G12D
PMID: 32686745
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Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival.

Heliyon
H Yokouchi, H Nishihara, T Harada, S Yamazaki, H Kikuchi, S Oizumi, H Uramoto, F Tanaka, M Harada, K Akie, F Sugaya, Y Fujita, K Takamura, T Kojima, M Higuchi, O Honjo, Y Minami, N Watanabe, M Nishimura, H Suzuki, H Dosaka-Akita, H Isobe
Publication Date: 2020-07

Variant appearance in text: KRAS: G12D
PMID: 32685741
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Cross-species oncogenic signatures of breast cancer in canine mammary tumors.

Nature Communications
TM Kim, IS Yang, BJ Seung, S Lee, D Kim, YJ Ha, MK Seo, KK Kim, HS Kim, JH Cheong, JH Sur, H Nam, S Kim
Publication Date: 2020-07-17

Variant appearance in text: KRAS: G12D
PMID: 32680987
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miRNAs-Based Molecular Signature for KRAS Mutated and Wild Type Colorectal Cancer: An Explorative Study.

Journal Of Immunology Research
E Milanesi, M Dobre, AI Bucuroiu, V Herlea, TE Manuc, A Salvi, G De Petro, M Manuc, G Becheanu
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32676506
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Clinical impact of the lung tissue transcriptome in a teenager with multifocal invasive mucinous adenocarcinoma-a case report.

Translational Lung Cancer Research
E Di Carlo, G Cipollone, F Mucilli, C Sorrentino
Publication Date: 2020-06

Variant appearance in text: KRAS: G12D
PMID: 32676340
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Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility.

Cell Reports
J Dooley, V Lagou, J Goveia, A Ulrich, K Rohlenova, N Heirman, T Karakach, Y Lampi, S Khan, J Wang, T Dresselaers, U Himmelreich, MJ Gunter, I Prokopenko, P Carmeliet, A Liston
Publication Date: 2020-07-14

Variant appearance in text: KRAS: G12D
PMID: 32668252
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BRAF and KRAS mutations in metastatic colorectal cancer: future perspectives for personalized therapy.

Gastroenterology Report
ZN Li, L Zhao, LF Yu, MJ Wei
Publication Date: 2020-06

Variant appearance in text: KRAS: G12D
PMID: 32665851
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Molecular Mechanisms and Potential Therapeutic Reversal of Pancreatic Cancer-Induced Immune Evasion.

Cancers
LL Gan, LW Hii, SF Wong, CO Leong, CW Mai
Publication Date: 2020-07-11

Variant appearance in text: KRAS: G12D
PMID: 32664564
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Personalised mapping of tumour development in synchronous colorectal cancer patients.

Npj Genomic Medicine
V Thomas, MB Cotter, M Tosetto, YL Khaw, R Geraghty, DC Winter, EJ Ryan, K Sheahan, SJ Furney
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32655884
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A Novel E2F1-EP300-VMP1 Pathway Mediates Gemcitabine-Induced Autophagy in Pancreatic Cancer Cells Carrying Oncogenic KRAS.

Frontiers In Endocrinology
A Ropolo, C Catrinacio, FJ Renna, V Boggio, T Orquera, CD Gonzalez, MI Vaccaro
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32655498
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Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer.

Cancers
M Porru, P Zizza, N Panera, A Alisi, A Biroccio, C Leonetti
Publication Date: 2020-07-08

Variant appearance in text: KRAS: G12D
PMID: 32650388
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Genomic characterization of Chinese ovarian clear cell carcinoma identifies driver genes by whole exome sequencing.

Neoplasia (New York, N.Y.)
Q Yang, C Zhang, Y Ren, H Yi, T Luo, F Xing, X Bai, L Cui, L Zhu, J Ouyang, P Jiang, W Fan, J Qiu, F Wang, X Xing, Z Zhang, X Zhang, R Zhang
Publication Date: 2020-07-07

Variant appearance in text: KRAS: G12D
PMID: 32650224
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Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma.

Communications Biology
AL Peille, V Vuaroqueaux, SS Wong, J Ting, K Klinger, B Zeitouni, M Landesfeind, WH Kim, HJ Lee, SH Kong, I Wulur, S Bray, P Bronsert, N Zanella, G Donoho, HK Yang, HH Fiebig, C Reinhard, A Aggarwal
Publication Date: 2020-07-09

Variant appearance in text: KRAS: G12D
PMID: 32647357
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Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer.

Journal Of Thoracic Disease
B Gini, N Thomas, CM Blakely
Publication Date: 2020-05

Variant appearance in text: KRAS: G12D
PMID: 32642201
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Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma.

Molecules And Cells
S Kim, J Kim, Y Jung, Y Jun, Y Jung, HY Lee, J Keum, BJ Park, J Lee, J Kim, S Lee, J Kim
Publication Date: 2020-07-08

Variant appearance in text: KRAS: G12D
PMID: 32638704
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Mutation profile of primary subungual melanomas in Caucasians.

Oncotarget
A Borkowska, A Szumera-Ciećkiewicz, M Spałek, P Teterycz, A Czarnecka, A Kowalik, P Rutkowski
Publication Date: 2020-06-23

Variant appearance in text: KRAS: 35G>A; G12D
PMID: 32637031
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The role of mucin cell-free DNA detection as a new marker for the study of acellular pseudomyxoma peritonei of appendicular origin by liquid biopsy.

Therapeutic Advances In Medical Oncology
D García-Olmo, S Olmedillas-López, D Cortés-Guiral, P Villarejo, I López Rojo, H Guadalajara, S García Gómez-Heras, M García-Arranz
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32636940
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Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition.

Scientific Reports
A Brannon, D Drouillard, N Steele, S Schoettle, EV Abel, HC Crawford, M Pasca di Magliano
Publication Date: 2020-07-07

Variant appearance in text: KRAS: G12D
PMID: 32636409
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Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer?

International Journal Of Molecular Sciences
C Huart, JW Chen, B Le Calvé, C Michiels, AC Wéra
Publication Date: 2020-07-04

Variant appearance in text: KRAS: G12D
PMID: 32635552
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Interleukin-1β and Cancer.

Cancers
C Rébé, F Ghiringhelli
Publication Date: 2020-07-04

Variant appearance in text: KRAS: G12D
PMID: 32635472
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T-Cell Gene Therapy in Cancer Immunotherapy: Why It Is No Longer Just CARs on The Road.

Cells
MD Crowther, IM Svane, Ö Met
Publication Date: 2020-06-30

Variant appearance in text: KRAS: G12D
PMID: 32630096
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KRAS, NRAS, and BRAF mutation prevalence, clinicopathological association, and their application in a predictive model in Mexican patients with metastatic colorectal cancer: A retrospective cohort study.

Plos One
HE Sanchez-Ibarra, X Jiang, EY Gallegos-Gonzalez, AC Cavazos-González, Y Chen, F Morcos, HA Barrera-Saldaña
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32628708
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Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy.

Frontiers In Pharmacology
E De Mattia, R Roncato, E Palazzari, G Toffoli, E Cecchin
Publication Date: 2020

Variant appearance in text: KRAS: Gly12Asp
PMID: 32625092
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High-level gain of mesenchymal-epithelial transition factor (MET) copy number using next-generation sequencing as a predictive biomarker for MET inhibitor efficacy.

Annals Of Translational Medicine
S Wu, G Li, X Zhao, J Xiang, A Lizaso, J Ye, C Shi, L Chen
Publication Date: 2020-06

Variant appearance in text: KRAS: G12D
PMID: 32617305
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Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis.

Plos One
Y Uesato, N Sasahira, M Ozaka, T Sasaki, M Takatsuki, H Zembutsu
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32614932
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Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology.

Jci Insight
Z Dantes, HY Yen, N Pfarr, C Winter, K Steiger, A Muckenhuber, A Hennig, S Lange, T Engleitner, R Öllinger, R Maresch, F Orben, I Heid, GA Kaissis, K Shi, GJ Topping, F Stögbauer, M Wirth, K Peschke, A Papargyriou, M Rezaee-Oghazi, K Feldmann, APG Schäfer, R Ranjan, C Lubeseder-Martellato, DE Stange, T Welsch, ME Martignoni, GO Ceyhan, H Friess, A Herner, L Liotta, M Treiber, G von Figura, M Abdelhafez, P Klare, C Schlag, H Algül, JT Siveke, RF Braren, G Weirich, W Weichert, D Saur, R Rad, R Schmid, G Schneider, M Reichert
Publication Date: 2020-07-02

Variant appearance in text: KRAS: G12D
PMID: 32614802
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Transgenic T-cell receptor immunotherapy for cancer: building on clinical success.

Therapeutic Advances In Vaccines And Immunotherapy
N Oppermans, G Kueberuwa, RE Hawkins, JS Bridgeman
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32613155
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Clinical characteristics and prognostic value of the KRAS G12C mutation in Chinese non-small cell lung cancer patients.

Biomarker Research
SY Liu, H Sun, JY Zhou, GL Jie, Z Xie, Y Shao, X Zhang, JY Ye, CX Chen, XC Zhang, Q Zhou, JJ Yang, YL Wu
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32607238
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In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines.

Drug Design, Development And Therapy
H Dokduang, W Jamnongkarn, B Promraksa, M Suksawat, S Padthaisong, M Thanee, J Phetcharaburanin, N Namwat, S Sangkhamanon, A Titapun, N Khuntikeo, P Klanrit, W Loilome
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32606601
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Cholangiocarcinoma 2020: the next horizon in mechanisms and management.

Nature Reviews. Gastroenterology & Hepatology
JM Banales, JJG Marin, A Lamarca, PM Rodrigues, SA Khan, LR Roberts, V Cardinale, G Carpino, JB Andersen, C Braconi, DF Calvisi, MJ Perugorria, L Fabris, L Boulter, RIR Macias, E Gaudio, D Alvaro, SA Gradilone, M Strazzabosco, M Marzioni, C Coulouarn, L Fouassier, C Raggi, P Invernizzi, JC Mertens, A Moncsek, S Rizvi, J Heimbach, BG Koerkamp, J Bruix, A Forner, J Bridgewater, JW Valle, GJ Gores
Publication Date: 2020-06-30

Variant appearance in text: KRAS: G12D
PMID: 32606456
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Immunotherapy in Myeloproliferative Diseases.

Cells
LM Braun, R Zeiser
Publication Date: 2020-06-26

Variant appearance in text: KRAS: G12D
PMID: 32604862
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Expression and prognosis analysis of DNMT family in acute myeloid leukemia.

Aging
TJ Zhang, LC Zhang, ZJ Xu, JD Zhou
Publication Date: 2020-06-26

Variant appearance in text: KRAS: G12D
PMID: 32597790
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KRAS and BRAF Concomitant Mutations in a Patient with Metastatic Colon Adenocarcinoma: An Interesting Case Report.

Case Reports In Oncology
C Cafiero, A Re, G D'Amato, PL Surico, G Surico, M Pirrelli, S Pisconti
Publication Date: 2020

Variant appearance in text: KRAS: 35G>A; G12D
PMID: 32595468
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A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS.

Nature Communications
N Bery, A Miller, T Rabbitts
Publication Date: 2020-06-26

Variant appearance in text: KRAS: G12D
PMID: 32591521
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Lung metastases share common immune features regardless of primary tumor origin.

Journal For Immunotherapy Of Cancer
S García-Mulero, MH Alonso, J Pardo, C Santos, X Sanjuan, R Salazar, V Moreno, JM Piulats, R Sanz-Pamplona
Publication Date: 2020-06

Variant appearance in text: KRAS: G12D
PMID: 32591432
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Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas harboring KRAS and BRCA mutations: case report and whole exome sequencing analysis.

Bmc Gastroenterology
G Yang, J Yin, K Ou, Q Du, W Ren, Y Jin, L Peng, L Yang
Publication Date: 2020-06-26

Variant appearance in text: KRAS: G12D
PMID: 32590950
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ZNF251 promotes the progression of lung cancer by activating ERK signaling.

Cancer Science
C Zhong, C Chen, F Yao, W Fang
Publication Date: 2020-06-26

Variant appearance in text: KRAS: G12D
PMID: 32589309
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Inactivation of APC Induces CD34 Upregulation to Promote Epithelial-Mesenchymal Transition and Cancer Stem Cell Traits in Pancreatic Cancer.

International Journal Of Molecular Sciences
MJ Hsieh, TJ Chiu, YC Lin, CC Weng, YT Weng, CC Hsiao, KH Cheng
Publication Date: 2020-06-23

Variant appearance in text: KRAS: G12D
PMID: 32586050
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Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma.

Frontiers In Oncology
J Chen, L Zhou, J Gao, T Lu, J Wang, H Wu, Z Liang
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32582557
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Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-Region Sequencing Analysis.

Frontiers In Oncology
S Tachibana, Y Mizukami, Y Ono, Y Sugiyama, T Okada, A Kitazaki, J Sasajima, M Tominaga, J Sakamoto, K Kimura, Y Omori, T Furukawa, T Kimura, S Tanaka, K Nagashima, H Karasaki, T Ohta, T Okumura
Publication Date: 2020

Variant appearance in text: KRAS: G12D
PMID: 32582528
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High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.

Cell Communication And Signaling : Ccs
A Tsutaho, A Hashimoto, S Hashimoto, S Hata, S Kachi, S Hirano, H Sabe
Publication Date: 2020-06-24

Variant appearance in text: KRAS: G12D
PMID: 32580737
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Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.

Cell Reports
T Kamata, TY So, Q Ahmed, S Giblett, B Patel, J Luo, R Reddel, C Pritchard
Publication Date: 2020-06-23

Variant appearance in text: KRAS: G12D
PMID: 32579928
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Reassessing the role of high dose cytarabine and mitoxantrone in relapsed/refractory acute myeloid leukemia.

Oncotarget
J Canaani, M Nagar, G Heering, C Gefen, R Yerushalmi, N Shem-Tov, Y Volchek, D Merkel, A Avigdor, A Shimoni, N Amariglio, G Rechavi, A Nagler
Publication Date: 2020-06-09

Variant appearance in text: KRAS: G12D
PMID: 32577167
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Genome-wide DNA methylation analysis of KRAS mutant cell lines.

Scientific Reports
BY Tew, JK Durand, KL Bryant, TK Hayes, S Peng, NL Tran, GC Gooden, DN Buckley, CJ Der, AS Baldwin, B Salhia
Publication Date: 2020-06-23

Variant appearance in text: KRAS: G12D
PMID: 32576853
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Application of Genetically Engineered Pigs in Biomedical Research.

Genes
M Hryhorowicz, D Lipiński, S Hryhorowicz, A Nowak-Terpiłowska, N Ryczek, J Zeyland
Publication Date: 2020-06-19

Variant appearance in text: KRAS: G12D
PMID: 32575461
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Ciliogenesis and Hedgehog signalling are supressed downstream of KRas during acinar-ductal metaplasia.

Disease Models & Mechanisms
FK Bangs, P Miller, E O'Neill
Publication Date: 2020-06-22

Variant appearance in text: KRAS: G12D
PMID: 32571902
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000256078.4 c.35G>A p.Gly12Asp missense_variant 2/6 -
ENST00000311936.3 c.35G>A p.Gly12Asp missense_variant 2/5 -
ENST00000556131.1 c.35G>A p.Gly12Asp missense_variant 2/3 -
ENST00000557334.1 c.35G>A p.Gly12Asp missense_variant 2/3 -
NM_001369786.1 c.35G>A p.Gly12Asp missense_variant 2/6 -
NM_001369787.1 c.35G>A p.Gly12Asp missense_variant 2/5 -
NM_004985.5 c.35G>A p.Gly12Asp missense_variant 2/5 -
NM_033360.4 c.35G>A p.Gly12Asp missense_variant 2/6 -